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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20598

FusionGeneSummary for MAL2_ARFGEF1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAL2_ARFGEF1
Fusion gene ID: 20598
HgeneTgene
Gene symbol

MAL2

ARFGEF1

Gene ID

114569

10565

Gene namemal, T cell differentiation protein 2 (gene/pseudogene)ADP ribosylation factor guanine nucleotide exchange factor 1
Synonyms-ARFGEP1|BIG1|P200
Cytomap

8q24.12

8q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein MAL2MAL proteolipid protein 2MAL2 proteolipid proteinmal, T-cell differentiation protein 2brefeldin A-inhibited guanine nucleotide-exchange protein 1ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)p200 ARF guanine nucleotide exchange factor
Modification date2018052320180523
UniProtAcc

Q969L2

Q9Y6D6

Ensembl transtripts involved in fusion geneENST00000276681, ENST00000521748, 
ENST00000520381, ENST00000262215, 
ENST00000517955, ENST00000518230, 
Fusion gene scores* DoF score4 X 2 X 4=327 X 5 X 3=105
# samples 47
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MAL2 [Title/Abstract] AND ARFGEF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARFGEF1

GO:0034260

negative regulation of GTPase activity

15644318


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-05-4422-01AMAL2chr8

120220844

+ARFGEF1chr8

68130373

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000276681ENST00000520381MAL2chr8

120220844

+ARFGEF1chr8

68130373

-
In-frameENST00000276681ENST00000262215MAL2chr8

120220844

+ARFGEF1chr8

68130373

-
5CDS-intronENST00000276681ENST00000517955MAL2chr8

120220844

+ARFGEF1chr8

68130373

-
5CDS-intronENST00000276681ENST00000518230MAL2chr8

120220844

+ARFGEF1chr8

68130373

-
3UTR-3CDSENST00000521748ENST00000520381MAL2chr8

120220844

+ARFGEF1chr8

68130373

-
3UTR-3CDSENST00000521748ENST00000262215MAL2chr8

120220844

+ARFGEF1chr8

68130373

-
3UTR-intronENST00000521748ENST00000517955MAL2chr8

120220844

+ARFGEF1chr8

68130373

-
3UTR-intronENST00000521748ENST00000518230MAL2chr8

120220844

+ARFGEF1chr8

68130373

-

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FusionProtFeatures for MAL2_ARFGEF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAL2

Q969L2

ARFGEF1

Q9Y6D6

Member of the machinery of polarized transport. Requiredfor the indirect transcytotic route at the step of the egress ofthe transcytosing cargo from perinuclear endosomes in order for itto travel to the apical surface via a raft-dependent pathway.{ECO:0000269|PubMed:12370246}. Promotes guanine-nucleotide exchange on ARF1 and ARF3.Promotes the activation of ARF1/ARF3 through replacement of GDPwith GTP. Involved in vesicular trafficking. Required for themaintenance of Golgi structure; the function may be independent ofits GEF activity. Required for the maturaion of integrin beta-1 inthe Golgi. Involved in the establishment and persistence of cellpolarity during directed cell movement in wound healing. Proposedto act as A kinase-anchoring protein (AKAP) and may mediatecrosstalk between Arf and PKA pathways. Inhibits GAP activity ofMYO9B probably through competetive RhoA binding. The function inthe nucleus remains to be determined.{ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318,ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857,ECO:0000269|PubMed:22084092}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAL2chr8:120220844chr8:68130373ENST00000276681+251_3444177Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAL2chr8:120220844chr8:68130373ENST00000276681+2531_17544177DomainMARVEL
HgeneMAL2chr8:120220844chr8:68130373ENST00000276681+25124_14944177Topological domainLumenal
HgeneMAL2chr8:120220844chr8:68130373ENST00000276681+25171_17644177Topological domainCytoplasmic
HgeneMAL2chr8:120220844chr8:68130373ENST00000276681+2556_6644177Topological domainLumenal
HgeneMAL2chr8:120220844chr8:68130373ENST00000276681+2588_10244177Topological domainCytoplasmic
HgeneMAL2chr8:120220844chr8:68130373ENST00000276681+25103_12344177TransmembraneHelical
HgeneMAL2chr8:120220844chr8:68130373ENST00000276681+25150_17044177TransmembraneHelical
HgeneMAL2chr8:120220844chr8:68130373ENST00000276681+2535_5544177TransmembraneHelical
HgeneMAL2chr8:120220844chr8:68130373ENST00000276681+2567_8744177TransmembraneHelical
TgeneARFGEF1chr8:120220844chr8:68130373ENST00000262215-2939709_84014461850DomainSEC7
TgeneARFGEF1chr8:120220844chr8:68130373ENST00000262215-2939711_71514461850MotifNote=Nuclear localization signal (NLS)


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FusionGeneSequence for MAL2_ARFGEF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000520381_chr8_68130373_-_399aa
MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEIKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQD
NEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEKPLDTISQKSVDIHDSIQPRSVD
NRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIKCVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYR
FLTSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLLNVCSEAL

>In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000262215_chr8_68130373_-_448aa
MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEIKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQD
NEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEKPLDTISQKSVDIHDSIQPRSVD
NRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIKCVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYR
FLTSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLLNVCSEAL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000520381_chr8_68130373_-_1197nt
ATGTCGGCCGGCGGAGCGTCAGTCCCGCCGCCCCCGAACCCCGCCGTGTCCTTCCCGCCGCCCCGGGTCACCCTGCCCGCCGGCCCCGAC
ATCCTGCGGACCTACTCGGGCGCCTTCGTCTGCCTGGAGATTAAAGCTGAATGGATGACAACAACTTGCAATCATGCACTTTATGCAATC
TGTGATGTATTCACTCAGTATTTAGAAGTACTCAGTGATGTACTTTTGGATGACATTTTTGCTCAGCTCTACTGGTGTGTGCAGCAAGAC
AATGAGCAGTTAGCGCGATCTGGTACAAACTGTTTAGAGAATGTTGTTATTCTGAATGGTGAAAAATTTACCCTAGAAATCTGGGATAAA
ACTTGCAACTGCACACTGGATATCTTCAAAACCACAATCCCACATGCGCTGTTGACCTGGCGACCCAATTCTGGAGAAACTGCCCCCCCA
CCTCCATCTCCTGTAAGTGAAAAGCCATTGGATACAATATCACAGAAGTCTGTAGATATTCATGATTCTATTCAACCAAGGTCTGTGGAT
AACAGACCACAAGCACCACTGGTTTCTGCGTCTGCTGTTAATGAAGAAGTCAGCAAAATTAAATCTACAGCAAAATTTCCAGAACAAAAA
TTGTTTGCTGCCCTGTTGATTAAATGTGTTGTGCAGCTGGAACTCATCCAGACTATCGACAACATTGTCTTCTTCCCAGCCACAAGTAAG
AAAGAAGATGCAGAAAACTTAGCTGCAGCACAGAGAGATGCGGTGGACTTTGATGTTCGCGTTGATACTCAAGACCAAGGAATGTACCGC
TTTTTAACATCACAACAACTTTTTAAGCTACTGGACTGCTTATTAGAGTCACATAGATTTGCAAAAGCGTTTAATTCCAACAACGAACAG
AGGACTGCCCTGTGGAAAGCAGGATTCAAAGGCAAATCCAAGCCCAACCTTCTGAAGCAGGAGACCAGCAGCCTGGCCTGTGGGCTGCGC
ATTCTCTTCCGGATGTACATGGATGAGAGCCGCGTTAGTGCCTGGGAGGAGGTCCAGCAGAGGCTTTTGAATGTCTGCAGTGAAGCACTA
AGTTACTTCCTCACTCTAACATCAGAAAGTCATCGAGAAGCCTGGACTAACTTACTGCTTTTGTTTCTAACTAAAGTTCTAAAGATAAGT

>In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000262215_chr8_68130373_-_1344nt
ATGTCGGCCGGCGGAGCGTCAGTCCCGCCGCCCCCGAACCCCGCCGTGTCCTTCCCGCCGCCCCGGGTCACCCTGCCCGCCGGCCCCGAC
ATCCTGCGGACCTACTCGGGCGCCTTCGTCTGCCTGGAGATTAAAGCTGAATGGATGACAACAACTTGCAATCATGCACTTTATGCAATC
TGTGATGTATTCACTCAGTATTTAGAAGTACTCAGTGATGTACTTTTGGATGACATTTTTGCTCAGCTCTACTGGTGTGTGCAGCAAGAC
AATGAGCAGTTAGCGCGATCTGGTACAAACTGTTTAGAGAATGTTGTTATTCTGAATGGTGAAAAATTTACCCTAGAAATCTGGGATAAA
ACTTGCAACTGCACACTGGATATCTTCAAAACCACAATCCCACATGCGCTGTTGACCTGGCGACCCAATTCTGGAGAAACTGCCCCCCCA
CCTCCATCTCCTGTAAGTGAAAAGCCATTGGATACAATATCACAGAAGTCTGTAGATATTCATGATTCTATTCAACCAAGGTCTGTGGAT
AACAGACCACAAGCACCACTGGTTTCTGCGTCTGCTGTTAATGAAGAAGTCAGCAAAATTAAATCTACAGCAAAATTTCCAGAACAAAAA
TTGTTTGCTGCCCTGTTGATTAAATGTGTTGTGCAGCTGGAACTCATCCAGACTATCGACAACATTGTCTTCTTCCCAGCCACAAGTAAG
AAAGAAGATGCAGAAAACTTAGCTGCAGCACAGAGAGATGCGGTGGACTTTGATGTTCGCGTTGATACTCAAGACCAAGGAATGTACCGC
TTTTTAACATCACAACAACTTTTTAAGCTACTGGACTGCTTATTAGAGTCACATAGATTTGCAAAAGCGTTTAATTCCAACAACGAACAG
AGGACTGCCCTGTGGAAAGCAGGATTCAAAGGCAAATCCAAGCCCAACCTTCTGAAGCAGGAGACCAGCAGCCTGGCCTGTGGGCTGCGC
ATTCTCTTCCGGATGTACATGGATGAGAGCCGCGTTAGTGCCTGGGAGGAGGTCCAGCAGAGGCTTTTGAATGTCTGCAGTGAAGCACTA
AGTTACTTCCTCACTCTAACATCAGAAAGTCATCGAGAAGCCTGGACTAACTTACTGCTTTTGTTTCTAACTAAAGTTCTAAAGATAAGT
GATAATAGGTTTAAAGCTCATGCATCATTCTACTACCCTCTCTTATGTGAAATTATGCAATTTGACTTGATTCCTGAACTTCGTGCTGTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000520381_chr8_68130373_-_3342nt
AGCCCGCGGAGCTGAGCGGCGGCGGCGGCGGCGGCAGGAGCCCGGGAGGCGGAGGCGGGAGGCGGCGGCGGCGCGCGGAGACGCAGCAGC
GGCAGCGGCAGCATGTCGGCCGGCGGAGCGTCAGTCCCGCCGCCCCCGAACCCCGCCGTGTCCTTCCCGCCGCCCCGGGTCACCCTGCCC
GCCGGCCCCGACATCCTGCGGACCTACTCGGGCGCCTTCGTCTGCCTGGAGATTAAAGCTGAATGGATGACAACAACTTGCAATCATGCA
CTTTATGCAATCTGTGATGTATTCACTCAGTATTTAGAAGTACTCAGTGATGTACTTTTGGATGACATTTTTGCTCAGCTCTACTGGTGT
GTGCAGCAAGACAATGAGCAGTTAGCGCGATCTGGTACAAACTGTTTAGAGAATGTTGTTATTCTGAATGGTGAAAAATTTACCCTAGAA
ATCTGGGATAAAACTTGCAACTGCACACTGGATATCTTCAAAACCACAATCCCACATGCGCTGTTGACCTGGCGACCCAATTCTGGAGAA
ACTGCCCCCCCACCTCCATCTCCTGTAAGTGAAAAGCCATTGGATACAATATCACAGAAGTCTGTAGATATTCATGATTCTATTCAACCA
AGGTCTGTGGATAACAGACCACAAGCACCACTGGTTTCTGCGTCTGCTGTTAATGAAGAAGTCAGCAAAATTAAATCTACAGCAAAATTT
CCAGAACAAAAATTGTTTGCTGCCCTGTTGATTAAATGTGTTGTGCAGCTGGAACTCATCCAGACTATCGACAACATTGTCTTCTTCCCA
GCCACAAGTAAGAAAGAAGATGCAGAAAACTTAGCTGCAGCACAGAGAGATGCGGTGGACTTTGATGTTCGCGTTGATACTCAAGACCAA
GGAATGTACCGCTTTTTAACATCACAACAACTTTTTAAGCTACTGGACTGCTTATTAGAGTCACATAGATTTGCAAAAGCGTTTAATTCC
AACAACGAACAGAGGACTGCCCTGTGGAAAGCAGGATTCAAAGGCAAATCCAAGCCCAACCTTCTGAAGCAGGAGACCAGCAGCCTGGCC
TGTGGGCTGCGCATTCTCTTCCGGATGTACATGGATGAGAGCCGCGTTAGTGCCTGGGAGGAGGTCCAGCAGAGGCTTTTGAATGTCTGC
AGTGAAGCACTAAGTTACTTCCTCACTCTAACATCAGAAAGTCATCGAGAAGCCTGGACTAACTTACTGCTTTTGTTTCTAACTAAAGTT
CTAAAGATAAGTGATAATAGGACCAAACGGACCCTGTGAGCATGGGGCTGCCAGTGAAAGGAGGATGCCTGGGAATGAAATCAATAGAAG
AGATGCAGAAAGCCTACGGAAAAACAGCGTGCTGATACTATTTGACACAGCAATGATTATTTCTTACCTTTGGCACCTTCCTGCATTTTT
ATTCTGTTCAGCCTCTTCTGCTGCTCTCTTAGCAGGGCTTGCTGCTGAATCTCTAAGGTGTGATGATCTCTTGGAGGATCCAGGTACATA
AATTTCAGATCAACTCGTGTTTCTGAATCTGGTATAAAAAATATGTTATATAACTAAGTTAAATGTTGTTTTCAAATGGGATTTTGTAAA
ACTTCACTGTAAGTAACATGAGTAACCTAATTTCAAAATCAAGGAAATGATAGAAATAGTGAAACATCACTAAAGTCAAAGGACAGTAAA
ATAGCCACAAAACTAAAGAATATGAAATTAATATTCTTTAATAAGTGTCTTTTCACAAACTTACCAACATAAGGAATACCCCAGAACAAG
CAGTGGATGTTGCATTGTCCATCTCTACCTGTCCTAGCCCTGCCAGGATGCCACCCAGAACACAGACTACGTGCAGGTATATCCAAGCAG
ATGGTCACATGGCTATGACTAAGGCAGCCATGAGACACTGTAATCACGGCTGATCTCTAAAATATACTGGAAACGTGAAAAAATAATGTT
ACTGGCCAATTAATATTTTAGTCCTTACAAATATCATGCAGAAAGCAAGATAAATGTAGACTGGCTGGAACTTGAGGGGGAATGCCATTT
CTTTTTTTTTTTTTTTCTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGGTCTTGGCTCACTGCCAGCTCTGCC
TCCTGGGTTCATGCCATTCTCCTGCCTCAGTCTCCCAAGTAGCTGGGACTACAAGCACCCACCACTATGCCCGGCTAATTTTTCTTGTAG
TTTTTAGTAGAGACGAGGTTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACACGCCTCGGCCTCTCAAAGTGC
TGGGATTACAGGCATTAGCCACTGTGCCTGGCCAAGAATAAAAATTTTTTAATCTTGAGAAGAAACATACAGTTCATACATATAAAAAGC
CTTGAAAATATTATTCCCTTTGACTCACTAATTACACTGCTGGAATATAAAGAAATGATCCTAAATATATATGTAGTTTTATGGTCCTAA
ATATGTATAAAGCTTTATGATCAGAAATTATCAAAAGAACAAAATAGTGAAAATGGTTAACAGCCATTTTCAGAAGTTAACAGAAGTTTC
TGGACACATAAACTTGGATTGGTCCCTGGCTTCACTGCTTCCAAACTCATTAAAAAAACAATACCAACCACCAAGTCATGGGTGAATGAG
GGCAAGATGTAGTAACACAGGGAAATGAACAGCCCAATTCTATGGCTTAAACCTTTTTGGTCTCAAGATCTTTTTTACACTCTTAAAAAT
TGAGGACCCCAAAGAGCTTTACTTATGTATGTCACACACACACACGCCATATTAGAAATTAAAACTAAGAGATTCCTAAAACACAAGAAT
ACACAAGGACACATTTTGCTAGCTTCAAAGAGATGAAATCATTACATGTCATGTAGTCTCTGGCCAATCTATATACACATGAGAGAATGA
GAATGAAAAAGACAAATAATGTCTTAGTTTATAATACAAACAGTTTTGACTTCAGACCAAACTCCTCATGAGACCCACTGGGTTAACACA
ATGCCTGGCAGATAGTAAGTAATCAATATTTGATAGCATAAAAAATAACAGTATACGTAATTGATAATACGTGTAAATCTAGGTGAAAAA
CAATAGAGAAAATTAAATAAATAACACAATTTATCTTTTTTTTTCTTTTAATTATGCTCAGAAAGACTAGAAAACATCCAAAATGATAAT
GGTACTTACATATAGGTAGTTTGACTAAAGTGATTTTTCCTTCTTACTATCTTTCTGTATTTTGAAAATTTGCTATAATAAACAGATAGT

>In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000262215_chr8_68130373_-_2731nt
AGCCCGCGGAGCTGAGCGGCGGCGGCGGCGGCGGCAGGAGCCCGGGAGGCGGAGGCGGGAGGCGGCGGCGGCGCGCGGAGACGCAGCAGC
GGCAGCGGCAGCATGTCGGCCGGCGGAGCGTCAGTCCCGCCGCCCCCGAACCCCGCCGTGTCCTTCCCGCCGCCCCGGGTCACCCTGCCC
GCCGGCCCCGACATCCTGCGGACCTACTCGGGCGCCTTCGTCTGCCTGGAGATTAAAGCTGAATGGATGACAACAACTTGCAATCATGCA
CTTTATGCAATCTGTGATGTATTCACTCAGTATTTAGAAGTACTCAGTGATGTACTTTTGGATGACATTTTTGCTCAGCTCTACTGGTGT
GTGCAGCAAGACAATGAGCAGTTAGCGCGATCTGGTACAAACTGTTTAGAGAATGTTGTTATTCTGAATGGTGAAAAATTTACCCTAGAA
ATCTGGGATAAAACTTGCAACTGCACACTGGATATCTTCAAAACCACAATCCCACATGCGCTGTTGACCTGGCGACCCAATTCTGGAGAA
ACTGCCCCCCCACCTCCATCTCCTGTAAGTGAAAAGCCATTGGATACAATATCACAGAAGTCTGTAGATATTCATGATTCTATTCAACCA
AGGTCTGTGGATAACAGACCACAAGCACCACTGGTTTCTGCGTCTGCTGTTAATGAAGAAGTCAGCAAAATTAAATCTACAGCAAAATTT
CCAGAACAAAAATTGTTTGCTGCCCTGTTGATTAAATGTGTTGTGCAGCTGGAACTCATCCAGACTATCGACAACATTGTCTTCTTCCCA
GCCACAAGTAAGAAAGAAGATGCAGAAAACTTAGCTGCAGCACAGAGAGATGCGGTGGACTTTGATGTTCGCGTTGATACTCAAGACCAA
GGAATGTACCGCTTTTTAACATCACAACAACTTTTTAAGCTACTGGACTGCTTATTAGAGTCACATAGATTTGCAAAAGCGTTTAATTCC
AACAACGAACAGAGGACTGCCCTGTGGAAAGCAGGATTCAAAGGCAAATCCAAGCCCAACCTTCTGAAGCAGGAGACCAGCAGCCTGGCC
TGTGGGCTGCGCATTCTCTTCCGGATGTACATGGATGAGAGCCGCGTTAGTGCCTGGGAGGAGGTCCAGCAGAGGCTTTTGAATGTCTGC
AGTGAAGCACTAAGTTACTTCCTCACTCTAACATCAGAAAGTCATCGAGAAGCCTGGACTAACTTACTGCTTTTGTTTCTAACTAAAGTT
CTAAAGATAAGTGATAATAGGTTTAAAGCTCATGCATCATTCTACTACCCTCTCTTATGTGAAATTATGCAATTTGACTTGATTCCTGAA
CTTCGTGCTGTTCTTAGAAGATTTTTTCTGCGAATCGGAGTAGTTTTTCAGATATCACAACCACCTGAACAGGAACTTGGAATAAACAAG
CAATGATGGGAACTTAATATTTTTGTTGGCATTTACATCCCTCTGCTCTTTAAAAGGACGCTGGAGCTGAGGTTTCCTACCTGAAAAATG
ATTTCTCTGGATTGCAGTGTCTGAGTTACTGGTAAAGATGCTTAGAAGTCTTACTCAAACTTGCAACACTCCAGTCCCTTTTAGTGCTGG
TGGATTTTGTGTGTTATATTGGCCTCATGTTGAGCAGAAAGCCTGTTTAAACAGTGTCAGCTCATGCTCACGGGTCCTTCCCTGTCTTCC
ACGGCAGGAAAAGCCCCACGTTTTTGGCAGGTGTGGAAGTGAAACTTACCCAAAGAACTATAGATGTAAAGATTGAACTTCTACAAGAAG
TACAACTCAGGAGAGCTGTATTTTGAAGGATAAAATGTTTATAATTGGGGAGTGGGGAGAGAAGAAGAAATTATTGTTCATGGTAAAAGA
TATTTAGCAACTATGGTATTCTTATTCTGAAGATTTTTGCACACTCAGGCTATCTGAGATACTGGTAATCATCCTGTGAAAAATGTACAG
AGATGCAGGTCTGTAATATAAAAATCTTAAAACATTATATAGTTCTTCCTGCACTGTTTTCTTTATTTTCTTATTCATTTGCTAAATACC
CATAATATTTTGTCAAATGCACTAAACATTTGGGTGGAACTTTCTTTTTTATTTTATAGGGATTTTTAGTTTTGCCCTTTTTGGTAGGTG
GTGATTTTGAGGCTGTAACATGCCCAGAAGCTGTTGTGGCCGACACTTCAACAATAGGGAAAAAAAGGTAGAAAATATCCCTACTGACAG
TAACTACCTGTCACATATTTCTCTTAGGACTTTTAAAGATGAGCCATTAAAATAGAATGATCCTTTATGGACCAAAACTTGAATCACTGC
AAAATGAATCCAGATTGCTGTCATTTTCTTTTCTTTTGGGTGGTGGGGCTTGATGTAGATTTTACTCTATGTACAGAATTTAACGTTGAA
TATATTAAAATAACAAATCTGGCATGGTTTGCGGAGGTTAGATTTACTGGAAATGTATTCATACTGTGAATTGTGCTCTGATGGTTAAAA
GACAAGATTGTCAAGCATTCCGTATTAACAGTGGATGTAGAAAATTTTTTCAGATGGACAAAATGTATATGGTACAGATGTAAAGTTTTC
TATGTAAAAAATTCTGTACAACTTTCTGTACAATATTGATTCCCATCTGGCATATTCTAATCAGGTTATAGGTCAATAAAGTTTTTGAAT


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FusionGenePPI for MAL2_ARFGEF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MAL2TPD52, TPD52L1, PPP1CA, ELAVL1, ATP4A, ABCG8, GAD2, PBX3, PTPN9, SH3GL1, TBRG4, ARFIP2, VARS2, FAM3A, TUBB, RAB37, CREB3ARFGEF1FKBP2, PRKAR1A, ARFGEF2, DPY30, NCL, FBL, NUP62, SSB, EGFR, SPINT2, CSGALNACT1, PVRIG, HLA-B, CD244, SLAMF1, TBC1D22A, ALDH3A2, TCL1B, NTRK1, SIGLECL1, EDNRB, LAMP3, NPY2R, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAL2_ARFGEF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAL2_ARFGEF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource