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Fusion gene ID: 20598 |
FusionGeneSummary for MAL2_ARFGEF1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: MAL2_ARFGEF1 | Fusion gene ID: 20598 | Hgene | Tgene | Gene symbol | MAL2 | ARFGEF1 | Gene ID | 114569 | 10565 |
Gene name | mal, T cell differentiation protein 2 (gene/pseudogene) | ADP ribosylation factor guanine nucleotide exchange factor 1 | |
Synonyms | - | ARFGEP1|BIG1|P200 | |
Cytomap | 8q24.12 | 8q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | protein MAL2MAL proteolipid protein 2MAL2 proteolipid proteinmal, T-cell differentiation protein 2 | brefeldin A-inhibited guanine nucleotide-exchange protein 1ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)p200 ARF guanine nucleotide exchange factor | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q969L2 | Q9Y6D6 | |
Ensembl transtripts involved in fusion gene | ENST00000276681, ENST00000521748, | ENST00000520381, ENST00000262215, ENST00000517955, ENST00000518230, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 7 X 5 X 3=105 |
# samples | 4 | 7 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: MAL2 [Title/Abstract] AND ARFGEF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ARFGEF1 | GO:0034260 | negative regulation of GTPase activity | 15644318 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-05-4422-01A | MAL2 | chr8 | 120220844 | + | ARFGEF1 | chr8 | 68130373 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000276681 | ENST00000520381 | MAL2 | chr8 | 120220844 | + | ARFGEF1 | chr8 | 68130373 | - |
In-frame | ENST00000276681 | ENST00000262215 | MAL2 | chr8 | 120220844 | + | ARFGEF1 | chr8 | 68130373 | - |
5CDS-intron | ENST00000276681 | ENST00000517955 | MAL2 | chr8 | 120220844 | + | ARFGEF1 | chr8 | 68130373 | - |
5CDS-intron | ENST00000276681 | ENST00000518230 | MAL2 | chr8 | 120220844 | + | ARFGEF1 | chr8 | 68130373 | - |
3UTR-3CDS | ENST00000521748 | ENST00000520381 | MAL2 | chr8 | 120220844 | + | ARFGEF1 | chr8 | 68130373 | - |
3UTR-3CDS | ENST00000521748 | ENST00000262215 | MAL2 | chr8 | 120220844 | + | ARFGEF1 | chr8 | 68130373 | - |
3UTR-intron | ENST00000521748 | ENST00000517955 | MAL2 | chr8 | 120220844 | + | ARFGEF1 | chr8 | 68130373 | - |
3UTR-intron | ENST00000521748 | ENST00000518230 | MAL2 | chr8 | 120220844 | + | ARFGEF1 | chr8 | 68130373 | - |
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FusionProtFeatures for MAL2_ARFGEF1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
MAL2 | ARFGEF1 |
Member of the machinery of polarized transport. Requiredfor the indirect transcytotic route at the step of the egress ofthe transcytosing cargo from perinuclear endosomes in order for itto travel to the apical surface via a raft-dependent pathway.{ECO:0000269|PubMed:12370246}. | Promotes guanine-nucleotide exchange on ARF1 and ARF3.Promotes the activation of ARF1/ARF3 through replacement of GDPwith GTP. Involved in vesicular trafficking. Required for themaintenance of Golgi structure; the function may be independent ofits GEF activity. Required for the maturaion of integrin beta-1 inthe Golgi. Involved in the establishment and persistence of cellpolarity during directed cell movement in wound healing. Proposedto act as A kinase-anchoring protein (AKAP) and may mediatecrosstalk between Arf and PKA pathways. Inhibits GAP activity ofMYO9B probably through competetive RhoA binding. The function inthe nucleus remains to be determined.{ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318,ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857,ECO:0000269|PubMed:22084092}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | MAL2 | chr8:120220844 | chr8:68130373 | ENST00000276681 | + | 2 | 5 | 1_34 | 44 | 177 | Topological domain | Cytoplasmic |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >MAL2 | chr8:120220844 | chr8:68130373 | ENST00000276681 | + | 2 | 5 | 31_175 | 44 | 177 | Domain | MARVEL |
Hgene | >MAL2 | chr8:120220844 | chr8:68130373 | ENST00000276681 | + | 2 | 5 | 124_149 | 44 | 177 | Topological domain | Lumenal |
Hgene | >MAL2 | chr8:120220844 | chr8:68130373 | ENST00000276681 | + | 2 | 5 | 171_176 | 44 | 177 | Topological domain | Cytoplasmic |
Hgene | >MAL2 | chr8:120220844 | chr8:68130373 | ENST00000276681 | + | 2 | 5 | 56_66 | 44 | 177 | Topological domain | Lumenal |
Hgene | >MAL2 | chr8:120220844 | chr8:68130373 | ENST00000276681 | + | 2 | 5 | 88_102 | 44 | 177 | Topological domain | Cytoplasmic |
Hgene | >MAL2 | chr8:120220844 | chr8:68130373 | ENST00000276681 | + | 2 | 5 | 103_123 | 44 | 177 | Transmembrane | Helical |
Hgene | >MAL2 | chr8:120220844 | chr8:68130373 | ENST00000276681 | + | 2 | 5 | 150_170 | 44 | 177 | Transmembrane | Helical |
Hgene | >MAL2 | chr8:120220844 | chr8:68130373 | ENST00000276681 | + | 2 | 5 | 35_55 | 44 | 177 | Transmembrane | Helical |
Hgene | >MAL2 | chr8:120220844 | chr8:68130373 | ENST00000276681 | + | 2 | 5 | 67_87 | 44 | 177 | Transmembrane | Helical |
Tgene | ARFGEF1 | chr8:120220844 | chr8:68130373 | ENST00000262215 | - | 29 | 39 | 709_840 | 1446 | 1850 | Domain | SEC7 |
Tgene | ARFGEF1 | chr8:120220844 | chr8:68130373 | ENST00000262215 | - | 29 | 39 | 711_715 | 1446 | 1850 | Motif | Note=Nuclear localization signal (NLS) |
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FusionGeneSequence for MAL2_ARFGEF1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000520381_chr8_68130373_-_399aa MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEIKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQD NEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEKPLDTISQKSVDIHDSIQPRSVD NRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIKCVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYR FLTSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLLNVCSEAL >In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000262215_chr8_68130373_-_448aa MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEIKAEWMTTTCNHALYAICDVFTQYLEVLSDVLLDDIFAQLYWCVQQD NEQLARSGTNCLENVVILNGEKFTLEIWDKTCNCTLDIFKTTIPHALLTWRPNSGETAPPPPSPVSEKPLDTISQKSVDIHDSIQPRSVD NRPQAPLVSASAVNEEVSKIKSTAKFPEQKLFAALLIKCVVQLELIQTIDNIVFFPATSKKEDAENLAAAQRDAVDFDVRVDTQDQGMYR FLTSQQLFKLLDCLLESHRFAKAFNSNNEQRTALWKAGFKGKSKPNLLKQETSSLACGLRILFRMYMDESRVSAWEEVQQRLLNVCSEAL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000520381_chr8_68130373_-_1197nt ATGTCGGCCGGCGGAGCGTCAGTCCCGCCGCCCCCGAACCCCGCCGTGTCCTTCCCGCCGCCCCGGGTCACCCTGCCCGCCGGCCCCGAC ATCCTGCGGACCTACTCGGGCGCCTTCGTCTGCCTGGAGATTAAAGCTGAATGGATGACAACAACTTGCAATCATGCACTTTATGCAATC TGTGATGTATTCACTCAGTATTTAGAAGTACTCAGTGATGTACTTTTGGATGACATTTTTGCTCAGCTCTACTGGTGTGTGCAGCAAGAC AATGAGCAGTTAGCGCGATCTGGTACAAACTGTTTAGAGAATGTTGTTATTCTGAATGGTGAAAAATTTACCCTAGAAATCTGGGATAAA ACTTGCAACTGCACACTGGATATCTTCAAAACCACAATCCCACATGCGCTGTTGACCTGGCGACCCAATTCTGGAGAAACTGCCCCCCCA CCTCCATCTCCTGTAAGTGAAAAGCCATTGGATACAATATCACAGAAGTCTGTAGATATTCATGATTCTATTCAACCAAGGTCTGTGGAT AACAGACCACAAGCACCACTGGTTTCTGCGTCTGCTGTTAATGAAGAAGTCAGCAAAATTAAATCTACAGCAAAATTTCCAGAACAAAAA TTGTTTGCTGCCCTGTTGATTAAATGTGTTGTGCAGCTGGAACTCATCCAGACTATCGACAACATTGTCTTCTTCCCAGCCACAAGTAAG AAAGAAGATGCAGAAAACTTAGCTGCAGCACAGAGAGATGCGGTGGACTTTGATGTTCGCGTTGATACTCAAGACCAAGGAATGTACCGC TTTTTAACATCACAACAACTTTTTAAGCTACTGGACTGCTTATTAGAGTCACATAGATTTGCAAAAGCGTTTAATTCCAACAACGAACAG AGGACTGCCCTGTGGAAAGCAGGATTCAAAGGCAAATCCAAGCCCAACCTTCTGAAGCAGGAGACCAGCAGCCTGGCCTGTGGGCTGCGC ATTCTCTTCCGGATGTACATGGATGAGAGCCGCGTTAGTGCCTGGGAGGAGGTCCAGCAGAGGCTTTTGAATGTCTGCAGTGAAGCACTA AGTTACTTCCTCACTCTAACATCAGAAAGTCATCGAGAAGCCTGGACTAACTTACTGCTTTTGTTTCTAACTAAAGTTCTAAAGATAAGT >In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000262215_chr8_68130373_-_1344nt ATGTCGGCCGGCGGAGCGTCAGTCCCGCCGCCCCCGAACCCCGCCGTGTCCTTCCCGCCGCCCCGGGTCACCCTGCCCGCCGGCCCCGAC ATCCTGCGGACCTACTCGGGCGCCTTCGTCTGCCTGGAGATTAAAGCTGAATGGATGACAACAACTTGCAATCATGCACTTTATGCAATC TGTGATGTATTCACTCAGTATTTAGAAGTACTCAGTGATGTACTTTTGGATGACATTTTTGCTCAGCTCTACTGGTGTGTGCAGCAAGAC AATGAGCAGTTAGCGCGATCTGGTACAAACTGTTTAGAGAATGTTGTTATTCTGAATGGTGAAAAATTTACCCTAGAAATCTGGGATAAA ACTTGCAACTGCACACTGGATATCTTCAAAACCACAATCCCACATGCGCTGTTGACCTGGCGACCCAATTCTGGAGAAACTGCCCCCCCA CCTCCATCTCCTGTAAGTGAAAAGCCATTGGATACAATATCACAGAAGTCTGTAGATATTCATGATTCTATTCAACCAAGGTCTGTGGAT AACAGACCACAAGCACCACTGGTTTCTGCGTCTGCTGTTAATGAAGAAGTCAGCAAAATTAAATCTACAGCAAAATTTCCAGAACAAAAA TTGTTTGCTGCCCTGTTGATTAAATGTGTTGTGCAGCTGGAACTCATCCAGACTATCGACAACATTGTCTTCTTCCCAGCCACAAGTAAG AAAGAAGATGCAGAAAACTTAGCTGCAGCACAGAGAGATGCGGTGGACTTTGATGTTCGCGTTGATACTCAAGACCAAGGAATGTACCGC TTTTTAACATCACAACAACTTTTTAAGCTACTGGACTGCTTATTAGAGTCACATAGATTTGCAAAAGCGTTTAATTCCAACAACGAACAG AGGACTGCCCTGTGGAAAGCAGGATTCAAAGGCAAATCCAAGCCCAACCTTCTGAAGCAGGAGACCAGCAGCCTGGCCTGTGGGCTGCGC ATTCTCTTCCGGATGTACATGGATGAGAGCCGCGTTAGTGCCTGGGAGGAGGTCCAGCAGAGGCTTTTGAATGTCTGCAGTGAAGCACTA AGTTACTTCCTCACTCTAACATCAGAAAGTCATCGAGAAGCCTGGACTAACTTACTGCTTTTGTTTCTAACTAAAGTTCTAAAGATAAGT GATAATAGGTTTAAAGCTCATGCATCATTCTACTACCCTCTCTTATGTGAAATTATGCAATTTGACTTGATTCCTGAACTTCGTGCTGTT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000520381_chr8_68130373_-_3342nt AGCCCGCGGAGCTGAGCGGCGGCGGCGGCGGCGGCAGGAGCCCGGGAGGCGGAGGCGGGAGGCGGCGGCGGCGCGCGGAGACGCAGCAGC GGCAGCGGCAGCATGTCGGCCGGCGGAGCGTCAGTCCCGCCGCCCCCGAACCCCGCCGTGTCCTTCCCGCCGCCCCGGGTCACCCTGCCC GCCGGCCCCGACATCCTGCGGACCTACTCGGGCGCCTTCGTCTGCCTGGAGATTAAAGCTGAATGGATGACAACAACTTGCAATCATGCA CTTTATGCAATCTGTGATGTATTCACTCAGTATTTAGAAGTACTCAGTGATGTACTTTTGGATGACATTTTTGCTCAGCTCTACTGGTGT GTGCAGCAAGACAATGAGCAGTTAGCGCGATCTGGTACAAACTGTTTAGAGAATGTTGTTATTCTGAATGGTGAAAAATTTACCCTAGAA ATCTGGGATAAAACTTGCAACTGCACACTGGATATCTTCAAAACCACAATCCCACATGCGCTGTTGACCTGGCGACCCAATTCTGGAGAA ACTGCCCCCCCACCTCCATCTCCTGTAAGTGAAAAGCCATTGGATACAATATCACAGAAGTCTGTAGATATTCATGATTCTATTCAACCA AGGTCTGTGGATAACAGACCACAAGCACCACTGGTTTCTGCGTCTGCTGTTAATGAAGAAGTCAGCAAAATTAAATCTACAGCAAAATTT CCAGAACAAAAATTGTTTGCTGCCCTGTTGATTAAATGTGTTGTGCAGCTGGAACTCATCCAGACTATCGACAACATTGTCTTCTTCCCA GCCACAAGTAAGAAAGAAGATGCAGAAAACTTAGCTGCAGCACAGAGAGATGCGGTGGACTTTGATGTTCGCGTTGATACTCAAGACCAA GGAATGTACCGCTTTTTAACATCACAACAACTTTTTAAGCTACTGGACTGCTTATTAGAGTCACATAGATTTGCAAAAGCGTTTAATTCC AACAACGAACAGAGGACTGCCCTGTGGAAAGCAGGATTCAAAGGCAAATCCAAGCCCAACCTTCTGAAGCAGGAGACCAGCAGCCTGGCC TGTGGGCTGCGCATTCTCTTCCGGATGTACATGGATGAGAGCCGCGTTAGTGCCTGGGAGGAGGTCCAGCAGAGGCTTTTGAATGTCTGC AGTGAAGCACTAAGTTACTTCCTCACTCTAACATCAGAAAGTCATCGAGAAGCCTGGACTAACTTACTGCTTTTGTTTCTAACTAAAGTT CTAAAGATAAGTGATAATAGGACCAAACGGACCCTGTGAGCATGGGGCTGCCAGTGAAAGGAGGATGCCTGGGAATGAAATCAATAGAAG AGATGCAGAAAGCCTACGGAAAAACAGCGTGCTGATACTATTTGACACAGCAATGATTATTTCTTACCTTTGGCACCTTCCTGCATTTTT ATTCTGTTCAGCCTCTTCTGCTGCTCTCTTAGCAGGGCTTGCTGCTGAATCTCTAAGGTGTGATGATCTCTTGGAGGATCCAGGTACATA AATTTCAGATCAACTCGTGTTTCTGAATCTGGTATAAAAAATATGTTATATAACTAAGTTAAATGTTGTTTTCAAATGGGATTTTGTAAA ACTTCACTGTAAGTAACATGAGTAACCTAATTTCAAAATCAAGGAAATGATAGAAATAGTGAAACATCACTAAAGTCAAAGGACAGTAAA ATAGCCACAAAACTAAAGAATATGAAATTAATATTCTTTAATAAGTGTCTTTTCACAAACTTACCAACATAAGGAATACCCCAGAACAAG CAGTGGATGTTGCATTGTCCATCTCTACCTGTCCTAGCCCTGCCAGGATGCCACCCAGAACACAGACTACGTGCAGGTATATCCAAGCAG ATGGTCACATGGCTATGACTAAGGCAGCCATGAGACACTGTAATCACGGCTGATCTCTAAAATATACTGGAAACGTGAAAAAATAATGTT ACTGGCCAATTAATATTTTAGTCCTTACAAATATCATGCAGAAAGCAAGATAAATGTAGACTGGCTGGAACTTGAGGGGGAATGCCATTT CTTTTTTTTTTTTTTTCTTGAGACGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCACGGTCTTGGCTCACTGCCAGCTCTGCC TCCTGGGTTCATGCCATTCTCCTGCCTCAGTCTCCCAAGTAGCTGGGACTACAAGCACCCACCACTATGCCCGGCTAATTTTTCTTGTAG TTTTTAGTAGAGACGAGGTTTCACTATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGATCCACACGCCTCGGCCTCTCAAAGTGC TGGGATTACAGGCATTAGCCACTGTGCCTGGCCAAGAATAAAAATTTTTTAATCTTGAGAAGAAACATACAGTTCATACATATAAAAAGC CTTGAAAATATTATTCCCTTTGACTCACTAATTACACTGCTGGAATATAAAGAAATGATCCTAAATATATATGTAGTTTTATGGTCCTAA ATATGTATAAAGCTTTATGATCAGAAATTATCAAAAGAACAAAATAGTGAAAATGGTTAACAGCCATTTTCAGAAGTTAACAGAAGTTTC TGGACACATAAACTTGGATTGGTCCCTGGCTTCACTGCTTCCAAACTCATTAAAAAAACAATACCAACCACCAAGTCATGGGTGAATGAG GGCAAGATGTAGTAACACAGGGAAATGAACAGCCCAATTCTATGGCTTAAACCTTTTTGGTCTCAAGATCTTTTTTACACTCTTAAAAAT TGAGGACCCCAAAGAGCTTTACTTATGTATGTCACACACACACACGCCATATTAGAAATTAAAACTAAGAGATTCCTAAAACACAAGAAT ACACAAGGACACATTTTGCTAGCTTCAAAGAGATGAAATCATTACATGTCATGTAGTCTCTGGCCAATCTATATACACATGAGAGAATGA GAATGAAAAAGACAAATAATGTCTTAGTTTATAATACAAACAGTTTTGACTTCAGACCAAACTCCTCATGAGACCCACTGGGTTAACACA ATGCCTGGCAGATAGTAAGTAATCAATATTTGATAGCATAAAAAATAACAGTATACGTAATTGATAATACGTGTAAATCTAGGTGAAAAA CAATAGAGAAAATTAAATAAATAACACAATTTATCTTTTTTTTTCTTTTAATTATGCTCAGAAAGACTAGAAAACATCCAAAATGATAAT GGTACTTACATATAGGTAGTTTGACTAAAGTGATTTTTCCTTCTTACTATCTTTCTGTATTTTGAAAATTTGCTATAATAAACAGATAGT >In-frame_MAL2_ENST00000276681_chr8_120220844_+_ARFGEF1_ENST00000262215_chr8_68130373_-_2731nt AGCCCGCGGAGCTGAGCGGCGGCGGCGGCGGCGGCAGGAGCCCGGGAGGCGGAGGCGGGAGGCGGCGGCGGCGCGCGGAGACGCAGCAGC GGCAGCGGCAGCATGTCGGCCGGCGGAGCGTCAGTCCCGCCGCCCCCGAACCCCGCCGTGTCCTTCCCGCCGCCCCGGGTCACCCTGCCC GCCGGCCCCGACATCCTGCGGACCTACTCGGGCGCCTTCGTCTGCCTGGAGATTAAAGCTGAATGGATGACAACAACTTGCAATCATGCA CTTTATGCAATCTGTGATGTATTCACTCAGTATTTAGAAGTACTCAGTGATGTACTTTTGGATGACATTTTTGCTCAGCTCTACTGGTGT GTGCAGCAAGACAATGAGCAGTTAGCGCGATCTGGTACAAACTGTTTAGAGAATGTTGTTATTCTGAATGGTGAAAAATTTACCCTAGAA ATCTGGGATAAAACTTGCAACTGCACACTGGATATCTTCAAAACCACAATCCCACATGCGCTGTTGACCTGGCGACCCAATTCTGGAGAA ACTGCCCCCCCACCTCCATCTCCTGTAAGTGAAAAGCCATTGGATACAATATCACAGAAGTCTGTAGATATTCATGATTCTATTCAACCA AGGTCTGTGGATAACAGACCACAAGCACCACTGGTTTCTGCGTCTGCTGTTAATGAAGAAGTCAGCAAAATTAAATCTACAGCAAAATTT CCAGAACAAAAATTGTTTGCTGCCCTGTTGATTAAATGTGTTGTGCAGCTGGAACTCATCCAGACTATCGACAACATTGTCTTCTTCCCA GCCACAAGTAAGAAAGAAGATGCAGAAAACTTAGCTGCAGCACAGAGAGATGCGGTGGACTTTGATGTTCGCGTTGATACTCAAGACCAA GGAATGTACCGCTTTTTAACATCACAACAACTTTTTAAGCTACTGGACTGCTTATTAGAGTCACATAGATTTGCAAAAGCGTTTAATTCC AACAACGAACAGAGGACTGCCCTGTGGAAAGCAGGATTCAAAGGCAAATCCAAGCCCAACCTTCTGAAGCAGGAGACCAGCAGCCTGGCC TGTGGGCTGCGCATTCTCTTCCGGATGTACATGGATGAGAGCCGCGTTAGTGCCTGGGAGGAGGTCCAGCAGAGGCTTTTGAATGTCTGC AGTGAAGCACTAAGTTACTTCCTCACTCTAACATCAGAAAGTCATCGAGAAGCCTGGACTAACTTACTGCTTTTGTTTCTAACTAAAGTT CTAAAGATAAGTGATAATAGGTTTAAAGCTCATGCATCATTCTACTACCCTCTCTTATGTGAAATTATGCAATTTGACTTGATTCCTGAA CTTCGTGCTGTTCTTAGAAGATTTTTTCTGCGAATCGGAGTAGTTTTTCAGATATCACAACCACCTGAACAGGAACTTGGAATAAACAAG CAATGATGGGAACTTAATATTTTTGTTGGCATTTACATCCCTCTGCTCTTTAAAAGGACGCTGGAGCTGAGGTTTCCTACCTGAAAAATG ATTTCTCTGGATTGCAGTGTCTGAGTTACTGGTAAAGATGCTTAGAAGTCTTACTCAAACTTGCAACACTCCAGTCCCTTTTAGTGCTGG TGGATTTTGTGTGTTATATTGGCCTCATGTTGAGCAGAAAGCCTGTTTAAACAGTGTCAGCTCATGCTCACGGGTCCTTCCCTGTCTTCC ACGGCAGGAAAAGCCCCACGTTTTTGGCAGGTGTGGAAGTGAAACTTACCCAAAGAACTATAGATGTAAAGATTGAACTTCTACAAGAAG TACAACTCAGGAGAGCTGTATTTTGAAGGATAAAATGTTTATAATTGGGGAGTGGGGAGAGAAGAAGAAATTATTGTTCATGGTAAAAGA TATTTAGCAACTATGGTATTCTTATTCTGAAGATTTTTGCACACTCAGGCTATCTGAGATACTGGTAATCATCCTGTGAAAAATGTACAG AGATGCAGGTCTGTAATATAAAAATCTTAAAACATTATATAGTTCTTCCTGCACTGTTTTCTTTATTTTCTTATTCATTTGCTAAATACC CATAATATTTTGTCAAATGCACTAAACATTTGGGTGGAACTTTCTTTTTTATTTTATAGGGATTTTTAGTTTTGCCCTTTTTGGTAGGTG GTGATTTTGAGGCTGTAACATGCCCAGAAGCTGTTGTGGCCGACACTTCAACAATAGGGAAAAAAAGGTAGAAAATATCCCTACTGACAG TAACTACCTGTCACATATTTCTCTTAGGACTTTTAAAGATGAGCCATTAAAATAGAATGATCCTTTATGGACCAAAACTTGAATCACTGC AAAATGAATCCAGATTGCTGTCATTTTCTTTTCTTTTGGGTGGTGGGGCTTGATGTAGATTTTACTCTATGTACAGAATTTAACGTTGAA TATATTAAAATAACAAATCTGGCATGGTTTGCGGAGGTTAGATTTACTGGAAATGTATTCATACTGTGAATTGTGCTCTGATGGTTAAAA GACAAGATTGTCAAGCATTCCGTATTAACAGTGGATGTAGAAAATTTTTTCAGATGGACAAAATGTATATGGTACAGATGTAAAGTTTTC TATGTAAAAAATTCTGTACAACTTTCTGTACAATATTGATTCCCATCTGGCATATTCTAATCAGGTTATAGGTCAATAAAGTTTTTGAAT |
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FusionGenePPI for MAL2_ARFGEF1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
MAL2 | TPD52, TPD52L1, PPP1CA, ELAVL1, ATP4A, ABCG8, GAD2, PBX3, PTPN9, SH3GL1, TBRG4, ARFIP2, VARS2, FAM3A, TUBB, RAB37, CREB3 | ARFGEF1 | FKBP2, PRKAR1A, ARFGEF2, DPY30, NCL, FBL, NUP62, SSB, EGFR, SPINT2, CSGALNACT1, PVRIG, HLA-B, CD244, SLAMF1, TBC1D22A, ALDH3A2, TCL1B, NTRK1, SIGLECL1, EDNRB, LAMP3, NPY2R, BRCA1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAL2_ARFGEF1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAL2_ARFGEF1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |