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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20886

FusionGeneSummary for MAP3K8_LYZL2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP3K8_LYZL2
Fusion gene ID: 20886
HgeneTgene
Gene symbol

MAP3K8

LYZL2

Gene ID

1326

119180

Gene namemitogen-activated protein kinase kinase kinase 8lysozyme like 2
SynonymsAURA2|COT|EST|ESTF|MEKK8|TPL2|Tpl-2|c-COTLYZD2
Cytomap

10p11.23

10p11.23

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 8Ewing sarcoma transformantaugmented in rheumatoid arthritis 2cot (cancer Osaka thyroid) oncogeneproto-oncogene c-Cotproto-oncogene serine/threoine protein kinasetumor progression locus 2lysozyme-like protein 2lysozyme D2lysozyme-2
Modification date2018052320180523
UniProtAcc

P41279

Q7Z4W2

Ensembl transtripts involved in fusion geneENST00000263056, ENST00000542547, 
ENST00000375322, ENST00000375321, 
ENST00000375318, 
Fusion gene scores* DoF score3 X 3 X 3=272 X 2 X 2=8
# samples 32
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: MAP3K8 [Title/Abstract] AND LYZL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A1Z4-06AMAP3K8chr10

30748430

+LYZL2chr10

30900953

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000263056ENST00000375318MAP3K8chr10

30748430

+LYZL2chr10

30900953

-
Frame-shitENST00000542547ENST00000375318MAP3K8chr10

30748430

+LYZL2chr10

30900953

-
intron-3CDSENST00000375322ENST00000375318MAP3K8chr10

30748430

+LYZL2chr10

30900953

-
Frame-shitENST00000375321ENST00000375318MAP3K8chr10

30748430

+LYZL2chr10

30900953

-

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FusionProtFeatures for MAP3K8_LYZL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP3K8

P41279

LYZL2

Q7Z4W2

Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thusbeing critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation ofT-helper cell differentiation and IFNG expression in T-cells.Involved in mediating host resistance to bacterial infectionthrough negative regulation of type I interferon (IFN) production.In vitro, activates MAPK/ERK pathway in response to IL1 in anIRAK1-independent manner, leading to up-regulation of IL8 andCCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulationof immunoglobulin production. May also play a role in thetransduction of TNF signals that activate JNK and NF-kappa-B insome cell types. In adipocytes, activates MAPK/ERK pathway in anIKBKB-dependent manner in response to IL1B and TNF, but notinsulin, leading to induction of lipolysis. Plays a role in thecell cycle. Isoform 1 shows some transforming activity, althoughit is much weaker than that of the activated oncogenic variant.{ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451,ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247,ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140,ECO:0000269|PubMed:19754427, ECO:0000269|PubMed:19808894}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP3K8_LYZL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP3K8_LYZL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP3K8NFKB1, NFKB2, RELA, REL, TNIP2, KSR2, CHUK, MAP3K14, MAP2K1, MAP2K4, TRAF2, AKT1, CD40, TRAF6, TAB2, HSP90AA1, RIPK1, STIP1, ACY3, XPO1LYZL2GALNT18, ENTPD5, LOXL2, B4GALNT4, COL6A2, FKBP14, SULF1, VWDE, PCYOX1L, TMEM67, FIGNL1, GAS6, NPTX1, EDEM1, ERO1LB, ASPH, TTC17, NLGN2, COL14A1, SEPN1, CERCAM, CRELD2, CNTNAP3, LAMB2, LRP11, TMTC3, GALNS, RSPRY1, HECTD3, ITGAV, DNAJB9, FSTL1, OS9, MAN2A2, LAMB1, ARSG, TXNDC16, C1QL4, GLB1L, NAGLU, FKBP7, IGF1R, CHST10, PROS1, ADAM9, ZZEF1, MGAT5, MAN2A1, MRC2, MANBA, TUBA4A, POGLUT1, HSP90B1, HSPA5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP3K8_LYZL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP3K8_LYZL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP3K8C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneMAP3K8C0151744Myocardial Ischemia1CTD_human