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Fusion gene ID: 20806 |
FusionGeneSummary for MAP2K2_ZDHHC12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAP2K2_ZDHHC12 | Fusion gene ID: 20806 | Hgene | Tgene | Gene symbol | MAP2K2 | ZDHHC12 | Gene ID | 5605 | 84885 |
| Gene name | mitogen-activated protein kinase kinase 2 | zinc finger DHHC-type containing 12 | |
| Synonyms | CFC4|MAPKK2|MEK2|MKK2|PRKMK2 | DHHC-12|ZNF400 | |
| Cytomap | 19p13.3 | 9q34.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | dual specificity mitogen-activated protein kinase kinase 2ERK activator kinase 2MAP kinase kinase 2MAPK/ERK kinase 2mitogen-activated protein kinase kinase 2, p45 | probable palmitoyltransferase ZDHHC12zinc finger DHHC domain-containing protein 12zinc finger protein 400 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P36507 | Q96GR4 | |
| Ensembl transtripts involved in fusion gene | ENST00000262948, ENST00000394867, ENST00000599345, | ENST00000372663, ENST00000372672, ENST00000372667, ENST00000467312, | |
| Fusion gene scores | * DoF score | 8 X 4 X 6=192 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/192*10)=-1.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MAP2K2 [Title/Abstract] AND ZDHHC12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAP2K2 | GO:0036289 | peptidyl-serine autophosphorylation | 8388392 |
| Hgene | MAP2K2 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 8388392 |
| Tgene | ZDHHC12 | GO:0018345 | protein palmitoylation | 23034182 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-G3-A7M7-01A | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000262948 | ENST00000372663 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| Frame-shift | ENST00000262948 | ENST00000372672 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| Frame-shift | ENST00000262948 | ENST00000372667 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| 5CDS-5UTR | ENST00000262948 | ENST00000467312 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| In-frame | ENST00000394867 | ENST00000372663 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| In-frame | ENST00000394867 | ENST00000372672 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| In-frame | ENST00000394867 | ENST00000372667 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| 5CDS-5UTR | ENST00000394867 | ENST00000467312 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| intron-3CDS | ENST00000599345 | ENST00000372663 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| intron-3CDS | ENST00000599345 | ENST00000372672 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| intron-3CDS | ENST00000599345 | ENST00000372667 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
| intron-5UTR | ENST00000599345 | ENST00000467312 | MAP2K2 | chr19 | 4097277 | - | ZDHHC12 | chr9 | 131484853 | - |
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FusionProtFeatures for MAP2K2_ZDHHC12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAP2K2 | ZDHHC12 |
| Catalyzes the concomitant phosphorylation of a threonineand a tyrosine residue in a Thr-Glu-Tyr sequence located in MAPkinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAP2K2_ZDHHC12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAP2K2_ENST00000394867_chr19_4097277_-_ZDHHC12_ENST00000372663_chr9_131484853_-_465aa MARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREK HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEA IFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNESCGNGRSRGSCSCPSPSCSWCWAPCCSTSLCHSWTLATX MCSPSLRRSSKRSRQPWFLQPSLFGAADTAWCCSPXGLGTAVSAAVASAATTTTAPGWRTVWESATTHSLWSTWRCSWWCFCGACTWHGQ ASGSSSPGVSGCGPAGSCSPPSCCCPSSRWWPACSSSRTSTWWPATPPPGNSSPHTASPISASAPATPSTEAXPATWPTSSVDGPQGPGR >In-frame_MAP2K2_ENST00000394867_chr19_4097277_-_ZDHHC12_ENST00000372672_chr9_131484853_-_413aa MARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREK HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEA IFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNESCGNGRSRGSCSCPSPSCSWCWAPCCSTSLCHSWTLATX MCSPSLRRSSKRSRQPWFLQPSLFGAADTAWCCSPXGLGTAVSAAVASAATTTTAPGWRTVWESATTHSLWSTWRCSWWCFCGACTWHGQ >In-frame_MAP2K2_ENST00000394867_chr19_4097277_-_ZDHHC12_ENST00000372667_chr9_131484853_-_465aa MARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREK HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEA IFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNESCGNGRSRGSCSCPSPSCSWCWAPCCSTSLCHSWTLATX MCSPSLRRSSKRSRQPWFLQPSLFGAADTAWCCSPXGLGTAVSAAVASAATTTTAPGWRTVWESATTHSLWSTWRCSWWCFCGACTWHGQ ASGSSSPGVSGCGPAGSCSPPSCCCPSSRWWPACSSSRTSTWWPATPPPGNSSPHTASPISASAPATPSTEAXPATWPTSSVDGPQGPGR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAP2K2_ENST00000394867_chr19_4097277_-_ZDHHC12_ENST00000372663_chr9_131484853_-_1397nt ATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAGGTCCTGCACGAATGCAACTCG CCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACACATGGACGGCGGCTCCCTGGACCAG GTGCTGAAAGAGGCCAAGAGGATTCCCGAGGAGATCCTGGGGAAAGTCAGCATCGCGGTTCTCCGGGGCTTGGCGTACCTCCGAGAGAAG CACCAGATCATGCACCGAGATGTGAAGCCCTCCAACATCCTCGTGAACTCTAGAGGGGAGATCAAGCTGTGTGACTTCGGGGTGAGCGGC CAGCTCATCGACTCCATGGCCAACTCCTTCGTGGGCACGCGCTCCTACATGGCTCCGGAGCGGTTGCAGGGCACACATTACTCGGTGCAG TCGGACATCTGGAGCATGGGCCTGTCCCTGGTGGAGCTGGCCGTCGGAAGGTACCCCATCCCCCCGCCCGACGCCAAAGAGCTGGAGGCC ATCTTTGGCCGGCCCGTGGTCGACGGGGAAGAAGGAGAGCCTCACAGCATCTCGCCTCGGCCGAGGCCCCCCGGGCGCCCCGTCAGCGGT CACGGGATGGATAGCCGGCCTGCCATGGCCATCTTTGAACTCCTGGACTATATTGTGAACGAGAGCTGCGGCAATGGGAGGAGCAGGGGG AGCTGCTCCTGCCCCTCACCTTCCTGCTCCTGGTGCTGGGCTCCCTGCTGCTCTACCTCGCTGTGTCACTCATGGACCCTGGCTACGTGA ATGTGCAGCCCCAGCCTCAGGAGGAGCTCAAAGAGGAGCAGACAGCCATGGTTCCTCCAGCCATCCCTCTTCGGCGCTGCAGATACTGCC TGGTGCTGCAGCCCCTGAGGGCTCGGCACTGCCGTGAGTGCCGCCGTTGCGTCCGCCGCTACGACCACCACTGCCCCTGGATGGAGAACT GTGTGGGAGAGCGCAACCACCCACTCTTTGTGGTCTACCTGGCGCTGCAGCTGGTGGTGCTTCTGTGGGGCCTGTACCTGGCATGGTCAG GCCTCCGGTTCTTCCAGCCCTGGGGTCAGTGGTTGCGGTCCAGCGGGCTCCTGTTCGCCACCTTCCTGCTGCTGTCCCTCTTCTCGTTGG TGGCCAGCCTGCTCCTCGTCTCGCACCTCTACCTGGTGGCCAGCAACACCACCACCTGGGAATTCATCTCCTCACACCGCATCGCCTATC TCCGCCAGCGCCCCAGCAACCCCTTCGACCGAGGCCTGACCCGCAACCTGGCCCACTTCTTCTGTGGATGGCCCTCAGGGTCCTGGGAGA >In-frame_MAP2K2_ENST00000394867_chr19_4097277_-_ZDHHC12_ENST00000372672_chr9_131484853_-_1241nt ATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAGGTCCTGCACGAATGCAACTCG CCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACACATGGACGGCGGCTCCCTGGACCAG GTGCTGAAAGAGGCCAAGAGGATTCCCGAGGAGATCCTGGGGAAAGTCAGCATCGCGGTTCTCCGGGGCTTGGCGTACCTCCGAGAGAAG CACCAGATCATGCACCGAGATGTGAAGCCCTCCAACATCCTCGTGAACTCTAGAGGGGAGATCAAGCTGTGTGACTTCGGGGTGAGCGGC CAGCTCATCGACTCCATGGCCAACTCCTTCGTGGGCACGCGCTCCTACATGGCTCCGGAGCGGTTGCAGGGCACACATTACTCGGTGCAG TCGGACATCTGGAGCATGGGCCTGTCCCTGGTGGAGCTGGCCGTCGGAAGGTACCCCATCCCCCCGCCCGACGCCAAAGAGCTGGAGGCC ATCTTTGGCCGGCCCGTGGTCGACGGGGAAGAAGGAGAGCCTCACAGCATCTCGCCTCGGCCGAGGCCCCCCGGGCGCCCCGTCAGCGGT CACGGGATGGATAGCCGGCCTGCCATGGCCATCTTTGAACTCCTGGACTATATTGTGAACGAGAGCTGCGGCAATGGGAGGAGCAGGGGG AGCTGCTCCTGCCCCTCACCTTCCTGCTCCTGGTGCTGGGCTCCCTGCTGCTCTACCTCGCTGTGTCACTCATGGACCCTGGCTACGTGA ATGTGCAGCCCCAGCCTCAGGAGGAGCTCAAAGAGGAGCAGACAGCCATGGTTCCTCCAGCCATCCCTCTTCGGCGCTGCAGATACTGCC TGGTGCTGCAGCCCCTGAGGGCTCGGCACTGCCGTGAGTGCCGCCGTTGCGTCCGCCGCTACGACCACCACTGCCCCTGGATGGAGAACT GTGTGGGAGAGCGCAACCACCCACTCTTTGTGGTCTACCTGGCGCTGCAGCTGGTGGTGCTTCTGTGGGGCCTGTACCTGGCATGGTCAG GCCTCCGGTTCTTCCAGCCCTGGGGTCAGTGGTTGCGGTCCAGCGGGCTCCTGTTCGCCACCTTCCTGCTGCTGGCCCACTTCTTCTGTG >In-frame_MAP2K2_ENST00000394867_chr19_4097277_-_ZDHHC12_ENST00000372667_chr9_131484853_-_1397nt ATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAGGTCCTGCACGAATGCAACTCG CCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACACATGGACGGCGGCTCCCTGGACCAG GTGCTGAAAGAGGCCAAGAGGATTCCCGAGGAGATCCTGGGGAAAGTCAGCATCGCGGTTCTCCGGGGCTTGGCGTACCTCCGAGAGAAG CACCAGATCATGCACCGAGATGTGAAGCCCTCCAACATCCTCGTGAACTCTAGAGGGGAGATCAAGCTGTGTGACTTCGGGGTGAGCGGC CAGCTCATCGACTCCATGGCCAACTCCTTCGTGGGCACGCGCTCCTACATGGCTCCGGAGCGGTTGCAGGGCACACATTACTCGGTGCAG TCGGACATCTGGAGCATGGGCCTGTCCCTGGTGGAGCTGGCCGTCGGAAGGTACCCCATCCCCCCGCCCGACGCCAAAGAGCTGGAGGCC ATCTTTGGCCGGCCCGTGGTCGACGGGGAAGAAGGAGAGCCTCACAGCATCTCGCCTCGGCCGAGGCCCCCCGGGCGCCCCGTCAGCGGT CACGGGATGGATAGCCGGCCTGCCATGGCCATCTTTGAACTCCTGGACTATATTGTGAACGAGAGCTGCGGCAATGGGAGGAGCAGGGGG AGCTGCTCCTGCCCCTCACCTTCCTGCTCCTGGTGCTGGGCTCCCTGCTGCTCTACCTCGCTGTGTCACTCATGGACCCTGGCTACGTGA ATGTGCAGCCCCAGCCTCAGGAGGAGCTCAAAGAGGAGCAGACAGCCATGGTTCCTCCAGCCATCCCTCTTCGGCGCTGCAGATACTGCC TGGTGCTGCAGCCCCTGAGGGCTCGGCACTGCCGTGAGTGCCGCCGTTGCGTCCGCCGCTACGACCACCACTGCCCCTGGATGGAGAACT GTGTGGGAGAGCGCAACCACCCACTCTTTGTGGTCTACCTGGCGCTGCAGCTGGTGGTGCTTCTGTGGGGCCTGTACCTGGCATGGTCAG GCCTCCGGTTCTTCCAGCCCTGGGGTCAGTGGTTGCGGTCCAGCGGGCTCCTGTTCGCCACCTTCCTGCTGCTGTCCCTCTTCTCGTTGG TGGCCAGCCTGCTCCTCGTCTCGCACCTCTACCTGGTGGCCAGCAACACCACCACCTGGGAATTCATCTCCTCACACCGCATCGCCTATC TCCGCCAGCGCCCCAGCAACCCCTTCGACCGAGGCCTGACCCGCAACCTGGCCCACTTCTTCTGTGGATGGCCCTCAGGGTCCTGGGAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAP2K2_ENST00000394867_chr19_4097277_-_ZDHHC12_ENST00000372663_chr9_131484853_-_2003nt GGACTCGGGCTGCGGCGTCAGCCTTCTTCGGGCCTCGGCAGCGGTAGCGGCTCGCTCGCCTCAGGCCCATCCCCTACCAGCGAGGGCGCC TCCGAGGCAAACCTGGTGGACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACC CAGAAAGCCAAGGTCGGCGAACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGTGGTCACCAAAGTC CAGCACAGACCCTCGGGCCTCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTG CAGGTCCTGCACGAATGCAACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACAC ATGGACGGCGGCTCCCTGGACCAGGTGCTGAAAGAGGCCAAGAGGATTCCCGAGGAGATCCTGGGGAAAGTCAGCATCGCGGTTCTCCGG GGCTTGGCGTACCTCCGAGAGAAGCACCAGATCATGCACCGAGATGTGAAGCCCTCCAACATCCTCGTGAACTCTAGAGGGGAGATCAAG CTGTGTGACTTCGGGGTGAGCGGCCAGCTCATCGACTCCATGGCCAACTCCTTCGTGGGCACGCGCTCCTACATGGCTCCGGAGCGGTTG CAGGGCACACATTACTCGGTGCAGTCGGACATCTGGAGCATGGGCCTGTCCCTGGTGGAGCTGGCCGTCGGAAGGTACCCCATCCCCCCG CCCGACGCCAAAGAGCTGGAGGCCATCTTTGGCCGGCCCGTGGTCGACGGGGAAGAAGGAGAGCCTCACAGCATCTCGCCTCGGCCGAGG CCCCCCGGGCGCCCCGTCAGCGGTCACGGGATGGATAGCCGGCCTGCCATGGCCATCTTTGAACTCCTGGACTATATTGTGAACGAGAGC TGCGGCAATGGGAGGAGCAGGGGGAGCTGCTCCTGCCCCTCACCTTCCTGCTCCTGGTGCTGGGCTCCCTGCTGCTCTACCTCGCTGTGT CACTCATGGACCCTGGCTACGTGAATGTGCAGCCCCAGCCTCAGGAGGAGCTCAAAGAGGAGCAGACAGCCATGGTTCCTCCAGCCATCC CTCTTCGGCGCTGCAGATACTGCCTGGTGCTGCAGCCCCTGAGGGCTCGGCACTGCCGTGAGTGCCGCCGTTGCGTCCGCCGCTACGACC ACCACTGCCCCTGGATGGAGAACTGTGTGGGAGAGCGCAACCACCCACTCTTTGTGGTCTACCTGGCGCTGCAGCTGGTGGTGCTTCTGT GGGGCCTGTACCTGGCATGGTCAGGCCTCCGGTTCTTCCAGCCCTGGGGTCAGTGGTTGCGGTCCAGCGGGCTCCTGTTCGCCACCTTCC TGCTGCTGTCCCTCTTCTCGTTGGTGGCCAGCCTGCTCCTCGTCTCGCACCTCTACCTGGTGGCCAGCAACACCACCACCTGGGAATTCA TCTCCTCACACCGCATCGCCTATCTCCGCCAGCGCCCCAGCAACCCCTTCGACCGAGGCCTGACCCGCAACCTGGCCCACTTCTTCTGTG GATGGCCCTCAGGGTCCTGGGAGACCCTCTGGGCTGAGGAGGAGGAAGAGGGCAGCAGCCCAGCTGTTTAGGGTTGCTGGAGGCCGGGCT ACCGTCTTGTGCCTGAAAACCACGGGGCCTGTCCCCAGCTGGGGTGAGCGCTCAGAGGGCCTGGGGCCCTCACTCCTGCCCACGCCTCCC AGACCCCAGAACGGAGCTTCAAGTCAGACAGATCCCTGCCTTGGTGGGCAGTTCTGCCTTCCAAGGAAGAAGGGGAAGAAAAGGACCTGT GGGTGGCTCAGGCCCAAGCAGACCCCGGGCTCCACCCCAGCCCCGCCCAGGCTGCTGCCAGTGCACACTTTTACAAATTTAATATAAAGC >In-frame_MAP2K2_ENST00000394867_chr19_4097277_-_ZDHHC12_ENST00000372672_chr9_131484853_-_1847nt GGACTCGGGCTGCGGCGTCAGCCTTCTTCGGGCCTCGGCAGCGGTAGCGGCTCGCTCGCCTCAGGCCCATCCCCTACCAGCGAGGGCGCC TCCGAGGCAAACCTGGTGGACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACC CAGAAAGCCAAGGTCGGCGAACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGTGGTCACCAAAGTC CAGCACAGACCCTCGGGCCTCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTG CAGGTCCTGCACGAATGCAACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACAC ATGGACGGCGGCTCCCTGGACCAGGTGCTGAAAGAGGCCAAGAGGATTCCCGAGGAGATCCTGGGGAAAGTCAGCATCGCGGTTCTCCGG GGCTTGGCGTACCTCCGAGAGAAGCACCAGATCATGCACCGAGATGTGAAGCCCTCCAACATCCTCGTGAACTCTAGAGGGGAGATCAAG CTGTGTGACTTCGGGGTGAGCGGCCAGCTCATCGACTCCATGGCCAACTCCTTCGTGGGCACGCGCTCCTACATGGCTCCGGAGCGGTTG CAGGGCACACATTACTCGGTGCAGTCGGACATCTGGAGCATGGGCCTGTCCCTGGTGGAGCTGGCCGTCGGAAGGTACCCCATCCCCCCG CCCGACGCCAAAGAGCTGGAGGCCATCTTTGGCCGGCCCGTGGTCGACGGGGAAGAAGGAGAGCCTCACAGCATCTCGCCTCGGCCGAGG CCCCCCGGGCGCCCCGTCAGCGGTCACGGGATGGATAGCCGGCCTGCCATGGCCATCTTTGAACTCCTGGACTATATTGTGAACGAGAGC TGCGGCAATGGGAGGAGCAGGGGGAGCTGCTCCTGCCCCTCACCTTCCTGCTCCTGGTGCTGGGCTCCCTGCTGCTCTACCTCGCTGTGT CACTCATGGACCCTGGCTACGTGAATGTGCAGCCCCAGCCTCAGGAGGAGCTCAAAGAGGAGCAGACAGCCATGGTTCCTCCAGCCATCC CTCTTCGGCGCTGCAGATACTGCCTGGTGCTGCAGCCCCTGAGGGCTCGGCACTGCCGTGAGTGCCGCCGTTGCGTCCGCCGCTACGACC ACCACTGCCCCTGGATGGAGAACTGTGTGGGAGAGCGCAACCACCCACTCTTTGTGGTCTACCTGGCGCTGCAGCTGGTGGTGCTTCTGT GGGGCCTGTACCTGGCATGGTCAGGCCTCCGGTTCTTCCAGCCCTGGGGTCAGTGGTTGCGGTCCAGCGGGCTCCTGTTCGCCACCTTCC TGCTGCTGGCCCACTTCTTCTGTGGATGGCCCTCAGGGTCCTGGGAGACCCTCTGGGCTGAGGAGGAGGAAGAGGGCAGCAGCCCAGCTG TTTAGGGTTGCTGGAGGCCGGGCTACCGTCTTGTGCCTGAAAACCACGGGGCCTGTCCCCAGCTGGGGTGAGCGCTCAGAGGGCCTGGGG CCCTCACTCCTGCCCACGCCTCCCAGACCCCAGAACGGAGCTTCAAGTCAGACAGATCCCTGCCTTGGTGGGCAGTTCTGCCTTCCAAGG AAGAAGGGGAAGAAAAGGACCTGTGGGTGGCTCAGGCCCAAGCAGACCCCGGGCTCCACCCCAGCCCCGCCCAGGCTGCTGCCAGTGCAC >In-frame_MAP2K2_ENST00000394867_chr19_4097277_-_ZDHHC12_ENST00000372667_chr9_131484853_-_2002nt GGACTCGGGCTGCGGCGTCAGCCTTCTTCGGGCCTCGGCAGCGGTAGCGGCTCGCTCGCCTCAGGCCCATCCCCTACCAGCGAGGGCGCC TCCGAGGCAAACCTGGTGGACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACC CAGAAAGCCAAGGTCGGCGAACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGTGGTCACCAAAGTC CAGCACAGACCCTCGGGCCTCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTG CAGGTCCTGCACGAATGCAACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACAC ATGGACGGCGGCTCCCTGGACCAGGTGCTGAAAGAGGCCAAGAGGATTCCCGAGGAGATCCTGGGGAAAGTCAGCATCGCGGTTCTCCGG GGCTTGGCGTACCTCCGAGAGAAGCACCAGATCATGCACCGAGATGTGAAGCCCTCCAACATCCTCGTGAACTCTAGAGGGGAGATCAAG CTGTGTGACTTCGGGGTGAGCGGCCAGCTCATCGACTCCATGGCCAACTCCTTCGTGGGCACGCGCTCCTACATGGCTCCGGAGCGGTTG CAGGGCACACATTACTCGGTGCAGTCGGACATCTGGAGCATGGGCCTGTCCCTGGTGGAGCTGGCCGTCGGAAGGTACCCCATCCCCCCG CCCGACGCCAAAGAGCTGGAGGCCATCTTTGGCCGGCCCGTGGTCGACGGGGAAGAAGGAGAGCCTCACAGCATCTCGCCTCGGCCGAGG CCCCCCGGGCGCCCCGTCAGCGGTCACGGGATGGATAGCCGGCCTGCCATGGCCATCTTTGAACTCCTGGACTATATTGTGAACGAGAGC TGCGGCAATGGGAGGAGCAGGGGGAGCTGCTCCTGCCCCTCACCTTCCTGCTCCTGGTGCTGGGCTCCCTGCTGCTCTACCTCGCTGTGT CACTCATGGACCCTGGCTACGTGAATGTGCAGCCCCAGCCTCAGGAGGAGCTCAAAGAGGAGCAGACAGCCATGGTTCCTCCAGCCATCC CTCTTCGGCGCTGCAGATACTGCCTGGTGCTGCAGCCCCTGAGGGCTCGGCACTGCCGTGAGTGCCGCCGTTGCGTCCGCCGCTACGACC ACCACTGCCCCTGGATGGAGAACTGTGTGGGAGAGCGCAACCACCCACTCTTTGTGGTCTACCTGGCGCTGCAGCTGGTGGTGCTTCTGT GGGGCCTGTACCTGGCATGGTCAGGCCTCCGGTTCTTCCAGCCCTGGGGTCAGTGGTTGCGGTCCAGCGGGCTCCTGTTCGCCACCTTCC TGCTGCTGTCCCTCTTCTCGTTGGTGGCCAGCCTGCTCCTCGTCTCGCACCTCTACCTGGTGGCCAGCAACACCACCACCTGGGAATTCA TCTCCTCACACCGCATCGCCTATCTCCGCCAGCGCCCCAGCAACCCCTTCGACCGAGGCCTGACCCGCAACCTGGCCCACTTCTTCTGTG GATGGCCCTCAGGGTCCTGGGAGACCCTCTGGGCTGAGGAGGAGGAAGAGGGCAGCAGCCCAGCTGTTTAGGGTTGCTGGAGGCCGGGCT ACCGTCTTGTGCCTGAAAACCACGGGGCCTGTCCCCAGCTGGGGTGAGCGCTCAGAGGGCCTGGGGCCCTCACTCCTGCCCACGCCTCCC AGACCCCAGAACGGAGCTTCAAGTCAGACAGATCCCTGCCTTGGTGGGCAGTTCTGCCTTCCAAGGAAGAAGGGGAAGAAAAGGACCTGT GGGTGGCTCAGGCCCAAGCAGACCCCGGGCTCCACCCCAGCCCCGCCCAGGCTGCTGCCAGTGCACACTTTTACAAATTTAATATAAAGC |
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FusionGenePPI for MAP2K2_ZDHHC12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAP2K2 | ARAF, MAPK3, MAPK1, MAP2K2, MEPCE, COPS5, YWHAB, MAP2K1, WDR83, RAF1, MAPK8, LIG4, BRAF, PEX14, ZNF207, FAM65B, IQGAP1, NFE2L2, EGFR, CCNDBP1, ART3, ACTL6A, TNF, PDLIM5, RPE, TXN, XPO1, SNW1, HSP90AA4P, HSP90AB3P, HSP90AB4P, HSP90AA5P, SERPINB2, HSPA8, TUBA4A, CD70, CCRN4L, DLD, TRIM25 | ZDHHC12 | RXRB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP2K2_ZDHHC12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | MAP2K2 | P36507 | DB06616 | Bosutinib | Dual specificity mitogen-activated protein kinase kinase 2 | small molecule | approved |
| Hgene | MAP2K2 | P36507 | DB08911 | Trametinib | Dual specificity mitogen-activated protein kinase kinase 2 | small molecule | approved |
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RelatedDiseases for MAP2K2_ZDHHC12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MAP2K2 | C3809007 | CARDIOFACIOCUTANEOUS SYNDROME 4 | 3 | UNIPROT |
| Hgene | MAP2K2 | C1275081 | Cardio-facio-cutaneous syndrome | 2 | CTD_human;ORPHANET |
| Hgene | MAP2K2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | MAP2K2 | C0025202 | melanoma | 1 | CTD_human |
| Hgene | MAP2K2 | C0028326 | Noonan Syndrome | 1 | CTD_human |
| Hgene | MAP2K2 | C0587248 | Costello syndrome (disorder) | 1 | CTD_human |
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