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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20774

FusionGeneSummary for MAOA_ACTB

check button Fusion gene summary
Fusion gene informationFusion gene name: MAOA_ACTB
Fusion gene ID: 20774
HgeneTgene
Gene symbol

MAOA

ACTB

Gene ID

4128

60

Gene namemonoamine oxidase Aactin beta
SynonymsBRNRS|MAO-ABRWS1|PS1TP5BP1
Cytomap

Xp11.3

7p22.1

Type of geneprotein-codingprotein-coding
Descriptionamine oxidase [flavin-containing] Amonoamine oxidase type Aactin, cytoplasmic 1I(2)-actinPS1TP5-binding protein 1beta cytoskeletal actin
Modification date2018051920180522
UniProtAcc

P21397

P60709

Ensembl transtripts involved in fusion geneENST00000338702, ENST00000542639, 
ENST00000497485, 
ENST00000464611, 
ENST00000331789, 
Fusion gene scores* DoF score3 X 3 X 1=910 X 10 X 3=300
# samples 311
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAOA [Title/Abstract] AND ACTB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneACTB

GO:0098974

postsynaptic actin cytoskeleton organization

18341992


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF803193MAOAchrX

43601227

-ACTBchr7

5568016

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000338702ENST00000464611MAOAchrX

43601227

-ACTBchr7

5568016

-
5CDS-intronENST00000338702ENST00000331789MAOAchrX

43601227

-ACTBchr7

5568016

-
5CDS-intronENST00000542639ENST00000464611MAOAchrX

43601227

-ACTBchr7

5568016

-
5CDS-intronENST00000542639ENST00000331789MAOAchrX

43601227

-ACTBchr7

5568016

-
intron-intronENST00000497485ENST00000464611MAOAchrX

43601227

-ACTBchr7

5568016

-
intron-intronENST00000497485ENST00000331789MAOAchrX

43601227

-ACTBchr7

5568016

-

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FusionProtFeatures for MAOA_ACTB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAOA

P21397

ACTB

P60709

Catalyzes the oxidative deamination of biogenic andxenobiotic amines and has important functions in the metabolism ofneuroactive and vasoactive amines in the central nervous systemand peripheral tissues. MAOA preferentially oxidizes biogenicamines such as 5-hydroxytryptamine (5-HT), norepinephrine andepinephrine.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAOA_ACTB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAOA_ACTB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAOA_ACTB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneMAOAP21397DB00780PhenelzineAmine oxidase [flavin-containing] Asmall moleculeapproved
HgeneMAOAP21397DB00805MinaprineAmine oxidase [flavin-containing] Asmall moleculeapproved
HgeneMAOAP21397DB01247IsocarboxazidAmine oxidase [flavin-containing] Asmall moleculeapproved
HgeneMAOAP21397DB01626PargylineAmine oxidase [flavin-containing] Asmall moleculeapproved
HgeneMAOAP21397DB09245ToloxatoneAmine oxidase [flavin-containing] Asmall moleculeapproved
HgeneMAOAP21397DB00191PhentermineAmine oxidase [flavin-containing] Asmall moleculeapproved|illicit
HgeneMAOAP21397DB01577MethamphetamineAmine oxidase [flavin-containing] Asmall moleculeapproved|illicit
HgeneMAOAP21397DB00182AmphetamineAmine oxidase [flavin-containing] Asmall moleculeapproved|illicit|investigational
HgeneMAOAP21397DB00752TranylcypromineAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational
HgeneMAOAP21397DB00909ZonisamideAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational
HgeneMAOAP21397DB01168ProcarbazineAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational
HgeneMAOAP21397DB01171MoclobemideAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational
HgeneMAOAP21397DB01171MoclobemideAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational
HgeneMAOAP21397DB00721ProcaineAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational|vet_approved
HgeneMAOAP21397DB01037SelegilineAmine oxidase [flavin-containing] Asmall moleculeapproved|investigational|vet_approved

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RelatedDiseases for MAOA_ACTB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMAOAC0001973Alcoholic Intoxication, Chronic5PSYGENET
HgeneMAOAC0005586Bipolar Disorder5PSYGENET
HgeneMAOAC0011570Mental Depression5PSYGENET
HgeneMAOAC0011581Depressive disorder5PSYGENET
HgeneMAOAC0041696Unipolar Depression5PSYGENET
HgeneMAOAC0525045Mood Disorders5PSYGENET
HgeneMAOAC1269683Major Depressive Disorder5PSYGENET
HgeneMAOAC0003431Antisocial Personality Disorder3CTD_human
HgeneMAOAC0004352Autistic Disorder3CTD_human;HPO
HgeneMAOAC0019151Hepatic Encephalopathy3CTD_human
HgeneMAOAC0036341Schizophrenia2PSYGENET
HgeneMAOAC0085762Alcohol abuse2PSYGENET
HgeneMAOAC0270458Severe major depression with psychotic features2PSYGENET
HgeneMAOAC2362914clinical depression2PSYGENET
HgeneMAOAC0004936Mental disorders1CTD_human
HgeneMAOAC0005587Depression, Bipolar1PSYGENET
HgeneMAOAC0009241Cognition Disorders1CTD_human
HgeneMAOAC0013415Dysthymic Disorder1PSYGENET
HgeneMAOAC0014175Endometriosis1CTD_human
HgeneMAOAC0020179Huntington Disease1CTD_human
HgeneMAOAC0020649Hypotension1CTD_human
HgeneMAOAC0026848Myopathy1CTD_human
HgeneMAOAC0030567Parkinson Disease1CTD_human
HgeneMAOAC0031511Pheochromocytoma1CTD_human
HgeneMAOAC0033054Prenatal Exposure Delayed Effects1CTD_human
HgeneMAOAC0033975Psychotic Disorders1PSYGENET
HgeneMAOAC0600427Cocaine Dependence1PSYGENET
HgeneMAOAC0745744End Stage Liver Disease1CTD_human
HgeneMAOAC1136249Mental Retardation, X-Linked1CTD_human
HgeneMAOAC1285261Fetal Nutrition Disorders1CTD_human
HgeneMAOAC2063866Depressive Disorder, Treatment-Resistant1PSYGENET
TgeneACTBC2239176Liver carcinoma2CTD_human
TgeneACTBC0005586Bipolar Disorder1PSYGENET
TgeneACTBC0009363Congenital ocular coloboma (disorder)1CTD_human
TgeneACTBC0013393Dysostoses1CTD_human
TgeneACTBC0013421Dystonia1CTD_human
TgeneACTBC0014859Esophageal Neoplasms1CTD_human
TgeneACTBC0018784Sensorineural Hearing Loss (disorder)1CTD_human;HPO
TgeneACTBC0024121Lung Neoplasms1CTD_human
TgeneACTBC0024667Animal Mammary Neoplasms1CTD_human
TgeneACTBC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneACTBC0027626Neoplasm Invasiveness1CTD_human
TgeneACTBC0029408Degenerative polyarthritis1CTD_human
TgeneACTBC0036341Schizophrenia1PSYGENET
TgeneACTBC0151744Myocardial Ischemia1CTD_human
TgeneACTBC0242184Hypoxia1CTD_human
TgeneACTBC0376634Craniofacial Abnormalities1CTD_human
TgeneACTBC0497552Congenital neurologic anomalies1CTD_human
TgeneACTBC1846331Juvenile-onset dystonia1CTD_human;ORPHANET;UNIPROT
TgeneACTBC1855722Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation1ORPHANET;UNIPROT