FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 20958

FusionGeneSummary for MAP7_ZBTB20

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP7_ZBTB20
Fusion gene ID: 20958
HgeneTgene
Gene symbol

MAP7

ZBTB20

Gene ID

9053

26137

Gene namemicrotubule associated protein 7zinc finger and BTB domain containing 20
SynonymsE-MAP-115|EMAP115DPZF|HOF|ODA-8S|PRIMS|ZNF288
Cytomap

6q23.3

3q13.31

Type of geneprotein-codingprotein-coding
DescriptionensconsinMAP-7dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))epithelial microtubule-associated protein of 115 kDazinc finger and BTB domain-containing protein 20BTB/POZ zinc finger protein DPZFdendritic cell-derived BTB/POZ zinc fingerzinc finger protein 288
Modification date2018052320180526
UniProtAcc

Q14244

Q9HC78

Ensembl transtripts involved in fusion geneENST00000354570, ENST00000454590, 
ENST00000544465, ENST00000438100, 
ENST00000432797, 
ENST00000462705, 
ENST00000393785, ENST00000481632, 
ENST00000471418, ENST00000357258, 
ENST00000464560, ENST00000488663, 
ENST00000474710, 
Fusion gene scores* DoF score12 X 9 X 8=8645 X 5 X 4=100
# samples 135
** MAII scorelog2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP7 [Title/Abstract] AND ZBTB20 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-BP-4346-01AMAP7chr6

136787899

-ZBTB20chr3

114619189

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000354570ENST00000462705MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000354570ENST00000393785MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000354570ENST00000481632MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000354570ENST00000471418MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000354570ENST00000357258MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000354570ENST00000464560MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000354570ENST00000488663MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000354570ENST00000474710MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000454590ENST00000462705MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000454590ENST00000393785MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000454590ENST00000481632MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000454590ENST00000471418MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000454590ENST00000357258MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000454590ENST00000464560MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000454590ENST00000488663MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000454590ENST00000474710MAP7chr6

136787899

-ZBTB20chr3

114619189

-
5CDS-5UTRENST00000544465ENST00000462705MAP7chr6

136787899

-ZBTB20chr3

114619189

-
5CDS-intronENST00000544465ENST00000393785MAP7chr6

136787899

-ZBTB20chr3

114619189

-
5CDS-intronENST00000544465ENST00000481632MAP7chr6

136787899

-ZBTB20chr3

114619189

-
5CDS-intronENST00000544465ENST00000471418MAP7chr6

136787899

-ZBTB20chr3

114619189

-
5CDS-5UTRENST00000544465ENST00000357258MAP7chr6

136787899

-ZBTB20chr3

114619189

-
5CDS-intronENST00000544465ENST00000464560MAP7chr6

136787899

-ZBTB20chr3

114619189

-
5CDS-5UTRENST00000544465ENST00000488663MAP7chr6

136787899

-ZBTB20chr3

114619189

-
5CDS-intronENST00000544465ENST00000474710MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000438100ENST00000462705MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000438100ENST00000393785MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000438100ENST00000481632MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000438100ENST00000471418MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000438100ENST00000357258MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000438100ENST00000464560MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000438100ENST00000488663MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000438100ENST00000474710MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000432797ENST00000462705MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000432797ENST00000393785MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000432797ENST00000481632MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000432797ENST00000471418MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000432797ENST00000357258MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000432797ENST00000464560MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-5UTRENST00000432797ENST00000488663MAP7chr6

136787899

-ZBTB20chr3

114619189

-
intron-intronENST00000432797ENST00000474710MAP7chr6

136787899

-ZBTB20chr3

114619189

-

Top

FusionProtFeatures for MAP7_ZBTB20


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP7

Q14244

ZBTB20

Q9HC78

May be a transcription factor that may be involved inhematopoiesis, oncogenesis, and immune responses(PubMed:11352661). Plays a role in postnatal myogenesis, may beinvolved in the regulation of satellite cells self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q8K0L9,ECO:0000269|PubMed:11352661}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for MAP7_ZBTB20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for MAP7_ZBTB20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP7TRPV4, SH3KBP1, TERF1, POT1, YBX3, DHX9, RECQL, MRE11A, GPRASP2, PASK, RNF219, CTDSP2, C9orf41, CHRNA9, MED23, SRPK2, CLK1, KIAA0753, SPICE1, DCTN1, LCA5, PPP2CB, SEC16A, PPP4R1, CDC5L, RC3H1, SSSCA1, KBTBD7, CAMK2D, PCDHGA5, PCDHA4, APP, IL17RA, PCDH20, PCDHB11, CBY1, TRIM25ZBTB20NR3C1, PPARG, CHD7, ELAVL1, HSP90AA1, FLNA, MYH9, IQGAP1, SYNPO, LIMA1, ANLN, MYO19


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MAP7_ZBTB20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for MAP7_ZBTB20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZBTB20C0038356Stomach Neoplasms1CTD_human
TgeneZBTB20C0796121Primrose syndrome1CTD_human;ORPHANET;UNIPROT