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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20985

FusionGeneSummary for MAPK1_CLIP2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK1_CLIP2
Fusion gene ID: 20985
HgeneTgene
Gene symbol

MAPK1

CLIP2

Gene ID

5594

7461

Gene namemitogen-activated protein kinase 1CAP-Gly domain containing linker protein 2
SynonymsERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPKCLIP|CLIP-115|CYLN2|WBSCR3|WBSCR4|WSCR3|WSCR4
Cytomap

22q11.22

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2CAP-Gly domain-containing linker protein 2Williams-Beuren syndrome chromosome region 3Williams-Beuren syndrome chromosome region 4cytoplasmic linker 2cytoplasmic linker protein 115cytoplasmic linker protein 2testicular tissue protein Li 40williams-
Modification date2018052920180519
UniProtAcc

P28482

Q9UDT6

Ensembl transtripts involved in fusion geneENST00000215832, ENST00000398822, 
ENST00000544786, ENST00000491588, 
ENST00000361545, ENST00000223398, 
ENST00000395060, 
Fusion gene scores* DoF score18 X 13 X 10=23404 X 4 X 3=48
# samples 234
** MAII scorelog2(23/2340*10)=-3.34680276352639
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPK1 [Title/Abstract] AND CLIP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPK1

GO:0006468

protein phosphorylation

23184662

HgeneMAPK1

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

16314496

HgeneMAPK1

GO:0018105

peptidyl-serine phosphorylation

15850461

HgeneMAPK1

GO:0034198

cellular response to amino acid starvation

11096076

HgeneMAPK1

GO:0038127

ERBB signaling pathway

15133037

HgeneMAPK1

GO:0051403

stress-activated MAPK cascade

11096076

HgeneMAPK1

GO:0070371

ERK1 and ERK2 cascade

16314496

HgeneMAPK1

GO:0070849

response to epidermal growth factor

18794356


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA989331MAPK1chr22

22171458

+CLIP2chr7

73800849

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000215832ENST00000361545MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000215832ENST00000223398MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000215832ENST00000395060MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000398822ENST00000361545MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000398822ENST00000223398MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000398822ENST00000395060MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000544786ENST00000361545MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000544786ENST00000223398MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000544786ENST00000395060MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000491588ENST00000361545MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000491588ENST00000223398MAPK1chr22

22171458

+CLIP2chr7

73800849

+
intron-3CDSENST00000491588ENST00000395060MAPK1chr22

22171458

+CLIP2chr7

73800849

+

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FusionProtFeatures for MAPK1_CLIP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK1

P28482

CLIP2

Q9UDT6

Serine/threonine kinase which acts as an essentialcomponent of the MAP kinase signal transduction pathway.MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an importantrole in the MAPK/ERK cascade. They participate also in a signalingcascade initiated by activated KIT and KITLG/SCF. Depending on thecellular context, the MAPK/ERK cascade mediates diverse biologicalfunctions such as cell growth, adhesion, survival anddifferentiation through the regulation of transcription,translation, cytoskeletal rearrangements. The MAPK/ERK cascadeplays also a role in initiation and regulation of meiosis,mitosis, and postmitotic functions in differentiated cells byphosphorylating a number of transcription factors. About 160substrates have already been discovered for ERKs. Many of thesesubstrates are localized in the nucleus, and seem to participatein the regulation of transcription upon stimulation. However,other substrates are found in the cytosol as well as in othercellular organelles, and those are responsible for processes suchas translation, mitosis and apoptosis. Moreover, the MAPK/ERKcascade is also involved in the regulation of the endosomaldynamics, including lysosome processing and endosome cyclingthrough the perinuclear recycling compartment (PNRC); as well asin the fragmentation of the Golgi apparatus during mitosis. Thesubstrates include transcription factors (such as ATF2, BCL6,ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such asCANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators ofapoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG),regulators of translation (such as EIF4EBP1) and a variety ofother signaling-related molecules (like ARHGEF2, DCC, FRS2 orGRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2,RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases(such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates whichenable the propagation the MAPK/ERK signal to additional cytosolicand nuclear targets, thereby extending the specificity of thecascade. Mediates phosphorylation of TPR in respons to EGFstimulation. May play a role in the spindle assembly checkpoint.Phosphorylates PML and promotes its interaction with PIN1, leadingto PML degradation. Phosphorylates CDK2AP2 (By similarity).{ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468,ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262,ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731,ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087,ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391,ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583,ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397,ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800,ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199,ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920,ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688,ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579,ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510,ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692,ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}. Acts as a transcriptional repressor. Binds to a[GC]AAA[GC] consensus sequence. Repress the expression ofinterferon gamma-induced genes. Seems to bind to the promoter ofCCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 andSTAT1. Transcriptional activity is independent of kinase activity.{ECO:0000269|PubMed:19879846}. Seems to link microtubules to dendritic lamellar body(DLB), a membranous organelle predominantly present in bulbousdendritic appendages of neurons linked by dendrodendritic gapjunctions. May operate in the control of brain-specific organelletranslocations (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAPK1_CLIP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPK1_CLIP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPK1_CLIP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAPK1P28482DB01064IsoprenalineMitogen-activated protein kinase 1small moleculeapproved|investigational
HgeneMAPK1P28482DB01169Arsenic trioxideMitogen-activated protein kinase 1small moleculeapproved|investigational

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RelatedDiseases for MAPK1_CLIP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAPK1C0020429Hyperalgesia2CTD_human
HgeneMAPK1C0024121Lung Neoplasms2CTD_human
HgeneMAPK1C0236736Cocaine-Related Disorders2CTD_human
HgeneMAPK1C0005586Bipolar Disorder1PSYGENET
HgeneMAPK1C0007137Squamous cell carcinoma1CTD_human
HgeneMAPK1C0007786Brain Ischemia1CTD_human
HgeneMAPK1C0017639Gliosis1CTD_human
HgeneMAPK1C0018671Head and Neck Neoplasms1CTD_human
HgeneMAPK1C0020564Hypertrophy1CTD_human
HgeneMAPK1C0021361Female infertility1CTD_human
HgeneMAPK1C0022665Kidney Neoplasm1CTD_human
HgeneMAPK1C0027626Neoplasm Invasiveness1CTD_human
HgeneMAPK1C0027627Neoplasm Metastasis1CTD_human
HgeneMAPK1C0027746Nerve Degeneration1CTD_human
HgeneMAPK1C0036341Schizophrenia1PSYGENET
HgeneMAPK1C0036920Sezary Syndrome1CTD_human
HgeneMAPK1C0038356Stomach Neoplasms1CTD_human
HgeneMAPK1C0038587Substance Withdrawal Syndrome1CTD_human
HgeneMAPK1C0040997Trigeminal Neuralgia1CTD_human
HgeneMAPK1C0155862Streptococcal pneumonia1CTD_human
HgeneMAPK1C0178417Anhedonia1PSYGENET
HgeneMAPK1C0243026Sepsis1CTD_human
HgeneMAPK1C0878544Cardiomyopathies1CTD_human
HgeneMAPK1C0919267ovarian neoplasm1CTD_human
HgeneMAPK1C1866282CEROID LIPOFUSCINOSIS, NEURONAL, 61CTD_human
HgeneMAPK1C3495559Juvenile arthritis1CTD_human