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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20768

FusionGeneSummary for MAN2C1_PTPN9

check button Fusion gene summary
Fusion gene informationFusion gene name: MAN2C1_PTPN9
Fusion gene ID: 20768
HgeneTgene
Gene symbol

MAN2C1

PTPN9

Gene ID

4123

5780

Gene namemannosidase alpha class 2C member 1protein tyrosine phosphatase, non-receptor type 9
SynonymsMAN6A8|MANA|MANA1MEG2|PTPMEG2
Cytomap

15q24.2

15q24.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-mannosidase 2C1alpha mannosidase 6A8Balpha-D-mannoside mannohydrolasemannosidase, alpha 6A8mannosidase, alpha A, cytoplasmictesticular tissue protein Li 115tyrosine-protein phosphatase non-receptor type 9PTPase-MEG2protein-tyrosine phosphatase MEG2
Modification date2018052320180520
UniProtAcc

Q9NTJ4

P43378

Ensembl transtripts involved in fusion geneENST00000569482, ENST00000565683, 
ENST00000563622, ENST00000267978, 
ENST00000563539, 
ENST00000306726, 
ENST00000564970, 
Fusion gene scores* DoF score6 X 6 X 3=1083 X 3 X 3=27
# samples 63
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAN2C1 [Title/Abstract] AND PTPN9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPN9

GO:0010977

negative regulation of neuron projection development

27655914

TgenePTPN9

GO:0035335

peptidyl-tyrosine dephosphorylation

27655914

TgenePTPN9

GO:1903078

positive regulation of protein localization to plasma membrane

27655914


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-4Z-AA7Q-01AMAN2C1chr15

75658863

-PTPN9chr15

75772255

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000569482ENST00000306726MAN2C1chr15

75658863

-PTPN9chr15

75772255

-
5CDS-intronENST00000569482ENST00000564970MAN2C1chr15

75658863

-PTPN9chr15

75772255

-
Frame-shitENST00000565683ENST00000306726MAN2C1chr15

75658863

-PTPN9chr15

75772255

-
5CDS-intronENST00000565683ENST00000564970MAN2C1chr15

75658863

-PTPN9chr15

75772255

-
Frame-shitENST00000563622ENST00000306726MAN2C1chr15

75658863

-PTPN9chr15

75772255

-
5CDS-intronENST00000563622ENST00000564970MAN2C1chr15

75658863

-PTPN9chr15

75772255

-
Frame-shitENST00000267978ENST00000306726MAN2C1chr15

75658863

-PTPN9chr15

75772255

-
5CDS-intronENST00000267978ENST00000564970MAN2C1chr15

75658863

-PTPN9chr15

75772255

-
5UTR-3CDSENST00000563539ENST00000306726MAN2C1chr15

75658863

-PTPN9chr15

75772255

-
5UTR-intronENST00000563539ENST00000564970MAN2C1chr15

75658863

-PTPN9chr15

75772255

-

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FusionProtFeatures for MAN2C1_PTPN9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAN2C1

Q9NTJ4

PTPN9

P43378

Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linkedmannose residues from glycoproteins. Involved in the degradationof free oligosaccharides in the cytoplasm.{ECO:0000269|PubMed:16848760}. Protein-tyrosine phosphatase that could participate inthe transfer of hydrophobic ligands or in functions of the Golgiapparatus. {ECO:0000269|PubMed:19167335}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAN2C1_PTPN9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAN2C1_PTPN9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAN2C1PRRC2A, BRCA1, EXOSC6, XRN1, CDC20B, PCMT1, TEX33, SGTB, NLGN3, SNCA, VWA5APTPN9RTN3, GHR, MYC, TP53BP1, VCP, AGTRAP, REEP6, MAL2, CMTM5, ENO1, MOV10, NXF1, NTRK1, CREB3, LZTR1, PC, EYA1, RAD51C, FAM26D, VSIG8, C5AR2, MDK, PDCD1, PTPN9, GEMIN8, FSIP1, SMN1, DDX20, GEMIN4, PMPCA, SLC39A7, STRAP, TUBA3C, AAR2, SMN2, TUBA3D, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAN2C1_PTPN9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAN2C1_PTPN9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource