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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20966

FusionGeneSummary for MAPK10_NUP188

check button Fusion gene summary
Fusion gene informationFusion gene name: MAPK10_NUP188
Fusion gene ID: 20966
HgeneTgene
Gene symbol

MAPK10

NUP188

Gene ID

5602

23511

Gene namemitogen-activated protein kinase 10nucleoporin 188
SynonymsJNK3|JNK3A|PRKM10|SAPK1b|p493F12|p54bSAPKKIAA0169|hNup188
Cytomap

4q21.3

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase 10JNK3 alpha protein kinaseMAP kinase 10MAP kinase p49 3F12c-Jun N-terminal kinase 3stress activated protein kinase betastress-activated protein kinase 1bstress-activated protein kinase JNK3nucleoporin NUP188 homolognucleoporin 188kDa
Modification date2018052420180523
UniProtAcc

P53779

Q5SRE5

Ensembl transtripts involved in fusion geneENST00000395169, ENST00000359221, 
ENST00000361569, ENST00000395166, 
ENST00000449047, ENST00000395161, 
ENST00000513839, ENST00000395157, 
ENST00000395160, 
ENST00000372577, 
ENST00000550219, 
Fusion gene scores* DoF score8 X 6 X 6=2883 X 3 X 2=18
# samples 93
** MAII scorelog2(9/288*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAPK10 [Title/Abstract] AND NUP188 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T07564MAPK10chr4

87205530

+NUP188chr9

131763874

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000395169ENST00000372577MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-intronENST00000395169ENST00000550219MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-3CDSENST00000359221ENST00000372577MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-intronENST00000359221ENST00000550219MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-3CDSENST00000361569ENST00000372577MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-intronENST00000361569ENST00000550219MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-3CDSENST00000395166ENST00000372577MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-intronENST00000395166ENST00000550219MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-3CDSENST00000449047ENST00000372577MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-intronENST00000449047ENST00000550219MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-3CDSENST00000395161ENST00000372577MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-intronENST00000395161ENST00000550219MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-3CDSENST00000513839ENST00000372577MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-intronENST00000513839ENST00000550219MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-3CDSENST00000395157ENST00000372577MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-intronENST00000395157ENST00000550219MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-3CDSENST00000395160ENST00000372577MAPK10chr4

87205530

+NUP188chr9

131763874

-
intron-intronENST00000395160ENST00000550219MAPK10chr4

87205530

+NUP188chr9

131763874

-

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FusionProtFeatures for MAPK10_NUP188


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAPK10

P53779

NUP188

Q5SRE5

Serine/threonine-protein kinase involved in variousprocesses such as neuronal proliferation, differentiation,migration and programmed cell death. Extracellular stimuli such asproinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK)signaling pathway. In this cascade, two dual specificity kinasesMAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activateMAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number oftranscription factors, primarily components of AP-1 such as JUNand ATF2 and thus regulates AP-1 transcriptional activity. Playsregulatory roles in the signaling pathways during neuronalapoptosis. Phosphorylates the neuronal microtubule regulatorSTMN2. Acts in the regulation of the amyloid-beta precursorprotein/APP signaling during neuronal differentiation byphosphorylating APP. Participates also in neurite growth in spiralganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimerand plays a role in the photic regulation of the circadian clock(PubMed:22441692). {ECO:0000269|PubMed:11718727,ECO:0000269|PubMed:22441692}. May function as a component of the nuclear pore complex(NPC).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAPK10_NUP188


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAPK10_NUP188


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAPK10_NUP188


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAPK10_NUP188


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource