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Fusion gene ID: 20813 |
FusionGeneSummary for MAP2K4_NIPSNAP1 |
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Fusion gene information | Fusion gene name: MAP2K4_NIPSNAP1 | Fusion gene ID: 20813 | Hgene | Tgene | Gene symbol | MAP2K4 | NIPSNAP1 | Gene ID | 6416 | 8508 |
Gene name | mitogen-activated protein kinase kinase 4 | nipsnap homolog 1 | |
Synonyms | JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1 | - | |
Cytomap | 17p12 | 22q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | dual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1 | protein NipSnap homolog 14-nitrophenylphosphatase domain and non-neuronal SNAP25-like 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P45985 | Q9BPW8 | |
Ensembl transtripts involved in fusion gene | ENST00000353533, ENST00000415385, ENST00000581941, | ENST00000216121, ENST00000494966, | |
Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 6 X 3 X 6=108 |
# samples | 7 | 6 | |
** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAP2K4 [Title/Abstract] AND NIPSNAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A0W7-01A | MAP2K4 | chr17 | 11924318 | + | NIPSNAP1 | chr22 | 29957851 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000353533 | ENST00000216121 | MAP2K4 | chr17 | 11924318 | + | NIPSNAP1 | chr22 | 29957851 | - |
5CDS-intron | ENST00000353533 | ENST00000494966 | MAP2K4 | chr17 | 11924318 | + | NIPSNAP1 | chr22 | 29957851 | - |
In-frame | ENST00000415385 | ENST00000216121 | MAP2K4 | chr17 | 11924318 | + | NIPSNAP1 | chr22 | 29957851 | - |
5CDS-intron | ENST00000415385 | ENST00000494966 | MAP2K4 | chr17 | 11924318 | + | NIPSNAP1 | chr22 | 29957851 | - |
intron-3CDS | ENST00000581941 | ENST00000216121 | MAP2K4 | chr17 | 11924318 | + | NIPSNAP1 | chr22 | 29957851 | - |
intron-intron | ENST00000581941 | ENST00000494966 | MAP2K4 | chr17 | 11924318 | + | NIPSNAP1 | chr22 | 29957851 | - |
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FusionProtFeatures for MAP2K4_NIPSNAP1 |
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Hgene | Tgene |
MAP2K4 | NIPSNAP1 |
Dual specificity protein kinase which acts as anessential component of the MAP kinase signal transduction pathway.Essential component of the stress-activated protein kinase/c-JunN-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7,is the one of the only known kinase to directly activate thestress-activated protein kinase/c-Jun N-terminal kinasesMAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 andMAP2K7/MKK7 both activate the JNKs by phosphorylation, but theydiffer in their preference for the phosphorylation site in theThr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation ofthe Tyr residue and MAP2K7/MKK7 for the Thr residue. Thephosphorylation of the Thr residue by MAP2K7/MKK7 seems to be theprerequisite for JNK activation at least in response toproinflammatory cytokines, while other stimuli activate bothMAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylateJNKs. MAP2K4 is required for maintaining peripheral lymphoidhomeostasis. The MKK/JNK signaling pathway is also involved inmitochondrial death signaling pathway, including the releasecytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7exclusively activates JNKs, MAP2K4/MKK4 additionally activates thep38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.{ECO:0000269|PubMed:7716521}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MAP2K4 | chr17:11924318 | chr22:29957851 | ENST00000353533 | + | 1 | 11 | 5_19 | 38 | 400 | Compositional bias | Note=Gly/Ser-rich |
Hgene | MAP2K4 | chr17:11924318 | chr22:29957851 | ENST00000415385 | + | 1 | 12 | 5_19 | 38 | 411 | Compositional bias | Note=Gly/Ser-rich |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >MAP2K4 | chr17:11924318 | chr22:29957851 | ENST00000353533 | + | 1 | 11 | 102_367 | 38 | 400 | Domain | Protein kinase |
Hgene | >MAP2K4 | chr17:11924318 | chr22:29957851 | ENST00000415385 | + | 1 | 12 | 102_367 | 38 | 411 | Domain | Protein kinase |
Hgene | >MAP2K4 | chr17:11924318 | chr22:29957851 | ENST00000353533 | + | 1 | 11 | 108_116 | 38 | 400 | Nucleotide binding | ATP |
Hgene | >MAP2K4 | chr17:11924318 | chr22:29957851 | ENST00000415385 | + | 1 | 12 | 108_116 | 38 | 411 | Nucleotide binding | ATP |
Hgene | >MAP2K4 | chr17:11924318 | chr22:29957851 | ENST00000353533 | + | 1 | 11 | 364_387 | 38 | 400 | Region | Note=DVD domain |
Hgene | >MAP2K4 | chr17:11924318 | chr22:29957851 | ENST00000353533 | + | 1 | 11 | 37_52 | 38 | 400 | Region | Note=D domain |
Hgene | >MAP2K4 | chr17:11924318 | chr22:29957851 | ENST00000415385 | + | 1 | 12 | 364_387 | 38 | 411 | Region | Note=DVD domain |
Hgene | >MAP2K4 | chr17:11924318 | chr22:29957851 | ENST00000415385 | + | 1 | 12 | 37_52 | 38 | 411 | Region | Note=D domain |
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FusionGeneSequence for MAP2K4_NIPSNAP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MAP2K4_ENST00000353533_chr17_11924318_+_NIPSNAP1_ENST00000216121_chr22_29957851_-_201aa MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWN EPQPRMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTV >In-frame_MAP2K4_ENST00000415385_chr17_11924318_+_NIPSNAP1_ENST00000216121_chr22_29957851_-_201aa MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQVHLWRFSGGYPALMDCMNKLKNNKEYLEFRRERSQMLLSRRNQLLLEFSFWN EPQPRMGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYVVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTV |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MAP2K4_ENST00000353533_chr17_11924318_+_NIPSNAP1_ENST00000216121_chr22_29957851_-_603nt ATGGCGGCTCCGAGCCCGAGCGGCGGCGGCGGCTCCGGGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGC CACCCGGCCGTCAGCAGCATGCAGGTGCACCTGTGGCGATTCTCAGGTGGCTACCCAGCCCTCATGGACTGCATGAACAAGCTCAAAAAC AATAAGGAGTACCTGGAGTTCCGAAGGGAGCGGAGCCAGATGCTGCTGTCCAGGAGAAACCAGCTGCTCCTCGAGTTCAGCTTCTGGAAT GAGCCACAGCCCAGAATGGGTCCCAACATCTATGAGCTGAGGACATACAAGCTCAAGCCAGGAACCATGATCGAGTGGGGGAACAACTGG GCTCGGGCCATCAAGTACCGGCAGGAGAACCAGGAGGCAGTGGGCGGCTTCTTCTCACAGATAGGAGAGCTCTACGTGGTGCACCATCTC TGGGCCTATAAAGACCTGCAGTCTCGGGAGGAGACTCGAAACGCTGCCTGGAGGAAGAGAGGCTGGGATGAAAATGTCTACTATACAGTC >In-frame_MAP2K4_ENST00000415385_chr17_11924318_+_NIPSNAP1_ENST00000216121_chr22_29957851_-_603nt ATGGCGGCTCCGAGCCCGAGCGGCGGCGGCGGCTCCGGGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGC CACCCGGCCGTCAGCAGCATGCAGGTGCACCTGTGGCGATTCTCAGGTGGCTACCCAGCCCTCATGGACTGCATGAACAAGCTCAAAAAC AATAAGGAGTACCTGGAGTTCCGAAGGGAGCGGAGCCAGATGCTGCTGTCCAGGAGAAACCAGCTGCTCCTCGAGTTCAGCTTCTGGAAT GAGCCACAGCCCAGAATGGGTCCCAACATCTATGAGCTGAGGACATACAAGCTCAAGCCAGGAACCATGATCGAGTGGGGGAACAACTGG GCTCGGGCCATCAAGTACCGGCAGGAGAACCAGGAGGCAGTGGGCGGCTTCTTCTCACAGATAGGAGAGCTCTACGTGGTGCACCATCTC TGGGCCTATAAAGACCTGCAGTCTCGGGAGGAGACTCGAAACGCTGCCTGGAGGAAGAGAGGCTGGGATGAAAATGTCTACTATACAGTC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MAP2K4_ENST00000353533_chr17_11924318_+_NIPSNAP1_ENST00000216121_chr22_29957851_-_1793nt GCGAGAGGCCGAGCTTGCTGCATTGCAGCCGCCGCGGCGCCGCTCGGCTCTTCACTCCCAACAATGGCGGCTCCGAGCCCGAGCGGCGGC GGCGGCTCCGGGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGCCACCCGGCCGTCAGCAGCATGCAGGTG CACCTGTGGCGATTCTCAGGTGGCTACCCAGCCCTCATGGACTGCATGAACAAGCTCAAAAACAATAAGGAGTACCTGGAGTTCCGAAGG GAGCGGAGCCAGATGCTGCTGTCCAGGAGAAACCAGCTGCTCCTCGAGTTCAGCTTCTGGAATGAGCCACAGCCCAGAATGGGTCCCAAC ATCTATGAGCTGAGGACATACAAGCTCAAGCCAGGAACCATGATCGAGTGGGGGAACAACTGGGCTCGGGCCATCAAGTACCGGCAGGAG AACCAGGAGGCAGTGGGCGGCTTCTTCTCACAGATAGGAGAGCTCTACGTGGTGCACCATCTCTGGGCCTATAAAGACCTGCAGTCTCGG GAGGAGACTCGAAACGCTGCCTGGAGGAAGAGAGGCTGGGATGAAAATGTCTACTATACAGTCCCCCTGGTGCGACACATGGAGTCTAGG ATCATGATCCCCTTGAAGATCTCGCCTCTGCAGTGATGCTGCCTACACCTCCACCTCCTTCCCCTTCTCCCTCAGGCAACCCCGACAGAC AGTGGCACTCCTGGTCCTGCTGTCTTGGTTTTGTCTTGGCTCTGGGAGGACTCTGAGGGGCAGTGCTCAGTTCAGACAAGGGGGAACTGA AGGCTGACAAGTTCTGAGGATTACAGCTCTGCCCAGGCCCTTTCTACTTTCCCTGCCTGCCTCCCTCCCCCTGCTAGAAGTAGTTTCTGA TTTCCCTGAATGAAAGATAGTGATCTTTTAGGCCTTCATTTATCTTCTAAAATTCCTCATCTCAAGGCCACCAGTCCCCAGTTATCACCC TTGGAAATCCTCTGTTTAGCTTAGTTGCACAAAAGGTAGTATGTCCAGTGGCTAGAGGTGGGGTGGGAAGAGAGGAGGCCAGGCCAGGCC CTCAGGAATTCCCTGGTTTCCACTGGGCCACCCACTTGCTGGACAGTCTGAGCCAAGTCCCTCCTGCTGGAGAAAAGCCTGGAACTGCCA AAACAAAAAAACAAATACAAACAAACCTCGTCACCACGGTCAGGAGGAGGTTCAGACATTCTGCCCAGAGGGGCTGGGGAAAGGGATGGG AGCCAGGAAAGATTTAGGGGCAGGAGACAGACACGTAACAGGAACTCGGAAGGTAGAACTTAGAATTCAGAACTTGGGTTTCAATTGTAG AATTTGGAATCTGGAATACAGAATTGGGAAGAAGAACAGAGATGACAAAAGACCACTTGAAGAGAGGTTCCTAATACTAGACAGATGGAG AGTGGCTTGGCTGTTTCCCCCTGCATATTGGGGTTGAAAACTTAAATGTGTAGTTCCAGTCCTTCTATGCAGAGTCTCTCCTGCCCTCCC TCCTTCCTGCAGGCAAATATACAAGCTAGACCCTGTTCCCTCACCCTGTATCCTGTCTCCCCTAATTGACATTCTATCAGCCCAACCCTC ATTCTGCAGGGCCACCTGGTGTGTGGAGGTGGCGGGAGGGGTCAGTGACTCTGGGGGTCTCCTCAGTGACCCCCATACCTCATCATGAAC >In-frame_MAP2K4_ENST00000415385_chr17_11924318_+_NIPSNAP1_ENST00000216121_chr22_29957851_-_1783nt GAGCTTGCTGCATTGCAGCCGCCGCGGCGCCGCTCGGCTCTTCACTCCCAACAATGGCGGCTCCGAGCCCGAGCGGCGGCGGCGGCTCCG GGGGCGGCAGCGGCAGCGGCACCCCCGGCCCCGTAGGGTCCCCGGCGCCAGGCCACCCGGCCGTCAGCAGCATGCAGGTGCACCTGTGGC GATTCTCAGGTGGCTACCCAGCCCTCATGGACTGCATGAACAAGCTCAAAAACAATAAGGAGTACCTGGAGTTCCGAAGGGAGCGGAGCC AGATGCTGCTGTCCAGGAGAAACCAGCTGCTCCTCGAGTTCAGCTTCTGGAATGAGCCACAGCCCAGAATGGGTCCCAACATCTATGAGC TGAGGACATACAAGCTCAAGCCAGGAACCATGATCGAGTGGGGGAACAACTGGGCTCGGGCCATCAAGTACCGGCAGGAGAACCAGGAGG CAGTGGGCGGCTTCTTCTCACAGATAGGAGAGCTCTACGTGGTGCACCATCTCTGGGCCTATAAAGACCTGCAGTCTCGGGAGGAGACTC GAAACGCTGCCTGGAGGAAGAGAGGCTGGGATGAAAATGTCTACTATACAGTCCCCCTGGTGCGACACATGGAGTCTAGGATCATGATCC CCTTGAAGATCTCGCCTCTGCAGTGATGCTGCCTACACCTCCACCTCCTTCCCCTTCTCCCTCAGGCAACCCCGACAGACAGTGGCACTC CTGGTCCTGCTGTCTTGGTTTTGTCTTGGCTCTGGGAGGACTCTGAGGGGCAGTGCTCAGTTCAGACAAGGGGGAACTGAAGGCTGACAA GTTCTGAGGATTACAGCTCTGCCCAGGCCCTTTCTACTTTCCCTGCCTGCCTCCCTCCCCCTGCTAGAAGTAGTTTCTGATTTCCCTGAA TGAAAGATAGTGATCTTTTAGGCCTTCATTTATCTTCTAAAATTCCTCATCTCAAGGCCACCAGTCCCCAGTTATCACCCTTGGAAATCC TCTGTTTAGCTTAGTTGCACAAAAGGTAGTATGTCCAGTGGCTAGAGGTGGGGTGGGAAGAGAGGAGGCCAGGCCAGGCCCTCAGGAATT CCCTGGTTTCCACTGGGCCACCCACTTGCTGGACAGTCTGAGCCAAGTCCCTCCTGCTGGAGAAAAGCCTGGAACTGCCAAAACAAAAAA ACAAATACAAACAAACCTCGTCACCACGGTCAGGAGGAGGTTCAGACATTCTGCCCAGAGGGGCTGGGGAAAGGGATGGGAGCCAGGAAA GATTTAGGGGCAGGAGACAGACACGTAACAGGAACTCGGAAGGTAGAACTTAGAATTCAGAACTTGGGTTTCAATTGTAGAATTTGGAAT CTGGAATACAGAATTGGGAAGAAGAACAGAGATGACAAAAGACCACTTGAAGAGAGGTTCCTAATACTAGACAGATGGAGAGTGGCTTGG CTGTTTCCCCCTGCATATTGGGGTTGAAAACTTAAATGTGTAGTTCCAGTCCTTCTATGCAGAGTCTCTCCTGCCCTCCCTCCTTCCTGC AGGCAAATATACAAGCTAGACCCTGTTCCCTCACCCTGTATCCTGTCTCCCCTAATTGACATTCTATCAGCCCAACCCTCATTCTGCAGG GCCACCTGGTGTGTGGAGGTGGCGGGAGGGGTCAGTGACTCTGGGGGTCTCCTCAGTGACCCCCATACCTCATCATGAACCCTTGGGTAG |
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FusionGenePPI for MAP2K4_NIPSNAP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAP2K4 | FLNC, SPAG9, MAPK8, MAP4K2, MAP2K7, MAP3K8, AKT1, MAPK8IP3, MAP3K11, MAP3K4, ARRB2, MAP3K2, MAP3K1, NPHS1, ITCH, MAPK9, BLNK, PML, MAPK10, MAP3K5, MAP2K6, MAP2K4, MAPK14, MAP3K3, LRRK2, APP, JUN, MAP3K7, ARRB1, MAPK1, GCH1, GEMIN5, RBBP8, EGFR, MAP3K10, NBR1, KTI12, VASP, FLNB, CDC5L, UBC, TRIM25 | NIPSNAP1 | RGS2, GABARAPL1, GABARAPL2, GBAS, MAP1LC3A, MAP1LC3B, SQSTM1, ICT1, PRKCI, DBI, CDH1, NPM1, AMOT, CTTNBP2NL, PARK2, VCP, ENO1, SHMT2, MOV10, NXF1, CUL7, OBSL1, FOXRED2, UBE2A, UBE2B, KCMF1, NTRK1, TCTN3, XPO1, CCT6A, FAT1, HSPD1, PLEC, PRKAA2, TCF20, TCP1, CCT3, BCL7B, GTF3C5, KNTC1, CCT7, CCT4, CCT2, IVNS1ABP, CCT8, HPSE, POP1, FNDC3A, CCT5, GANAB, ARHGEF12, ZNF281, C10orf12, HP1BP3, HAUS6, MRPS18A, ASCC2, TNRC18, DNAJC21, NSMCE2, GABARAP, COQ9, NDUFA4, CISD3, NDUFS3, C15orf48, CHCHD2, PTPMT1, IFT140, WDR19 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP2K4_NIPSNAP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP2K4_NIPSNAP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |