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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20830

FusionGeneSummary for MAP2_NAV1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP2_NAV1
Fusion gene ID: 20830
HgeneTgene
Gene symbol

MAP2

NAV1

Gene ID

10988

89796

Gene namemethionyl aminopeptidase 2neuron navigator 1
SynonymsMAP2|MNPEP|p67eIF2POMFIL3|STEERIN1|UNC53H1
Cytomap

12q22

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionmethionine aminopeptidase 2eIF-2-associated p67 homologinitiation factor 2-associated 67 kDa glycoproteinpeptidase M 2testicular tissue protein Li 17neuron navigator 1pore membrane and/or filament interacting like protein 3unc-53 homolog 1
Modification date2018051920180523
UniProtAcc

P11137

Q8NEY1

Ensembl transtripts involved in fusion geneENST00000199940, ENST00000360351, 
ENST00000361559, ENST00000392194, 
ENST00000447185, ENST00000475600, 
ENST00000367302, ENST00000367296, 
ENST00000295624, ENST00000367297, 
ENST00000367300, ENST00000367295, 
ENST00000469130, 
Fusion gene scores* DoF score6 X 5 X 4=1207 X 6 X 3=126
# samples 69
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/126*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAP2 [Title/Abstract] AND NAV1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP2

GO:0016485

protein processing

8858118

HgeneMAP2

GO:0018206

peptidyl-methionine modification

8858118

HgeneMAP2

GO:0031365

N-terminal protein amino acid modification

8858118


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T05560MAP2chr2

210393936

-NAV1chr1

201788982

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000199940ENST00000367302MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000199940ENST00000367296MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000199940ENST00000295624MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000199940ENST00000367297MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000199940ENST00000367300MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000199940ENST00000367295MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-intronENST00000199940ENST00000469130MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000360351ENST00000367302MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000360351ENST00000367296MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000360351ENST00000295624MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000360351ENST00000367297MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000360351ENST00000367300MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000360351ENST00000367295MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-intronENST00000360351ENST00000469130MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000361559ENST00000367302MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000361559ENST00000367296MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000361559ENST00000295624MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000361559ENST00000367297MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000361559ENST00000367300MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000361559ENST00000367295MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-intronENST00000361559ENST00000469130MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000392194ENST00000367302MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000392194ENST00000367296MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000392194ENST00000295624MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000392194ENST00000367297MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000392194ENST00000367300MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000392194ENST00000367295MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-intronENST00000392194ENST00000469130MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000447185ENST00000367302MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000447185ENST00000367296MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000447185ENST00000295624MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000447185ENST00000367297MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000447185ENST00000367300MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000447185ENST00000367295MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-intronENST00000447185ENST00000469130MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000475600ENST00000367302MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000475600ENST00000367296MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000475600ENST00000295624MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000475600ENST00000367297MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000475600ENST00000367300MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-3CDSENST00000475600ENST00000367295MAP2chr2

210393936

-NAV1chr1

201788982

+
intron-intronENST00000475600ENST00000469130MAP2chr2

210393936

-NAV1chr1

201788982

+

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FusionProtFeatures for MAP2_NAV1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP2

P11137

NAV1

Q8NEY1

The exact function of MAP2 is unknown but MAPs maystabilize the microtubules against depolymerization. They alsoseem to have a stiffening effect on microtubules.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP2_NAV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP2_NAV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for MAP2_NAV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAP2P11137DB01196EstramustineMicrotubule-associated protein 2small moleculeapproved|investigational
HgeneMAP2P11137DB01248DocetaxelMicrotubule-associated protein 2small moleculeapproved|investigational
HgeneMAP2P11137DB01229PaclitaxelMicrotubule-associated protein 2small moleculeapproved|vet_approved

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RelatedDiseases for MAP2_NAV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAP2C0000786Spontaneous abortion1CTD_human
HgeneMAP2C0005586Bipolar Disorder1PSYGENET
HgeneMAP2C0036341Schizophrenia1PSYGENET
HgeneMAP2C0041696Unipolar Depression1PSYGENET
HgeneMAP2C0525045Mood Disorders1PSYGENET
HgeneMAP2C1269683Major Depressive Disorder1PSYGENET
HgeneMAP2C3495559Juvenile arthritis1CTD_human
TgeneNAV1C0036341Schizophrenia1PSYGENET