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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20780

FusionGeneSummary for MAP1B_C9orf85

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP1B_C9orf85
Fusion gene ID: 20780
HgeneTgene
Gene symbol

MAP1B

C9orf85

Gene ID

4131

138241

Gene namemicrotubule associated protein 1Bchromosome 9 open reading frame 85
SynonymsFUTSCH|MAP5|PPP1R102-
Cytomap

5q13.2

9q21.13

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-associated protein 1Bprotein phosphatase 1, regulatory subunit 102uncharacterized protein C9orf85
Modification date2018052320180403
UniProtAcc

P46821

Q96MD7

Ensembl transtripts involved in fusion geneENST00000296755, ENST00000504183, 
ENST00000334731, ENST00000377031, 
ENST00000486911, 
Fusion gene scores* DoF score9 X 8 X 5=3602 X 2 X 2=8
# samples 112
** MAII scorelog2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: MAP1B [Title/Abstract] AND C9orf85 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP1B

GO:0009987

cellular process

19567321


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW882863MAP1Bchr5

71491639

+C9orf85chr9

74573963

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000296755ENST00000334731MAP1Bchr5

71491639

+C9orf85chr9

74573963

-
5CDS-intronENST00000296755ENST00000377031MAP1Bchr5

71491639

+C9orf85chr9

74573963

-
5CDS-intronENST00000296755ENST00000486911MAP1Bchr5

71491639

+C9orf85chr9

74573963

-
intron-intronENST00000504183ENST00000334731MAP1Bchr5

71491639

+C9orf85chr9

74573963

-
intron-intronENST00000504183ENST00000377031MAP1Bchr5

71491639

+C9orf85chr9

74573963

-
intron-intronENST00000504183ENST00000486911MAP1Bchr5

71491639

+C9orf85chr9

74573963

-

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FusionProtFeatures for MAP1B_C9orf85


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP1B

P46821

C9orf85

Q96MD7

Facilitates tyrosination of alpha-tubulin in neuronalmicrotubules (By similarity). Phosphorylated MAP1B may play a rolein the cytoskeletal changes that accompany neurite extension.Possibly MAP1B binds to at least two tubulin subunits in thepolymer, and this bridging of subunits might be involved innucleating microtubule polymerization and in stabilizingmicrotubules. Acts as a positive cofactor in DAPK1-mediatedautophagic vesicle formation and membrane blebbing. {ECO:0000250,ECO:0000269|PubMed:18195017}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP1B_C9orf85


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP1B_C9orf85


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP1B_C9orf85


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAP1B_C9orf85


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource