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Fusion gene ID: 20578 |
FusionGeneSummary for MAGI1_SPRY4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAGI1_SPRY4 | Fusion gene ID: 20578 | Hgene | Tgene | Gene symbol | MAGI1 | SPRY4 | Gene ID | 154043 | 81848 |
| Gene name | CNKSR family member 3 | sprouty RTK signaling antagonist 4 | |
| Synonyms | CNK3|CNK3/IPCEF1|MAGI1 | HH17 | |
| Cytomap | 6q25.2 | 5q31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | connector enhancer of kinase suppressor of ras 3CNK homolog protein 3connector enhancer of KSR 3maguin-like proteinmembrane associated guanylate kinase, WW and PDZ domain containing 1membrane-associated guanylate kinase-interacting protein-like 1 | protein sprouty homolog 4sprouty homolog 4 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96QZ7 | Q9C004 | |
| Ensembl transtripts involved in fusion gene | ENST00000330909, ENST00000402939, ENST00000483466, ENST00000497477, ENST00000470990, | ENST00000344120, ENST00000434127, ENST00000503582, | |
| Fusion gene scores | * DoF score | 10 X 6 X 6=360 | 2 X 2 X 1=4 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: MAGI1 [Title/Abstract] AND SPRY4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF990231 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000330909 | ENST00000344120 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-intron | ENST00000330909 | ENST00000434127 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-intron | ENST00000330909 | ENST00000503582 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-3UTR | ENST00000402939 | ENST00000344120 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-intron | ENST00000402939 | ENST00000434127 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-intron | ENST00000402939 | ENST00000503582 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-3UTR | ENST00000483466 | ENST00000344120 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-intron | ENST00000483466 | ENST00000434127 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-intron | ENST00000483466 | ENST00000503582 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-3UTR | ENST00000497477 | ENST00000344120 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-intron | ENST00000497477 | ENST00000434127 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-intron | ENST00000497477 | ENST00000503582 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-3UTR | ENST00000470990 | ENST00000344120 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-intron | ENST00000470990 | ENST00000434127 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
| intron-intron | ENST00000470990 | ENST00000503582 | MAGI1 | chr3 | 65718046 | + | SPRY4 | chr5 | 141690881 | - |
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FusionProtFeatures for MAGI1_SPRY4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAGI1 | SPRY4 |
| May play a role as scaffolding protein at cell-celljunctions. May regulate acid-induced ASIC3 currents by modulatingits expression at the cell surface (By similarity). {ECO:0000250}. | Suppresses the insulin receptor and EGFR-transduced MAPKsignaling pathway, but does not inhibit MAPK activation by aconstitutively active mutant Ras. Probably impairs the formationof GTP-Ras. Inhibits Ras-independent, but not Ras-dependent,activation of RAF1. {ECO:0000269|PubMed:12717443}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAGI1_SPRY4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAGI1_SPRY4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAGI1_SPRY4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAGI1_SPRY4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | MAGI1 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
| Hgene | MAGI1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | MAGI1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Hgene | MAGI1 | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | PSYGENET |
| Tgene | SPRY4 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Tgene | SPRY4 | C3808971 | HYPOGONADOTROPIC HYPOGONADISM 17 WITH OR WITHOUT ANOSMIA | 1 | UNIPROT |
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