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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20567

FusionGeneSummary for MAGED2_MAGED2

check button Fusion gene summary
Fusion gene informationFusion gene name: MAGED2_MAGED2
Fusion gene ID: 20567
HgeneTgene
Gene symbol

MAGED2

MAGED2

Gene ID

10916

10916

Gene nameMAGE family member D2MAGE family member D2
Synonyms11B6|BARTS5|BCG-1|BCG1|HCA10|MAGE-D211B6|BARTS5|BCG-1|BCG1|HCA10|MAGE-D2
Cytomap

Xp11.21

Xp11.21

Type of geneprotein-codingprotein-coding
Descriptionmelanoma-associated antigen D2MAGE-D2 antigenbreast cancer-associated gene 1 proteinhepatocellular carcinoma-associated protein JCL-1melanoma antigen family D, 2melanoma antigen family D2melanoma-associated antigen D2MAGE-D2 antigenbreast cancer-associated gene 1 proteinhepatocellular carcinoma-associated protein JCL-1melanoma antigen family D, 2melanoma antigen family D2
Modification date2018051920180519
UniProtAcc

Q9UNF1

Q9UNF1

Ensembl transtripts involved in fusion geneENST00000375068, ENST00000375053, 
ENST00000347546, ENST00000375062, 
ENST00000218439, ENST00000375058, 
ENST00000375060, ENST00000396224, 
ENST00000497484, 		ENST00000375068, 
ENST00000375053, ENST00000347546, 
ENST00000375062, ENST00000218439, 
ENST00000375058, ENST00000375060, 
ENST00000396224, ENST00000497484, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 3 X 1=9
# samples 54
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/9*10)=2.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MAGED2 [Title/Abstract] AND MAGED2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB569084MAGED2chrX

54841216

+MAGED2chrX

54838588

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000375068ENST00000375068MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375068ENST00000375053MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375068ENST00000347546MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375068ENST00000375062MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375068ENST00000218439MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375068ENST00000375058MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375068ENST00000375060MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375068ENST00000396224MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-intronENST00000375068ENST00000497484MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375053ENST00000375068MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375053ENST00000375053MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375053ENST00000347546MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375053ENST00000375062MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375053ENST00000218439MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375053ENST00000375058MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375053ENST00000375060MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375053ENST00000396224MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-intronENST00000375053ENST00000497484MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000347546ENST00000375068MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000347546ENST00000375053MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000347546ENST00000347546MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000347546ENST00000375062MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000347546ENST00000218439MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000347546ENST00000375058MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000347546ENST00000375060MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000347546ENST00000396224MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-intronENST00000347546ENST00000497484MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375062ENST00000375068MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375062ENST00000375053MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375062ENST00000347546MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375062ENST00000375062MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375062ENST00000218439MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375062ENST00000375058MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375062ENST00000375060MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375062ENST00000396224MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-intronENST00000375062ENST00000497484MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000218439ENST00000375068MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000218439ENST00000375053MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000218439ENST00000347546MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000218439ENST00000375062MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000218439ENST00000218439MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000218439ENST00000375058MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000218439ENST00000375060MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000218439ENST00000396224MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-intronENST00000218439ENST00000497484MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375058ENST00000375068MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375058ENST00000375053MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375058ENST00000347546MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375058ENST00000375062MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375058ENST00000218439MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375058ENST00000375058MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375058ENST00000375060MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375058ENST00000396224MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-intronENST00000375058ENST00000497484MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375060ENST00000375068MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375060ENST00000375053MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375060ENST00000347546MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375060ENST00000375062MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375060ENST00000218439MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375060ENST00000375058MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375060ENST00000375060MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000375060ENST00000396224MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-intronENST00000375060ENST00000497484MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000396224ENST00000375068MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000396224ENST00000375053MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000396224ENST00000347546MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000396224ENST00000375062MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000396224ENST00000218439MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000396224ENST00000375058MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000396224ENST00000375060MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000396224ENST00000396224MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-intronENST00000396224ENST00000497484MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000497484ENST00000375068MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000497484ENST00000375053MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000497484ENST00000347546MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000497484ENST00000375062MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000497484ENST00000218439MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000497484ENST00000375058MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000497484ENST00000375060MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-3CDSENST00000497484ENST00000396224MAGED2chrX

54841216

+MAGED2chrX

54838588

+
intron-intronENST00000497484ENST00000497484MAGED2chrX

54841216

+MAGED2chrX

54838588

+

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FusionProtFeatures for MAGED2_MAGED2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAGED2

Q9UNF1

MAGED2

Q9UNF1

Regulates the expression, localization to the plasmamembrane and function of the sodium chloride cotransportersSLC12A1 and SLC12A3, two key components of salt reabsorption inthe distal renal tubule. {ECO:0000269|PubMed:27120771}. Regulates the expression, localization to the plasmamembrane and function of the sodium chloride cotransportersSLC12A1 and SLC12A3, two key components of salt reabsorption inthe distal renal tubule. {ECO:0000269|PubMed:27120771}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAGED2_MAGED2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAGED2_MAGED2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAGED2_MAGED2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAGED2_MAGED2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource