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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20919

FusionGeneSummary for MAP4_CCDC85B

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4_CCDC85B
Fusion gene ID: 20919
HgeneTgene
Gene symbol

MAP4

CCDC85B

Gene ID

4134

11007

Gene namemicrotubule associated protein 4coiled-coil domain containing 85B
Synonyms-DIPA
Cytomap

3p21.31

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein 4MAP-4coiled-coil domain-containing protein 85Bdelta-interacting protein Ahepatitis delta antigen-interacting protein A
Modification date2018052320180522
UniProtAcc

P27816

Q15834

Ensembl transtripts involved in fusion geneENST00000383737, ENST00000395734, 
ENST00000426837, ENST00000360240, 
ENST00000439356, ENST00000264724, 
ENST00000420772, ENST00000441748, 
ENST00000462206, ENST00000434267, 
ENST00000312579, 
Fusion gene scores* DoF score23 X 16 X 14=51521 X 1 X 1=1
# samples 311
** MAII scorelog2(31/5152*10)=-4.05479247284038
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: MAP4 [Title/Abstract] AND CCDC85B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCDC85B

GO:0030308

negative regulation of cell growth

17873903

TgeneCCDC85B

GO:0045892

negative regulation of transcription, DNA-templated

17014843


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1467-01AMAP4chr3

48040128

-CCDC85Bchr11

65658328

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000383737ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
Frame-shiftENST00000395734ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
Frame-shiftENST00000426837ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
Frame-shiftENST00000360240ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
Frame-shiftENST00000439356ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
intron-3CDSENST00000264724ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
intron-3CDSENST00000420772ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
intron-3CDSENST00000441748ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
intron-3CDSENST00000462206ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+
In-frameENST00000434267ENST00000312579MAP4chr3

48040128

-CCDC85Bchr11

65658328

+

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FusionProtFeatures for MAP4_CCDC85B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4

P27816

CCDC85B

Q15834

Non-neuronal microtubule-associated protein. Promotesmicrotubule assembly. {ECO:0000269|PubMed:10791892}. Functions as a transcriptional repressor(PubMed:17014843). May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (PubMed:17873903).May function in adipocyte differentiation, negatively regulatingmitotic clonal expansion (By similarity).{ECO:0000250|UniProtKB:Q6PDY0, ECO:0000269|PubMed:17014843,ECO:0000269|PubMed:17873903}. (Microbial infection) Plays a role in hepatitis deltavirus (HDV) genomic replication. {ECO:0000269|PubMed:8810253}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP4_CCDC85B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MAP4_ENST00000434267_chr3_48040128_-_CCDC85B_ENST00000312579_chr11_65658328_+_155aa
MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEEALLPPRRRPPGLLPE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MAP4_ENST00000434267_chr3_48040128_-_CCDC85B_ENST00000312579_chr11_65658328_+_465nt
ATGGCTGACCTCAGTCTTGCAGATGCATTAACAGAACCATCTCCAGACATTGAGGGAGAGATAAAGCGGGACTTCATTGCCACACTAGAG
GCAGAGGCCTTTGATGATGTTGTGGGAGAAACTGTTGGAAAAACAGACTATATTCCTCTCCTGGATGTTGATGAGAAAACCGGGAACTCA
GAGTCAAAGAAGAAACCGTGCTCAGAAACTAGCCAGATTGAAGAGGCACTGCTTCCTCCACGCCGACGCCCGCCCGGATTGCTCCCCGAG
CCCCGGGACCGCTGTGGACCTCGGGACCTGGACGCCGTCCTGGCTGCGCAGGAGGGGCCGCTGGCATGGACTAAGAAATCCTGACACCAA
GAAGGGCCCCTCGCTCTTGCTGGCAGGGCAGCAGGGGGACTGAAGGCTGGAGCGGAGGGACTTGCTGGGGGTTGGATTGGGGGTAATAAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_MAP4_ENST00000434267_chr3_48040128_-_CCDC85B_ENST00000312579_chr11_65658328_+_1098nt
GGACAGAAATGTTGAAGGCAGGTGCCTGATCCAAAATGCATTTAGTCAGGACTGAACACAAGCTGCCTGGATAGTTCCTGCAGTTGCAGT
GGTGCAGAATGGCTGACCTCAGTCTTGCAGATGCATTAACAGAACCATCTCCAGACATTGAGGGAGAGATAAAGCGGGACTTCATTGCCA
CACTAGAGGCAGAGGCCTTTGATGATGTTGTGGGAGAAACTGTTGGAAAAACAGACTATATTCCTCTCCTGGATGTTGATGAGAAAACCG
GGAACTCAGAGTCAAAGAAGAAACCGTGCTCAGAAACTAGCCAGATTGAAGGCGGCGCCTGCGGCGGGAGGAGGCGGCGCGCCTGGCGGC
ACTGGTGCAGCGCGGCCGCCTCATGCAGGAGGTGAATCGGCAGCTGCAGGGCCACCTGGGCGAGATCCGCGAGCTCAAGCAGCTCAACCG
GCGTCTGCAGGCAGAGAACCGTGAGCTGCGCGACCTCTGCTGCTTCCTGGACTCGGAGCGCCAGCGCGGGCGGCGCGCCGCACGCCAGTG
GCAGCTCTTCGGGACCCAAGCATCCCGGGCCGTGCGCGAGGACCTGGGCGGCTGTTGGCAGAAGCTGGCCGAGCTGGAGGGCCGCCAGGA
GGAGCTGCTGCGGGAGAACCTAGCGCTTAAGGAGCTCTGCCTGGCGCTGGGCGAAGAATGGGGCCCCCGCGGCGGCCCCAGCGGCGCCGG
GGGATCAGGAGCCGGGCCAGCACCCGAGCTTGCCTTGCCCCCGTGCGGGCCCCGCGACCTAGGCGATGGAAGCTCCAGCACTGGCAGCGT
GGGCAGTCCGGATCAGTTGCCCCTGGCCTGTTCCCCCGATGATTGAAGGCACTGCTTCCTCCACGCCGACGCCCGCCCGGATTGCTCCCC
GAGCCCCGGGACCGCTGTGGACCTCGGGACCTGGACGCCGTCCTGGCTGCGCAGGAGGGGCCGCTGGCATGGACTAAGAAATCCTGACAC
CAAGAAGGGCCCCTCGCTCTTGCTGGCAGGGCAGCAGGGGGACTGAAGGCTGGAGCGGAGGGACTTGCTGGGGGTTGGATTGGGGGTAAT


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FusionGenePPI for MAP4_CCDC85B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP4MARK4, ENO2, CDK1, FYCO1, NR1I3, RXRB, RXRG, GSK3B, HDGF, SIRT7, SH3KBP1, ISG15, TERF1, POT1, CUL4A, USP21, GRK5, EPS15, AP2M1, RPS20, UBC, TRAF3IP1, FN1, IL7R, ERBB2IP, SNTA1, BAG3, LDLR, TARDBP, HNRNPF, COG7, CSTF2, EIF2S1, HNRNPR, IARS, MTA2, POLR2A, POLR2C, PPP4R1, WDHD1, LSM8, PDCD6, RPA3, RPA2, RPA1, LGR4, CCDC8, ABCE1, FLNB, LSM3, HSPA5, LASP1, SERBP1, SLK, NTRK1, SRPK2, KIF11, CRY2, OTUB1, CDH1, EGFR, G3BP1, BRCA1, YAP1CCDC85BFAM27E3, ZNF250, KANSL1, NEK6, PBXIP1, ZNF821, NIF3L1, CCNK, ZNF337, PLOD3, ALS2CR11, NGFRAP1, ZNF165, TCEANC, SMARCD1, TSPYL4, CFAP53, AKAP17A, TUBGCP4, TNNT1, KRT20, EPS8, PRPF3, COPS4, FBF1, THAP7, MEAF6, PSMC6, FXR2, ZNF417, CCDC112, BEX2, CHCHD3, SYT17, ZNF426, FAM214B, FAM208B, CCDC33, HNRNPC, LNX1, CWC25, CDK18, LZTS2, EZH2, IKZF5, TNNI1, CCDC185, RBM7, USP2, SETD5, FAM50B, KRT6A, SYTL4, MOAP1, ZNF205, SIX1, FASTKD5, RBM41, CCDC120, C10orf10, AKIRIN2, DTNB, KRT17, ZFP36, AGGF1, PKN1, MCM10, CCDC116, TCHP, TEAD4, CCDC67, FCHSD2, DOK5, LMO3, KIAA0408, MBIP, RIBC2, POLR2L, EXOC7, VPS72, MCRS1, KRT18, ZNF638, C19orf25, GCC1, RNF8, RALYL, SF3A3, TTC14, SCNM1, HMG20B, DUSP13, ZBTB5, NDUFA5, C1orf111, PSMA1, EXOC8, UTP14A, ENKD1, SLU7, CEP70, EIF3H, PSMF1, APEX2, CDKN1A, LDOC1, PLEKHF2, FAM13C, PSMC1, CARD9, FAM107A, ZC2HC1C, GPANK1, ZNF764, PRC1, C7orf50, MOB1A, PIDD1, ZBTB16, C20orf195, C21orf91, MOB4, C8orf48, NRIP1, ZFC3H1, FAM124B, AQP1, UTP6, NUP54, GFI1B, TTC25, ZNF564, FAM74A4, MAGEA4, PPP1CC, PPP1CA, CRYAB, RPL22L1, PPP1R13B, TP53BP2, PPP1R3A, RASSF9, SKA3, SSSCA1, CCDC136, TSKS, RGS6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP4_CCDC85B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAP4P27816DB01248DocetaxelMicrotubule-associated protein 4small moleculeapproved|investigational
HgeneMAP4P27816DB11638ArtenimolMicrotubule-associated protein 4small moleculeapproved|investigational
HgeneMAP4P27816DB01229PaclitaxelMicrotubule-associated protein 4small moleculeapproved|vet_approved

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RelatedDiseases for MAP4_CCDC85B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP4C0043094Weight Gain1CTD_human