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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20676

FusionGeneSummary for MALAT1_TPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: MALAT1_TPM1
Fusion gene ID: 20676
HgeneTgene
Gene symbol

MALAT1

TPM1

Gene ID

378938

7168

Gene namemetastasis associated lung adenocarcinoma transcript 1tropomyosin 1
SynonymsHCN|LINC00047|NCRNA00047|NEAT2|PRO2853C15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSA
Cytomap

11q13.1

15q22.2

Type of genencRNAprotein-coding
Descriptionhepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding)tropomyosin alpha-1 chainalpha-tropomyosincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappatropomyosin 1 (alpha)
Modification date2018052720180523
UniProtAcc

P09493

Ensembl transtripts involved in fusion geneENST00000534336, ENST00000288398, 
ENST00000358278, ENST00000560445, 
ENST00000403994, ENST00000357980, 
ENST00000559556, ENST00000559397, 
ENST00000267996, ENST00000334895, 
ENST00000404484, ENST00000560959, 
ENST00000559281, ENST00000317516, 
Fusion gene scores* DoF score83 X 128 X 5=531206 X 6 X 4=144
# samples 1417
** MAII scorelog2(141/53120*10)=-5.23548807894813
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MALAT1 [Title/Abstract] AND TPM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW864167MALAT1chr11

65266579

-TPM1chr15

63351847

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000534336ENST00000288398MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-3CDSENST00000534336ENST00000358278MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000560445MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000403994MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000357980MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000559556MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000559397MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000267996MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000334895MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000404484MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000560959MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000559281MALAT1chr11

65266579

-TPM1chr15

63351847

-
3UTR-intronENST00000534336ENST00000317516MALAT1chr11

65266579

-TPM1chr15

63351847

-

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FusionProtFeatures for MALAT1_TPM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MALAT1

TPM1

P09493

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MALAT1_TPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MALAT1_TPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MALAT1_TPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTPM1P09493DB11638ArtenimolTropomyosin alpha-1 chainsmall moleculeapproved|investigational

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RelatedDiseases for MALAT1_TPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMALAT1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneMALAT1C0023903Liver neoplasms1CTD_human
HgeneMALAT1C0027626Neoplasm Invasiveness1CTD_human
HgeneMALAT1C0027627Neoplasm Metastasis1CTD_human
HgeneMALAT1C0032460Polycystic Ovary Syndrome1CTD_human
HgeneMALAT1C0236663Alcohol withdrawal syndrome1PSYGENET
HgeneMALAT1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTPM1C1861863CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder)5CTD_human;UNIPROT
TgeneTPM1C2678476Cardiomyopathy, Dilated, 1y2CTD_human;UNIPROT
TgeneTPM1C0014859Esophageal Neoplasms1CTD_human
TgeneTPM1C0020538Hypertensive disease1CTD_human
TgeneTPM1C0022548Keloid1CTD_human
TgeneTPM1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTPM1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTPM1C0949658Cardiomyopathy, Hypertrophic, Familial1CTD_human