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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20921

FusionGeneSummary for MAP4_DHX30

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4_DHX30
Fusion gene ID: 20921
HgeneTgene
Gene symbol

MAP4

DHX30

Gene ID

4134

22907

Gene namemicrotubule associated protein 4DExH-box helicase 30
Synonyms-DDX30|NEDMIAL|RETCOR
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein 4MAP-4putative ATP-dependent RNA helicase DHX30DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 30DEAH (Asp-Glu-Ala-His) box helicase 30DEAH (Asp-Glu-Ala-His) box polypeptide 30DEAH box protein 30DEAH-box helicase 30retina co-repressor
Modification date2018052320180523
UniProtAcc

P27816

Q7L2E3

Ensembl transtripts involved in fusion geneENST00000383737, ENST00000395734, 
ENST00000426837, ENST00000360240, 
ENST00000439356, ENST00000264724, 
ENST00000420772, ENST00000441748, 
ENST00000462206, ENST00000434267, 
ENST00000446256, ENST00000445061, 
ENST00000476446, ENST00000348968, 
ENST00000457607, 
Fusion gene scores* DoF score23 X 16 X 14=51525 X 3 X 5=75
# samples 316
** MAII scorelog2(31/5152*10)=-4.05479247284038
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP4 [Title/Abstract] AND DHX30 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-B0-4822-01AMAP4chr3

48130263

-DHX30chr3

47846816

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000383737ENST00000446256MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000383737ENST00000445061MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-3UTRENST00000383737ENST00000476446MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000383737ENST00000348968MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-intronENST00000383737ENST00000457607MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000395734ENST00000446256MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000395734ENST00000445061MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-3UTRENST00000395734ENST00000476446MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000395734ENST00000348968MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-intronENST00000395734ENST00000457607MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000426837ENST00000446256MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000426837ENST00000445061MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-3UTRENST00000426837ENST00000476446MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000426837ENST00000348968MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-intronENST00000426837ENST00000457607MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000360240ENST00000446256MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000360240ENST00000445061MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-3UTRENST00000360240ENST00000476446MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000360240ENST00000348968MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-intronENST00000360240ENST00000457607MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000439356ENST00000446256MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000439356ENST00000445061MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-3UTRENST00000439356ENST00000476446MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-5UTRENST00000439356ENST00000348968MAP4chr3

48130263

-DHX30chr3

47846816

+
5UTR-intronENST00000439356ENST00000457607MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000264724ENST00000446256MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000264724ENST00000445061MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-3UTRENST00000264724ENST00000476446MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000264724ENST00000348968MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-intronENST00000264724ENST00000457607MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000420772ENST00000446256MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000420772ENST00000445061MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-3UTRENST00000420772ENST00000476446MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000420772ENST00000348968MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-intronENST00000420772ENST00000457607MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000441748ENST00000446256MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000441748ENST00000445061MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-3UTRENST00000441748ENST00000476446MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000441748ENST00000348968MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-intronENST00000441748ENST00000457607MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000462206ENST00000446256MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000462206ENST00000445061MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-3UTRENST00000462206ENST00000476446MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000462206ENST00000348968MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-intronENST00000462206ENST00000457607MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000434267ENST00000446256MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000434267ENST00000445061MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-3UTRENST00000434267ENST00000476446MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-5UTRENST00000434267ENST00000348968MAP4chr3

48130263

-DHX30chr3

47846816

+
intron-intronENST00000434267ENST00000457607MAP4chr3

48130263

-DHX30chr3

47846816

+

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FusionProtFeatures for MAP4_DHX30


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4

P27816

DHX30

Q7L2E3

Non-neuronal microtubule-associated protein. Promotesmicrotubule assembly. {ECO:0000269|PubMed:10791892}. Plays an important role in the assembly of themitochondrial large ribosomal subunit (PubMed:25683715). Requiredfor optimal function of the zinc-finger antiviral protein ZC3HAV1(By similarity). Associates with mitochondrial DNA(PubMed:18063578). {ECO:0000250|UniProtKB:Q5BJS0,ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:25683715}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP4_DHX30


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP4_DHX30


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP4MARK4, ENO2, CDK1, FYCO1, NR1I3, RXRB, RXRG, GSK3B, HDGF, SIRT7, SH3KBP1, ISG15, TERF1, POT1, CUL4A, USP21, GRK5, EPS15, AP2M1, RPS20, UBC, TRAF3IP1, FN1, IL7R, ERBB2IP, SNTA1, BAG3, LDLR, TARDBP, HNRNPF, COG7, CSTF2, EIF2S1, HNRNPR, IARS, MTA2, POLR2A, POLR2C, PPP4R1, WDHD1, LSM8, PDCD6, RPA3, RPA2, RPA1, LGR4, CCDC8, ABCE1, FLNB, LSM3, HSPA5, LASP1, SERBP1, SLK, NTRK1, SRPK2, KIF11, CRY2, OTUB1, CDH1, EGFR, G3BP1, BRCA1, YAP1DHX30H2AFX, ICT1, DHX58, OAS3, EIF2AK2, HDGF, SIRT7, HNRNPA1, CUL3, CUL4B, CUL5, CUL1, COPS5, CAND1, GRK5, ILF3, GNAI2, RAB31, NDUFA2, ESR1, FN1, SKIL, HNRNPD, TARDBP, NEDD4, WWOX, GRSF1, IVNS1ABP, STAU1, ENO1, MOV10, NXF1, OBSL1, CCDC8, EZH2, SUZ12, RNF2, HIST1H1A, PRR11, ILF2, NTRK1, IFI16, TCTN2, HNRNPU, RPL10, NOP56, IBTK, LDHD, KMT2E, NF2, FAM136A, CISD3, ZNF746, MCMBP, WDR46, RRS1, GLTSCR2, RPL18A, ZNF2, FGF8, RRP8, ZC3HAV1, ZNF324B, CDX1, RPL30, CPNE4, GPATCH4, RPL37A, PDGFB, ZNF71, PPAN, HIST1H1E, DGCR8, RPL18, RBM34, CNBP, FGF3, SART3, LTF, ZFC3H1, GSPT2, RPS14, STUB1, NKRF, NCL, CYLD, INO80B, COX15, PDHA1, G3BP1, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP4_DHX30


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAP4P27816DB01248DocetaxelMicrotubule-associated protein 4small moleculeapproved|investigational
HgeneMAP4P27816DB11638ArtenimolMicrotubule-associated protein 4small moleculeapproved|investigational
HgeneMAP4P27816DB01229PaclitaxelMicrotubule-associated protein 4small moleculeapproved|vet_approved

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RelatedDiseases for MAP4_DHX30


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP4C0043094Weight Gain1CTD_human