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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20777

FusionGeneSummary for MAP1A_SPHK2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAP1A_SPHK2
Fusion gene ID: 20777
HgeneTgene
Gene symbol

MAP1A

SPHK2

Gene ID

23173

56848

Gene namemethionyl aminopeptidase 1sphingosine kinase 2
SynonymsMAP1A|MetAP1ASK 2|SK-2|SPK 2|SPK-2
Cytomap

4q23

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionmethionine aminopeptidase 1MAP 1metAP 1peptidase M 1sphingosine kinase 2sphingosine kinase type 2
Modification date2018051920180519
UniProtAcc

P78559

Q9NRA0

Ensembl transtripts involved in fusion geneENST00000382031, ENST00000399453, 
ENST00000300231, 
ENST00000340932, 
ENST00000245222, ENST00000601712, 
ENST00000600537, ENST00000598088, 
ENST00000599033, ENST00000599748, 
ENST00000443164, ENST00000599029, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: MAP1A [Title/Abstract] AND SPHK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1C02583MAP1Achr15

43815229

+SPHK2chr19

49133508

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000382031ENST00000340932MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-3UTRENST00000382031ENST00000245222MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000382031ENST00000601712MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000382031ENST00000600537MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-3UTRENST00000382031ENST00000598088MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000382031ENST00000599033MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-3UTRENST00000382031ENST00000599748MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000382031ENST00000443164MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000382031ENST00000599029MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000399453ENST00000340932MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-3UTRENST00000399453ENST00000245222MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000399453ENST00000601712MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000399453ENST00000600537MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-3UTRENST00000399453ENST00000598088MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000399453ENST00000599033MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-3UTRENST00000399453ENST00000599748MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000399453ENST00000443164MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000399453ENST00000599029MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000300231ENST00000340932MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-3UTRENST00000300231ENST00000245222MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000300231ENST00000601712MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000300231ENST00000600537MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-3UTRENST00000300231ENST00000598088MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000300231ENST00000599033MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-3UTRENST00000300231ENST00000599748MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000300231ENST00000443164MAP1Achr15

43815229

+SPHK2chr19

49133508

+
5CDS-intronENST00000300231ENST00000599029MAP1Achr15

43815229

+SPHK2chr19

49133508

+

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FusionProtFeatures for MAP1A_SPHK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP1A

P78559

SPHK2

Q9NRA0

Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements. Catalyzes the phosphorylation of sphingosine to formsphingosine 1-phosphate (SPP), a lipid mediator with bothintra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D-erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides.{ECO:0000269|PubMed:19168031}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAP1A_SPHK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAP1A_SPHK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAP1A_SPHK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAP1AP78559DB01196EstramustineMicrotubule-associated protein 1Asmall moleculeapproved|investigational

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RelatedDiseases for MAP1A_SPHK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSPHK2C0025261Memory Disorders1CTD_human
TgeneSPHK2C0740392Infarction, Middle Cerebral Artery1CTD_human