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Fusion gene ID: 20804 |
FusionGeneSummary for MAP2K2_PSMD9 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MAP2K2_PSMD9 | Fusion gene ID: 20804 | Hgene | Tgene | Gene symbol | MAP2K2 | PSMD9 | Gene ID | 5605 | 5715 |
Gene name | mitogen-activated protein kinase kinase 2 | proteasome 26S subunit, non-ATPase 9 | |
Synonyms | CFC4|MAPKK2|MEK2|MKK2|PRKMK2 | Rpn4|p27 | |
Cytomap | 19p13.3 | 12q24.31 | |
Type of gene | protein-coding | protein-coding | |
Description | dual specificity mitogen-activated protein kinase kinase 2ERK activator kinase 2MAP kinase kinase 2MAPK/ERK kinase 2mitogen-activated protein kinase kinase 2, p45 | 26S proteasome non-ATPase regulatory subunit 926S proteasome regulatory subunit p27homolog of rat Bridge 1proteasome (prosome, macropain) 26S subunit, non-ATPase, 9proteasome 26S non-ATPase regulatory subunit 9 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P36507 | O00233 | |
Ensembl transtripts involved in fusion gene | ENST00000262948, ENST00000394867, ENST00000599345, | ENST00000541212, ENST00000340175, ENST00000261817, ENST00000542602, | |
Fusion gene scores | * DoF score | 8 X 4 X 6=192 | 2 X 1 X 2=4 |
# samples | 7 | 2 | |
** MAII score | log2(7/192*10)=-1.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: MAP2K2 [Title/Abstract] AND PSMD9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MAP2K2 | GO:0036289 | peptidyl-serine autophosphorylation | 8388392 |
Hgene | MAP2K2 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 8388392 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-BA-A4IG-01A | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000262948 | ENST00000541212 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
5CDS-intron | ENST00000262948 | ENST00000340175 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
5CDS-intron | ENST00000262948 | ENST00000261817 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
5CDS-intron | ENST00000262948 | ENST00000542602 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
Frame-shift | ENST00000394867 | ENST00000541212 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
5CDS-intron | ENST00000394867 | ENST00000340175 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
5CDS-intron | ENST00000394867 | ENST00000261817 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
5CDS-intron | ENST00000394867 | ENST00000542602 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
5UTR-3CDS | ENST00000599345 | ENST00000541212 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
5UTR-intron | ENST00000599345 | ENST00000340175 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
5UTR-intron | ENST00000599345 | ENST00000261817 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
5UTR-intron | ENST00000599345 | ENST00000542602 | MAP2K2 | chr19 | 4110507 | - | PSMD9 | chr12 | 122353762 | + |
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FusionProtFeatures for MAP2K2_PSMD9 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MAP2K2 | PSMD9 |
Catalyzes the concomitant phosphorylation of a threonineand a tyrosine residue in a Thr-Glu-Tyr sequence located in MAPkinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).{ECO:0000250}. | Acts as a chaperone during the assembly of the 26Sproteasome, specifically of the base subcomplex of the PA700/19Sregulatory complex (RC). During the base subcomplex assembly ispart of an intermediate PSMD9:PSMC6:PSMC3 module, also known asmodulator trimer complex; PSMD9 is released during the furtherbase assembly process. {ECO:0000269|PubMed:19490896}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MAP2K2 | chr19:4110507 | chr12:122353762 | ENST00000262948 | - | 3 | 11 | 78_86 | 150 | 401 | Nucleotide binding | ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >MAP2K2 | chr19:4110507 | chr12:122353762 | ENST00000262948 | - | 3 | 11 | 266_315 | 150 | 401 | Compositional bias | Note=Pro-rich |
Hgene | >MAP2K2 | chr19:4110507 | chr12:122353762 | ENST00000262948 | - | 3 | 11 | 72_369 | 150 | 401 | Domain | Protein kinase |
Tgene | PSMD9 | chr19:4110507 | chr12:122353762 | ENST00000541212 | + | 3 | 6 | 108_195 | 185 | 224 | Domain | Note=PDZ |
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FusionGeneSequence for MAP2K2_PSMD9 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MAP2K2_ENST00000262948_chr19_4110507_-_PSMD9_ENST00000541212_chr12_122353762_+_189aa MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQ HRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMKPLNVTVIRRGEKHQLRLVPTRWAGKGLLG |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MAP2K2_ENST00000262948_chr19_4110507_-_PSMD9_ENST00000541212_chr12_122353762_+_567nt ATGCTGGCCCGGAGGAAGCCGGTGCTGCCGGCGCTCACCATCAACCCTACCATCGCCGAGGGCCCATCCCCTACCAGCGAGGGCGCCTCC GAGGCAAACCTGGTGGACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACCCAG AAAGCCAAGGTCGGCGAACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGTGGTCACCAAAGTCCAG CACAGACCCTCGGGCCTCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAG GTCCTGCACGAATGCAACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACACATG AAGCCCCTGAATGTGACAGTGATCCGCAGGGGGGAAAAACACCAGCTTAGACTTGTTCCAACACGCTGGGCAGGAAAAGGACTGCTGGGC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MAP2K2_ENST00000262948_chr19_4110507_-_PSMD9_ENST00000541212_chr12_122353762_+_2807nt CCCCTGCCTCTCGGACTCGGGCTGCGGCGTCAGCCTTCTTCGGGCCTCGGCAGCGGTAGCGGCTCGCTCGCCTCAGCCCCAGCGCCCCTC GGCTACCCTCGGCCCAGGCCCGCAGCGCCGCCCGCCCTCGGCCGCCCCGACGCCGGCCTGGGCCGCGGCCGCAGCCCCGGGCTCGCGTAG GCGCCGACCGCTCCCGGCCCGCCCCCTATGGGCCCCGGCTAGAGGCGCCGCCGCCGCCGGCCCGCGGAGCCCCGATGCTGGCCCGGAGGA AGCCGGTGCTGCCGGCGCTCACCATCAACCCTACCATCGCCGAGGGCCCATCCCCTACCAGCGAGGGCGCCTCCGAGGCAAACCTGGTGG ACCTGCAGAAGAAGCTGGAGGAGCTGGAACTTGACGAGCAGCAGAAGAAGCGGCTGGAAGCCTTTCTCACCCAGAAAGCCAAGGTCGGCG AACTCAAAGACGATGACTTCGAAAGGATCTCAGAGCTGGGCGCGGGCAACGGCGGGGTGGTCACCAAAGTCCAGCACAGACCCTCGGGCC TCATCATGGCCAGGAAGCTGATCCACCTTGAGATCAAGCCGGCCATCCGGAACCAGATCATCCGCGAGCTGCAGGTCCTGCACGAATGCA ACTCGCCGTACATCGTGGGCTTCTACGGGGCCTTCTACAGTGACGGGGAGATCAGCATTTGCATGGAACACATGAAGCCCCTGAATGTGA CAGTGATCCGCAGGGGGGAAAAACACCAGCTTAGACTTGTTCCAACACGCTGGGCAGGAAAAGGACTGCTGGGCTGCAACATTATTCCTC TGCAAAGATGATTGTCCCTGGGGAACAGTAACAGGAAAGCATCTTCCCTTGCCCTGGACTTGGGTCTAGGGATTTCCAACTTGTCTTCTC TCCCTGAAGCATAAGGATCTGGAAGAGGCTTGTAACCTGAACTTCTGTGTGGTGGCAGTACTGTGGCCCACCAGTGTAATCTCCCTGGAT TAAGGCATTCTTAAAAACTTAGGCTTGGCCTCTTTCACAAATTAGGCCACGGCCCTAAATAGGAATTCCCTGGATTGTGGGCAAGTGGGC GGAAGTTATTCTGGCAGGTACTGGTGTGATTATTATTATTATTTTTAATAAAGAGTTTTACAGTGCTGATATGACCCTGTTGTCACCCCA GCTGAATTTCTTATGACCCTCCCAAACCAAAGCTCAGATGGGGTCAGAAGAGCTTCATAGAAAGTTGGGCAAAACAGGCTAGCAATTGCA AAGTCAGGCTTTGACCAACATATTTCTTTGCACTGAGGCCTTGCTGCTGTGGATACGGAAATGGTTAAGTACTGTGCTTCCTCAGCAGCT GGGCTGTCAGGGCCATAGTAGCTCCCTTTGGAGAACAGGGAAAGCCTGGAGGCTTCCCAGGTGGCCCAGCGTGGTGTCCTGTCAGCTTCC TCTTTAGGAACCCACCAGAGGGCAGCAAGCTCCTTTCACTTCGCTAGTAAGAACCCCTCCGTTTTTGTGTGTTTTTGTTTTTGTTTTCTG GAGACAAGGTCTTGCTTTGTCACCCAGGCTGGAGTGCAGTGTCGTGATCAAGGTTCACTGAAGCCTTGACGCTGTGGGCACTGCCTCAGC CGCCCAAGTATCTGGGACCACAGGCGTGCACCACCATGCATAGCTAATTTATTTTTTGTAGAGACAGGGTCTCCCTGTGTTGACCAGGTT GGTCTCGAACTCCTGGGCTCAAGCAGTCCTCCTGCCTTGGCCTCCTAAAGTGCTGGGATCACAGGCGTGAGCCACTGCGCCCAGCCCACT GCTAGTTTGACTTTTTATAATTGAACCTCCTGGCTATGCCCTGAGATCAGCGCTATTTTGTAAACCGCTGAGGTATGGATAGGAACGAGT AGATCAGACCTCTTGAAAATGCTTATTCTTCCTCCCTTTTATTTTTTGTCTCTTTTAAGATGGTAAAATGGTTCTCAGGGATTCCTGCCA ATACTTTGAATTATTTTTTCCTCTCCATGGTATCAGTGTTCATTTCCCCAGTTCTTGCACACCGCTTTCTGTTTTGGCAGTTCTGCCAGG CAAGCCCTGTGTTCCTTGGGACTGGTTTTGCTGTGGTTGGATACAGATACCAGCTTGCCTTGATGGGATTGGTATTGCTGTGTGCTTCCA GCCACAGGTTCTCACACTCAATTCCAAAGCCTTCCTATTGGGCGAATTCCCTCAAACTCTATTTGACCTGACAGCCATACGTATTCCCCT CTGGTAGCCACAGACATGCTGTGTTTACCAATGTTTGCTGTTTAAATTGCATGTTCTAATTCCACGTATCTTCCAGTCTCTTTTATAAAG TCTCAGACTATAATAAACACAGCTTGCCCAGTTTATCCTTTCTTTTTTATTTTAAGATGTATGCATATTAATCAATTTACCATCACTGGG GCATGGCAGTGTGGGCGGGGAGAATTATTCACATTCTCCTAAAATGACAGCAGCAGAGAGCCTTCTGCCTCAGTGGCTCTGGCTGGTTTC CTGCAGGGGTCCCAGTGGAAACCCGTGTGGCCACCTGTTGCCGTCTTCCATGAGATGTTAGTGGAGAGCCACTTTGACGTGGAATGATCC TAATAGATATAGCCAGACCGGTTTTGCGGAAACGCTTTGTGCTGAGAACCGCAAGCTGGTGCACCCTGTGTCATATCTGCCCCCAGCCAG CTGGAATTGTCTGCAACACGCGGTGCCCGGTGAGGAGGCAGGCAGGACGGTTGTGTGCTGCATCCATGAGACCTGGAAATTCAGTTTGCT |
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FusionGenePPI for MAP2K2_PSMD9 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAP2K2 | ARAF, MAPK3, MAPK1, MAP2K2, MEPCE, COPS5, YWHAB, MAP2K1, WDR83, RAF1, MAPK8, LIG4, BRAF, PEX14, ZNF207, FAM65B, IQGAP1, NFE2L2, EGFR, CCNDBP1, ART3, ACTL6A, TNF, PDLIM5, RPE, TXN, XPO1, SNW1, HSP90AA4P, HSP90AB3P, HSP90AB4P, HSP90AA5P, SERPINB2, HSPA8, TUBA4A, CD70, CCRN4L, DLD, TRIM25 | PSMD9 | PSMC6, SKP2, CKS1B, MGMT, YY1, CDK2, CDK4, ELAVL1, PSMC3, CD2BP2, NUDCD2, CPLX1, UBE2I, DSTN, PARK2, BAG3, TNIP2, AMOTL2, HNRNPF, HNRNPH1, PFKL, GNPDA1, H2AFZ, P4HB, PABPC1, PYGL, TMOD3, TWF2, XPNPEP1, HNRNPA1, CHUK, TNF, PSMB4, SHFM1, CSH1, ELSPBP1, AHCYL1, NCKIPSD, BANP, TRIM39, CCDC136, TRIM42, BRCA1, AKT2, PPP3CA, PSMC2, PSMC5, PSMD12, PSMD13, PSMD14, PSMD2, PSMD4, PSMD6, PSMD7, PSMD8, CDV3, CSK, ISYNA1, PSMC4, PSMD1, PSMD11, PSMD3, PSMD5, RIN3, ERI3, CCDC40, PKN3, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, RABGAP1L, GOLGA5, CLOCK, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, HAUS6, GIT2, RPRD1A, ARNTL, MAX, RABGEF1, NUF2, THAP11, VPS51, TSSC1, KDM1A, RABEP1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAP2K2_PSMD9 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | MAP2K2 | P36507 | DB06616 | Bosutinib | Dual specificity mitogen-activated protein kinase kinase 2 | small molecule | approved |
Hgene | MAP2K2 | P36507 | DB08911 | Trametinib | Dual specificity mitogen-activated protein kinase kinase 2 | small molecule | approved |
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RelatedDiseases for MAP2K2_PSMD9 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | MAP2K2 | C3809007 | CARDIOFACIOCUTANEOUS SYNDROME 4 | 3 | UNIPROT |
Hgene | MAP2K2 | C1275081 | Cardio-facio-cutaneous syndrome | 2 | CTD_human;ORPHANET |
Hgene | MAP2K2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | MAP2K2 | C0025202 | melanoma | 1 | CTD_human |
Hgene | MAP2K2 | C0028326 | Noonan Syndrome | 1 | CTD_human |
Hgene | MAP2K2 | C0587248 | Costello syndrome (disorder) | 1 | CTD_human |