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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20983

FusionGeneSummary for MAPK1_ATP1A1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK1_ATP1A1
Fusion gene ID: 20983
HgeneTgene
Gene symbol

MAPK1

ATP1A1

Gene ID

5594

480

Gene namemitogen-activated protein kinase 1ATPase Na+/K+ transporting subunit alpha 4
SynonymsERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPKATP1A1|ATP1AL2
Cytomap

22q11.22

1q23.2

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2sodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase su
Modification date2018052920180523
UniProtAcc

P28482

P05023

Ensembl transtripts involved in fusion geneENST00000215832, ENST00000398822, 
ENST00000544786, ENST00000491588, 
ENST00000295598, ENST00000537345, 
ENST00000369496, ENST00000491156, 
Fusion gene scores* DoF score18 X 13 X 10=234013 X 20 X 3=780
# samples 2321
** MAII scorelog2(23/2340*10)=-3.34680276352639
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(21/780*10)=-1.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAPK1 [Title/Abstract] AND ATP1A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAPK1

GO:0006468

protein phosphorylation

23184662

HgeneMAPK1

GO:0010800

positive regulation of peptidyl-threonine phosphorylation

16314496

HgeneMAPK1

GO:0018105

peptidyl-serine phosphorylation

15850461

HgeneMAPK1

GO:0034198

cellular response to amino acid starvation

11096076

HgeneMAPK1

GO:0038127

ERBB signaling pathway

15133037

HgeneMAPK1

GO:0051403

stress-activated MAPK cascade

11096076

HgeneMAPK1

GO:0070371

ERK1 and ERK2 cascade

16314496

HgeneMAPK1

GO:0070849

response to epidermal growth factor

18794356

TgeneATP1A1

GO:0030317

flagellated sperm motility

12112599

TgeneATP1A1

GO:0030641

regulation of cellular pH

12112599


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG877408MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000215832ENST00000295598MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000215832ENST00000537345MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000215832ENST00000369496MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-intronENST00000215832ENST00000491156MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000398822ENST00000295598MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000398822ENST00000537345MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000398822ENST00000369496MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-intronENST00000398822ENST00000491156MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000544786ENST00000295598MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000544786ENST00000537345MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000544786ENST00000369496MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-intronENST00000544786ENST00000491156MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000491588ENST00000295598MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000491588ENST00000537345MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-3CDSENST00000491588ENST00000369496MAPK1chr22

22115665

-ATP1A1chr1

116941300

+
intron-intronENST00000491588ENST00000491156MAPK1chr22

22115665

-ATP1A1chr1

116941300

+

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FusionProtFeatures for MAPK1_ATP1A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK1

P28482

ATP1A1

P05023

Serine/threonine kinase which acts as an essentialcomponent of the MAP kinase signal transduction pathway.MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an importantrole in the MAPK/ERK cascade. They participate also in a signalingcascade initiated by activated KIT and KITLG/SCF. Depending on thecellular context, the MAPK/ERK cascade mediates diverse biologicalfunctions such as cell growth, adhesion, survival anddifferentiation through the regulation of transcription,translation, cytoskeletal rearrangements. The MAPK/ERK cascadeplays also a role in initiation and regulation of meiosis,mitosis, and postmitotic functions in differentiated cells byphosphorylating a number of transcription factors. About 160substrates have already been discovered for ERKs. Many of thesesubstrates are localized in the nucleus, and seem to participatein the regulation of transcription upon stimulation. However,other substrates are found in the cytosol as well as in othercellular organelles, and those are responsible for processes suchas translation, mitosis and apoptosis. Moreover, the MAPK/ERKcascade is also involved in the regulation of the endosomaldynamics, including lysosome processing and endosome cyclingthrough the perinuclear recycling compartment (PNRC); as well asin the fragmentation of the Golgi apparatus during mitosis. Thesubstrates include transcription factors (such as ATF2, BCL6,ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such asCANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators ofapoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG),regulators of translation (such as EIF4EBP1) and a variety ofother signaling-related molecules (like ARHGEF2, DCC, FRS2 orGRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2,RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases(such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates whichenable the propagation the MAPK/ERK signal to additional cytosolicand nuclear targets, thereby extending the specificity of thecascade. Mediates phosphorylation of TPR in respons to EGFstimulation. May play a role in the spindle assembly checkpoint.Phosphorylates PML and promotes its interaction with PIN1, leadingto PML degradation. Phosphorylates CDK2AP2 (By similarity).{ECO:0000250|UniProtKB:P63086, ECO:0000269|PubMed:10617468,ECO:0000269|PubMed:10637505, ECO:0000269|PubMed:11154262,ECO:0000269|PubMed:12110590, ECO:0000269|PubMed:12356731,ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:12794087,ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:15184391,ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:15616583,ECO:0000269|PubMed:15664191, ECO:0000269|PubMed:15788397,ECO:0000269|PubMed:15952796, ECO:0000269|PubMed:16581800,ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:19265199,ECO:0000269|PubMed:19879846, ECO:0000269|PubMed:22033920,ECO:0000269|PubMed:7588608, ECO:0000269|PubMed:8622688,ECO:0000269|PubMed:9480836, ECO:0000269|PubMed:9596579,ECO:0000269|PubMed:9649500, ECO:0000269|PubMed:9687510,ECO:0000303|PubMed:15526160, ECO:0000303|PubMed:16393692,ECO:0000303|PubMed:19565474, ECO:0000303|PubMed:21779493}. Acts as a transcriptional repressor. Binds to a[GC]AAA[GC] consensus sequence. Repress the expression ofinterferon gamma-induced genes. Seems to bind to the promoter ofCCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 andSTAT1. Transcriptional activity is independent of kinase activity.{ECO:0000269|PubMed:19879846}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAPK1_ATP1A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPK1_ATP1A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPK1_ATP1A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAPK1P28482DB01064IsoprenalineMitogen-activated protein kinase 1small moleculeapproved|investigational
HgeneMAPK1P28482DB01169Arsenic trioxideMitogen-activated protein kinase 1small moleculeapproved|investigational
TgeneATP1A1P05023DB00390DigoxinSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
TgeneATP1A1P05023DB00511AcetyldigitoxinSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
TgeneATP1A1P05023DB01078DeslanosideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
TgeneATP1A1P05023DB01092OuabainSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
TgeneATP1A1P05023DB01119DiazoxideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
TgeneATP1A1P05023DB01430AlmitrineSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
TgeneATP1A1P05023DB00774HydroflumethiazideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
TgeneATP1A1P05023DB00903Etacrynic acidSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
TgeneATP1A1P05023DB01188CiclopiroxSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
TgeneATP1A1P05023DB01345PotassiumSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
TgeneATP1A1P05023DB01370AluminiumSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
TgeneATP1A1P05023DB01396DigitoxinSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
TgeneATP1A1P05023DB01378MagnesiumSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|nutraceutical
TgeneATP1A1P05023DB01021TrichlormethiazideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|vet_approved
TgeneATP1A1P05023DB01244BepridilSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|withdrawn

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RelatedDiseases for MAPK1_ATP1A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAPK1C0020429Hyperalgesia2CTD_human
HgeneMAPK1C0024121Lung Neoplasms2CTD_human
HgeneMAPK1C0236736Cocaine-Related Disorders2CTD_human
HgeneMAPK1C0005586Bipolar Disorder1PSYGENET
HgeneMAPK1C0007137Squamous cell carcinoma1CTD_human
HgeneMAPK1C0007786Brain Ischemia1CTD_human
HgeneMAPK1C0017639Gliosis1CTD_human
HgeneMAPK1C0018671Head and Neck Neoplasms1CTD_human
HgeneMAPK1C0020564Hypertrophy1CTD_human
HgeneMAPK1C0021361Female infertility1CTD_human
HgeneMAPK1C0022665Kidney Neoplasm1CTD_human
HgeneMAPK1C0027626Neoplasm Invasiveness1CTD_human
HgeneMAPK1C0027627Neoplasm Metastasis1CTD_human
HgeneMAPK1C0027746Nerve Degeneration1CTD_human
HgeneMAPK1C0036341Schizophrenia1PSYGENET
HgeneMAPK1C0036920Sezary Syndrome1CTD_human
HgeneMAPK1C0038356Stomach Neoplasms1CTD_human
HgeneMAPK1C0038587Substance Withdrawal Syndrome1CTD_human
HgeneMAPK1C0040997Trigeminal Neuralgia1CTD_human
HgeneMAPK1C0155862Streptococcal pneumonia1CTD_human
HgeneMAPK1C0178417Anhedonia1PSYGENET
HgeneMAPK1C0243026Sepsis1CTD_human
HgeneMAPK1C0878544Cardiomyopathies1CTD_human
HgeneMAPK1C0919267ovarian neoplasm1CTD_human
HgeneMAPK1C1866282CEROID LIPOFUSCINOSIS, NEURONAL, 61CTD_human
HgeneMAPK1C3495559Juvenile arthritis1CTD_human
TgeneATP1A1C0001430Adenoma2CTD_human
TgeneATP1A1C0005586Bipolar Disorder1PSYGENET
TgeneATP1A1C0020428Hyperaldosteronism1CTD_human
TgeneATP1A1C0020538Hypertensive disease1CTD_human
TgeneATP1A1C0042594Vestibular Diseases1CTD_human
TgeneATP1A1C0151744Myocardial Ischemia1CTD_human