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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20853

FusionGeneSummary for MAP3K19_ARL6

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP3K19_ARL6
Fusion gene ID: 20853
HgeneTgene
Gene symbol

MAP3K19

ARL6

Gene ID

80122

84100

Gene namemitogen-activated protein kinase kinase kinase 19ADP ribosylation factor like GTPase 6
SynonymsRCK|YSK4BBS3|RP55
Cytomap

2q21.3

3q11.2

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 19SPS1/STE20-related protein kinase YSK4YSK4 Sps1/Ste20-related kinase homologregulated in COPD kinaseregulated in COPD, protein kinaseyeast Sps1/Ste20-related kinase 4ADP-ribosylation factor-like protein 6Bardet-Biedl syndrome 3 protein
Modification date2018052320180523
UniProtAcc

Q56UN5

Q9H0F7

Ensembl transtripts involved in fusion geneENST00000486077, ENST00000375845, 
ENST00000392917, ENST00000358371, 
ENST00000375844, ENST00000392918, 
ENST00000392915, ENST00000315513, 
ENST00000463745, ENST00000394206, 
ENST00000335979, ENST00000496713, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: MAP3K19 [Title/Abstract] AND ARL6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB235086MAP3K19chr2

135804755

-ARL6chr3

97516865

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000486077ENST00000463745MAP3K19chr2

135804755

-ARL6chr3

97516865

+
5UTR-3CDSENST00000486077ENST00000394206MAP3K19chr2

135804755

-ARL6chr3

97516865

+
5UTR-3CDSENST00000486077ENST00000335979MAP3K19chr2

135804755

-ARL6chr3

97516865

+
5UTR-intronENST00000486077ENST00000496713MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000375845ENST00000463745MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000375845ENST00000394206MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000375845ENST00000335979MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-intronENST00000375845ENST00000496713MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000392917ENST00000463745MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000392917ENST00000394206MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000392917ENST00000335979MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-intronENST00000392917ENST00000496713MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000358371ENST00000463745MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000358371ENST00000394206MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000358371ENST00000335979MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-intronENST00000358371ENST00000496713MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000375844ENST00000463745MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000375844ENST00000394206MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000375844ENST00000335979MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-intronENST00000375844ENST00000496713MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000392918ENST00000463745MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000392918ENST00000394206MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000392918ENST00000335979MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-intronENST00000392918ENST00000496713MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000392915ENST00000463745MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000392915ENST00000394206MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000392915ENST00000335979MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-intronENST00000392915ENST00000496713MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000315513ENST00000463745MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000315513ENST00000394206MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-3CDSENST00000315513ENST00000335979MAP3K19chr2

135804755

-ARL6chr3

97516865

+
intron-intronENST00000315513ENST00000496713MAP3K19chr2

135804755

-ARL6chr3

97516865

+

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FusionProtFeatures for MAP3K19_ARL6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP3K19

Q56UN5

ARL6

Q9H0F7

Involved in membrane protein trafficking at the base ofthe ciliary organelle. Mediates recruitment onto plasma membraneof the BBSome complex which would constitute a coat complexrequired for sorting of specific membrane proteins to the primarycilia (PubMed:20603001). Together with BBS1, is necessary forcorrect trafficking of PKD1 to primary cilia (By similarity).Together with the BBSome complex and LTZL1, controls SMO ciliarytrafficking and contributes to the sonic hedgehog (SHH) pathwayregulation (PubMed:22072986). May regulate cilia assembly anddisassembly and subsequent ciliary signaling events such as theWnt signaling cascade (PubMed:20207729). Isoform 2 may be requiredfor proper retinal function and organization (By similarity).{ECO:0000250|UniProtKB:O88848, ECO:0000269|PubMed:20207729,ECO:0000269|PubMed:20603001, ECO:0000269|PubMed:22072986}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP3K19_ARL6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP3K19_ARL6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP3K19_ARL6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP3K19_ARL6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneARL6C1859564Bardet-Biedl syndrome 34UNIPROT
TgeneARL6C3150808RETINITIS PIGMENTOSA 551CTD_human;UNIPROT