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Fusion gene ID: 20733 |
FusionGeneSummary for MAN1A1_MAGT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAN1A1_MAGT1 | Fusion gene ID: 20733 | Hgene | Tgene | Gene symbol | MAN1A1 | MAGT1 | Gene ID | 4121 | 84061 |
| Gene name | mannosidase alpha class 1A member 1 | magnesium transporter 1 | |
| Synonyms | HUMM3|HUMM9|MAN9 | IAP|MRX95|OST3B|PRO0756|XMEN|bA217H1.1 | |
| Cytomap | 6q22.31 | Xq21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mannosyl-oligosaccharide 1,2-alpha-mannosidase IAMan9-mannosidasealpha-1,2-mannosidase IAman(9)-alpha-mannosidaseprocessing alpha-1,2-mannosidase IA | magnesium transporter protein 1implantation-associated proteinoligosaccharyltransferase 3 homolog B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P33908 | Q9H0U3 | |
| Ensembl transtripts involved in fusion gene | ENST00000368468, ENST00000368466, | ENST00000358075, ENST00000373336, | |
| Fusion gene scores | * DoF score | 9 X 6 X 5=270 | 3 X 2 X 3=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/270*10)=-1.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAN1A1 [Title/Abstract] AND MAGT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB2F-01A | MAN1A1 | chr6 | 119611848 | - | MAGT1 | chrX | 77086392 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368468 | ENST00000358075 | MAN1A1 | chr6 | 119611848 | - | MAGT1 | chrX | 77086392 | - |
| 5CDS-intron | ENST00000368468 | ENST00000373336 | MAN1A1 | chr6 | 119611848 | - | MAGT1 | chrX | 77086392 | - |
| In-frame | ENST00000368466 | ENST00000358075 | MAN1A1 | chr6 | 119611848 | - | MAGT1 | chrX | 77086392 | - |
| 5CDS-intron | ENST00000368466 | ENST00000373336 | MAN1A1 | chr6 | 119611848 | - | MAGT1 | chrX | 77086392 | - |
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FusionProtFeatures for MAN1A1_MAGT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAN1A1 | MAGT1 |
| Involved in the maturation of Asn-linkedoligosaccharides. Progressively trim alpha-1,2-linked mannoseresidues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). | Acts as accessory component of the N-oligosaccharyltransferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donorto an asparagine residue within an Asn-X-Ser/Thr consensus motifin nascent polypeptide chains. Involved in N-glycosylation ofSTT3B-dependent substrates. Specifically required for theglycosylation of a subset of acceptor sites that are near cysteineresidues; in this function seems to act redundantly with TUSC3. Inits oxidized form proposed to form transient mixed disulfides witha glycoprotein substrate to facilitate access of STT3B to theunmodified acceptor site. Has also oxidoreductase-independentfunctions in the STT3B-containing OST complex possibly involvingsubstrate recognition. {ECO:0000269|PubMed:25135935,ECO:0000269|PubMed:26864433, ECO:0000305}. May be involved in Mg(2+) transport in epithelial cells.{ECO:0000305|PubMed:15804357, ECO:0000305|PubMed:19717468}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MAN1A1 | chr6:119611848 | chrX:77086392 | ENST00000368468 | - | 5 | 13 | 1_41 | 299 | 654 | Topological domain | Cytoplasmic |
| Hgene | MAN1A1 | chr6:119611848 | chrX:77086392 | ENST00000368468 | - | 5 | 13 | 42_62 | 299 | 654 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >MAN1A1 | chr6:119611848 | chrX:77086392 | ENST00000368468 | - | 5 | 13 | 63_653 | 299 | 654 | Topological domain | Lumenal |
| Tgene | MAGT1 | chr6:119611848 | chrX:77086392 | ENST00000358075 | - | 7 | 10 | 47_175 | 332 | 368 | Domain | Note=Thioredoxin |
| Tgene | MAGT1 | chr6:119611848 | chrX:77086392 | ENST00000358075 | - | 7 | 10 | 206_209 | 332 | 368 | Topological domain | Cytoplasmic |
| Tgene | MAGT1 | chr6:119611848 | chrX:77086392 | ENST00000358075 | - | 7 | 10 | 231_270 | 332 | 368 | Topological domain | Extracellular |
| Tgene | MAGT1 | chr6:119611848 | chrX:77086392 | ENST00000358075 | - | 7 | 10 | 292_300 | 332 | 368 | Topological domain | Cytoplasmic |
| Tgene | MAGT1 | chr6:119611848 | chrX:77086392 | ENST00000358075 | - | 7 | 10 | 30_184 | 332 | 368 | Topological domain | Extracellular |
| Tgene | MAGT1 | chr6:119611848 | chrX:77086392 | ENST00000358075 | - | 7 | 10 | 322_335 | 332 | 368 | Topological domain | Extracellular |
| Tgene | MAGT1 | chr6:119611848 | chrX:77086392 | ENST00000358075 | - | 7 | 10 | 185_205 | 332 | 368 | Transmembrane | Helical |
| Tgene | MAGT1 | chr6:119611848 | chrX:77086392 | ENST00000358075 | - | 7 | 10 | 210_230 | 332 | 368 | Transmembrane | Helical |
| Tgene | MAGT1 | chr6:119611848 | chrX:77086392 | ENST00000358075 | - | 7 | 10 | 271_291 | 332 | 368 | Transmembrane | Helical |
| Tgene | MAGT1 | chr6:119611848 | chrX:77086392 | ENST00000358075 | - | 7 | 10 | 301_321 | 332 | 368 | Transmembrane | Helical |
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FusionGeneSequence for MAN1A1_MAGT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_MAN1A1_ENST00000368468_chr6_119611848_-_MAGT1_ENST00000358075_chrX_77086392_-_334aa MPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLSGVLFHSSPALQPAADHKPGP GARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPI GVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDF >In-frame_MAN1A1_ENST00000368466_chr6_119611848_-_MAGT1_ENST00000358075_chrX_77086392_-_357aa MPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVLLLVFSAFITLCFGAIFFLPDSSKLLSGVLFHSSPALQPAADHKPGP GARAEDAAEGRARRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQDQLRDKAPFRGLPPVDFVPPI GVESREPADAAIREKRAKIKEEIEARKGQANCPGSSSSCEVEIQMMKHAWNNYKGYAWGLNELKPISKGGHSSSLFGNIKGATIVDALDT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_MAN1A1_ENST00000368468_chr6_119611848_-_MAGT1_ENST00000358075_chrX_77086392_-_1004nt ATGCCCGTGGGGGGCCTGTTGCCGCTCTTCAGCAGCCCCGCGGGCGGCGTCCTGGGCGGGGGGCTCGGCGGCGGCGGTGGCAGGAAGGGG TCGGGCCCCGCCGCCCTCCGCCTGACGGAGAAGTTCGTGCTGCTGCTGGTATTCAGCGCCTTCATCACGCTCTGCTTCGGGGCGATCTTC TTCCTGCCAGACTCCTCCAAGCTGCTCAGCGGGGTCCTGTTCCACTCCAGCCCCGCCTTGCAGCCGGCCGCCGACCACAAGCCCGGGCCC GGGGCGCGCGCCGAGGACGCGGCCGAGGGGCGAGCCCGGCGCCGCGAGGAGGGGGCACCCGGGGACCCGGAGGCCGCCCTGGAGGACAAC TTGGCCAGGATCCGCGAAAACCACGAGCGGGCTCTCAGGGAAGCCAAGGAGACCCTGCAGAAGCTGCCCGAGGAGATCCAAAGAGACATC CTACTGGAGAAGAAGAAGGTGGCCCAGGACCAGCTGCGTGACAAGGCGCCGTTCAGAGGCCTGCCCCCGGTGGACTTCGTGCCCCCAATC GGGGTGGAGAGCCGGGAGCCCGCCGACGCCGCCATCCGCGAGAAAAGGGCAAAGATCAAAGAGATGATGAAACATGCTTGGAATAATTAT AAAGGTTATGCCTGGGGATTAAATGAACTCAAACCTATATCAAAAGGAGGCCATTCAAGCAGTTTGTTTGGTAACATCAAAGGAGCAACT ATAGTAGATGCCCTGGATACACTTTTTATTATGGAAATGAAACATGAATTTGAAGAAGCAAAATCATGGGTTGAAGAAAATTTAGATTTT AATGTGAATGCTGAAATTTCTGTCTTTGAAGTAAATATACGCTTTGTTGGTGGACTACTCTCAGCCTACTATCTGTCTGGAGAAGAGTAA TGTGTGTGGCTGGTATTGGACTTGTTGTATTATTCTTCAGTTGGATGCTCTCTATTTTTAGATCTAAATATCATGGCTACCCATACAGCT >In-frame_MAN1A1_ENST00000368466_chr6_119611848_-_MAGT1_ENST00000358075_chrX_77086392_-_1073nt ATGCCCGTGGGGGGCCTGTTGCCGCTCTTCAGCAGCCCCGCGGGCGGCGTCCTGGGCGGGGGGCTCGGCGGCGGCGGTGGCAGGAAGGGG TCGGGCCCCGCCGCCCTCCGCCTGACGGAGAAGTTCGTGCTGCTGCTGGTATTCAGCGCCTTCATCACGCTCTGCTTCGGGGCGATCTTC TTCCTGCCAGACTCCTCCAAGCTGCTCAGCGGGGTCCTGTTCCACTCCAGCCCCGCCTTGCAGCCGGCCGCCGACCACAAGCCCGGGCCC GGGGCGCGCGCCGAGGACGCGGCCGAGGGGCGAGCCCGGCGCCGCGAGGAGGGGGCACCCGGGGACCCGGAGGCCGCCCTGGAGGACAAC TTGGCCAGGATCCGCGAAAACCACGAGCGGGCTCTCAGGGAAGCCAAGGAGACCCTGCAGAAGCTGCCCGAGGAGATCCAAAGAGACATC CTACTGGAGAAGAAGAAGGTGGCCCAGGACCAGCTGCGTGACAAGGCGCCGTTCAGAGGCCTGCCCCCGGTGGACTTCGTGCCCCCAATC GGGGTGGAGAGCCGGGAGCCCGCCGACGCCGCCATCCGCGAGAAAAGGGCAAAGATCAAAGAGGAAATTGAAGCCAGGAAGGGGCAAGCA AATTGCCCAGGGTCGAGCAGCTCCTGCGAGGTTGAAATCCAGATGATGAAACATGCTTGGAATAATTATAAAGGTTATGCCTGGGGATTA AATGAACTCAAACCTATATCAAAAGGAGGCCATTCAAGCAGTTTGTTTGGTAACATCAAAGGAGCAACTATAGTAGATGCCCTGGATACA CTTTTTATTATGGAAATGAAACATGAATTTGAAGAAGCAAAATCATGGGTTGAAGAAAATTTAGATTTTAATGTGAATGCTGAAATTTCT GTCTTTGAAGTAAATATACGCTTTGTTGGTGGACTACTCTCAGCCTACTATCTGTCTGGAGAAGAGTAATGTGTGTGGCTGGTATTGGAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_MAN1A1_ENST00000368468_chr6_119611848_-_MAGT1_ENST00000358075_chrX_77086392_-_4302nt AGTGCTCGCGGGGCCGCGGCGGAGTGTACCGTGCTGCTCTACTCGCTGCCATTCGCCCGCAGGTCGGCGCGCTCGCCCACCTGAGCCGCG CCGGGGCTGCGGGACCGTGGGACAGCGCGCTCAGCCCAGCCTAGGAAAGAGGCAGCAGTCTCAGCGCGGAGATGGGGAGCGGGCGAAGTT GACGAGTCTCCCGCCCACGCTGCGCCCCTCCTGCCCAGAGGGGCTGCAGCCAGCGGTCTGTCGCGCGTGCCTGTGTGCCCGAGGAGCCGC CCCGGGGAGAAGACCCGGCGCGGAGTTGTTCCCCCAGGGAGGATCCGCAGCCCAGCCGAGGGGGTCGGGCGGCCTGGCTACGCAGGACCC AGCCCCGCAGCCGCGGACTCCCAGCGGCGGCGAAGTTTGGCTGCTGAGCGGCGCGGCGCCGGACCACTGGACAGCGGGAGCGATGCCCGT GGGGGGCCTGTTGCCGCTCTTCAGCAGCCCCGCGGGCGGCGTCCTGGGCGGGGGGCTCGGCGGCGGCGGTGGCAGGAAGGGGTCGGGCCC CGCCGCCCTCCGCCTGACGGAGAAGTTCGTGCTGCTGCTGGTATTCAGCGCCTTCATCACGCTCTGCTTCGGGGCGATCTTCTTCCTGCC AGACTCCTCCAAGCTGCTCAGCGGGGTCCTGTTCCACTCCAGCCCCGCCTTGCAGCCGGCCGCCGACCACAAGCCCGGGCCCGGGGCGCG CGCCGAGGACGCGGCCGAGGGGCGAGCCCGGCGCCGCGAGGAGGGGGCACCCGGGGACCCGGAGGCCGCCCTGGAGGACAACTTGGCCAG GATCCGCGAAAACCACGAGCGGGCTCTCAGGGAAGCCAAGGAGACCCTGCAGAAGCTGCCCGAGGAGATCCAAAGAGACATCCTACTGGA GAAGAAGAAGGTGGCCCAGGACCAGCTGCGTGACAAGGCGCCGTTCAGAGGCCTGCCCCCGGTGGACTTCGTGCCCCCAATCGGGGTGGA GAGCCGGGAGCCCGCCGACGCCGCCATCCGCGAGAAAAGGGCAAAGATCAAAGAGATGATGAAACATGCTTGGAATAATTATAAAGGTTA TGCCTGGGGATTAAATGAACTCAAACCTATATCAAAAGGAGGCCATTCAAGCAGTTTGTTTGGTAACATCAAAGGAGCAACTATAGTAGA TGCCCTGGATACACTTTTTATTATGGAAATGAAACATGAATTTGAAGAAGCAAAATCATGGGTTGAAGAAAATTTAGATTTTAATGTGAA TGCTGAAATTTCTGTCTTTGAAGTAAATATACGCTTTGTTGGTGGACTACTCTCAGCCTACTATCTGTCTGGAGAAGAGTAATGTGTGTG GCTGGTATTGGACTTGTTGTATTATTCTTCAGTTGGATGCTCTCTATTTTTAGATCTAAATATCATGGCTACCCATACAGCTTTCTGATG AGTTAAAAAGGTCCCAGAGATATATAGACACTGGAGTACTGGAAATTGAAAAACGAAAATCGTGTGTGTTTGAAAAGAAGAATGCAACTT GTATATTTTGTATTACCTCTTTTTTTCAAGTGATTTAAATAGTTAATCATTTAACCAAAGAAGATGTGTAGTGCCTTAACAAGCAATCCT CTGTCAAAATCTGAGGTATTTGAAAATAATTATCCTCTTAACCTTCTCTTCCCAGTGAACTTTATGGAACATTTAATTTAGTACAATTAA GTATATTATAAAAATTGTAAAACTACTACTTTGTTTTAGTTAGAACAAAGCTCAAAACTACTTTAGTTAACTTGGTCATCTGATTTTATA TTGCCTTATCCAAAGATGGGGAAAGTAAGTCCTGACCAGGTGTTCCCACATATGCCTGTTACAGATAACTACATTAGGAATTCATTCTTA GCTTCTTCATCTTTGTGTGGATGTGTATACTTTACGCATCTTTCCTTTTGAGTAGAGAAATTATGTGTGTCATGTGGTCTTCTGAAAATG GAACACCATTCTTCAGAGCACACGTCTAGCCCTCAGCAAGACAGTTGTTTCTCCTCCTCCTTGCATATTTCCTACTGAAATACAGTGCTG TCTATGATTGTTTTTGTTTTGTTGTTTTTTTGAGACGGTCTCGCTGTGTCACACAGGCTGGAGTGCAGTGGCGTGAGCTCGGCTGACTGC AAACTCTGCCTCCCAGGTTTAAGCGATTCTCCTGTCACAGCTTCCCAAGTAGCTGGGATTTACAGGTGTGCACCGCCATGCCAGGCTAAT TTTTGTGTTTTTAGTAGAGACAGGGTTTCGCCAAGTTGTCCAGGCTGGTCTTGAACTCCTGGGCTCAAGTGATCCGCCCGCCTCAGTCTC CCAAAGTGCGAGGATGACATGTGTGAGCTACCACACCAGCAATGTCTATGCTTCTCGATAGCTGTGAACATGAAAAGACATCTATTGGGA GTCCGAGGCAGGTGGATTGCTTGAGGCCAGGAGTTAGAGACCAGCCTGGCCAACAAGGCAAAACCCCGTCTCTACTAAAAATATGAAAAT TAGCTGGGCTTGGTGGCTCATGCCTATAATCCTAGCTACTTGGGAGGCTGAGGCACGAGACTTGCTTAATACCTGGGAGGCGGAGATTGC AGTGAGCCGAGATCACGCTACTGCGCTCCAGCCTGAGTGATAGAGTGAGACTCTGTCTCAAAAAAAAGTATCTCTAAATACAGGATTATA ATTTCTGCTTGAGTATGGTGTTAACTACCTTGTATTTAGAAAGATTTCAGATTCATTCCATCTCCTTAGTTTTCTTTTAAGGTGACCCAT CTGTGATAAAAATATAGCTTAGTGCTAAAATCAGTGTAACTTATACATGGCCTAAAATGTTTCTACAAATTAGAGTTTGTCACTTATTCC ATTTGTACCTAAGAGAAAAATAGGCTCAGTTAGAAAAGGACTCCCTGGCCAGGCGCAGTGACTTACGCCTGTAATCTCAGCACTTTGGGA GGCCAAGGCAGGCAGATCACGAGGTCAGGAGTTCGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAAATTA GCTGGGTGTGGTGGCAGGAGCCTGTAATCCCAGCTACACAGGAGGCTGAGGCACGAGAATCACTTGAACTCAGGAGATGGAGGTTTCAGT GAGCCAAGATCACACCACTGCACTCCAGCCTGGCAACAGAGCGAGACTCCATCTCAAAAAAAAAAAAAAAAGTAAGAAAGAAAAGGACTC CCTTAGAATGGGAAAGAAAAATCATAAAATATTGAGCTGATGCCTGTATATAGAAATTAAGCGTTTCTCGAAAGCTGTTCTATGTTTTGC TGTTATTTTAGTCTTTATTCTCTTCCTTTAGGTGGAGAAACAAAGTACCAATTTGAAGGGATTTTTTTTATTTTGTCTTTTGGTTTCTGT CAGTAGAAATAACCATATGTGCTAACCAAATTTCTGTGAAGAATGTTTTCATGGTTATCATTATATCTAACTATAACCTCCCCCATAGTT ATGAAGAGTAACCTGAAATGCCACTATTGTGGAAATAGGATAATTGTAATTGTGAAAAAATAATTTTAAGGAAATCTTACAAGTATTACA TTAAAAAGATACTATGACTGCCACCTGCCATTTACCTTCTAATAACCCTGCCATGTGGTTTGCAGAAAGAGATGGATATAGTAGCCTCAG AAGAAATATTTTATGTGGGTTTTTTGTTTTTCGTTACTAGATTTCATGGATGAGGGGATATGGTTGACCTTTTACTTTTTAATGGAGCAG CCAGTTTTTGTTAATTACTCACTTGTAAATTGTGAGATTCTGAATTCCTTACCTGCTATTCTTGTACTTGTCTCAGGCCAAATCTATGCT GTGGTTCTTATGAGACTTGTATGAAGATGCCCTGATTTGTACAGATTGACCACGGGAATACTACTGCCATGTAATCTGTATAGTTCCAGA TAATTTGTCATGAACATTGACAGAATGACAATTTTTTGTATTTGCTTTTTCTCCCTTTAAGAGCACATTCTTCTGTAAGGAGAAAGGCAG CATTCTGGCTAAAATGTGTAGAAGGTAATTTACTACACTTATAAAATAGTGTGACTTTTGTGAAAATTTTGAATTAGCTTTCATATGAAG TGCCTTAAGTAGACTCTTCATTTACTTTTCTGGTAATGGTTTAAATATCATTTGTTATGCATTTTTAAGATACAGTTCAGAATGACACAT >In-frame_MAN1A1_ENST00000368466_chr6_119611848_-_MAGT1_ENST00000358075_chrX_77086392_-_4346nt GTACCGTGCTGCTCTACTCGCTGCCATTCGCCCGCAGGTCGGCGCGCTCGCCCACCTGAGCCGCGCCGGGGCTGCGGGACCGTGGGACAG CGCGCTCAGCCCAGCCTAGGAAAGAGGCAGCAGTCTCAGCGCGGAGATGGGGAGCGGGCGAAGTTGACGAGTCTCCCGCCCACGCTGCGC CCCTCCTGCCCAGAGGGGCTGCAGCCAGCGGTCTGTCGCGCGTGCCTGTGTGCCCGAGGAGCCGCCCCGGGGAGAAGACCCGGCGCGGAG TTGTTCCCCCAGGGAGGATCCGCAGCCCAGCCGAGGGGGTCGGGCGGCCTGGCTACGCAGGACCCAGCCCCGCAGCCGCGGACTCCCAGC GGCGGCGAAGTTTGGCTGCTGAGCGGCGCGGCGCCGGACCACTGGACAGCGGGAGCGATGCCCGTGGGGGGCCTGTTGCCGCTCTTCAGC AGCCCCGCGGGCGGCGTCCTGGGCGGGGGGCTCGGCGGCGGCGGTGGCAGGAAGGGGTCGGGCCCCGCCGCCCTCCGCCTGACGGAGAAG TTCGTGCTGCTGCTGGTATTCAGCGCCTTCATCACGCTCTGCTTCGGGGCGATCTTCTTCCTGCCAGACTCCTCCAAGCTGCTCAGCGGG GTCCTGTTCCACTCCAGCCCCGCCTTGCAGCCGGCCGCCGACCACAAGCCCGGGCCCGGGGCGCGCGCCGAGGACGCGGCCGAGGGGCGA GCCCGGCGCCGCGAGGAGGGGGCACCCGGGGACCCGGAGGCCGCCCTGGAGGACAACTTGGCCAGGATCCGCGAAAACCACGAGCGGGCT CTCAGGGAAGCCAAGGAGACCCTGCAGAAGCTGCCCGAGGAGATCCAAAGAGACATCCTACTGGAGAAGAAGAAGGTGGCCCAGGACCAG CTGCGTGACAAGGCGCCGTTCAGAGGCCTGCCCCCGGTGGACTTCGTGCCCCCAATCGGGGTGGAGAGCCGGGAGCCCGCCGACGCCGCC ATCCGCGAGAAAAGGGCAAAGATCAAAGAGGAAATTGAAGCCAGGAAGGGGCAAGCAAATTGCCCAGGGTCGAGCAGCTCCTGCGAGGTT GAAATCCAGATGATGAAACATGCTTGGAATAATTATAAAGGTTATGCCTGGGGATTAAATGAACTCAAACCTATATCAAAAGGAGGCCAT TCAAGCAGTTTGTTTGGTAACATCAAAGGAGCAACTATAGTAGATGCCCTGGATACACTTTTTATTATGGAAATGAAACATGAATTTGAA GAAGCAAAATCATGGGTTGAAGAAAATTTAGATTTTAATGTGAATGCTGAAATTTCTGTCTTTGAAGTAAATATACGCTTTGTTGGTGGA CTACTCTCAGCCTACTATCTGTCTGGAGAAGAGTAATGTGTGTGGCTGGTATTGGACTTGTTGTATTATTCTTCAGTTGGATGCTCTCTA TTTTTAGATCTAAATATCATGGCTACCCATACAGCTTTCTGATGAGTTAAAAAGGTCCCAGAGATATATAGACACTGGAGTACTGGAAAT TGAAAAACGAAAATCGTGTGTGTTTGAAAAGAAGAATGCAACTTGTATATTTTGTATTACCTCTTTTTTTCAAGTGATTTAAATAGTTAA TCATTTAACCAAAGAAGATGTGTAGTGCCTTAACAAGCAATCCTCTGTCAAAATCTGAGGTATTTGAAAATAATTATCCTCTTAACCTTC TCTTCCCAGTGAACTTTATGGAACATTTAATTTAGTACAATTAAGTATATTATAAAAATTGTAAAACTACTACTTTGTTTTAGTTAGAAC AAAGCTCAAAACTACTTTAGTTAACTTGGTCATCTGATTTTATATTGCCTTATCCAAAGATGGGGAAAGTAAGTCCTGACCAGGTGTTCC CACATATGCCTGTTACAGATAACTACATTAGGAATTCATTCTTAGCTTCTTCATCTTTGTGTGGATGTGTATACTTTACGCATCTTTCCT TTTGAGTAGAGAAATTATGTGTGTCATGTGGTCTTCTGAAAATGGAACACCATTCTTCAGAGCACACGTCTAGCCCTCAGCAAGACAGTT GTTTCTCCTCCTCCTTGCATATTTCCTACTGAAATACAGTGCTGTCTATGATTGTTTTTGTTTTGTTGTTTTTTTGAGACGGTCTCGCTG TGTCACACAGGCTGGAGTGCAGTGGCGTGAGCTCGGCTGACTGCAAACTCTGCCTCCCAGGTTTAAGCGATTCTCCTGTCACAGCTTCCC AAGTAGCTGGGATTTACAGGTGTGCACCGCCATGCCAGGCTAATTTTTGTGTTTTTAGTAGAGACAGGGTTTCGCCAAGTTGTCCAGGCT GGTCTTGAACTCCTGGGCTCAAGTGATCCGCCCGCCTCAGTCTCCCAAAGTGCGAGGATGACATGTGTGAGCTACCACACCAGCAATGTC TATGCTTCTCGATAGCTGTGAACATGAAAAGACATCTATTGGGAGTCCGAGGCAGGTGGATTGCTTGAGGCCAGGAGTTAGAGACCAGCC TGGCCAACAAGGCAAAACCCCGTCTCTACTAAAAATATGAAAATTAGCTGGGCTTGGTGGCTCATGCCTATAATCCTAGCTACTTGGGAG GCTGAGGCACGAGACTTGCTTAATACCTGGGAGGCGGAGATTGCAGTGAGCCGAGATCACGCTACTGCGCTCCAGCCTGAGTGATAGAGT GAGACTCTGTCTCAAAAAAAAGTATCTCTAAATACAGGATTATAATTTCTGCTTGAGTATGGTGTTAACTACCTTGTATTTAGAAAGATT TCAGATTCATTCCATCTCCTTAGTTTTCTTTTAAGGTGACCCATCTGTGATAAAAATATAGCTTAGTGCTAAAATCAGTGTAACTTATAC ATGGCCTAAAATGTTTCTACAAATTAGAGTTTGTCACTTATTCCATTTGTACCTAAGAGAAAAATAGGCTCAGTTAGAAAAGGACTCCCT GGCCAGGCGCAGTGACTTACGCCTGTAATCTCAGCACTTTGGGAGGCCAAGGCAGGCAGATCACGAGGTCAGGAGTTCGAGACCATCCTG GCCAACATGGTGAAACCCCGTCTCTACTAAAAATATAAAAATTAGCTGGGTGTGGTGGCAGGAGCCTGTAATCCCAGCTACACAGGAGGC TGAGGCACGAGAATCACTTGAACTCAGGAGATGGAGGTTTCAGTGAGCCAAGATCACACCACTGCACTCCAGCCTGGCAACAGAGCGAGA CTCCATCTCAAAAAAAAAAAAAAAAGTAAGAAAGAAAAGGACTCCCTTAGAATGGGAAAGAAAAATCATAAAATATTGAGCTGATGCCTG TATATAGAAATTAAGCGTTTCTCGAAAGCTGTTCTATGTTTTGCTGTTATTTTAGTCTTTATTCTCTTCCTTTAGGTGGAGAAACAAAGT ACCAATTTGAAGGGATTTTTTTTATTTTGTCTTTTGGTTTCTGTCAGTAGAAATAACCATATGTGCTAACCAAATTTCTGTGAAGAATGT TTTCATGGTTATCATTATATCTAACTATAACCTCCCCCATAGTTATGAAGAGTAACCTGAAATGCCACTATTGTGGAAATAGGATAATTG TAATTGTGAAAAAATAATTTTAAGGAAATCTTACAAGTATTACATTAAAAAGATACTATGACTGCCACCTGCCATTTACCTTCTAATAAC CCTGCCATGTGGTTTGCAGAAAGAGATGGATATAGTAGCCTCAGAAGAAATATTTTATGTGGGTTTTTTGTTTTTCGTTACTAGATTTCA TGGATGAGGGGATATGGTTGACCTTTTACTTTTTAATGGAGCAGCCAGTTTTTGTTAATTACTCACTTGTAAATTGTGAGATTCTGAATT CCTTACCTGCTATTCTTGTACTTGTCTCAGGCCAAATCTATGCTGTGGTTCTTATGAGACTTGTATGAAGATGCCCTGATTTGTACAGAT TGACCACGGGAATACTACTGCCATGTAATCTGTATAGTTCCAGATAATTTGTCATGAACATTGACAGAATGACAATTTTTTGTATTTGCT TTTTCTCCCTTTAAGAGCACATTCTTCTGTAAGGAGAAAGGCAGCATTCTGGCTAAAATGTGTAGAAGGTAATTTACTACACTTATAAAA TAGTGTGACTTTTGTGAAAATTTTGAATTAGCTTTCATATGAAGTGCCTTAAGTAGACTCTTCATTTACTTTTCTGGTAATGGTTTAAAT ATCATTTGTTATGCATTTTTAAGATACAGTTCAGAATGACACATTGTAGTGGCAAAGATAACCAAATGTCTGGCTGTTTGCTTTTTGACC 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FusionGenePPI for MAN1A1_MAGT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| MAN1A1 | CLDND1, GINM1, PLAUR, TMEM30B, CDCP1, CLU, UST, MMP10, OCLN, CD1B | MAGT1 | DDOST, STT3B, RPL6, LMNB1, PPIB, FBXO6, MOV10, NXF1, EED, RNF2, COX4I1, COX2, SEC61A1, SSR3, SSR4, VDAC1, VDAC2, VDAC3, SSR1, TECR, TCTN2, TCTN3, EVC2, TCTN1, TMEM67, NCSTN, NEDD1, LDHD, FOXG1, FOXS1, TMEM258, RNF157 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAN1A1_MAGT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAN1A1_MAGT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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