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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20898

FusionGeneSummary for MAP4K4_ASH1L

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4K4_ASH1L
Fusion gene ID: 20898
HgeneTgene
Gene symbol

MAP4K4

ASH1L

Gene ID

9448

55870

Gene namemitogen-activated protein kinase kinase kinase kinase 4ASH1 like histone lysine methyltransferase
SynonymsFLH21957|HEL-S-31|HGK|MEKKK4|NIKASH1|ASH1L1|KMT2H|MRD52
Cytomap

2q11.2

1q22

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 4HPK/GCK-like kinase HGKMAPK/ERK kinase kinase kinase 4MEK kinase kinase 4Ste20 group protein kinase HGKepididymis secretory protein Li 31hepatocyte progenitor kinase-like/germinal center kinase-histone-lysine N-methyltransferase ASH1LASH1-like proteinabsent small and homeotic disks protein 1 homologash1 (absent, small, or homeotic)-likelysine N-methyltransferase 2Hprobable histone-lysine N-methyltransferase ASH1L
Modification date2018052320180519
UniProtAcc

O95819

Q9NR48

Ensembl transtripts involved in fusion geneENST00000425019, ENST00000324219, 
ENST00000350198, ENST00000302217, 
ENST00000413150, ENST00000347699, 
ENST00000456652, ENST00000350878, 
ENST00000498066, 
ENST00000368346, 
ENST00000392403, ENST00000548830, 
Fusion gene scores* DoF score11 X 7 X 8=6169 X 8 X 5=360
# samples 119
** MAII scorelog2(11/616*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/360*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP4K4 [Title/Abstract] AND ASH1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP4K4

GO:0006468

protein phosphorylation

9890973

HgeneMAP4K4

GO:0035556

intracellular signal transduction

9890973

HgeneMAP4K4

GO:0046328

regulation of JNK cascade

14966141

TgeneASH1L

GO:0097676

histone H3-K36 dimethylation

26002201


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE929112MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000425019ENST00000368346MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000425019ENST00000392403MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
5CDS-3UTRENST00000425019ENST00000548830MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000324219ENST00000368346MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000324219ENST00000392403MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
5CDS-3UTRENST00000324219ENST00000548830MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000350198ENST00000368346MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000350198ENST00000392403MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
5CDS-3UTRENST00000350198ENST00000548830MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
intron-3CDSENST00000302217ENST00000368346MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
intron-3CDSENST00000302217ENST00000392403MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
intron-3UTRENST00000302217ENST00000548830MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000413150ENST00000368346MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000413150ENST00000392403MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
5CDS-3UTRENST00000413150ENST00000548830MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000347699ENST00000368346MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000347699ENST00000392403MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
5CDS-3UTRENST00000347699ENST00000548830MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
intron-3CDSENST00000456652ENST00000368346MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
intron-3CDSENST00000456652ENST00000392403MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
intron-3UTRENST00000456652ENST00000548830MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000350878ENST00000368346MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
Frame-shitENST00000350878ENST00000392403MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
5CDS-3UTRENST00000350878ENST00000548830MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
intron-3CDSENST00000498066ENST00000368346MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
intron-3CDSENST00000498066ENST00000392403MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+
intron-3UTRENST00000498066ENST00000548830MAP4K4chr2

102456351

+ASH1Lchr1

155451874

+

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FusionProtFeatures for MAP4K4_ASH1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4K4

O95819

ASH1L

Q9NR48

Serine/threonine kinase that may play a role in theresponse to environmental stress and cytokines such as TNF-alpha.Appears to act upstream of the JUN N-terminal pathway.Phosphorylates SMAD1 on Thr-322. {ECO:0000269|PubMed:21690388,ECO:0000269|PubMed:9890973}. Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). {ECO:0000269|PubMed:21239497}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP4K4_ASH1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP4K4_ASH1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP4K4_ASH1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP4K4_ASH1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneASH1LC0023903Liver neoplasms1CTD_human