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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20906

FusionGeneSummary for MAP4K4_REV1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4K4_REV1
Fusion gene ID: 20906
HgeneTgene
Gene symbol

MAP4K4

REV1

Gene ID

9448

51455

Gene namemitogen-activated protein kinase kinase kinase kinase 4REV1, DNA directed polymerase
SynonymsFLH21957|HEL-S-31|HGK|MEKKK4|NIKAIBP80|REV1L
Cytomap

2q11.2

2q11.2

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase-DNA repair protein REV1REV1 homologREV1, polymerase (DNA directed)REV1- likealpha integrin-binding protein 80rev1-like terminal deoxycytidyl transferase
Modification date2018052320180522
UniProtAcc

O95819

Q9UBZ9

Ensembl transtripts involved in fusion geneENST00000425019, ENST00000324219, 
ENST00000350198, ENST00000302217, 
ENST00000413150, ENST00000347699, 
ENST00000456652, ENST00000350878, 
ENST00000498066, 		ENST00000393445, 
ENST00000258428, ENST00000465835, 
Fusion gene scores* DoF score11 X 7 X 8=6162 X 2 X 2=8
# samples 112
** MAII scorelog2(11/616*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: MAP4K4 [Title/Abstract] AND REV1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP4K4

GO:0006468

protein phosphorylation

9890973

HgeneMAP4K4

GO:0035556

intracellular signal transduction

9890973

HgeneMAP4K4

GO:0046328

regulation of JNK cascade

14966141

TgeneREV1

GO:0009411

response to UV

11485998


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-PG-A914-01AMAP4K4chr2

102472600

+REV1chr2

100055772

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000425019ENST00000393445MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000425019ENST00000258428MAP4K4chr2

102472600

+REV1chr2

100055772

-
5CDS-5UTRENST00000425019ENST00000465835MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000324219ENST00000393445MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000324219ENST00000258428MAP4K4chr2

102472600

+REV1chr2

100055772

-
5CDS-5UTRENST00000324219ENST00000465835MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000350198ENST00000393445MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000350198ENST00000258428MAP4K4chr2

102472600

+REV1chr2

100055772

-
5CDS-5UTRENST00000350198ENST00000465835MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000302217ENST00000393445MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000302217ENST00000258428MAP4K4chr2

102472600

+REV1chr2

100055772

-
5CDS-5UTRENST00000302217ENST00000465835MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000413150ENST00000393445MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000413150ENST00000258428MAP4K4chr2

102472600

+REV1chr2

100055772

-
5CDS-5UTRENST00000413150ENST00000465835MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000347699ENST00000393445MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000347699ENST00000258428MAP4K4chr2

102472600

+REV1chr2

100055772

-
5CDS-5UTRENST00000347699ENST00000465835MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000456652ENST00000393445MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000456652ENST00000258428MAP4K4chr2

102472600

+REV1chr2

100055772

-
5CDS-5UTRENST00000456652ENST00000465835MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000350878ENST00000393445MAP4K4chr2

102472600

+REV1chr2

100055772

-
Frame-shiftENST00000350878ENST00000258428MAP4K4chr2

102472600

+REV1chr2

100055772

-
5CDS-5UTRENST00000350878ENST00000465835MAP4K4chr2

102472600

+REV1chr2

100055772

-
intron-3CDSENST00000498066ENST00000393445MAP4K4chr2

102472600

+REV1chr2

100055772

-
intron-3CDSENST00000498066ENST00000258428MAP4K4chr2

102472600

+REV1chr2

100055772

-
intron-5UTRENST00000498066ENST00000465835MAP4K4chr2

102472600

+REV1chr2

100055772

-

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FusionProtFeatures for MAP4K4_REV1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4K4

O95819

REV1

Q9UBZ9

Serine/threonine kinase that may play a role in theresponse to environmental stress and cytokines such as TNF-alpha.Appears to act upstream of the JUN N-terminal pathway.Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388,ECO:0000269|PubMed:9890973}. Deoxycytidyl transferase involved in DNA repair.Transfers a dCMP residue from dCTP to the 3'-end of a DNA primerin a template-dependent reaction. May assist in the first step inthe bypass of abasic lesions by the insertion of a nucleotideopposite the lesion. Required for normal induction of mutations byphysical and chemical agents. {ECO:0000269|PubMed:10536157,ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384,ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP4K4_REV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP4K4_REV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP4K4BRCA1, RASA1, ITGB1, NCK1, MAP3K1, GBP3, ZRANB1, KIF5A, PRKCE, SLC9A1, HIST2H2BE, KIF26B, PPP1CA, GRK5, PAXIP1, PPP1CC, HSP90AA1, NME7, MOB1B, TBPL2, OBSL1, MINK1, SLC25A41, TEX264, NCK2, PTGER3, LTBR, HEPACAM2, NTRK1, CDK12, NOP2, CEP152, CNTRL, TMEM17, XPO1, PPP2CB, RNH1, STRN, FGFR1OP2, STRN3, RAP2C, NANOS2, ATG14, CNOT11, MANSC1, TRIM25, G3BP1REV1MAD2L2, POLH, POLDIP2, HSP90AA1, HSP90AB1, PCNA, UBC, MYC, POLK, POLI, REV3L, C1orf86, REV1, CDC27, BRCA1, MSH2, POLD3, RELA, CLK1, PIAS4, TP53, FANCD2, FANCI, FHL2, TSC22D2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP4K4_REV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP4K4_REV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource