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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20890

FusionGeneSummary for MAP4K2_NETO2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP4K2_NETO2
Fusion gene ID: 20890
HgeneTgene
Gene symbol

MAP4K2

NETO2

Gene ID

5871

81831

Gene namemitogen-activated protein kinase kinase kinase kinase 2neuropilin and tolloid like 2
SynonymsBL44|GCK|RAB8IPBTCL2|NEOT2
Cytomap

11q13.1

16q12.1

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 2B lymphocyte serine/threonine protein kinaseMAPK/ERK kinase kinase kinase 2MEK kinase kinase 2MEKKK 2Rab8 interacting proteingerminal centre kinase (GC kinase)neuropilin and tolloid-like protein 2brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2neuropilin (NRP) and tolloid (TLL)-like 2
Modification date2018052320180519
UniProtAcc

Q12851

Q8NC67

Ensembl transtripts involved in fusion geneENST00000377350, ENST00000294066, 
ENST00000468062, 
ENST00000562435, 
ENST00000303155, 
Fusion gene scores* DoF score1 X 2 X 1=22 X 3 X 2=12
# samples 13
** MAII scorelog2(1/2*10)=2.32192809488736log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAP4K2 [Title/Abstract] AND NETO2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP4K2

GO:0006468

protein phosphorylation

11784851

HgeneMAP4K2

GO:0007257

activation of JUN kinase activity

17584736

HgeneMAP4K2

GO:0035556

intracellular signal transduction

11784851

HgeneMAP4K2

GO:0046330

positive regulation of JNK cascade

17584736


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A0C3-01AMAP4K2chr11

64566266

-NETO2chr16

47143622

-
TCGALDBRCATCGA-BH-A0C3-01AMAP4K2chr11

64566893

-NETO2chr16

47120250

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000377350ENST00000562435MAP4K2chr11

64566266

-NETO2chr16

47143622

-
Frame-shitENST00000377350ENST00000303155MAP4K2chr11

64566266

-NETO2chr16

47143622

-
Frame-shitENST00000294066ENST00000562435MAP4K2chr11

64566266

-NETO2chr16

47143622

-
Frame-shitENST00000294066ENST00000303155MAP4K2chr11

64566266

-NETO2chr16

47143622

-
intron-3CDSENST00000468062ENST00000562435MAP4K2chr11

64566266

-NETO2chr16

47143622

-
intron-3CDSENST00000468062ENST00000303155MAP4K2chr11

64566266

-NETO2chr16

47143622

-
Frame-shitENST00000377350ENST00000562435MAP4K2chr11

64566893

-NETO2chr16

47120250

-
Frame-shitENST00000377350ENST00000303155MAP4K2chr11

64566893

-NETO2chr16

47120250

-
Frame-shitENST00000294066ENST00000562435MAP4K2chr11

64566893

-NETO2chr16

47120250

-
Frame-shitENST00000294066ENST00000303155MAP4K2chr11

64566893

-NETO2chr16

47120250

-
intron-3CDSENST00000468062ENST00000562435MAP4K2chr11

64566893

-NETO2chr16

47120250

-
intron-3CDSENST00000468062ENST00000303155MAP4K2chr11

64566893

-NETO2chr16

47120250

-

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FusionProtFeatures for MAP4K2_NETO2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP4K2

Q12851

NETO2

Q8NC67

Serine/threonine-protein kinase which acts as anessential component of the MAP kinase signal transduction pathway.Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstreamactivator of the stress-activated protein kinase/c-Jun N-terminalkinase (SAP/JNK) signaling pathway and to a lesser extent of thep38 MAPKs signaling pathway. Required for the efficient activationof JNKs by TRAF6-dependent stimuli, including pathogen-associatedmolecular patterns (PAMPs) such as polyinosine-polycytidine(poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan(PGN), or bacterial flagellin. To a lesser degree, IL-1 andengagement of CD40 also stimulate MAP4K2-mediated JNKs activation.The requirement for MAP4K2/GCK is most pronounced for LPSsignaling, and extends to LPS stimulation of c-Jun phosphorylationand induction of IL-8. Enhances MAP3K1 oligomerization, which mayrelieve N-terminal mediated MAP3K1 autoinhibition and lead toactivation following autophosphorylation. Mediates also theSAP/JNK signaling pathway and the p38 MAPKs signaling pathwaythrough activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3.May play a role in the regulation of vesicle targeting or fusion.regulation of vesicle targeting or fusion.{ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:15456887,ECO:0000269|PubMed:17584736, ECO:0000269|PubMed:7477268,ECO:0000269|PubMed:7515885, ECO:0000269|PubMed:9712898}. Accessory subunit of neuronal kainate-sensitiveglutamate receptors, GRIK2 and GRIK3. Increases kainate-receptorchannel activity, slowing the decay kinetics of the receptors,without affecting their expression at the cell surface, andincreasing the open probability of the receptor channels.Modulates the agonist sensitivity of kainate receptors. Slows thedecay of kainate receptor-mediated excitatory postsynapticcurrents (EPSCs), thus directly influencing synaptic transmission(By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP4K2_NETO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP4K2_NETO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP4K2MAP3K1, MAP2K4, TRAF2, RAB8A, HNRNPA2B1, XRCC6, SERPINA4, MCM3AP-AS1, SNRNP35, NACAD, DEFB1, PRDX4, POT1, MAP3K11, HSP90AA1NETO2ELAVL1, HLA-DRA, CD1B, NRG1, TMEM30A, IL9R, HLA-C, BTNL8, PTCH1, HTR3C, CHRNA9, PON2, TMEM17, KRT17, TIA1, AIMP2, IRS2, WDHD1, NELFCD, TRMT6, TMEM168, CCDC82, HS6ST2, ASIC4, TMED6, HTR3A, TMPRSS3, TMEM30B, ZNRF4, CLEC2D, ADAM33, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP4K2_NETO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP4K2_NETO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNETO2C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneNETO2C0036095Salivary Gland Neoplasms1CTD_human