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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21008

FusionGeneSummary for MAPK8IP3_HN1L

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK8IP3_HN1L
Fusion gene ID: 21008
HgeneTgene
Gene symbol

MAPK8IP3

HN1L

Gene ID

23162

57585

Gene namemitogen-activated protein kinase 8 interacting protein 3cramped chromatin regulator homolog 1
SynonymsJIP-3|JIP3|JSAP1|SYD2|sydCRAMP1L|HN1L|TCE4
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionC-Jun-amino-terminal kinase-interacting protein 3C-jun-amino-terminal kinase interacting protein 3JNK MAP kinase scaffold protein 3JNK-interacting protein 3JNK/SAPK-associated protein-1JNK/stress-activated protein kinase-associated protein 1homolog protein cramped-likeCrm, cramped-likeT-complex expressed gene 4hematological and neurological expressed 1-like protein
Modification date2018052320180523
UniProtAcc

Q9UPT6

Ensembl transtripts involved in fusion geneENST00000250894, ENST00000356010, 
ENST00000568271, 
ENST00000569256, 
ENST00000248098, ENST00000562684, 
ENST00000561516, ENST00000382711, 
ENST00000569765, ENST00000382710, 
Fusion gene scores* DoF score8 X 8 X 4=2567 X 6 X 6=252
# samples 97
** MAII scorelog2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPK8IP3 [Title/Abstract] AND HN1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-E6-A8L9-01AMAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000250894ENST00000569256MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000250894ENST00000248098MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000250894ENST00000562684MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000250894ENST00000561516MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000250894ENST00000382711MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000250894ENST00000569765MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000250894ENST00000382710MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000356010ENST00000569256MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000356010ENST00000248098MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000356010ENST00000562684MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000356010ENST00000561516MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000356010ENST00000382711MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000356010ENST00000569765MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
5CDS-3UTRENST00000356010ENST00000382710MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
intron-3UTRENST00000568271ENST00000569256MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
intron-3UTRENST00000568271ENST00000248098MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
intron-3UTRENST00000568271ENST00000562684MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
intron-3UTRENST00000568271ENST00000561516MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
intron-3UTRENST00000568271ENST00000382711MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
intron-3UTRENST00000568271ENST00000569765MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+
intron-3UTRENST00000568271ENST00000382710MAPK8IP3chr16

1756658

+HN1Lchr16

1747813

+

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FusionProtFeatures for MAPK8IP3_HN1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK8IP3

Q9UPT6

HN1L

The JNK-interacting protein (JIP) group of scaffoldproteins selectively mediates JNK signaling by aggregatingspecific components of the MAPK cascade to form a functional JNKsignaling module. May function as a regulator of vesicletransport, through interactions with the JNK-signaling componentsand motor proteins (By similarity). {ECO:0000250|UniProtKB:Q9ESN9,ECO:0000269|PubMed:12189133}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAPK8IP3_HN1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPK8IP3_HN1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAPK8IP3KLC1, MAPK10, ARL4D, RIC8A, PTK2, SRC, MAP2K1, RAF1, MAPK8, MAPK9, MAP2K4, MAP3K1, MAP2K7, MAP3K11, MAPK8IP2, KLC2, MAP3K5, ALK, KAT2A, BCL6, MAP2K3, KIF1A, NTRK1, RAD51, TNKS2, MAPK8IP1, SPAG9, RCCD1, SMCO1, TNKS, DCTN6, ACTR10, WDR54, DCTN4HN1LCSNK1D, SEPT2, CNTFR, LMNA, EGR2, WWOX, HSPB1, STMN1, UBA5, U2AF2, CDH1, FIGNL1, CARM1, YAP1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPK8IP3_HN1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAPK8IP3_HN1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAPK8IP3C0032460Polycystic Ovary Syndrome1CTD_human