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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 21004

FusionGeneSummary for MAPK8IP1_CPSF7

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK8IP1_CPSF7
Fusion gene ID: 21004
HgeneTgene
Gene symbol

MAPK8IP1

CPSF7

Gene ID

9479

79869

Gene namemitogen-activated protein kinase 8 interacting protein 1cleavage and polyadenylation specific factor 7
SynonymsIB1|JIP-1|JIP1|PRKM8IPCFIm59
Cytomap

11p11.2

11q12.2

Type of geneprotein-codingprotein-coding
DescriptionC-Jun-amino-terminal kinase-interacting protein 1IB-1JNK MAP kinase scaffold protein 1JNK-interacting protein 1PRKM8 interacting proteinislet-brain 1cleavage and polyadenylation specificity factor subunit 7CPSF 59 kDa subunitcleavage and polyadenylation specificity factor 59 kDa subunitcleavage factor Im complex 59 kDa subunitpre-mRNA cleavage factor I, 59 kDa subunitpre-mRNA cleavage factor Im 5
Modification date2018052220180519
UniProtAcc

Q9UQF2

Q8N684

Ensembl transtripts involved in fusion geneENST00000241014, ENST00000395629, 
ENST00000340437, ENST00000394888, 
ENST00000439958, ENST00000494016, 
ENST00000448745, ENST00000541963, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 4=100
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPK8IP1 [Title/Abstract] AND CPSF7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCPSF7

GO:0051262

protein tetramerization

20695905

TgeneCPSF7

GO:0051290

protein heterotetramerization

23187700

TgeneCPSF7

GO:1990120

messenger ribonucleoprotein complex assembly

29276085


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM823483MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000241014ENST00000340437MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-3UTRENST00000241014ENST00000394888MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-3UTRENST00000241014ENST00000439958MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-intronENST00000241014ENST00000494016MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-intronENST00000241014ENST00000448745MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-intronENST00000241014ENST00000541963MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-3UTRENST00000395629ENST00000340437MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-3UTRENST00000395629ENST00000394888MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-3UTRENST00000395629ENST00000439958MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-intronENST00000395629ENST00000494016MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-intronENST00000395629ENST00000448745MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-
3UTR-intronENST00000395629ENST00000541963MAPK8IP1chr11

45927510

+CPSF7chr11

61170585

-

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FusionProtFeatures for MAPK8IP1_CPSF7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK8IP1

Q9UQF2

CPSF7

Q8N684

The JNK-interacting protein (JIP) group of scaffoldproteins selectively mediates JNK signaling by aggregatingspecific components of the MAPK cascade to form a functional JNKsignaling module. Required for JNK activation in response toexcitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm andinhibiting JNK phosphorylation of c-Jun. May also participate inApoER2-specific reelin signaling. Directly, or indirectly,regulates GLUT2 gene expression and beta-cell function. Appears tohave a role in cell signaling in mature and developing nerveterminals. May function as a regulator of vesicle transport,through interactions with the JNK-signaling components and motorproteins. Functions as an anti-apoptotic protein and whose levelseems to influence the beta-cell death or survival response. Actsas a scaffold protein that coordinates with SH3RF1 in organizingdifferent components of the JNK pathway, including RAC1 or RAC2,MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/orMAPK9/JNK2 into a functional multiprotein complex to ensure theeffective activation of the JNK signaling pathway. Regulates theactivation of MAPK8/JNK1 and differentiation of CD8(+) T-cells.{ECO:0000250|UniProtKB:Q9WVI9}. Component of the cleavage factor Im (CFIm) complex thatfunctions as an activator of the pre-mRNA 3'-end cleavage andpolyadenylation processing required for the maturation of pre-mRNAinto functional mRNAs (PubMed:8626397, PubMed:17024186,PubMed:29276085). CFIm contributes to the recruitment ofmultiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals)(PubMed:8626397, PubMed:17024186). Most pre-mRNAs contain multiplepA signals, resulting in alternative cleavage and polyadenylation(APA) producing mRNAs with variable 3'-end formation(PubMed:23187700, PubMed:29276085). The CFIm complex acts as a keyregulator of cleavage and polyadenylation site choice during APAthrough its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs(PubMed:20695905, PubMed:29276085). CPSF7 activates directly themRNA 3'-processing machinery (PubMed:29276085). Binds to pAsignals in RNA substrates (PubMed:8626397, PubMed:17024186).{ECO:0000269|PubMed:17024186, ECO:0000269|PubMed:20695905,ECO:0000269|PubMed:23187700, ECO:0000269|PubMed:29276085,ECO:0000269|PubMed:8626397}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAPK8IP1_CPSF7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPK8IP1_CPSF7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPK8IP1_CPSF7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAPK8IP1Q9UQF2DB11157AnthralinC-Jun-amino-terminal kinase-interacting protein 1small moleculeapproved

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RelatedDiseases for MAPK8IP1_CPSF7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAPK8IP1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human;UNIPROT