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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20870

FusionGeneSummary for MAP3K4_XAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP3K4_XAF1
Fusion gene ID: 20870
HgeneTgene
Gene symbol

MAP3K4

XAF1

Gene ID

4216

54739

Gene namemitogen-activated protein kinase kinase kinase 4XIAP associated factor 1
SynonymsMAPKKK4|MEKK 4|MEKK4|MTK1|PRO0412BIRC4BP|HSXIAPAF1|XIAPAF1
Cytomap

6q26

17p13.1

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 4MAP three kinase 1MAP/ERK kinase kinase 4MAPK/ERK kinase kinase 4MEK kinase 4SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog ofdJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)predicteXIAP-associated factor 1BIRC4-binding protein
Modification date2018052420180520
UniProtAcc

Q9Y6R4

Q6GPH4

Ensembl transtripts involved in fusion geneENST00000366919, ENST00000392142, 
ENST00000348824, ENST00000366920, 
ENST00000446500, 
ENST00000438512, 
ENST00000441631, ENST00000346752, 
ENST00000361842, ENST00000576459, 
Fusion gene scores* DoF score5 X 3 X 5=751 X 1 X 1=1
# samples 51
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: MAP3K4 [Title/Abstract] AND XAF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP3K4

GO:0000186

activation of MAPKK activity

9305639|9827804

HgeneMAP3K4

GO:0043507

positive regulation of JUN kinase activity

9305639

HgeneMAP3K4

GO:1900745

positive regulation of p38MAPK cascade

9305639

TgeneXAF1

GO:0035456

response to interferon-beta

18035482


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3M1-01AMAP3K4chr6

161502070

+XAF1chr17

6673962

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000366919ENST00000438512MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000366919ENST00000441631MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000366919ENST00000346752MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000366919ENST00000361842MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000366919ENST00000576459MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000392142ENST00000438512MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000392142ENST00000441631MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000392142ENST00000346752MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000392142ENST00000361842MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000392142ENST00000576459MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000348824ENST00000438512MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000348824ENST00000441631MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000348824ENST00000346752MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000348824ENST00000361842MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000348824ENST00000576459MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000366920ENST00000438512MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000366920ENST00000441631MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000366920ENST00000346752MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000366920ENST00000361842MAP3K4chr6

161502070

+XAF1chr17

6673962

+
5CDS-intronENST00000366920ENST00000576459MAP3K4chr6

161502070

+XAF1chr17

6673962

+
intron-intronENST00000446500ENST00000438512MAP3K4chr6

161502070

+XAF1chr17

6673962

+
intron-intronENST00000446500ENST00000441631MAP3K4chr6

161502070

+XAF1chr17

6673962

+
intron-intronENST00000446500ENST00000346752MAP3K4chr6

161502070

+XAF1chr17

6673962

+
intron-intronENST00000446500ENST00000361842MAP3K4chr6

161502070

+XAF1chr17

6673962

+
intron-intronENST00000446500ENST00000576459MAP3K4chr6

161502070

+XAF1chr17

6673962

+

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FusionProtFeatures for MAP3K4_XAF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP3K4

Q9Y6R4

XAF1

Q6GPH4

Component of a protein kinase signal transductioncascade. Activates the CSBP2, P38 and JNK MAPK pathways, but notthe ERK pathway. Specifically phosphorylates and activates MAP2K4and MAP2K6. {ECO:0000269|PubMed:12052864,ECO:0000269|PubMed:9305639}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP3K4_XAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP3K4_XAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAP3K4CDC42, RAC1, MAP2K1, MAP2K4, MAP2K3, MAP2K6, GADD45G, GADD45B, GADD45A, ALK, SH3KBP1, TPR, YWHAZ, CNTRL, ZFP36, TRAF4, MAP2K7, RIPK2, MAPK8, CHUK, GSK3B, MAP3K4, AXIN1, HNRNPD, POLR2F, RAP1B, SORT1, SRPR, KIF23, BAG3, SYNCRIP, AP4E1, GOLT1B, SGTB, KIF21A, VWA9, CNTROB, NEDD1, KIF7, BAG6, USF1, MAPK13, SPATA1, ACTBL2, SIGLECL1, BTK, TOP1, TOP2A, TOP3AXAF1XIAP, BIRC3, BIRC2, NAIP, BIRC7, APP, RNF114, TP53, SIAH2, HIPK2, CREBBP, TRAF2, RIPK1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP3K4_XAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP3K4_XAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP3K4C0014170Endometrial Neoplasms1CTD_human
TgeneXAF1C0009375Colonic Neoplasms2CTD_human
TgeneXAF1C0009404Colorectal Neoplasms1CTD_human
TgeneXAF1C0021400Influenza1CTD_human
TgeneXAF1C0038356Stomach Neoplasms1CTD_human