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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20929

FusionGeneSummary for MAP4_MON1A

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4_MON1A
Fusion gene ID: 20929
HgeneTgene
Gene symbol

MAP4

MON1A

Gene ID

4134

84315

Gene namemicrotubule associated protein 4MON1 homolog A, secretory trafficking associated
Synonyms-SAND1
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein 4MAP-4vacuolar fusion protein MON1 homolog AMON1 secretory trafficking family member A
Modification date2018052320180523
UniProtAcc

P27816

Q86VX9

Ensembl transtripts involved in fusion geneENST00000383737, ENST00000395734, 
ENST00000426837, ENST00000360240, 
ENST00000439356, ENST00000264724, 
ENST00000420772, ENST00000441748, 
ENST00000462206, ENST00000434267, 
ENST00000296473, ENST00000455683, 
ENST00000417270, ENST00000483022, 
Fusion gene scores* DoF score23 X 16 X 14=51522 X 1 X 3=6
# samples 313
** MAII scorelog2(31/5152*10)=-4.05479247284038
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/6*10)=2.32192809488736
Context

PubMed: MAP4 [Title/Abstract] AND MON1A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-8265-01AMAP4chr3

48130263

-MON1Achr3

49950792

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000383737ENST00000296473MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000383737ENST00000455683MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000383737ENST00000417270MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-5UTRENST00000383737ENST00000483022MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000395734ENST00000296473MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000395734ENST00000455683MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000395734ENST00000417270MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-5UTRENST00000395734ENST00000483022MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000426837ENST00000296473MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000426837ENST00000455683MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000426837ENST00000417270MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-5UTRENST00000426837ENST00000483022MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000360240ENST00000296473MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000360240ENST00000455683MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000360240ENST00000417270MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-5UTRENST00000360240ENST00000483022MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000439356ENST00000296473MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000439356ENST00000455683MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-3CDSENST00000439356ENST00000417270MAP4chr3

48130263

-MON1Achr3

49950792

-
5UTR-5UTRENST00000439356ENST00000483022MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000264724ENST00000296473MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000264724ENST00000455683MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000264724ENST00000417270MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-5UTRENST00000264724ENST00000483022MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000420772ENST00000296473MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000420772ENST00000455683MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000420772ENST00000417270MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-5UTRENST00000420772ENST00000483022MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000441748ENST00000296473MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000441748ENST00000455683MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000441748ENST00000417270MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-5UTRENST00000441748ENST00000483022MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000462206ENST00000296473MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000462206ENST00000455683MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000462206ENST00000417270MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-5UTRENST00000462206ENST00000483022MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000434267ENST00000296473MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000434267ENST00000455683MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-3CDSENST00000434267ENST00000417270MAP4chr3

48130263

-MON1Achr3

49950792

-
intron-5UTRENST00000434267ENST00000483022MAP4chr3

48130263

-MON1Achr3

49950792

-

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FusionProtFeatures for MAP4_MON1A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4

P27816

MON1A

Q86VX9

Non-neuronal microtubule-associated protein. Promotesmicrotubule assembly. {ECO:0000269|PubMed:10791892}. Plays an important role in membrane trafficking throughthe secretory apparatus. Not involved in endocytic trafficking tolysosomes (By similarity). Acts in concert with CCZ1, as a guanineexchange factor (GEF) for RAB7, promotes the exchange of GDP toGTP, converting it from an inactive GDP-bound form into an activeGTP-bound form (PubMed:23084991). {ECO:0000250|UniProtKB:Q6PDG8,ECO:0000269|PubMed:23084991}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP4_MON1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP4_MON1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP4MARK4, ENO2, CDK1, FYCO1, NR1I3, RXRB, RXRG, GSK3B, HDGF, SIRT7, SH3KBP1, ISG15, TERF1, POT1, CUL4A, USP21, GRK5, EPS15, AP2M1, RPS20, UBC, TRAF3IP1, FN1, IL7R, ERBB2IP, SNTA1, BAG3, LDLR, TARDBP, HNRNPF, COG7, CSTF2, EIF2S1, HNRNPR, IARS, MTA2, POLR2A, POLR2C, PPP4R1, WDHD1, LSM8, PDCD6, RPA3, RPA2, RPA1, LGR4, CCDC8, ABCE1, FLNB, LSM3, HSPA5, LASP1, SERBP1, SLK, NTRK1, SRPK2, KIF11, CRY2, OTUB1, CDH1, EGFR, G3BP1, BRCA1, YAP1MON1AMAPK6, RGS2, TAB1, GFI1B, RABGEF1, VPS33A, SP6, AP1M2, XPO1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP4_MON1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAP4P27816DB01248DocetaxelMicrotubule-associated protein 4small moleculeapproved|investigational
HgeneMAP4P27816DB11638ArtenimolMicrotubule-associated protein 4small moleculeapproved|investigational
HgeneMAP4P27816DB01229PaclitaxelMicrotubule-associated protein 4small moleculeapproved|vet_approved

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RelatedDiseases for MAP4_MON1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP4C0043094Weight Gain1CTD_human
TgeneMON1AC0012715Iron Metabolism Disorders1CTD_human