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Fusion gene ID: 20977 |
FusionGeneSummary for MAPK14_SIN3A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAPK14_SIN3A | Fusion gene ID: 20977 | Hgene | Tgene | Gene symbol | MAPK14 | SIN3A | Gene ID | 1432 | 25942 |
| Gene name | mitogen-activated protein kinase 14 | SIN3 transcription regulator family member A | |
| Synonyms | CSBP|CSBP1|CSBP2|CSPB1|EXIP|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38ALPHA | WITKOS | |
| Cytomap | 6p21.31 | 15q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase 14CSAID-binding proteinCsaids binding proteinMAP kinase 14MAP kinase Mxi2MAP kinase p38 alphaMAX-interacting protein 2cytokine suppressive anti-inflammatory drug binding proteinmitogen-activated protein kinase p38 | paired amphipathic helix protein Sin3aSIN3 homolog A, transcription regulatorhistone deacetylase complex subunit Sin3atranscriptional co-repressor Sin3Atranscriptional corepressor Sin3atranscriptional regulator, SIN3A | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q16539 | Q96ST3 | |
| Ensembl transtripts involved in fusion gene | ENST00000229795, ENST00000229794, ENST00000468133, ENST00000310795, | ENST00000394947, ENST00000360439, ENST00000394949, ENST00000567289, | |
| Fusion gene scores | * DoF score | 7 X 6 X 5=210 | 5 X 5 X 3=75 |
| # samples | 7 | 5 | |
| ** MAII score | log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAPK14 [Title/Abstract] AND SIN3A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAPK14 | GO:0035556 | intracellular signal transduction | 10838079 |
| Hgene | MAPK14 | GO:0071222 | cellular response to lipopolysaccharide | 23776175 |
| Hgene | MAPK14 | GO:1900015 | regulation of cytokine production involved in inflammatory response | 15251176 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EB-A44Q-06A | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000229795 | ENST00000394947 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000229795 | ENST00000360439 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000229795 | ENST00000394949 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000229795 | ENST00000567289 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000229794 | ENST00000394947 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000229794 | ENST00000360439 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000229794 | ENST00000394949 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000229794 | ENST00000567289 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5UTR-5UTR | ENST00000468133 | ENST00000394947 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5UTR-5UTR | ENST00000468133 | ENST00000360439 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5UTR-5UTR | ENST00000468133 | ENST00000394949 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5UTR-5UTR | ENST00000468133 | ENST00000567289 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000310795 | ENST00000394947 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000310795 | ENST00000360439 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000310795 | ENST00000394949 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
| 5CDS-5UTR | ENST00000310795 | ENST00000567289 | MAPK14 | chr6 | 35996050 | + | SIN3A | chr15 | 75722749 | - |
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FusionProtFeatures for MAPK14_SIN3A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAPK14 | SIN3A |
| Acts as a transcriptional repressor. Corepressor forREST. Interacts with MXI1 to repress MYC responsive genes andantagonize MYC oncogenic activities. Also interacts with MXD1-MAXheterodimers to repress transcription by tethering SIN3A to DNA.Acts cooperatively with OGT to repress transcription in parallelwith histone deacetylation. Involved in he control of thecircadian rhythms. Required for the transcriptional repression ofcircadian target genes, such as PER1, mediated by the large PERcomplex through histone deacetylation. Cooperates with FOXK1 toregulate cell cycle progression probably by repressing cell cycleinhibitor genes expression (By similarity).{ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAPK14_SIN3A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAPK14_SIN3A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAPK14 | HTRA2, DUSP10, ZFP36L1, CDC25A, SLC12A2, STK39, MAP2K6, MAPK1, MAPK3, SMAD7, RPS6KA4, AKT1, MAPKAPK2, EGFR, ATF2, SPAG9, MEF2A, DUSP16, DUSP6, DUSP1, CSNK2A1, DYRK1B, CDC25B, CDC25C, GMFB, ETV1, MAPKAPK3, RPS6KA3, RPS6KA5, MKNK1, TAB1, MAPK14, DUSP4, MAP2K3, PLCB2, MAP2K7, DDIT3, KRT8, TGFBR1, CAMKK2, AES, FLNA, MKNK2, HIVEP1, MEF2C, MEF2D, NKTR, ROBO1, SPTBN1, TCF20, ZNF142, MAPKAPK5, YY1AP1, SUPT20H, SMEK1, KMT2C, CCDC14, MOB3B, CCDC97, ELMSAN1, DDX26B, MUC12, PI4K2B, TFCP2, SP1, MYEF2, CD4, ZNHIT1, GDF15, SRSF5, CENPC, COPS5, EEF1A1, EPB42, RPL22, RPL41, SNAPIN, CSNK2B, NFKBIA, IKBKB, BTRC, PAK6, RELA, MAPK11, NCOA3, HDGF, KAT2B, EP300, HDAC3, TP53, PHC2, BMI1, SMARCD3, CBL, TOLLIP, IRAK1, RB1, MAP2K4, SQSTM1, MBP, EIF4EBP1, ATM, STAB2, CDK13, GORASP2, ARHGAP9, SH2D1A, TSC1, LIMK1, MAP3K10, CREB1, ACTA1, ARRB1, ADRB2, PLG, UGT2B10, TMEM63B, BICD1, CEP164, RRP1B, EEF2, OBSL1, MAZ, NEB, CCDC8, TCEAL1, IQGAP1, CNBP, MARCKSL1, USP11, DUSP9, SRPK1, ADSS, HSPD1, NME1, OXCT1, PTPN11, TYMS, WDR1, ATF6, CUL7, PDX1, JUN, SLX4IP, HOXB9, HOXB6, HOXA5, HOXA10, HOXC9, USP47, LRRC1, FLYWCH2, RICTOR, RHBDF1, RECQL4, KIF22, PPIL2, PRKY, DCUN1D5, DUSP7, AMMECR1L, MYLK3, FOXK1, FBXW8, ARL13B, CIZ1, TPX2, TRMT1L, ERF, RNF138, CSNK1G2, PTPRR, GATA3, HDAC1, YWHAE, PPM1G, CDT1, MYO19, BCAR1, VPRBP, MAX, NFATC4, PTPN7, EPS15, F2R, TAB2, CALM1, S100A9, DUSP2, RALB, GTSF1, MYF6, GPR156, HOXC10, LCOR, FAM19A3, LIPG, GFER, PTPN5, MAPK8, PAK1, PAK2, PAK3, BCL2L1, TRIM25, HSPB1, CDKN1A, CASP3, CASP8 | SIN3A | MBD3L1, HDAC9, IKZF1, HCFC1, DNMT3B, HDAC1, HDAC2, MTA2, MTA1, ARID4B, SUDS3, SAP30, SAP130, PTMA, EFCAB6, SETDB1, MORF4, PFN2, MORF4L2, RBPJ, SNW1, KDM1A, PML, NCOR1, SKI, SMARCB1, SMARCA4, SMARCA2, SMARCC1, PHB, RBBP4, RBBP7, SAP18, HBP1, MXD1, KLF11, KLF16, KLF13, KLF9, KLF10, ZBTB16, CABIN1, NCOR2, SATB1, PHF12, IKZF3, IKZF2, IKZF4, MBD2, ING1, HEY2, COPS2, BCL6, RLIM, TAL1, RUNX1T1, MNT, MXD3, OGT, MECP2, MBD4, ING2, WHSC1, SFPQ, ZBTB7A, MKX, NR4A2, GPS2, TBL1X, HDAC4, HSP90AA1, NR0B2, ADD1, ESR1, HDAC5, SAP30L, ID2, MGEA5, SAP25, NKX3-2, PRMT5, SMARCE1, MEN1, PA2G4, SMARCA5, NFX1, CBFA2T2, BCL6B, TAF1, CHD3, SMARCC2, ALL1, TAF6, TBP, MBD3, TAF9, RAN, TFCP2, CYP4V2, NKX2-2, TGIF1, ZBTB4, PFDN5, SPI1, KLF1, SP1, ETV6, SMAD3, ARID4A, SYT1, CTCF, TP53, REST, SKIL, CHD4, MYB, TRIM28, SMN1, RUNX1, CSNK2A1, TOPORS, E2F4, MAF, TADA2A, IRF5, MORF4L1, THAP11, KMT2A, NONO, SMARCAD1, SOX2, DACH1, KDM2B, HINT1, LAMTOR5, NR2C1, ISG15, BRMS1L, GRK5, AR, TAB2, SNCA, SLC9A3R2, S100A10, SEPT11, PDLIM5, ACO2, TOM1L2, SEC22B, NOTCH2, THADA, TTLL12, AHCYL1, SF1, IGBP1, EPAS1, BRMS1, BHLHE40, STAT3, MAD1L1, SHFM1, HIF1A, DDB1, CUL4B, CHFR, NXF1, HIST3H3, LOXL2, EED, EDA, LACC1, MIER2, UNK, NTRK1, GTF2E2, CAB39, CSNK2A2, DDX46, FUBP1, KHSRP, PIR, VAPA, TCF20, SIN3B, SNAI1, MAX, FOXK1, FOXK2, FBXW7, KMT2E, NANOG, POU5F1, GATAD1, FAM60A, ZNF704, PHF23, DDX41, TFAP4, MDK, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAPK14_SIN3A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MAPK14 | Q16539 | DB01254 | Dasatinib | Mitogen-activated protein kinase 14 | small molecule | approved|investigational |
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RelatedDiseases for MAPK14_SIN3A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MAPK14 | C0008370 | Cholestasis | 1 | CTD_human |
| Hgene | MAPK14 | C0023473 | Myeloid Leukemia, Chronic | 1 | CTD_human |
| Hgene | MAPK14 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Hgene | MAPK14 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | MAPK14 | C0024809 | Marijuana Abuse | 1 | PSYGENET |
| Hgene | MAPK14 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | MAPK14 | C0086132 | Depressive Symptoms | 1 | PSYGENET |
| Hgene | MAPK14 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
| Hgene | MAPK14 | C0233477 | Dysphoric mood | 1 | PSYGENET |
| Hgene | MAPK14 | C0338715 | Drug-induced depressive state | 1 | PSYGENET |
| Hgene | MAPK14 | C0878544 | Cardiomyopathies | 1 | CTD_human |
| Tgene | SIN3A | C0013336 | Dwarfism | 1 | CTD_human |
| Tgene | SIN3A | C0020255 | Hydrocephalus | 1 | CTD_human |
| Tgene | SIN3A | C0025958 | Microcephaly | 1 | CTD_human |
| Tgene | SIN3A | C0175754 | Agenesis of corpus callosum | 1 | CTD_human |
| Tgene | SIN3A | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Tgene | SIN3A | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
| Tgene | SIN3A | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |
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