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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21035

FusionGeneSummary for MAPKAPK5_CCDC38

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPKAPK5_CCDC38
Fusion gene ID: 21035
HgeneTgene
Gene symbol

MAPKAPK5

CCDC38

Gene ID

8550

120935

Gene namemitogen-activated protein kinase-activated protein kinase 5coiled-coil domain containing 38
SynonymsMAPKAP-K5|MK-5|MK5|PRAK-
Cytomap

12q24.12-q24.13

12q23.1

Type of geneprotein-codingprotein-coding
DescriptionMAP kinase-activated protein kinase 5MAPK-activated protein kinase 5MAPKAP kinase 5MAPKAPK-5p38-regulated/activated protein kinasecoiled-coil domain-containing protein 38
Modification date2018052320180329
UniProtAcc

Q8IW41

Q502W7

Ensembl transtripts involved in fusion geneENST00000550735, ENST00000551404, 
ENST00000547305, ENST00000546394, 
ENST00000344280, ENST00000549752, 
ENST00000546386, 
Fusion gene scores* DoF score8 X 8 X 7=4482 X 2 X 2=8
# samples 122
** MAII scorelog2(12/448*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: MAPKAPK5 [Title/Abstract] AND CCDC38 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPKAPK5

GO:0006417

regulation of translation

21329882

HgeneMAPKAPK5

GO:0007265

Ras protein signal transduction

17254968

HgeneMAPKAPK5

GO:0046777

protein autophosphorylation

21329882

HgeneMAPKAPK5

GO:0090400

stress-induced premature senescence

17254968


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-3B-A9HO-01AMAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000550735ENST00000344280MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
5CDS-intronENST00000550735ENST00000549752MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
5CDS-intronENST00000550735ENST00000546386MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
In-frameENST00000551404ENST00000344280MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
5CDS-intronENST00000551404ENST00000549752MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
5CDS-intronENST00000551404ENST00000546386MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
In-frameENST00000547305ENST00000344280MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
5CDS-intronENST00000547305ENST00000549752MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
5CDS-intronENST00000547305ENST00000546386MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
3UTR-3CDSENST00000546394ENST00000344280MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
3UTR-intronENST00000546394ENST00000549752MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-
3UTR-intronENST00000546394ENST00000546386MAPKAPK5chr12

112280573

+CCDC38chr12

96266238

-

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FusionProtFeatures for MAPKAPK5_CCDC38


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPKAPK5

Q8IW41

CCDC38

Q502W7

Tumor suppressor serine/threonine-protein kinaseinvolved in mTORC1 signaling and post-transcriptional regulation.Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1,p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation ofFOXO3: phosphorylation of FOXO3 leads to promote nuclearlocalization of FOXO3, enabling expression of miR-34b and miR-34c,2 post-transcriptional regulators of MYC that bind to the 3'UTR ofMYC transcript and prevent MYC translation. Acts as a negativeregulator of mTORC1 signaling by mediating phosphorylation andinhibition of RHEB. Part of the atypical MAPK signaling via itsinteraction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of thecomplex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, butthe complex follows a complex set of phosphorylation events: uponinteraction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4),ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediatesphosphorylation and activation of MAPKAPK5, which in turnphosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediatesphosphorylation of HSP27/HSPB1 in response to PKA/PRKACAstimulation, inducing F-actin rearrangement.{ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103,ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882,ECO:0000269|PubMed:9628874}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC38chr12:112280573chr12:96266238ENST00000344280-1216497_522426564Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAPKAPK5chr12:112280573chr12:96266238ENST00000550735+114409_44012472Coiled coilOntology_term=ECO:0000255
HgeneMAPKAPK5chr12:112280573chr12:96266238ENST00000551404+114409_44012474Coiled coilOntology_term=ECO:0000255
HgeneMAPKAPK5chr12:112280573chr12:96266238ENST00000550735+11422_30412472DomainProtein kinase
HgeneMAPKAPK5chr12:112280573chr12:96266238ENST00000551404+11422_30412474DomainProtein kinase
HgeneMAPKAPK5chr12:112280573chr12:96266238ENST00000550735+11428_3612472Nucleotide bindingATP
HgeneMAPKAPK5chr12:112280573chr12:96266238ENST00000551404+11428_3612474Nucleotide bindingATP
TgeneCCDC38chr12:112280573chr12:96266238ENST00000344280-1216129_212426564Coiled coilOntology_term=ECO:0000255
TgeneCCDC38chr12:112280573chr12:96266238ENST00000344280-1216384_415426564Coiled coilOntology_term=ECO:0000255


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FusionGeneSequence for MAPKAPK5_CCDC38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MAPKAPK5_ENST00000550735_chr12_112280573_+_CCDC38_ENST00000344280_chr12_96266238_-_150aa
MSEESDMDKAIKEILIDSLSKKITQVYKVCIGDAEDDGLNPIQKLVKVESRLVELCDLIESIPKENVEAIERMKQKEWRQKFRDEKMKEK

>In-frame_MAPKAPK5_ENST00000551404_chr12_112280573_+_CCDC38_ENST00000344280_chr12_96266238_-_150aa
MSEESDMDKAIKEILIDSLSKKITQVYKVCIGDAEDDGLNPIQKLVKVESRLVELCDLIESIPKENVEAIERMKQKEWRQKFRDEKMKEK

>In-frame_MAPKAPK5_ENST00000547305_chr12_112280573_+_CCDC38_ENST00000344280_chr12_96266238_-_150aa
MSEESDMDKAIKEILIDSLSKKITQVYKVCIGDAEDDGLNPIQKLVKVESRLVELCDLIESIPKENVEAIERMKQKEWRQKFRDEKMKEK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MAPKAPK5_ENST00000550735_chr12_112280573_+_CCDC38_ENST00000344280_chr12_96266238_-_450nt
ATGTCGGAGGAGAGCGACATGGACAAAGCCATCAAGGAAATACTGATAGACTCACTTAGTAAAAAGATTACTCAAGTATACAAAGTCTGC
ATTGGAGATGCTGAGGATGACGGCCTCAACCCAATTCAAAAGCTGGTAAAAGTAGAATCTCGCCTGGTAGAACTGTGTGACCTCATCGAA
TCCATTCCCAAAGAAAATGTGGAGGCAATTGAGAGGATGAAACAGAAAGAATGGCGGCAAAAGTTTCGTGATGAGAAAATGAAAGAAAAA
CAAAGACACCAACAGGAAAGGCTAAAAGCTGCTCTGGAAAAAGCAGTAGCACAACCAAAGAAAAAGTTGGGAAGACGACTTGTCTTTCAT
TCAAAACCTCCATCTGGTAACAAACAGCAGCTACCTTTAGTCAATGAAACAAAAACAAAATCACAAGAGGAAGAATATTTTTTTACTTGA

>In-frame_MAPKAPK5_ENST00000551404_chr12_112280573_+_CCDC38_ENST00000344280_chr12_96266238_-_450nt
ATGTCGGAGGAGAGCGACATGGACAAAGCCATCAAGGAAATACTGATAGACTCACTTAGTAAAAAGATTACTCAAGTATACAAAGTCTGC
ATTGGAGATGCTGAGGATGACGGCCTCAACCCAATTCAAAAGCTGGTAAAAGTAGAATCTCGCCTGGTAGAACTGTGTGACCTCATCGAA
TCCATTCCCAAAGAAAATGTGGAGGCAATTGAGAGGATGAAACAGAAAGAATGGCGGCAAAAGTTTCGTGATGAGAAAATGAAAGAAAAA
CAAAGACACCAACAGGAAAGGCTAAAAGCTGCTCTGGAAAAAGCAGTAGCACAACCAAAGAAAAAGTTGGGAAGACGACTTGTCTTTCAT
TCAAAACCTCCATCTGGTAACAAACAGCAGCTACCTTTAGTCAATGAAACAAAAACAAAATCACAAGAGGAAGAATATTTTTTTACTTGA

>In-frame_MAPKAPK5_ENST00000547305_chr12_112280573_+_CCDC38_ENST00000344280_chr12_96266238_-_450nt
ATGTCGGAGGAGAGCGACATGGACAAAGCCATCAAGGAAATACTGATAGACTCACTTAGTAAAAAGATTACTCAAGTATACAAAGTCTGC
ATTGGAGATGCTGAGGATGACGGCCTCAACCCAATTCAAAAGCTGGTAAAAGTAGAATCTCGCCTGGTAGAACTGTGTGACCTCATCGAA
TCCATTCCCAAAGAAAATGTGGAGGCAATTGAGAGGATGAAACAGAAAGAATGGCGGCAAAAGTTTCGTGATGAGAAAATGAAAGAAAAA
CAAAGACACCAACAGGAAAGGCTAAAAGCTGCTCTGGAAAAAGCAGTAGCACAACCAAAGAAAAAGTTGGGAAGACGACTTGTCTTTCAT
TCAAAACCTCCATCTGGTAACAAACAGCAGCTACCTTTAGTCAATGAAACAAAAACAAAATCACAAGAGGAAGAATATTTTTTTACTTGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MAPKAPK5_ENST00000550735_chr12_112280573_+_CCDC38_ENST00000344280_chr12_96266238_-_1233nt
ATTAGCGCAGCGCCATCGCCGCGGAAGGCCCAGGGGCCTGTCCTGTATGCGGCGTGTCTTAGGGAGGCCCAGGCGGACGCCTGCAAGTCG
GGTGCGCGGTTCGGGGGCGGCTCGGAAACCCCAGCGGAAGGCAGCAAGGGGCGCGTGGGGCCGTGGAGTCACGAAGCTGGGCGGCAGGAG
GGGCGGCCTGGAGCTCCCGCGGGGCACAGCGCGTGCGTGAGGGCGGCCGGCGGGGCTGCCCGGCGCGGGTGTCCCGGCGATGTGTGGCGC
TGAGGCGGCGGCGGGAGCAGCGGCGCCGAGCTCTGCTTCGGCTTCGGCTTCGGCTTCGCGGCGGTGCAGGCGGCGGAGGCGGAGGCGCAG
GCTCTTCTTTAGGACCTGGCGAGCCCAGGTCTAAGCGGCGGCCCCGCGAGGCCCTTGCACGGCGCCCCGGGTCGAGGCCCTCCCCGCCTC
GCCCTACCCCAGGAGCCTGCCTCCCCAGCTGGGGATGAGGCTAGGAGGCGGCCGCGTGGGGCCCAGCACAAAGACCTGTCCCCAGGGGCC
GCCGCCTCCGCCGCTGCTGCTGCCGCCAGCCTAGAGCCGCCCGCCGAAGCAGAGCCGGCGCCGGGGTCCTCATCCCCACCGGTCCCGAGG
GGCGGCTGCTGCCCGTCGCCACGAGGCCCAGGGGCCCGAGTGCCGAGCCCTTTGCTCCCTCGGCCGCGCGGGGACAGGGCTGCTGAGCAG
CCTCCGCCTCTCCCGGCTGTGGGGGCCCCACTGAGTATGTCGGAGGAGAGCGACATGGACAAAGCCATCAAGGAAATACTGATAGACTCA
CTTAGTAAAAAGATTACTCAAGTATACAAAGTCTGCATTGGAGATGCTGAGGATGACGGCCTCAACCCAATTCAAAAGCTGGTAAAAGTA
GAATCTCGCCTGGTAGAACTGTGTGACCTCATCGAATCCATTCCCAAAGAAAATGTGGAGGCAATTGAGAGGATGAAACAGAAAGAATGG
CGGCAAAAGTTTCGTGATGAGAAAATGAAAGAAAAACAAAGACACCAACAGGAAAGGCTAAAAGCTGCTCTGGAAAAAGCAGTAGCACAA
CCAAAGAAAAAGTTGGGAAGACGACTTGTCTTTCATTCAAAACCTCCATCTGGTAACAAACAGCAGCTACCTTTAGTCAATGAAACAAAA

>In-frame_MAPKAPK5_ENST00000551404_chr12_112280573_+_CCDC38_ENST00000344280_chr12_96266238_-_585nt
CCACGAGGCCCAGGGGCCCGAGTGCCGAGCCCTTTGCTCCCTCGGCCGCGCGGGGACAGGGCTGCTGAGCAGCCTCCGCCTCTCCCGGCT
GTGGGGGCCCCACTGAGTATGTCGGAGGAGAGCGACATGGACAAAGCCATCAAGGAAATACTGATAGACTCACTTAGTAAAAAGATTACT
CAAGTATACAAAGTCTGCATTGGAGATGCTGAGGATGACGGCCTCAACCCAATTCAAAAGCTGGTAAAAGTAGAATCTCGCCTGGTAGAA
CTGTGTGACCTCATCGAATCCATTCCCAAAGAAAATGTGGAGGCAATTGAGAGGATGAAACAGAAAGAATGGCGGCAAAAGTTTCGTGAT
GAGAAAATGAAAGAAAAACAAAGACACCAACAGGAAAGGCTAAAAGCTGCTCTGGAAAAAGCAGTAGCACAACCAAAGAAAAAGTTGGGA
AGACGACTTGTCTTTCATTCAAAACCTCCATCTGGTAACAAACAGCAGCTACCTTTAGTCAATGAAACAAAAACAAAATCACAAGAGGAA

>In-frame_MAPKAPK5_ENST00000547305_chr12_112280573_+_CCDC38_ENST00000344280_chr12_96266238_-_736nt
GCGGCCGCGTGGGGCCCAGCACAAAGACCTGTCCCCAGGGGCCGCCGCCTCCGCCGCTGCTGCTGCCGCCAGCCTAGAGCCGCCCGCCGA
AGCAGAGCCGGCGCCGGGGTCCTCATCCCCACCGGTCCCGAGGGGCGGCTGCTGCCCGTCGCCACGAGGCCCAGGGGCCCGAGTGCCGAG
CCCTTTGCTCCCTCGGCCGCGCGGGGACAGGGCTGCTGAGCAGCCTCCGCCTCTCCCGGCTGTGGGGGCCCCACTGAGTATGTCGGAGGA
GAGCGACATGGACAAAGCCATCAAGGAAATACTGATAGACTCACTTAGTAAAAAGATTACTCAAGTATACAAAGTCTGCATTGGAGATGC
TGAGGATGACGGCCTCAACCCAATTCAAAAGCTGGTAAAAGTAGAATCTCGCCTGGTAGAACTGTGTGACCTCATCGAATCCATTCCCAA
AGAAAATGTGGAGGCAATTGAGAGGATGAAACAGAAAGAATGGCGGCAAAAGTTTCGTGATGAGAAAATGAAAGAAAAACAAAGACACCA
ACAGGAAAGGCTAAAAGCTGCTCTGGAAAAAGCAGTAGCACAACCAAAGAAAAAGTTGGGAAGACGACTTGTCTTTCATTCAAAACCTCC
ATCTGGTAACAAACAGCAGCTACCTTTAGTCAATGAAACAAAAACAAAATCACAAGAGGAAGAATATTTTTTTACTTGAATAAAAGCAGT


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FusionGenePPI for MAPKAPK5_CCDC38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAPKAPK5HSPB1, HSPB2, MAPK6, MAPK14, RPL13, ZNF282, TAB1, MAPK4, MAPKAPK2, LSR, CDCA8, ZNF576, SRPK2, SRPK1, TP53, MAPK9, MAPK1, EIF4EBP1, MAPKAPK5CCDC38


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPKAPK5_CCDC38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAPKAPK5_CCDC38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource