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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20654

FusionGeneSummary for MALAT1_PLEKHB1

check button Fusion gene summary
Fusion gene informationFusion gene name: MALAT1_PLEKHB1
Fusion gene ID: 20654
HgeneTgene
Gene symbol

MALAT1

PLEKHB1

Gene ID

378938

58473

Gene namemetastasis associated lung adenocarcinoma transcript 1pleckstrin homology domain containing B1
SynonymsHCN|LINC00047|NCRNA00047|NEAT2|PRO2853KPL1|PHR1|PHRET1
Cytomap

11q13.1

11q13.4

Type of genencRNAprotein-coding
Descriptionhepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding)pleckstrin homology domain-containing family B member 1PH domain containing, retinal 1PH domain-containing family B member 1PH domain-containing protein in retina 1evectin-1pleckstrin homology domain containing, family B (evectins) member 1pleckstri
Modification date2018052720180523
UniProtAcc

Q9UF11

Ensembl transtripts involved in fusion geneENST00000534336, ENST00000354190, 
ENST00000398492, ENST00000227214, 
ENST00000398494, ENST00000543085, 
ENST00000544532, ENST00000535129, 
Fusion gene scores* DoF score83 X 128 X 5=531206 X 6 X 4=144
# samples 1417
** MAII scorelog2(141/53120*10)=-5.23548807894813
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MALAT1 [Title/Abstract] AND PLEKHB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DC328276MALAT1chr11

65272578

+PLEKHB1chr11

73359991

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000534336ENST00000354190MALAT1chr11

65272578

+PLEKHB1chr11

73359991

+
3UTR-intronENST00000534336ENST00000398492MALAT1chr11

65272578

+PLEKHB1chr11

73359991

+
3UTR-intronENST00000534336ENST00000227214MALAT1chr11

65272578

+PLEKHB1chr11

73359991

+
3UTR-intronENST00000534336ENST00000398494MALAT1chr11

65272578

+PLEKHB1chr11

73359991

+
3UTR-intronENST00000534336ENST00000543085MALAT1chr11

65272578

+PLEKHB1chr11

73359991

+
3UTR-intronENST00000534336ENST00000544532MALAT1chr11

65272578

+PLEKHB1chr11

73359991

+
3UTR-5UTRENST00000534336ENST00000535129MALAT1chr11

65272578

+PLEKHB1chr11

73359991

+

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FusionProtFeatures for MALAT1_PLEKHB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MALAT1

PLEKHB1

Q9UF11

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MALAT1_PLEKHB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MALAT1_PLEKHB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MALAT1_PLEKHB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MALAT1_PLEKHB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMALAT1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneMALAT1C0023903Liver neoplasms1CTD_human
HgeneMALAT1C0027626Neoplasm Invasiveness1CTD_human
HgeneMALAT1C0027627Neoplasm Metastasis1CTD_human
HgeneMALAT1C0032460Polycystic Ovary Syndrome1CTD_human
HgeneMALAT1C0236663Alcohol withdrawal syndrome1PSYGENET
HgeneMALAT1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgenePLEKHB1C0023893Liver Cirrhosis, Experimental1CTD_human