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Fusion gene ID: 20744 |
FusionGeneSummary for MAN1A2_TTF2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAN1A2_TTF2 | Fusion gene ID: 20744 | Hgene | Tgene | Gene symbol | MAN1A2 | TTF2 | Gene ID | 10905 | 8458 |
| Gene name | mannosidase alpha class 1A member 2 | transcription termination factor 2 | |
| Synonyms | MAN1B | HuF2|ZGRF6 | |
| Cytomap | 1p12 | 1p13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mannosyl-oligosaccharide 1,2-alpha-mannosidase IBalpha-1,2-mannosidase IBalpha1,2-mannosidaseprocessing alpha-1,2-mannosidase IB | transcription termination factor 2F2RNA polymerase II termination factorhuman factor 2lodestar homologlodestar proteintranscription release factor 2transcription termination factor, RNA polymerase IIzinc finger, GRF-type containing 6 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O60476 | Q9UNY4 | |
| Ensembl transtripts involved in fusion gene | ENST00000356554, ENST00000482811, | ENST00000369466, ENST00000480701, | |
| Fusion gene scores | * DoF score | 11 X 12 X 6=792 | 2 X 4 X 3=24 |
| # samples | 19 | 4 | |
| ** MAII score | log2(19/792*10)=-2.05950101174866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAN1A2 [Title/Abstract] AND TTF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-B6-A0I1-01A | MAN1A2 | chr1 | 117963271 | + | TTF2 | chr1 | 117639973 | + |
| TCGA | RV | UCEC | TCGA-A5-A2K4-01A | MAN1A2 | chr1 | 117957453 | + | TTF2 | chr1 | 117629039 | + |
| TCGA | RV | UCEC | TCGA-AJ-A3QS-01A | MAN1A2 | chr1 | 118003234 | + | TTF2 | chr1 | 117641455 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000356554 | ENST00000369466 | MAN1A2 | chr1 | 117963271 | + | TTF2 | chr1 | 117639973 | + |
| 5CDS-intron | ENST00000356554 | ENST00000480701 | MAN1A2 | chr1 | 117963271 | + | TTF2 | chr1 | 117639973 | + |
| intron-3CDS | ENST00000482811 | ENST00000369466 | MAN1A2 | chr1 | 117963271 | + | TTF2 | chr1 | 117639973 | + |
| intron-intron | ENST00000482811 | ENST00000480701 | MAN1A2 | chr1 | 117963271 | + | TTF2 | chr1 | 117639973 | + |
| Frame-shift | ENST00000356554 | ENST00000369466 | MAN1A2 | chr1 | 117957453 | + | TTF2 | chr1 | 117629039 | + |
| 5CDS-intron | ENST00000356554 | ENST00000480701 | MAN1A2 | chr1 | 117957453 | + | TTF2 | chr1 | 117629039 | + |
| 3UTR-3CDS | ENST00000482811 | ENST00000369466 | MAN1A2 | chr1 | 117957453 | + | TTF2 | chr1 | 117629039 | + |
| 3UTR-intron | ENST00000482811 | ENST00000480701 | MAN1A2 | chr1 | 117957453 | + | TTF2 | chr1 | 117629039 | + |
| Frame-shift | ENST00000356554 | ENST00000369466 | MAN1A2 | chr1 | 118003234 | + | TTF2 | chr1 | 117641455 | + |
| 5CDS-3UTR | ENST00000356554 | ENST00000480701 | MAN1A2 | chr1 | 118003234 | + | TTF2 | chr1 | 117641455 | + |
| intron-3CDS | ENST00000482811 | ENST00000369466 | MAN1A2 | chr1 | 118003234 | + | TTF2 | chr1 | 117641455 | + |
| intron-3UTR | ENST00000482811 | ENST00000480701 | MAN1A2 | chr1 | 118003234 | + | TTF2 | chr1 | 117641455 | + |
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FusionProtFeatures for MAN1A2_TTF2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAN1A2 | TTF2 |
| Involved in the maturation of Asn-linkedoligosaccharides. Progressively trim alpha-1,2-linked mannoseresidues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). | DsDNA-dependent ATPase which acts as a transcriptiontermination factor by coupling ATP hydrolysis with removal of RNApolymerase II from the DNA template. May contribute to mitotictranscription repression. May also be involved in pre-mRNAsplicing. {ECO:0000269|PubMed:10455150,ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840,ECO:0000269|PubMed:9748214}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAN1A2 | chr1:117963271 | chr1:117639973 | ENST00000356554 | + | 5 | 13 | 2_36 | 285 | 642 | Topological domain | Cytoplasmic |
| Hgene | MAN1A2 | chr1:117963271 | chr1:117639973 | ENST00000356554 | + | 5 | 13 | 37_57 | 285 | 642 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MAN1A2 | chr1:117963271 | chr1:117639973 | ENST00000356554 | + | 5 | 13 | 58_641 | 285 | 642 | Topological domain | Lumenal |
| Tgene | TTF2 | chr1:117963271 | chr1:117639973 | ENST00000369466 | + | 19 | 23 | 583_786 | 1062 | 1163 | Domain | Helicase ATP-binding |
| Tgene | TTF2 | chr1:117963271 | chr1:117639973 | ENST00000369466 | + | 19 | 23 | 995_1157 | 1062 | 1163 | Domain | Helicase C-terminal |
| Tgene | TTF2 | chr1:117963271 | chr1:117639973 | ENST00000369466 | + | 19 | 23 | 737_740 | 1062 | 1163 | Motif | Note=DEAH box |
| Tgene | TTF2 | chr1:117963271 | chr1:117639973 | ENST00000369466 | + | 19 | 23 | 596_603 | 1062 | 1163 | Nucleotide binding | ATP |
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FusionGeneSequence for MAN1A2_TTF2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAN1A2_ENST00000356554_chr1_117963271_+_TTF2_ENST00000369466_chr1_117639973_+_386aa MTTPALLPLSGRRIPPLNLGPPSFPHHRATLRLSEKFILLLILSAFITLCFGAFFFLPDSSKHKRFDLGLEDVLIPHVDAGKGAKNPGVF LIHGPDEHRHREEEERLRNKIRADHEKALEEAKEKLRKSREEIRAEIQTEKNKVVQEMKIKENKPLPPVPIPNLVGIRGGDPEDNDIREK REKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGSSQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIR FIGGLLAAYYLSGEEVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQQKDVVIHRFVCEGTVEEKILQLQEKKKDLA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAN1A2_ENST00000356554_chr1_117963271_+_TTF2_ENST00000369466_chr1_117639973_+_1158nt ATGACTACCCCAGCCCTGCTGCCCCTCTCTGGACGTAGGATACCACCTCTGAACCTGGGGCCGCCTTCCTTCCCACATCACAGGGCTACC TTGAGACTTTCTGAGAAGTTTATTCTTCTCCTTATTCTTAGTGCCTTCATCACTCTGTGTTTTGGGGCATTCTTTTTCCTTCCAGACTCT TCAAAACACAAACGCTTTGATTTGGGTTTAGAAGATGTGTTAATTCCACATGTAGATGCCGGTAAAGGGGCTAAAAACCCCGGAGTCTTC CTGATCCATGGACCCGATGAACATAGACACAGGGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCATGAGAAGGCCTTGGAA GAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAGAAAAATAAGGTAGTCCAAGAAATGAAGATA AAAGAGAACAAGCCACTGCCACCAGTCCCTATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAATGACATAAGAGAGAAA AGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGGGGACATAATGAACTCAGACCTATTGCAAGG AAAGGACACTCCCCTAACATATTTGGAAGTTCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTATATCATGGGACTTCAT GATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCAGAGGTGTCTGTGTTTGAAGTCAACATTCGA TTTATTGGAGGCCTACTTGCAGCATATTACCTATCAGGAGAGGAGGTAATGCTAATCTCTCTCTTGGCCGGAGGTGTTGGTCTAAACCTG ACTGGAGGAAATCACCTCTTTCTTTTGGACATGCACTGGAATCCATCACTTGAAGATCAAGCTTGTGACCGAATTTACCGAGTAGGGCAG CAGAAAGATGTTGTCATACACAGATTTGTTTGTGAGGGAACAGTAGAAGAAAAGATCTTACAGCTCCAAGAAAAAAAGAAAGATTTGGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAN1A2_ENST00000356554_chr1_117963271_+_TTF2_ENST00000369466_chr1_117639973_+_7822nt AGACCCGTGCGGTAGCAACAGCGGCGGCGGCCGCGGCGGCTGGCCGGACTCAGGTGTTTCGGACGCTATTGCCCTTCGCGCCAGCCGTCG AGTGGGCAGCAGCGGGACTCAGCCGGGCGCCAGGTTCCTGCCAGGCAGCGCCGGGAAGCGCGGGCGGCCGAGAACTCCTTCCTGCTACTT CGCCCAGCGCCGCTGCTTCGGCTTCCCAGCGAAGTGGGAGACCTTCCTCCCTGTTTGCAGACGTCCGTGGGAGACCCTTATTTTTTCCAC CGCTAAGGTTAAGAGATTCTGGAATAGAAGCGTCGAAGGAGATCAAGTGAACCTTCTACAACTCCTCGGATGTCGCCAGTCTCCCTTTCG GGGCGGAAGACTACGTTTGAGCATCTCACTGAGGTGCAGGAATGGAAGAACCCACCTTGCAGCTTTTCTGCAGTGTGGCTTGCCTGATCT ACCCCTAGGAATGAAGAGGAGGCTTGTAATAATCCGATGAAGTACAGATGTTGAAGAGGATATCGCAGGACCTAAACTTGTGATCGTTTG GGGGAGGTCACACACGTTTCTGAGTGGGAATGGATGGGCGTGAATGACGTGCCCTCTTAAAAAGCACAACAGTCCTTTAAGAGGAGCAAA ATTGAGTTTTCCCATTTTGGCCAAGATTTTGAAGACAGTTCAATGTATTCTACATTTGACATAAGATGAGAACTTTCTAAAGTATTCTCT CCAAGAGCGTAAACGATGACTACCCCAGCCCTGCTGCCCCTCTCTGGACGTAGGATACCACCTCTGAACCTGGGGCCGCCTTCCTTCCCA CATCACAGGGCTACCTTGAGACTTTCTGAGAAGTTTATTCTTCTCCTTATTCTTAGTGCCTTCATCACTCTGTGTTTTGGGGCATTCTTT TTCCTTCCAGACTCTTCAAAACACAAACGCTTTGATTTGGGTTTAGAAGATGTGTTAATTCCACATGTAGATGCCGGTAAAGGGGCTAAA AACCCCGGAGTCTTCCTGATCCATGGACCCGATGAACATAGACACAGGGAAGAGGAAGAACGTCTGAGAAATAAAATTCGAGCTGATCAT GAGAAGGCCTTGGAAGAAGCAAAAGAAAAATTAAGAAAGTCAAGAGAGGAAATTCGAGCAGAAATTCAGACAGAGAAAAATAAGGTAGTC CAAGAAATGAAGATAAAAGAGAACAAGCCACTGCCACCAGTCCCTATTCCCAACCTTGTAGGAATACGTGGTGGAGACCCAGAAGATAAT GACATAAGAGAGAAAAGGGAAAAAATTAAAGAGATGATGAAACATGCTTGGGATAACTATAGGACATATGGGTGGGGACATAATGAACTC AGACCTATTGCAAGGAAAGGACACTCCCCTAACATATTTGGAAGTTCACAAATGGGTGCTACCATAGTAGATGCTTTGGATACCCTTTAT ATCATGGGACTTCATGATGAATTCCTAGATGGGCAAAGATGGATTGAAGACAACCTTGATTTCAGTGTGAATTCAGAGGTGTCTGTGTTT GAAGTCAACATTCGATTTATTGGAGGCCTACTTGCAGCATATTACCTATCAGGAGAGGAGGTAATGCTAATCTCTCTCTTGGCCGGAGGT GTTGGTCTAAACCTGACTGGAGGAAATCACCTCTTTCTTTTGGACATGCACTGGAATCCATCACTTGAAGATCAAGCTTGTGACCGAATT TACCGAGTAGGGCAGCAGAAAGATGTTGTCATACACAGATTTGTTTGTGAGGGAACAGTAGAAGAAAAGATCTTACAGCTCCAAGAAAAA AAGAAAGATTTGGCCAAACAAGTTCTATCAGGGTCTGGAGAATCTGTCACCAAGCTCACCTTGGCTGACCTCAGAGTCCTTTTTGGCATC TAACCTCCTGTGGATAAGGGCTCAGAATAGCACCATTGCTGGTTTGTATTAGGATCTGGGAATAACAACCTAACCATGAGCCTTGAACTC TGTTCTTTGCATTTCAATTTCACCGTCAAGCCTTTCACCTTCCTCAAAATGAGGCATAATCTTATCCCCAGAATTGAGGAGGGGTTGTGT TAACCAATTAGTTAACCAATTATGTTAATAATTTATTTAATGAGTGGTATGGAAACCAATTGATTTTTTTAGATAAAAGAATATGTTTTA GAGTTGGATGATTTTGGAAAACAACTCTGGCAGAATTGTATATAAGCTTCAGTAAAGTTCAAAAAGCGGGCCAGGTGTGGTGGCTCATGC CTGTAATCCCGACACTTTGGGAGGCCAAGGCAGGAGGATGGCTTGAAGCCAGTAGTTCAAGACCAGCCTGGGCAACATAGTAAGACCCCA TCTCTATGAAGAATAAAAAAATGAGCTAGGCGTGGTAGTGCACACCTGTAGTCCTAGCTACTTGGGAGGCTGAGGCAGGAGGATCCCTTG AGTCCAGGAGGTTGAGGCTGCAGTGAGCTGTGATTGTGCCACTGTTTTCCAGCCTGGGCAATACAGTGAGACCCTGTCTCAAAAAAAGGA AAAAAAAGCTCAAAAAGTTCTGTGTTGCCTTTCTCTTCTTAGCTGATGATGGGAGAACCAGTTACTACCTTCTCTAACACAGGCTCCATC CTATCTCTTCATCTCTTCTTGCCAGTGATGTTGCACCTGTAACCATCTTTTTATGGGTGGAGCAGAGAGTCAATCCCTGCAGCCACCCTG CAGCCAGCCATCTCTGCAGTTCTCTCAGTGCAGGCAGTTCTTCCTCTCAGGCTGAAGATCAAGGAGATGCTTTGTACATGAACAGATGCT GAGTATCTGTTATCATTGTATTGTTTAGTGTCAGTGTATCATTTAGTATTTGTATCACTGTACCATTTAGTGTTGTATATCACTCAGTCA TTTAATATTGGTTATCACCATACAGTTTAATATTTGTATCATTTGGTTCATTGTATCGTTTAGTATTTCTATTATAACATTTCTATTTGT AGTATTTGTATAATATTTGTGTCATTTTTAATAGTATTTGTATTTTTACAAATTTGCAGTATTTGTAGCATTTAGTATCATTGTTTCATT TAGTATTTGGTACAATCTAATAAATACTAATCCAGTCCAATACTAATCCAATCCAATACTAATAATACTATTGGTACAATCCAATACTAA TAATACTATTGGTACAATCCAATACTAATAATACTAACAGTAGTATTGATACAATCTAATAAATAATGTGTTTGACAGTGTAGCAGAAAT AATGCTATGTGTTCACCAAACCCACTTCCTTTTCCTCCCGGGCACCCAGAGAGACTGTATTTCCCAGTTTTTGCTGCAGTTTGACGGGGT CCATATCAATGGACTGTGGAGAGAAGCGATTGATGTAAGTCACTTCTAGGTGGCCCTCTACCACTTTCCAAAAGATCATTCATGCTGTTT CTTCCCTCCTCAGCCTATGGGATGCAAAGGAACTGATGGAAGATTACAAGGCCCTAGGGAAGGTGAAGCCACTAGCTCAGCAGTTCTTAG CCTAGTTTTTGGCCATCAGCCCTTCTATTAGACTAGTGAAGCCTCAGTCCCAGGATGGCTCCCCATGTACACTTCCCTCCTCGCCCCAGC TCACCTACACTGGACTATGACATGATCAAGGAATCTTTTTTTTTAAGCTACTGAGATTTCTGTGTTGTTTACATAGCAGTTTGTACCCTA AACAAACACTTGAGATTTTATACTTCAGGAAACTATTCAGATTTCCTTCTCATTAGCAATTGTTCCAAAAACACTTACTCTGCTAATTTC TGCTAGAAAGAATCACAGTTCTTCTAACACAGAAACATTTCTGTCCCTTGAGTTGGGAAACAAGACCCTATGTTAACCCAGTCAGAGTGT GGACTGAGGCATTCGGAGCCTATTTAAGCAGAAGTTTTCTATAAGGACAAGATTTAAAGGCTTACAAAGGTAAAGACAATGGCCTGGTGG GAAGAATTCTAGTCTAGAACGTTTGAGATTTGACTCTAGTTCTAGGTTCATCTTAGCTGGGTGTGTAACGTTGAAAAAATTGGCCGGGTG CAGTGGCTCAGGCCTGTCATCCCAGCACTTTGGGAGGCCGAGGCAGACGGATCACGAGGTCAAGAGATCAAGACCATCTTGGCCAACATG GTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGAGCGTGGTGGCGTGCGCCTGTAGTCCCAGCTACTGGGGAGGATAAGGCAGG AGAATCGCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAGATCGCGCCATTGCACTCCAGCCTGGTGACAGAGCGAGACTCCGTCTC AAAAAAAAAAAAAAAAAAAAAGAGAGAGAAAAAAATCCTTACTTTCTCTACACTCTGATTTCCTCATTTGTAAGGTGGGCAGTTTTCAGA ACTTAGCAGCAATAAGGTTTCTGATAAAATCAAGAAGCAAAGGAAGTAACATTGCCTTTTTGAAGTTTTGCTATAAGATTGACATACCAA GGTAAAGATTGAGTCACCTGAGAAGCAGTGGCTCCCAGGCCAGCAAGAATGTACAAACCTGGCTCTGCCATTTGCTGATTGATATTAGGC AAGTTGCAGATTCCTTGGACATCTCAATCCTTTCATCTGTAAAATGTGTGGATTAGCATGTATCTCATGCTCCACTGGGAATTTCATAGC AAATATATATACTACAACATGGTTGACCAGATAGATCAGTAATGTCAACTAGAAGGTATTAGATGAACATTGTCAGTCTCCAATCAAGCA TTGTTTAGGGGAGAGGAATTCTTTCAGGTTCAAGCATTCTGGCTTTTAGTTTGGAGAGGGATGCAGGGATTGTAACTTAAAATCTTCAGA TATTGAGGCCATTGACAAGTAATCTACTGTAAGGTAGATGCCTCCTGGTATTTTAAAACAGCTTTTCTAATTTCTCATGTTATTGTACAT AAGCAAAGCAACCTAGTTATGTCTTGGGTAGGTGTTCTTATAGCCGTGAGATGCTACTGACTTGAGGTGGATGCAGAAAAAAATGGAACC ACTGCCTTAATGGGATGGAATATACTAAACATGCATTCTTAAATCCTAGTGCTGGGATGGATTACATGAATTACATTGTGGAGCTGCATA TGTGTCTCCCCTCTTCCCTCCCTGGGGGTTAGGCTGGGTTTGTTTGGTTTTTTTTGTTTTGTCCTCATGAGGCTTAGCATCTAAGGGAGA CAGGCATGAATTAACAGAAGTGGCATTCTGGTATCTGTCTCAGCCTCATATTCATTTTAGTGTAAATCAGTTTCGTCAAGTCTAGGTATG ACAAGGTGGGTCTTTGCACCTTCTAGCGATGGGCAGCATCCCACAACACAGTGGTCTAATTGAGGTGCTGCACTATGAGTCCTGCCTGTG TTAACCAGCCTTCCTTCATGTCACAATACTGCTGCTGGATTTGCTTTTTACATCTGCCTATTGCACCTGACTTGGGCATGGATGATATGA GGTAATAAATGCTTTGAAAACCATGAAGGGCCACACAAGTGCTAGTGTTATTGCTGTGGGACAAGGTCTGGGAATATGAGAACCAGCAGC AGCATGGGTGCAGCTGAGAACCAGATGGTGAACATCTGTCTCCAAAGTGCAACATTCCTGAGCACCGGATTTATAAGGCATTTCTTACTC GACAGAATTGACTTCATGGAAGGTATGTAGTTTGACTTTGCCTTAGCCATGTTGATCAAATAGGAGTATTGTGCATGCCGCAGCTAGACA GAGTCCTGGGCCCTTTAAAAACCTTGTCAGTGACTCCCATTGCAGGCCCAGCGCAGTGGTTCACACCTGTAATCCCAGCATTTGGGAGGC TGAGGCAGGCAGATCACTTGAGGCCAAGAGTTCGAGACCAGACTGGCCAACATGGCAAAACCTCCTCTCTACTAAAAATACAAAAGTTAG CCAGGCGTGATGTTGGGTGCCTGTAATTGCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAATCCAGGAGGCGGAGGTTACAGTG AGCTGAGATCATACCACTGCACTCCAGCCTGGGCCACAGAGAAAGAACGGTGATTCTTTCTAGCAGAAATTAGCAGAGTAAGTGTTTTTG GAACAATTGCTAATGAAAAGAAGGAAAAACAGAAAAAAAAAATTTTCTGTTTATGGGAGGTGACTTATTTCTCTATCAATCCTGTGAGTG ATTTAGCATGGCAATTCATGAACACTGAGTTGTTTCCTTGCTCTGATTGTCTGTTGCTCAATGAAATGGCTTTTAGCAGGGCTCAAAGGT GAAGCCAGATTCTCCTGCACTAATAGGATAAGCATGGAGACACCAGTGTTCAGTGTGGCCTCTGGTTGTCTGAAATTTTGCTGTCAACTC TAATACCTTGAAAGAATTAGGTTTCCAAAGTGGGATATTGTGCTGCTGTTTGTGATATAGCATCTAGACTTAGGAAAGGGCAGGAACAAT TTAAAAGCACATCTGTAGGCACAAAGAGAATTATAATAGAAATTCAGAATTCCTAGGCATATGACCTAGACTAAAATGTCTTCATAACTA CAAATGAAATCAGGGTCATTTATAGTACAAACTACCACAGAAGTCAGTAGTTAGGGGATGGAGATAGATATGAAAAAAAAAAAAAGCAAA CCCAGCCTAACTCCCAGGGAGGGAAGAGGGGCGACAGATATGCAGCTACACAATGTTTTTACTATCTTGAGTTCTTTTTACCCAGATTCC ATAGCTAAATCCAGATGTATTAATAGGTAGAGACTACTTCAGAAAGGATGAGACTATTTTCTTGCTTAATTATCCACACAGTAATTCAGA AATGTATATTGAACACTTTTTATATGCCAGGCACTGCTGGGCACTGGAAATATAAAAGTAAGCAAAAATGAAAAACTATCCTGTCCTCCT GAGGCTTAGCATCTAAGGGAGACAGGCATTAGTCAACCCCGTGTGGCTGTGAATCAGCCATGATGCTGAGTGCTACAAGAGAGGACTGTG CGGCTGGGAGGGCTTATAACAGGATTTGACCTAGTTAGGGAAGATCTGAGGAAGTGATGAAAGAATGGAAATCAATATGTAAGAGCTCAC AAGTCAGAGTGAGATGTTTCTTCCTATACTGCCTGCTTCTAATGAGCATCCACTTCATTGAACCACCTCTTCATTGAGCCAAACCTACCA TACAGGGATACATTCTCTGGAGGAAAGTTGAGCAACTATTGCATTTGGGACATTAGAGTATGGGTGGGCTGACAGGTATGTGTATGTTTA TTATCCAAGACAGCCAAGGTGTTTATCCTGTTACAACATCCCAGAGGACAGAGGCTCTTATTTGTGACTCTTTTTTCTTACCTGTAACAC CAGAGGCATAACGTACATCATAATGCTGCATCTTGTTGACGCTTCAATGCTCACAATTCAAAGGTGATTTCTGAAGCACTTTGTTACACT GGGGACAGCTCCTAAATCCTCCCACTCTTTTTTTGCCTCACCTTGGAGTCTTGGGCTCTGTTGATCACTGACTCTGCCAGGTCTTTCAGC AGGCAAGACAGCTCAGTTAAATTGAGTTTGGACTCCACTGTAGTGCATGCATGAGACAGCACCCCCAATCCCCAACACCCACACACAAAC TTTAAATATTTGTAACAGAATTGTTACCATTAATATTGCTTAAAGGCTAACACATTAGCCAGAACCTAGATGTCTTCTGGAAATTTTTTA 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FusionGenePPI for MAN1A2_TTF2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAN1A2 | SMAD9, CLDND1, CD1B, SCARA3, CLU, C5AR2, CD1E, SCGB2A2, TMEM30B, IL13RA2, ADAM32, PMEL, B4GAT1, TLR5, TRHDE, PTPRO | TTF2 | DRAP1, CDC5L, TNIP1, DCP1A, PDCD6IP, PRDX4, CLPB, TACC3, NVL, ZSCAN1, SIRT3, TFAP4, HINFP, ACAT1, SMAD7, SKIL, SMAD1, HDAC11, CDKL3, PPP6R1, HDAC7, PEX19, SKAP1, CBWD1, RABL2A, TOP3A, MYBL2, PCM1, CEP162, CEP120, CEP152, CNTROB, CEP128, CNTRL, NINL, NIN, DCTN1, CETN2, RPGR, XPO1, CREB1, FOXL2, FOXN1, FOXP1, CETN1, IQCF1, RAB2B, PSMC4, COMMD1, HAVCR2, FAM131B, IL17RA, DKK3, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAN1A2_TTF2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAN1A2_TTF2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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