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Fusion gene ID: 20906 |
FusionGeneSummary for MAP4K4_REV1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MAP4K4_REV1 | Fusion gene ID: 20906 | Hgene | Tgene | Gene symbol | MAP4K4 | REV1 | Gene ID | 9448 | 51455 |
Gene name | mitogen-activated protein kinase kinase kinase kinase 4 | REV1, DNA directed polymerase | |
Synonyms | FLH21957|HEL-S-31|HGK|MEKKK4|NIK | AIBP80|REV1L | |
Cytomap | 2q11.2 | 2q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | mitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase- | DNA repair protein REV1REV1 homologREV1, polymerase (DNA directed)REV1- likealpha integrin-binding protein 80rev1-like terminal deoxycytidyl transferase | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | O95819 | Q9UBZ9 | |
Ensembl transtripts involved in fusion gene | ENST00000425019, ENST00000324219, ENST00000350198, ENST00000302217, ENST00000413150, ENST00000347699, ENST00000456652, ENST00000350878, ENST00000498066, | ENST00000393445, ENST00000258428, ENST00000465835, | |
Fusion gene scores | * DoF score | 11 X 7 X 8=616 | 2 X 2 X 2=8 |
# samples | 11 | 2 | |
** MAII score | log2(11/616*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: MAP4K4 [Title/Abstract] AND REV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAP4K4 | GO:0006468 | protein phosphorylation | 9890973 |
Hgene | MAP4K4 | GO:0035556 | intracellular signal transduction | 9890973 |
Hgene | MAP4K4 | GO:0046328 | regulation of JNK cascade | 14966141 |
Tgene | REV1 | GO:0009411 | response to UV | 11485998 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | UCEC | TCGA-PG-A914-01A | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000425019 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000425019 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
5CDS-5UTR | ENST00000425019 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000324219 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000324219 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
5CDS-5UTR | ENST00000324219 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000350198 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000350198 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
5CDS-5UTR | ENST00000350198 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000302217 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000302217 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
5CDS-5UTR | ENST00000302217 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000413150 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000413150 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
5CDS-5UTR | ENST00000413150 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000347699 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000347699 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
5CDS-5UTR | ENST00000347699 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000456652 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000456652 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
5CDS-5UTR | ENST00000456652 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000350878 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
Frame-shift | ENST00000350878 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
5CDS-5UTR | ENST00000350878 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
intron-3CDS | ENST00000498066 | ENST00000393445 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
intron-3CDS | ENST00000498066 | ENST00000258428 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
intron-5UTR | ENST00000498066 | ENST00000465835 | MAP4K4 | chr2 | 102472600 | + | REV1 | chr2 | 100055772 | - |
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FusionProtFeatures for MAP4K4_REV1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MAP4K4 | REV1 |
Serine/threonine kinase that may play a role in theresponse to environmental stress and cytokines such as TNF-alpha.Appears to act upstream of the JUN N-terminal pathway.Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388,ECO:0000269|PubMed:9890973}. | Deoxycytidyl transferase involved in DNA repair.Transfers a dCMP residue from dCTP to the 3'-end of a DNA primerin a template-dependent reaction. May assist in the first step inthe bypass of abasic lesions by the insertion of a nucleotideopposite the lesion. Required for normal induction of mutations byphysical and chemical agents. {ECO:0000269|PubMed:10536157,ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384,ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP4K4_REV1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAP4K4_REV1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAP4K4 | BRCA1, RASA1, ITGB1, NCK1, MAP3K1, GBP3, ZRANB1, KIF5A, PRKCE, SLC9A1, HIST2H2BE, KIF26B, PPP1CA, GRK5, PAXIP1, PPP1CC, HSP90AA1, NME7, MOB1B, TBPL2, OBSL1, MINK1, SLC25A41, TEX264, NCK2, PTGER3, LTBR, HEPACAM2, NTRK1, CDK12, NOP2, CEP152, CNTRL, TMEM17, XPO1, PPP2CB, RNH1, STRN, FGFR1OP2, STRN3, RAP2C, NANOS2, ATG14, CNOT11, MANSC1, TRIM25, G3BP1 | REV1 | MAD2L2, POLH, POLDIP2, HSP90AA1, HSP90AB1, PCNA, UBC, MYC, POLK, POLI, REV3L, C1orf86, REV1, CDC27, BRCA1, MSH2, POLD3, RELA, CLK1, PIAS4, TP53, FANCD2, FANCI, FHL2, TSC22D2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP4K4_REV1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP4K4_REV1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |