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Fusion gene ID: 21075 |
FusionGeneSummary for MARK2_GLYATL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MARK2_GLYATL2 | Fusion gene ID: 21075 | Hgene | Tgene | Gene symbol | MARK2 | GLYATL2 | Gene ID | 2011 | 219970 |
| Gene name | microtubule affinity regulating kinase 2 | glycine-N-acyltransferase like 2 | |
| Synonyms | EMK-1|EMK1|PAR-1|Par-1b|Par1b | BXMAS2-10|GATF-B | |
| Cytomap | 11q13.1 | 11q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase MARK2ELKL motif kinase 1MAP/microtubule affinity-regulating kinase 2PAR1 homolog bSer/Thr protein kinase PAR-1Bserine/threonine protein kinase EMKtesticular tissue protein Li 117 | glycine N-acyltransferase-like protein 2acyl-CoA:glycine N-acyltransferase-like protein 2glycine acyltransferase family-B | |
| Modification date | 20180523 | 20180402 | |
| UniProtAcc | Q7KZI7 | Q8WU03 | |
| Ensembl transtripts involved in fusion gene | ENST00000377809, ENST00000402010, ENST00000413835, ENST00000377810, ENST00000315032, ENST00000508192, ENST00000361128, ENST00000350490, ENST00000502399, ENST00000509502, ENST00000513765, ENST00000408948, ENST00000425897, | ENST00000287275, ENST00000532258, ENST00000533636, | |
| Fusion gene scores | * DoF score | 11 X 7 X 11=847 | 5 X 3 X 5=75 |
| # samples | 18 | 6 | |
| ** MAII score | log2(18/847*10)=-2.23436506300252 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MARK2 [Title/Abstract] AND GLYATL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MARK2 | GO:0006468 | protein phosphorylation | 14976552 |
| Hgene | MARK2 | GO:0010976 | positive regulation of neuron projection development | 12429843 |
| Hgene | MARK2 | GO:0018105 | peptidyl-serine phosphorylation | 10542369 |
| Hgene | MARK2 | GO:0030010 | establishment of cell polarity | 12429843 |
| Hgene | MARK2 | GO:0035556 | intracellular signal transduction | 14976552 |
| Hgene | MARK2 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity | 15324659 |
| Hgene | MARK2 | GO:0070507 | regulation of microtubule cytoskeleton organization | 10542369 |
| Tgene | GLYATL2 | GO:0042758 | long-chain fatty acid catabolic process | 20305126 |
| Tgene | GLYATL2 | GO:0051793 | medium-chain fatty acid catabolic process | 20305126 |
| Tgene | GLYATL2 | GO:1903965 | monounsaturated fatty acid catabolic process | 20305126 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-A2-A1G4-01A | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000377809 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000377809 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-intron | ENST00000377809 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000402010 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000402010 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-intron | ENST00000402010 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000413835 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000413835 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-intron | ENST00000413835 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5UTR-5UTR | ENST00000377810 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5UTR-5UTR | ENST00000377810 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5UTR-intron | ENST00000377810 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000315032 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000315032 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-intron | ENST00000315032 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000508192 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000508192 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-intron | ENST00000508192 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000361128 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000361128 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-intron | ENST00000361128 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000350490 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000350490 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-intron | ENST00000350490 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000502399 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-5UTR | ENST00000502399 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| 5CDS-intron | ENST00000502399 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-5UTR | ENST00000509502 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-5UTR | ENST00000509502 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-intron | ENST00000509502 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-5UTR | ENST00000513765 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-5UTR | ENST00000513765 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-intron | ENST00000513765 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-5UTR | ENST00000408948 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-5UTR | ENST00000408948 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-intron | ENST00000408948 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-5UTR | ENST00000425897 | ENST00000287275 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-5UTR | ENST00000425897 | ENST00000532258 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
| intron-intron | ENST00000425897 | ENST00000533636 | MARK2 | chr11 | 63607032 | + | GLYATL2 | chr11 | 58611997 | - |
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FusionProtFeatures for MARK2_GLYATL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MARK2 | GLYATL2 |
| Serine/threonine-protein kinase (PubMed:23666762).Involved in cell polarity and microtubule dynamics regulation.Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 andRAB11FIP2. Phosphorylates the microtubule-associated proteinMAPT/TAU (PubMed:23666762). Plays a key role in cell polarity byphosphorylating the microtubule-associated proteins MAP2, MAP4 andMAPT/TAU at KXGS motifs, causing detachment from microtubules, andtheir disassembly. Regulates epithelial cell polarity byphosphorylating RAB11FIP2. Involved in the regulation of neuronalmigration through its dual activities in regulating cellularpolarity and microtubule dynamics, possibly by phosphorylating andregulating DCX. Regulates axogenesis by phosphorylating KIF13B,promoting interaction between KIF13B and 14-3-3 and inhibitingmicrotubule-dependent accumulation of KIF13B. Also required forneurite outgrowth and establishment of neuronal polarity.Regulates localization and activity of some histone deacetylasesby mediating phosphorylation of HDAC7, promoting subsequentinteraction between HDAC7 and 14-3-3 and export from the nucleus.Also acts as a positive regulator of the Wnt signaling pathway,probably by mediating phosphorylation of dishevelled proteins(DVL1, DVL2 and/or DVL3). Modulates the developmental decision tobuild a columnar versus a hepatic epithelial cell apparently bypromoting a switch from a direct to a transcytotic mode of apicalprotein delivery. Essential for the asymmetric development ofmembrane domains of polarized epithelial cells.{ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843,ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914,ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179,ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613,ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617,ECO:0000269|PubMed:23666762}. | Mitochondrial acyltransferase which transfers the acylgroup to the N-terminus of glycine. Conjugates numeroussubstrates, such as arachidonoyl-CoA and saturated medium andlong-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference formonounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyldonor. Does not exhibit any activity toward C22:6-CoA andchenodeoxycholoyl-CoA, nor toward serine or alanine.{ECO:0000269|PubMed:20305126}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MARK2_GLYATL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MARK2_GLYATL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MARK2 | YWHAG, YWHAQ, MAP3K3, SFN, AKT1, DTNA, USP21, FUCA1, KIF5B, MARK1, MARK3, PRKCI, SNTB2, UTRN, YWHAH, ARHGEF2, GPRASP1, COL4A3BP, C11orf58, CLASP2, PMPCA, PHLPP1, MTCL1, KIF13B, UTP18, MARK4, CEP85L, HDAC7, TADA2A, PRKAA1, NEDD4, PARD6A, YWHAZ, PARD6G, MARK2, NEDD4L, STK11, YWHAE, RAB11FIP2, PPP2R4, YWHAB, DMD, RHOA, PINK1, PRKCE, PKD1, VCP, GAB1, GAB2, PARD3, RNF41, CAMK1, AURKB, CDKN1A, CEP57, MAPT, BAIAP2, CCDC8, NAP1L5, CDK15, HNRNPA1, NTRK1, CEP89, DCTN1, TMEM17, CAPZA1, CAPZA2, CAPZB, AP2M1, APC, LDHD, PPP2R1A, PPP2R5E, HERC2, DLG5, WDR46, PDCD7, PRDX3, NUPL2, CAMSAP2, CLASP1, RSF1, CCDC82, SOGA1, FBXL16, FRYL, CDC5L, SMURF1, CDH1, TMCC2, NRROS, NUAK2, SIX2, MANSC1, CDH19, CAV3, CBY1 | GLYATL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MARK2_GLYATL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | GLYATL2 | Q8WU03 | DB00145 | Glycine | Glycine N-acyltransferase-like protein 2 | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for MARK2_GLYATL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MARK2 | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | MARK2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | MARK2 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
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