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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21017

FusionGeneSummary for MAPK8_PARG

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK8_PARG
Fusion gene ID: 21017
HgeneTgene
Gene symbol

MAPK8

PARG

Gene ID

5599

8505

Gene namemitogen-activated protein kinase 8poly(ADP-ribose) glycohydrolase
SynonymsJNK|JNK-46|JNK1|JNK1A2|JNK21B1/2|PRKM8|SAPK1|SAPK1cPARG99
Cytomap

10q11.22

10q11.23

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 8JUN N-terminal kinaseMAP kinase 8c-Jun N-terminal kinase 1mitogen-activated protein kinase 8 isoform JNK1 alpha1mitogen-activated protein kinase 8 isoform JNK1 beta2stress-activated protein kinase 1stress-activatedpoly(ADP-ribose) glycohydrolasemitochondrial poly(ADP-ribose) glycohydrolasepoly(ADP-ribose) glycohydrolase 60 kDa isoform
Modification date2018052720180523
UniProtAcc

P45983

Q86W56

Ensembl transtripts involved in fusion geneENST00000374189, ENST00000374182, 
ENST00000360332, ENST00000374174, 
ENST00000395611, ENST00000459755, 
ENST00000402038, ENST00000492350, 
Fusion gene scores* DoF score4 X 3 X 4=487 X 6 X 4=168
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPK8 [Title/Abstract] AND PARG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPK8

GO:0006468

protein phosphorylation

21856198

HgeneMAPK8

GO:0007254

JNK cascade

8654373

HgeneMAPK8

GO:0007258

JUN phosphorylation

14967141|21095239

HgeneMAPK8

GO:0009411

response to UV

14967141

HgeneMAPK8

GO:0018105

peptidyl-serine phosphorylation

15850461|20027304|21095239

HgeneMAPK8

GO:0018107

peptidyl-threonine phosphorylation

21095239

HgeneMAPK8

GO:0032091

negative regulation of protein binding

21095239

HgeneMAPK8

GO:0032880

regulation of protein localization

20027304

HgeneMAPK8

GO:0034198

cellular response to amino acid starvation

11096076

HgeneMAPK8

GO:0043066

negative regulation of apoptotic process

14967141|21095239

HgeneMAPK8

GO:0051403

stress-activated MAPK cascade

11096076

HgeneMAPK8

GO:0071222

cellular response to lipopolysaccharide

23776175

TgenePARG

GO:1990966

ATP generation from poly-ADP-D-ribose

27257257


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-39-5027-01AMAPK8chr10

49514864

+PARGchr10

51093341

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000374189ENST00000402038MAPK8chr10

49514864

+PARGchr10

51093341

-
5UTR-intronENST00000374189ENST00000492350MAPK8chr10

49514864

+PARGchr10

51093341

-
intron-3CDSENST00000374182ENST00000402038MAPK8chr10

49514864

+PARGchr10

51093341

-
intron-intronENST00000374182ENST00000492350MAPK8chr10

49514864

+PARGchr10

51093341

-
intron-3CDSENST00000360332ENST00000402038MAPK8chr10

49514864

+PARGchr10

51093341

-
intron-intronENST00000360332ENST00000492350MAPK8chr10

49514864

+PARGchr10

51093341

-
intron-3CDSENST00000374174ENST00000402038MAPK8chr10

49514864

+PARGchr10

51093341

-
intron-intronENST00000374174ENST00000492350MAPK8chr10

49514864

+PARGchr10

51093341

-
intron-3CDSENST00000395611ENST00000402038MAPK8chr10

49514864

+PARGchr10

51093341

-
intron-intronENST00000395611ENST00000492350MAPK8chr10

49514864

+PARGchr10

51093341

-
intron-3CDSENST00000459755ENST00000402038MAPK8chr10

49514864

+PARGchr10

51093341

-
intron-intronENST00000459755ENST00000492350MAPK8chr10

49514864

+PARGchr10

51093341

-

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FusionProtFeatures for MAPK8_PARG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK8

P45983

PARG

Q86W56


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAPK8_PARG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPK8_PARG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAPK8IRS1, DUSP10, TNFRSF10B, FADD, FASLG, BID, EZR, RHOA, ARHGDIA, FAS, MSN, CASP10, CASP8, TNFRSF1A, JUN, SPIB, SPI1, SH3BP5, MAP3K1, IKBKAP, PRKD1, ATF2, SPAG9, MAP2K4, CRK, BCAR1, SNCG, SNCA, JUND, SH2D3A, MAPK8IP1, MAPK8IP3, PAX2, PRKDC, TP53, REL, JUNB, DUSP16, ETV1, DUSP4, ELK1, DUSP1, MAP2K7, GSTP1, MYC, MAP3K2, PDPK1, NR4A1, CEBPA, CDKN1A, SIRT1, H2AFX, HDAC9, HDAC1, TFCP2, NFATC2, NFE2, PIAS2, ZNF605, DUSP8, FAM193B, BMPR2, PNRC1, HSPA8, CCDC88C, ZNF219, RBM15, SCAND1, STAT3, KRT8, NCOA3, CBL, FZR1, ITCH, RAD18, FLNB, RPTOR, MTOR, MAP3K7, TRAF2, MAP3K4, SP1, MAPK8, BCL2, MAP2K1, MAP2K2, CTNNB1, STAB2, CDKN1B, APP, HSF1, GORASP2, WDR62, DCP1A, IRF3, AIMP1, ELK4, BCL2L11, BMF, JKAMP, MAPKAP1, NFATC4, NFATC3, VRK2, CASP3, PKMYT1, SERPINB3, SERPINB4, CDKN2A, CDKN2C, RB1, ATF7, WWOX, MAPT, APLP2, GEMIN5, HIVEP1, CAMP, SSU72, SCOC, GARS, GFPT1, MKNK2, GUCY1A3, HSD17B4, ID2, RAF1, RPLP2, RPS6KB1, GANAB, C11orf57, MAPK9, NFE2L2, YWHAZ, EP300, EGFR, AKT1, CCT2, CCT3, CCT4, CCT6A, CCT8, NUP98, TCP1, TKT, SUN2, ATE1, KCNAB3, PPM1B, ANXA7, BCL7A, BLMH, CTSC, CSNK2A2, PSMD2, SF1, HIST2H2AA3, TJP2, COG2, PHLPP1, CRTC3, TAF1D, C2orf44, PRR3, STK11IP, RABL3, CDC42, BCL2L1, SMAD3, GPS1, GPS2, HRAS, MBP, VANGL2, LAMP3, MAPK14, BANPPARGCASP3, KIAA0101, NTRK1, HIST1H2BG, BRCA1, BARD1, ATF6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPK8_PARG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAPK8_PARG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAPK8C0011570Mental Depression2PSYGENET
HgeneMAPK8C0011581Depressive disorder2PSYGENET
HgeneMAPK8C0007621Neoplastic Cell Transformation1CTD_human
HgeneMAPK8C0011615Dermatitis, Atopic1CTD_human
HgeneMAPK8C0020429Hyperalgesia1CTD_human
HgeneMAPK8C0032927Precancerous Conditions1CTD_human
HgeneMAPK8C0035126Reperfusion Injury1CTD_human
HgeneMAPK8C0036341Schizophrenia1PSYGENET
HgeneMAPK8C0038356Stomach Neoplasms1CTD_human
HgeneMAPK8C0040997Trigeminal Neuralgia1CTD_human
HgeneMAPK8C0162557Liver Failure, Acute1CTD_human
TgenePARGC0007621Neoplastic Cell Transformation2CTD_human
TgenePARGC0752351Embryo Loss1CTD_human