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Fusion gene ID: 21032 |
FusionGeneSummary for MAPKAPK3_HEMK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPKAPK3_HEMK1 | Fusion gene ID: 21032 | Hgene | Tgene | Gene symbol | MAPKAPK3 | HEMK1 | Gene ID | 7867 | 51409 |
| Gene name | mitogen-activated protein kinase-activated protein kinase 3 | HemK methyltransferase family member 1 | |
| Synonyms | 3PK|MAPKAP-K3|MAPKAP3|MAPKAPK-3|MDPT3|MK-3 | HEMK|MTQ1 | |
| Cytomap | 3p21.2 | 3p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | MAP kinase-activated protein kinase 3MAPK-activated protein kinase 3MAPKAP kinase 3chromosome 3p kinase | hemK methyltransferase family member 1HEMK homolog 7kbm.HsaHemKPtestis secretory sperm-binding protein Li 225n | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q16644 | Q9Y5R4 | |
| Ensembl transtripts involved in fusion gene | ENST00000446044, ENST00000497283, ENST00000357955, | ENST00000434410, ENST00000232854, ENST00000455834, | |
| Fusion gene scores | * DoF score | 2 X 1 X 3=6 | 2 X 2 X 3=12 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/6*10)=2.32192809488736 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAPKAPK3 [Title/Abstract] AND HEMK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAPKAPK3 | GO:0018105 | peptidyl-serine phosphorylation | 15850461 |
| Hgene | MAPKAPK3 | GO:0034097 | response to cytokine | 8774846 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-2Y-A9H0-01A | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
| TCGA | RV | LUAD | TCGA-05-4405-01A | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000446044 | ENST00000434410 | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
| In-frame | ENST00000446044 | ENST00000232854 | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
| In-frame | ENST00000446044 | ENST00000455834 | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
| intron-3CDS | ENST00000497283 | ENST00000434410 | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
| intron-3CDS | ENST00000497283 | ENST00000232854 | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
| intron-3CDS | ENST00000497283 | ENST00000455834 | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
| In-frame | ENST00000357955 | ENST00000434410 | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
| In-frame | ENST00000357955 | ENST00000232854 | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
| In-frame | ENST00000357955 | ENST00000455834 | MAPKAPK3 | chr3 | 50655215 | + | HEMK1 | chr3 | 50609141 | + |
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FusionProtFeatures for MAPKAPK3_HEMK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPKAPK3 | HEMK1 |
| Stress-activated serine/threonine-protein kinaseinvolved in cytokines production, endocytosis, cell migration,chromatin remodeling and transcriptional regulation. Followingstress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates.Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S,where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3,share the same function and substrate specificity, but MAPKAPK3kinase activity and level in protein expression are lower comparedto MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1,RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation ofHSP27/HSPB1 in response to stress, leading to dissociateHSP27/HSPB1 from large small heat-shock protein (sHsps) oligomersand impair their chaperone activities and ability to protectagainst oxidative stress effectively. Involved in inflammatoryresponse by regulating tumor necrosis factor (TNF) and IL6production post-transcriptionally: acts by phosphorylating AU-richelements (AREs)-binding proteins, such as TTP/ZFP36, leading toregulate the stability and translation of TNF and IL6 mRNAs.Phosphorylation of TTP/ZFP36, a major post-transcriptionalregulator of TNF, promotes its binding to 14-3-3 proteins andreduces its ARE mRNA affinity leading to inhibition of dependentdegradation of ARE-containing transcript. Involved in toll-likereceptor signaling pathway (TLR) in dendritic cells: required foracute TLR-induced macropinocytosis by phosphorylating andactivating RPS6KA3. Also acts as a modulator of Polycomb-mediatedrepression. {ECO:0000269|PubMed:10383393,ECO:0000269|PubMed:15563468, ECO:0000269|PubMed:18021073,ECO:0000269|PubMed:20599781, ECO:0000269|PubMed:8626550,ECO:0000269|PubMed:8774846}. | N5-glutamine methyltransferase responsible for themethylation of the GGQ triplet of the mitochondrial translationrelease factor MTRF1L. {ECO:0000269|PubMed:18541145}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000357955 | + | 2 | 11 | 50_58 | 73 | 383 | Nucleotide binding | ATP |
| Hgene | MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000446044 | + | 4 | 13 | 50_58 | 73 | 383 | Nucleotide binding | ATP |
| Tgene | >HEMK1 | chr3:50655215 | chr3:50609141 | ENST00000232854 | + | 1 | 11 | 167_171 | 76 | 339 | Region | S-adenosyl-L-methionine binding |
| Tgene | >HEMK1 | chr3:50655215 | chr3:50609141 | ENST00000232854 | + | 1 | 11 | 239_242 | 76 | 339 | Region | Substrate binding |
| Tgene | >HEMK1 | chr3:50655215 | chr3:50609141 | ENST00000434410 | + | 1 | 11 | 167_171 | 76 | 339 | Region | S-adenosyl-L-methionine binding |
| Tgene | >HEMK1 | chr3:50655215 | chr3:50609141 | ENST00000434410 | + | 1 | 11 | 239_242 | 76 | 339 | Region | Substrate binding |
| Tgene | >HEMK1 | chr3:50655215 | chr3:50609141 | ENST00000455834 | + | 1 | 11 | 167_171 | 76 | 339 | Region | S-adenosyl-L-methionine binding |
| Tgene | >HEMK1 | chr3:50655215 | chr3:50609141 | ENST00000455834 | + | 1 | 11 | 239_242 | 76 | 339 | Region | Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000357955 | + | 2 | 11 | 44_304 | 73 | 383 | Domain | Protein kinase |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000446044 | + | 4 | 13 | 44_304 | 73 | 383 | Domain | Protein kinase |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000357955 | + | 2 | 11 | 335_344 | 73 | 383 | Motif | Nuclear export signal (NES) |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000357955 | + | 2 | 11 | 350_353 | 73 | 383 | Motif | Bipartite nuclear localization signal 1 |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000357955 | + | 2 | 11 | 364_368 | 73 | 383 | Motif | Bipartite nuclear localization signal 2 |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000446044 | + | 4 | 13 | 335_344 | 73 | 383 | Motif | Nuclear export signal (NES) |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000446044 | + | 4 | 13 | 350_353 | 73 | 383 | Motif | Bipartite nuclear localization signal 1 |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000446044 | + | 4 | 13 | 364_368 | 73 | 383 | Motif | Bipartite nuclear localization signal 2 |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000357955 | + | 2 | 11 | 307_343 | 73 | 383 | Region | Autoinhibitory helix |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000357955 | + | 2 | 11 | 345_369 | 73 | 383 | Region | p38 MAPK-binding site |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000446044 | + | 4 | 13 | 307_343 | 73 | 383 | Region | Autoinhibitory helix |
| Hgene | >MAPKAPK3 | chr3:50655215 | chr3:50609141 | ENST00000446044 | + | 4 | 13 | 345_369 | 73 | 383 | Region | p38 MAPK-binding site |
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FusionGeneSequence for MAPKAPK3_HEMK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAPKAPK3_HEMK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAPKAPK3 | MAPK14, TCF3, NEDD4, RAB2A, SUMO3, COPS6, SMS, EZH2, IGHM, NEDD4L, PHC2, BMI1, RNF2, APP, HSPB1, MAPK11, PRKY, SRPK2, MAPK13, MEF2A, ATF1, PRKRIR, RCSD1, BECN1, PTPDC1, PTPN5, PTPN7, PTPRR | HEMK1 | CHN1, CDC23, MTRF1L, NDUFS7, TMCO3, TRMT1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAPKAPK3_HEMK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAPKAPK3_HEMK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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