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Fusion gene ID: 20911 |
FusionGeneSummary for MAP4K5_L2HGDH |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP4K5_L2HGDH | Fusion gene ID: 20911 | Hgene | Tgene | Gene symbol | MAP4K5 | L2HGDH | Gene ID | 11183 | 79944 |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 5 | L-2-hydroxyglutarate dehydrogenase | |
| Synonyms | GCKR|KHS|KHS1|MAPKKKK5 | C14orf160|L2HGA | |
| Cytomap | 14q22.1 | 14q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase kinase 5MAPK/ERK kinase kinase kinase 5MEK kinase kinase 5MEKKK 5germinal center kinase-relatedkinase homologous to SPS1/STE20 | L-2-hydroxyglutarate dehydrogenase, mitochondrial2-hydroxyglutarate dehydrogenaseL-alpha-hydroxyglutarate dehydrogenasealpha-hydroxyglutarate oxidoreductasealpha-ketoglutarate reductaseduranin | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y4K4 | Q9H9P8 | |
| Ensembl transtripts involved in fusion gene | ENST00000013125, ENST00000557578, | ENST00000261699, ENST00000267436, ENST00000421284, ENST00000555423, ENST00000555610, ENST00000556393, | |
| Fusion gene scores | * DoF score | 9 X 9 X 8=648 | 6 X 5 X 4=120 |
| # samples | 13 | 6 | |
| ** MAII score | log2(13/648*10)=-2.31748218985617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAP4K5 [Title/Abstract] AND L2HGDH [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP4K5 | GO:0006468 | protein phosphorylation | 9038372 |
| Hgene | MAP4K5 | GO:0035556 | intracellular signal transduction | 9038372 |
| Tgene | L2HGDH | GO:0044267 | cellular protein metabolic process | 16005139 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-2H-A9GQ-01A | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000013125 | ENST00000261699 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| In-frame | ENST00000013125 | ENST00000267436 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| In-frame | ENST00000013125 | ENST00000421284 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| 5CDS-intron | ENST00000013125 | ENST00000555423 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| 5CDS-intron | ENST00000013125 | ENST00000555610 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| 5CDS-intron | ENST00000013125 | ENST00000556393 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| intron-3CDS | ENST00000557578 | ENST00000261699 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| intron-3CDS | ENST00000557578 | ENST00000267436 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| intron-3CDS | ENST00000557578 | ENST00000421284 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| intron-intron | ENST00000557578 | ENST00000555423 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| intron-intron | ENST00000557578 | ENST00000555610 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
| intron-intron | ENST00000557578 | ENST00000556393 | MAP4K5 | chr14 | 50901112 | - | L2HGDH | chr14 | 50736048 | - |
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FusionProtFeatures for MAP4K5_L2HGDH |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP4K5 | L2HGDH |
| May play a role in the response to environmental stress.Appears to act upstream of the JUN N-terminal pathway.{ECO:0000269|PubMed:9038372}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAP4K5 | chr14:50901112 | chr14:50736048 | ENST00000013125 | - | 27 | 32 | 20_277 | 721 | 847 | Domain | Protein kinase |
| Hgene | MAP4K5 | chr14:50901112 | chr14:50736048 | ENST00000013125 | - | 27 | 32 | 26_34 | 721 | 847 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MAP4K5 | chr14:50901112 | chr14:50736048 | ENST00000013125 | - | 27 | 32 | 506_819 | 721 | 847 | Domain | CNH |
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FusionGeneSequence for MAP4K5_L2HGDH |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAP4K5_ENST00000013125_chr14_50901112_-_L2HGDH_ENST00000261699_chr14_50736048_-_917aa MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER LLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGD GISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRN PYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG AGRGNSMSVCCDMCRTLLRPYFRVEWLHSXSSNCTIPGRLPAFEARKMLSCKRKYLSGPRXPVSFPRSSLHTKDGWQYLARAXCSSCLXT RGLQTLXLQCHRCYGYNYQXWLDXTGIPEFFLWSYXNVXSMFSWCNSEVSSKIHPXNYYQXYTXAGGCERTELAMAATHESEXXQHLLFP >In-frame_MAP4K5_ENST00000013125_chr14_50901112_-_L2HGDH_ENST00000267436_chr14_50736048_-_939aa MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER LLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGD GISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRN PYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG AGRGNSMSVCCDMCRTLLRPYFRVEWLHSXSSNCTIPGRLPAFEARKMLSCKRKYLSGPRXPVSFPRSSLHTKDGWQYLARAXCSSCLXT RGLQTLXLQCHRCYGYNYQXWLDXTGIPEFFLWSYXNVXSMFSWCNSEVSSKIHPXNYYQXYTXGPSWSKSPGPGXRWKSGRRFCIXCRS >In-frame_MAP4K5_ENST00000013125_chr14_50901112_-_L2HGDH_ENST00000421284_chr14_50736048_-_939aa MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKL WICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAER LLTHTFVAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTASEINFDKLQFEPPLRKETEARDEMGL SSDPNFMLQWNPFVDGANTGKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGD GISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNE LHEATMEQLFPRKCTWLYVINNTLMSLSVGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHKCCIVRN PYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIG AGRGNSMSVCCDMCRTLLRPYFRVEWLHSXSSNCTIPGRLPAFEARKMLSCKRKYLSGPRXPVSFPRSSLHTKDGWQYLARAXCSSCLXT RGLQTLXLQCHRCYGYNYQXWLDXTGIPEFFLWSYXNVXSMFSWCNSEVSSKIHPXNYYQXYTXGPSWSKSPGPGXRWKSGRRFCIXCRS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAP4K5_ENST00000013125_chr14_50901112_-_L2HGDH_ENST00000261699_chr14_50736048_-_2752nt ATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCGGAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACC TACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGAGCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCT TTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACATTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTA TGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGATATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTA TGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAAAGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGAC CATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAAAATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTAC TGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGGCTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAA CTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAATGAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTA AAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGTCAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGA CTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAGAGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCAC GCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCATGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCT GAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATTTGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTG TCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGTTGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCT CCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGACAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGAT TCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAGCCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGAT GGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGCACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAA CCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGATGGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAAT TGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTACATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAG CTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTGTACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGA AAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTTTGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGG TTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAACAAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAAC CCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTCTGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTG ATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGTTTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTA GCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTTTGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGT GCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTGCAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGA TCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGAAGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGA TAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGATGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACG AGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTATGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTT TTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTGGTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAG TGATATACTTAGGCAGGTGGCTGTGAGAGGACCGAGCTGGCTATGGCAGCAACCCATGAAAGTGAGTGATAACAACATTTATTGTTTCCT >In-frame_MAP4K5_ENST00000013125_chr14_50901112_-_L2HGDH_ENST00000267436_chr14_50736048_-_2818nt ATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCGGAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACC TACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGAGCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCT TTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACATTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTA TGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGATATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTA TGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAAAGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGAC CATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAAAATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTAC TGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGGCTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAA CTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAATGAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTA AAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGTCAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGA CTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAGAGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCAC GCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCATGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCT GAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATTTGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTG TCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGTTGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCT CCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGACAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGAT TCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAGCCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGAT GGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGCACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAA CCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGATGGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAAT TGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTACATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAG CTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTGTACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGA AAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTTTGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGG TTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAACAAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAAC CCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTCTGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTG ATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGTTTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTA GCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTTTGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGT GCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTGCAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGA TCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGAAGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGA TAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGATGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACG AGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTATGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTT TTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTGGTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAG TGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCCTGGATAGAGATGGAAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGT TGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCACCTTCTCCTGCTGCTACTTCTTCCATTGCAATTTCTGGAATGATTGCAGA >In-frame_MAP4K5_ENST00000013125_chr14_50901112_-_L2HGDH_ENST00000421284_chr14_50736048_-_2818nt ATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCGGAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACC TACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGAGCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCT TTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACATTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTA TGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGATATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTA TGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAAAGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGAC CATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAAAATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTAC TGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGGCTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAA CTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAATGAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTA AAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGTCAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGA CTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAGAGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCAC GCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCATGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCT GAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATTTGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTG TCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGTTGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCT CCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGACAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGAT TCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAGCCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGAT GGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGCACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAA CCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGATGGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAAT TGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTACATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAG CTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTGTACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGA AAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTTTGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGG TTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAACAAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAAC CCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTCTGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTG ATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGTTTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTA GCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTTTGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGT GCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTGCAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGA TCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGAAGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGA TAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGATGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACG AGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTATGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTT TTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTGGTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAG TGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCCTGGATAGAGATGGAAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGT TGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCACCTTCTCCTGCTGCTACTTCTTCCATTGCAATTTCTGGAATGATTGCAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAP4K5_ENST00000013125_chr14_50901112_-_L2HGDH_ENST00000261699_chr14_50736048_-_3104nt GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCTTTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACA TTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTATGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGA TATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTATGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAA AGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGACCATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAA AATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTACTGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGG CTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAACTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAAT GAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTAAAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGT CAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGACTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAG AGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCACGCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCA TGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCTGAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATT TGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTGTCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGT TGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCTCCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGA CAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGATTCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAG CCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGATGGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGC ACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAACCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGAT GGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAATTGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTA CATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAGCTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTG TACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGAAAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTT TGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGGTTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAAC AAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAACCCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTC TGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTGATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGT TTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTAGCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTT TGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGTGCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTG CAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGA AGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGA TGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTA TGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTG GTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGCAGGTGGCTGTGAGAGGACCGAGCTGGC TATGGCAGCAACCCATGAAAGTGAGTGATAACAACATTTATTGTTTCCTGTGGCGTTGCTTTGCTTTGCTATTGACTGGTAGCGCTTGTA >In-frame_MAP4K5_ENST00000013125_chr14_50901112_-_L2HGDH_ENST00000267436_chr14_50736048_-_4793nt GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCTTTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACA TTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTATGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGA TATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTATGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAA AGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGACCATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAA AATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTACTGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGG CTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAACTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAAT GAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTAAAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGT CAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGACTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAG AGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCACGCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCA TGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCTGAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATT TGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTGTCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGT TGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCTCCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGA CAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGATTCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAG CCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGATGGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGC ACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAACCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGAT GGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAATTGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTA CATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAGCTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTG TACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGAAAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTT TGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGGTTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAAC AAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAACCCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTC TGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTGATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGT TTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTAGCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTT TGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGTGCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTG CAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGA AGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGA TGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTA TGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTG GTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCC TGGATAGAGATGGAAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCAC CTTCTCCTGCTGCTACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGATTTGAATTATAAATAATGAAAGGAG CTAGGTATGCACTGTAATCTTCATGTCAGCAACAAGAATGTACTAATTGCATTCTTTAATTTAAAAAATGGTTTTTAAACTTTAGTTTTT AGGTCAAAGATAACCACTGCATTGTTAAAATGATGTAACATAGAAATAATAATTTTCTACAAAAATTAGCCAGGCATGGTGGCGCATGCC TGTAATCTCAGCTACTCAGGAGGCTGAGGCAGGAGAATCAATTGAACCGAGCAGACGGAGGTGAGCTGAGAGCTGAGATTGCACCACTGC ACTCCAGCCTGGGTGACAGAGCAAGAAAATAATAATAATAATAATTTTCAAAATGTTAGGCTGGGGGCCGTGGCCAGCACTTTGGGAAGC CAAGGCAGGTAGATTGTAGCCCAGGAGTTTGAGAACAGCCTGGGCAACATGGCAAAACCCTGTTTCTACACAAAGTTAGCTGGGTCTGGT GCCTCTGTAGTTCCAGCTCCTCAGTAGGCTGAGGTGAGAGGATCACTTGAGCCCAGGAGGTCTAGGCTGCAGTGAGCTTATGTTCATGAC ACTGCATTCCAGGCTGGATGATAGAGCAAGATCTTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAAATCCAGCCTGGGCAACATAGTGAAT GAAACCCCATCTCTACAAAAAATACAAAAATTAGCTGGGCATGATGGTGTGTGCCTGTAGTCCCAGCTACTTGGGGGCTGAGGCAGGAGG ATCGCTTGAGCCCGGGAGATCAAGGCTACAGTGAGCTGTGTTCATGCCACTATACCCCAGCCTGGGCAACAAAGTGAGTCCCTGACTCAA AAAATAAAAACAACAACAAAAAATAAATTCCATGCTTATTTACTTTGCGAATAAAGAGGCAAGGTACAGTTTTATCTGTCCGAATCCCTG ACTTTTATTTATTTTTTTTTTCAGACGGAGTTTCACTCTTGTTGCCCAGGCTTGAGTGCAATGGTACGATCTTGGCTCACTGCAACCTCT GCCTCCCGGGTTCCAGCGATTCTCTTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCTGGCTAATTTTTTGTA TTTTTAGTAGAGACGGGGTTTTGCCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAAT GCTGGGATTACAGGTGCGAGCCATCATGCTCAGCCCTGAATCCCTGACTTTGTTAATGACCTGTCCTTACCAACCATGACCTAGAGAAGA TTTGGCTTTTTAAGAGTTTTGGAGAAAGATGGCATAAAAATAGATTATTTCCTTAAATCAATTTTTTAGCATTACGCTACCTAAGCTCGT TTGGTCTCTCATAGACAAGAAAATACATTATATTGTAGGTTACATTCTTTTAATTTTGAAGAGTCACAAAACTCACATTATTTAGAGCAA CAATATTTGTATTTGGAAATTAAAAATTCATGATTTCAAGAAAATACATAAAATTTACATTTTTGAGTAGTTTGAATAAGTTTCTATCTT AATTATAATATTTGTAGGAAATAACAAAACAAACTCAAAGCCTTTATTATTTCCAGTCTCTTTGTAACTGATGTGGTATGGTATCATCAT >In-frame_MAP4K5_ENST00000013125_chr14_50901112_-_L2HGDH_ENST00000421284_chr14_50736048_-_3624nt GGGTGGGGAACGTGGTGCGGCGGCGGCGGCGGCGGCGACTGTACGCGCCTCCGCCGCCCCCGAGAGGACGCGCCGTGCAGCGGCTGAGTG GCGGCGGCGGCGACGGCAAACCCGGAGCTGCCGGCCGGCGCGCGGGAGGAGGACGCGGGTGCGGTCTAGGAAGTAGGTCCCGGGCTCCGC GCTCAACAAAGACGGGGCCGCCCCCATTAGACGGAGCTGCGGGCGGAGGCTCCATGTTGGGAAGCGGCGCCGTTCGTGCTTGTTAGCGGG AATCCGGGAGCCGCGGGGTGAGCTGGCGGGGGCCGGGCCCTAAGTGAAGATGGAGGCCCCGCTGCGGCCTGCCGCGGACATCCTGAGGCG GAACCCGCAGCAGGACTACGAACTCGTCCAGAGGGTCGGCAGCGGCACCTACGGGGACGTCTATAAGGCCAGAAATGTACACACAGGAGA GCTGGCTGCAGTAAAAATCATTAAATTGGAGCCTGGAGATGATTTTTCTTTGATTCAACAAGAAATATTTATGGTTAAAGAATGTAAACA TTGTAACATCGTTGCCTACTTTGGGAGTTATCTTAGTCGGGAAAAACTATGGATTTGTATGGAATACTGTGGTGGCGGATCACTTCAAGA TATTTACCATGTTACTGGACCATTATCAGAATTGCAAATAGCCTATGTATGCAGAGAAACCTTACAGGGTCTTGCCTATTTGCATACTAA AGGCAAAATGCATAGAGATATCAAAGGTGCTAATATTTTATTGACAGACCATGGCGATGTAAAATTAGCTGACTTTGGTGTGGCTGCAAA AATAACAGCTACCATTGCAAAACGAAAATCTTTCATTGGCACCCCTTACTGGATGGCCCCAGAAGTTGCAGCAGTAGAGAAGAATGGTGG CTACAACCAACTCTGTGATATCTGGGCAGTAGGAATAACAGCAATTGAACTTGGAGAACTTCAGCCACCTATGTTTGATCTCCACCCAAT GAGGGCTCTCTTCTTAATGTCAAAAAGTAATTTTCAGCCTCCAAAACTAAAGGACAAAACAAAATGGTCATCAACATTCCATAATTTTGT CAAAATAGCACTAACCAAAAACCCAAAAAAAAGACCAACTGCTGAAAGACTTCTGACTCACACTTTTGTTGCACAGCCAGGTCTCTCTAG AGCCCTAGCAGTTGAACTGTTAGACAAAGTGAACAATCCAGATAACCACGCACATTACACTGAAGCAGATGACGATGACTTTGAGCCCCA TGCAATCATTCGTCATACCATTAGATCTACAAACAGGAATGCCAGAGCTGAACGGACAGCTTCAGAAATAAATTTTGACAAATTACAATT TGAACCTCCTCTGAGAAAAGAAACAGAAGCACGAGATGAAATGGGATTGTCATCAGACCCAAATTTCATGTTACAGTGGAATCCTTTTGT TGATGGTGCAAATACTGGCAAATCAACCTCAAAACGTGCAATACCACCTCCCCTACCTCCTAAGCCAAGGATAAGCAGTTACCCTGAAGA CAACTTTCCGGATGAAGAAAAAGCATCAACCATAAAACATTGTCCTGATTCAGAAAGCAGAGCTCCCCAAATTCTCAGAAGACAGAGTAG CCCAAGTTGTGGGCCTGTGGCAGAGACTTCTTCTATTGGAAATGGTGATGGTATTTCAAAACTGATGAGTGAAAATACAGAAGGATCAGC ACAAGCACCACAGTTACCACGAAAAAAGGACAAACGAGACTTCCCTAAACCAGCCATCAATGGCCTTCCACCCACCCCAAAAGTTCTGAT GGGAGCATGCTTTTCAAAAGTTTTTGATGGCTGTCCTTTGAAAATTAATTGTGCAACATCCTGGATACATCCTGATACAAAAGATCAGTA CATTATTTTTGGAACTGAAGATGGTATTTACACACTGAATCTCAATGAGCTACATGAGGCAACGATGGAACAGTTATTTCCACGGAAGTG TACTTGGCTGTATGTTATCAATAATACTTTAATGTCATTATCAGTAGGAAAAACCTTTCAGCTCTACTCTCACAATCTTATAGCTTTGTT TGAACATGCCAAAAAACCAGGATTAGCTGCCCATATTCAAACTCACAGGTTTCCAGACCGAATACTACCAAGAAAATTCGCTTTAACAAC AAAGATTCCTGATACAAAAGGCTGCCACAAATGTTGCATAGTCAGAAACCCTTACACGGGACATAAATACCTCTGTGGAGCTTTACAGTC TGGAATTGTTTTACTTCAGTGGTATGAGCCAATGCAGAAATTCATGTTGATAAAGCACTTTGATTTTCCTTTGCCAAGTCCTTTGAATGT TTTTGAAATGCTGGTGATACCTGAACAGGAATACCCTATGGTCTGTGTAGCTATTAGCAAAGGCACTGAATCGAATCAGGTAGTTCAGTT TGAGACAATCAATTTGAACTCTGCATCTTCATGGTTTACAGAAATTGGTGCAGGGAGAGGAAATTCGATGTCAGTATGTTGTGACATGTG CAGGACTTTACTCAGACCGTATTTCAGAGTTGAGTGGCTGCACTCCTGATCCTCGAATTGTACCATTCCGGGGAGATTACCTGCTTTTGA AGCCAGAAAAATGTTATCTTGTAAAAGGAAATATTTATCCGGTCCCAGATAGCCGGTTTCCTTTCCTAGGAGTTCACTTCACACCAAGGA TGGATGGCAGTATTTGGCTAGGGCCTAATGCAGTTCTTGCCTTTAAACGAGAGGGTTACAGACCCTTTGACTTCAGTGCCACAGATGTTA TGGATATAATTATCAATAGTGGCTTGATTAAACTGGCATCCCAGAATTTTTCCTATGGAGTTACTGAAATGTATAAAGCATGTTTTCTTG GTGCAACAGTGAAGTATCTTCAAAAATTCATCCCTGAAATTACTATCAGTGATATACTTAGGGGCCCAGCTGGAGTAAGAGCCCAGGCCC TGGATAGAGATGGAAATCTGGTAGAAGATTTTGTATTTGATGCAGGAGTTGGGGATATTGGAAATCGCATTCTTCATGTGAGAAATGCAC CTTCTCCTGCTGCTACTTCTTCCATTGCAATTTCTGGAATGATTGCAGATGAAGTACAACAAAGATTTGAATTATAAATAATGAAAGGAG CTAGACGGAGTTTCACTCTTGTTGCCCAGGCTTGAGTGCAATGGTACGATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCCAGCGAT TCTCTTGCCTCAACCTCCTGAGTAGCTGGGATTACAGGCGCCCACCACCATGCCTGGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTT TTGCCATGTTGGCCAGGCTGGTCTCGAATTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAATGCTGGGATTACAGGTGCGAG CCATCATGCTCAGCCCTGAATCCCTGACTTTGTTAATGACCTGTCCTTACCAACCATGACCTAGAGAAGATTTGGCTTTTTAAGAGTTTT GGAGAAAGATGGCATAAAAATAGATTATTTCCTTAAATCAATTTTTTAGCATTACGCTACCTAAGCTCGTTTGGTCTCTCATAGACAAGA |
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FusionGenePPI for MAP4K5_L2HGDH |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAP4K5 | CRK, CRKL, TRAF2, HCK, COPS5, GRB2, ZNF440, SETDB1, NEDD4, ELAVL1, CDRT15, NTRK1, PPM1A, PPM1B, SMURF1, MAP4K3 | L2HGDH | A2ML1, TGM1, LCN2, GM2A, CTSV, IVL, KLK10, ATL3, POU5F1, COQ9, COQ5, ITGB8, ACPP, SERPINB4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP4K5_L2HGDH |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP4K5_L2HGDH |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | L2HGDH | C1855995 | L-2-HYDROXYGLUTARIC ACIDURIA | 3 | ORPHANET;UNIPROT |
| Tgene | L2HGDH | C2746066 | Combined D-2- and L-2-hydroxyglutaric aciduria | 3 | CTD_human |
| Tgene | L2HGDH | C0014544 | Epilepsy | 1 | CTD_human |
| Tgene | L2HGDH | C0497552 | Congenital neurologic anomalies | 1 | CTD_human |
| Tgene | L2HGDH | C3714756 | Intellectual Disability | 1 | CTD_human |
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