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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20736

FusionGeneSummary for MAN1A1_PDSS2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAN1A1_PDSS2
Fusion gene ID: 20736
HgeneTgene
Gene symbol

MAN1A1

PDSS2

Gene ID

4121

57107

Gene namemannosidase alpha class 1A member 1decaprenyl diphosphate synthase subunit 2
SynonymsHUMM3|HUMM9|MAN9C6orf210|COQ10D3|DLP1|bA59I9.3|hDLP1
Cytomap

6q22.31

6q21

Type of geneprotein-codingprotein-coding
Descriptionmannosyl-oligosaccharide 1,2-alpha-mannosidase IAMan9-mannosidasealpha-1,2-mannosidase IAman(9)-alpha-mannosidaseprocessing alpha-1,2-mannosidase IAdecaprenyl-diphosphate synthase subunit 2all-trans-decaprenyl-diphosphate synthase subunit 2decaprenyl pyrophosphate synthase subunit 2decaprenyl pyrophosphate synthetase subunit 2prenyl (decaprenyl) diphosphate synthase, subunit 2subunit 2 of decapr
Modification date2018052320180527
UniProtAcc

P33908

Q86YH6

Ensembl transtripts involved in fusion geneENST00000368468, ENST00000368466, 
ENST00000369037, ENST00000453874, 
ENST00000369031, 
Fusion gene scores* DoF score9 X 6 X 5=2707 X 5 X 6=210
# samples 78
** MAII scorelog2(7/270*10)=-1.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAN1A1 [Title/Abstract] AND PDSS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDSS2

GO:0006744

ubiquinone biosynthetic process

16262699

TgenePDSS2

GO:0008299

isoprenoid biosynthetic process

16262699


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1RF-01AMAN1A1chr6

119669628

-PDSS2chr6

107475981

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000368468ENST00000369037MAN1A1chr6

119669628

-PDSS2chr6

107475981

-
Frame-shitENST00000368468ENST00000453874MAN1A1chr6

119669628

-PDSS2chr6

107475981

-
5CDS-intronENST00000368468ENST00000369031MAN1A1chr6

119669628

-PDSS2chr6

107475981

-
Frame-shitENST00000368466ENST00000369037MAN1A1chr6

119669628

-PDSS2chr6

107475981

-
In-frameENST00000368466ENST00000453874MAN1A1chr6

119669628

-PDSS2chr6

107475981

-
5CDS-intronENST00000368466ENST00000369031MAN1A1chr6

119669628

-PDSS2chr6

107475981

-

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FusionProtFeatures for MAN1A1_PDSS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAN1A1

P33908

PDSS2

Q86YH6

Involved in the maturation of Asn-linkedoligosaccharides. Progressively trim alpha-1,2-linked mannoseresidues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). Supplies decaprenyl diphosphate, the precursor for theside chain of the isoprenoid quinones ubiquinone-10.{ECO:0000269|PubMed:16262699}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAN1A1_PDSS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MAN1A1_ENST00000368466_chr6_119669628_-_PDSS2_ENST00000453874_chr6_107475981_-_254aa
MPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLSGVLFHSSPALQPAADHKPGP
GARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MAN1A1_ENST00000368466_chr6_119669628_-_PDSS2_ENST00000453874_chr6_107475981_-_762nt
ATGCCCGTGGGGGGCCTGTTGCCGCTCTTCAGCAGCCCCGCGGGCGGCGTCCTGGGCGGGGGGCTCGGCGGCGGCGGTGGCAGGAAGGGG
TCGGGCCCCGCCGCCCTCCGCCTGACGGAGAAGTTCGTGCTGCTGCTGGTATTCAGCGCCTTCATCACGCTCTGCTTCGGGGCGATCTTC
TTCCTGCCAGACTCCTCCAAGCTGCTCAGCGGGGTCCTGTTCCACTCCAGCCCCGCCTTGCAGCCGGCCGCCGACCACAAGCCCGGGCCC
GGGGCGCGCGCCGAGGACGCGGCCGAGGGGCGAGCCCGGCGCCGCGAGGAGGGGGCACCCGGGGACCCGGAGGCCGCCCTGGAGGACAAC
TTGGCCAGGATCCGCGAAAACCACGAGCGGGCTCTCAGGGAAGCCAAGGAGACCCTGCAGAAGCTGCCCGAGGAGATCCAAAGAGACATC
CTACTGGAGAAGAAGAAGGTGGCCCAGGACCAGCTGCGTGACAAGGCGCCGTTCAGAGGCCTGCCCCCGGTGGACTTCGTGCCCCCAATC
GGGGTGGAGAGCCGGGAGCCCGCCGACGCCGCCATCCGCGAGAAAAGGGCAAAGATCAAAGAGTTGCGAGAAAGAATCAAAGCTGGCAAA
GGTGTGACTTCAGCTATTGACCTGTGTCGTTACCATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCCCTCGGAGGCCAGATCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MAN1A1_ENST00000368466_chr6_119669628_-_PDSS2_ENST00000453874_chr6_107475981_-_1352nt
GTACCGTGCTGCTCTACTCGCTGCCATTCGCCCGCAGGTCGGCGCGCTCGCCCACCTGAGCCGCGCCGGGGCTGCGGGACCGTGGGACAG
CGCGCTCAGCCCAGCCTAGGAAAGAGGCAGCAGTCTCAGCGCGGAGATGGGGAGCGGGCGAAGTTGACGAGTCTCCCGCCCACGCTGCGC
CCCTCCTGCCCAGAGGGGCTGCAGCCAGCGGTCTGTCGCGCGTGCCTGTGTGCCCGAGGAGCCGCCCCGGGGAGAAGACCCGGCGCGGAG
TTGTTCCCCCAGGGAGGATCCGCAGCCCAGCCGAGGGGGTCGGGCGGCCTGGCTACGCAGGACCCAGCCCCGCAGCCGCGGACTCCCAGC
GGCGGCGAAGTTTGGCTGCTGAGCGGCGCGGCGCCGGACCACTGGACAGCGGGAGCGATGCCCGTGGGGGGCCTGTTGCCGCTCTTCAGC
AGCCCCGCGGGCGGCGTCCTGGGCGGGGGGCTCGGCGGCGGCGGTGGCAGGAAGGGGTCGGGCCCCGCCGCCCTCCGCCTGACGGAGAAG
TTCGTGCTGCTGCTGGTATTCAGCGCCTTCATCACGCTCTGCTTCGGGGCGATCTTCTTCCTGCCAGACTCCTCCAAGCTGCTCAGCGGG
GTCCTGTTCCACTCCAGCCCCGCCTTGCAGCCGGCCGCCGACCACAAGCCCGGGCCCGGGGCGCGCGCCGAGGACGCGGCCGAGGGGCGA
GCCCGGCGCCGCGAGGAGGGGGCACCCGGGGACCCGGAGGCCGCCCTGGAGGACAACTTGGCCAGGATCCGCGAAAACCACGAGCGGGCT
CTCAGGGAAGCCAAGGAGACCCTGCAGAAGCTGCCCGAGGAGATCCAAAGAGACATCCTACTGGAGAAGAAGAAGGTGGCCCAGGACCAG
CTGCGTGACAAGGCGCCGTTCAGAGGCCTGCCCCCGGTGGACTTCGTGCCCCCAATCGGGGTGGAGAGCCGGGAGCCCGCCGACGCCGCC
ATCCGCGAGAAAAGGGCAAAGATCAAAGAGTTGCGAGAAAGAATCAAAGCTGGCAAAGGTGTGACTTCAGCTATTGACCTGTGTCGTTAC
CATGGAAACAAGGCACTGGAGGCCCTGGAGAGCTTTCCTCCCTCGGAGGCCAGATCTGCTTTAGAAAACATTGTGTTTGCTGTGACCAGA
TTTTCATGACATCAAATTAAAAAGACACTATTGTTAGTTAGCTGAAAATCCTAGGGAATGAGGTTGATTGGGAGCGCTTTCACGATGCGT
TAATGACTTTTAAAACATATGCATTTTTCCTTCCTTTTATCACATTGCTAAATGAGTTCTGCTTTCTTTTTGGAACTGCTACAAACAAAA


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FusionGenePPI for MAN1A1_PDSS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAN1A1CLDND1, GINM1, PLAUR, TMEM30B, CDCP1, CLU, UST, MMP10, OCLN, CD1BPDSS2ELAVL1, APP, OXLD1, ACAD9, SDHA, THEM4, FDPS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAN1A1_PDSS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAN1A1_PDSS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePDSS2C3553358COENZYME Q10 DEFICIENCY, PRIMARY, 31UNIPROT