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Fusion gene ID: 20949 |
FusionGeneSummary for MAP7_CITED2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP7_CITED2 | Fusion gene ID: 20949 | Hgene | Tgene | Gene symbol | MAP7 | CITED2 | Gene ID | 9053 | 10370 |
| Gene name | microtubule associated protein 7 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 | |
| Synonyms | E-MAP-115|EMAP115 | ASD8|MRG-1|MRG1|P35SRJ|VSD2 | |
| Cytomap | 6q23.3 | 6q24.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ensconsinMAP-7dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115))epithelial microtubule-associated protein of 115 kDa | cbp/p300-interacting transactivator 2MSG-related protein 1MSG1-related gene 1melanocyte-specific gene 1-related gene 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q14244 | Q99967 | |
| Ensembl transtripts involved in fusion gene | ENST00000354570, ENST00000454590, ENST00000544465, ENST00000438100, ENST00000432797, | ENST00000367651, ENST00000537332, ENST00000536159, | |
| Fusion gene scores | * DoF score | 12 X 9 X 8=864 | 1 X 1 X 1=1 |
| # samples | 13 | 1 | |
| ** MAII score | log2(13/864*10)=-2.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MAP7 [Title/Abstract] AND CITED2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CITED2 | GO:0001666 | response to hypoxia | 9887100 |
| Tgene | CITED2 | GO:0008283 | cell proliferation | 15051727 |
| Tgene | CITED2 | GO:0010628 | positive regulation of gene expression | 15051727 |
| Tgene | CITED2 | GO:0010629 | negative regulation of gene expression | 15051727 |
| Tgene | CITED2 | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway | 15051727 |
| Tgene | CITED2 | GO:0043627 | response to estrogen | 11581164 |
| Tgene | CITED2 | GO:0045892 | negative regulation of transcription, DNA-templated | 15051727 |
| Tgene | CITED2 | GO:0045893 | positive regulation of transcription, DNA-templated | 9434189|15051727 |
| Tgene | CITED2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22735262 |
| Tgene | CITED2 | GO:0061428 | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia | 22735262 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-EJ-A65F-01A | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000354570 | ENST00000367651 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| 5CDS-5UTR | ENST00000354570 | ENST00000537332 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| 5CDS-5UTR | ENST00000354570 | ENST00000536159 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000454590 | ENST00000367651 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000454590 | ENST00000537332 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000454590 | ENST00000536159 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000544465 | ENST00000367651 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000544465 | ENST00000537332 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000544465 | ENST00000536159 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000438100 | ENST00000367651 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000438100 | ENST00000537332 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000438100 | ENST00000536159 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000432797 | ENST00000367651 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000432797 | ENST00000537332 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
| intron-5UTR | ENST00000432797 | ENST00000536159 | MAP7 | chr6 | 136871480 | - | CITED2 | chr6 | 139695089 | - |
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FusionProtFeatures for MAP7_CITED2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP7 | CITED2 |
| Transcriptional coactivator of the p300/CBP-mediatedtranscription complex. Acts as a bridge, linking TFAP2transcription factors and the p300/CBP transcriptional coactivatorcomplex in order to stimulate TFAP2-mediated transcriptionalactivation. Positively regulates TGF-beta signaling through itsassociation with the SMAD/p300/CBP-mediated transcriptionalcoactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhancesestrogen-dependent transactivation mediated by estrogen receptors.Acts also as a transcriptional corepressor; interferes with thebinding of the transcription factors HIF1A or STAT2 and thep300/CBP transcriptional coactivator complex. Participates in sexdetermination and early gonad development by stimulatingtranscription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptionalactivation of NODAL-mediated gene transcription in the leftlateral plate mesoderm (LPM). Plays an essential role indifferentiation of the adrenal cortex from the adrenogonadalprimordium (AGP); stimulates WT1-mediated transcription activationthereby up-regulating the nuclear hormone receptor NR5A1 promoteractivity. Associates with chromatin to the PITX2 P1 promoterregion. {ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:12586840,ECO:0000269|PubMed:15051727}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP7_CITED2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAP7_CITED2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAP7 | TRPV4, SH3KBP1, TERF1, POT1, YBX3, DHX9, RECQL, MRE11A, GPRASP2, PASK, RNF219, CTDSP2, C9orf41, CHRNA9, MED23, SRPK2, CLK1, KIAA0753, SPICE1, DCTN1, LCA5, PPP2CB, SEC16A, PPP4R1, CDC5L, RC3H1, SSSCA1, KBTBD7, CAMK2D, PCDHGA5, PCDHA4, APP, IL17RA, PCDH20, PCDHB11, CBY1, TRIM25 | CITED2 | TFAP2A, TFAP2C, EP300, LHX2, TFAP2B, CREBBP, LHX3, TBP, SMAD3, SMAD2, ELAVL1, MAPK1, FBXL5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP7_CITED2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP7_CITED2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CITED2 | C0018816 | Heart Septal Defects | 1 | CTD_human |
| Tgene | CITED2 | C0026846 | Muscular Atrophy | 1 | CTD_human |
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