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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20564

FusionGeneSummary for MAGED1_MAGED1

check button Fusion gene summary
Fusion gene informationFusion gene name: MAGED1_MAGED1
Fusion gene ID: 20564
HgeneTgene
Gene symbol

MAGED1

MAGED1

Gene ID

9500

9500

Gene nameMAGE family member D1MAGE family member D1
SynonymsDLXIN-1|NRAGEDLXIN-1|NRAGE
Cytomap

Xp11.22

Xp11.22

Type of geneprotein-codingprotein-coding
Descriptionmelanoma-associated antigen D1MAGE tumor antigen CCFMAGE-D1 antigenmelanoma antigen family D, 1melanoma antigen family D1neurotrophin receptor-interacting MAGE homologmelanoma-associated antigen D1MAGE tumor antigen CCFMAGE-D1 antigenmelanoma antigen family D, 1melanoma antigen family D1neurotrophin receptor-interacting MAGE homolog
Modification date2018052220180522
UniProtAcc

Q9Y5V3

Q9Y5V3

Ensembl transtripts involved in fusion geneENST00000375772, ENST00000375722, 
ENST00000326587, ENST00000375695, 
ENST00000494718, 		ENST00000375772, 
ENST00000375722, ENST00000326587, 
ENST00000375695, ENST00000494718, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 2 X 1=4
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/4*10)=2.32192809488736
Context

PubMed: MAGED1 [Title/Abstract] AND MAGED1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAGED1

GO:0050680

negative regulation of epithelial cell proliferation

15930293

TgeneMAGED1

GO:0050680

negative regulation of epithelial cell proliferation

15930293


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU675238MAGED1chrX

51645002

-MAGED1chrX

51644812

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000375772ENST00000375772MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375772ENST00000375722MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375772ENST00000326587MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375772ENST00000375695MAGED1chrX

51645002

-MAGED1chrX

51644812

+
5CDS-3UTRENST00000375772ENST00000494718MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375722ENST00000375772MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375722ENST00000375722MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375722ENST00000326587MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375722ENST00000375695MAGED1chrX

51645002

-MAGED1chrX

51644812

+
5CDS-3UTRENST00000375722ENST00000494718MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000326587ENST00000375772MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000326587ENST00000375722MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000326587ENST00000326587MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000326587ENST00000375695MAGED1chrX

51645002

-MAGED1chrX

51644812

+
5CDS-3UTRENST00000326587ENST00000494718MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375695ENST00000375772MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375695ENST00000375722MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375695ENST00000326587MAGED1chrX

51645002

-MAGED1chrX

51644812

+
Frame-shiftENST00000375695ENST00000375695MAGED1chrX

51645002

-MAGED1chrX

51644812

+
5CDS-3UTRENST00000375695ENST00000494718MAGED1chrX

51645002

-MAGED1chrX

51644812

+
3UTR-3CDSENST00000494718ENST00000375772MAGED1chrX

51645002

-MAGED1chrX

51644812

+
3UTR-3CDSENST00000494718ENST00000375722MAGED1chrX

51645002

-MAGED1chrX

51644812

+
3UTR-3CDSENST00000494718ENST00000326587MAGED1chrX

51645002

-MAGED1chrX

51644812

+
3UTR-3CDSENST00000494718ENST00000375695MAGED1chrX

51645002

-MAGED1chrX

51644812

+
3UTR-3UTRENST00000494718ENST00000494718MAGED1chrX

51645002

-MAGED1chrX

51644812

+

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FusionProtFeatures for MAGED1_MAGED1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAGED1

Q9Y5V3

MAGED1

Q9Y5V3

Involved in the apoptotic response after nerve growthfactor (NGF) binding in neuronal cells. Inhibits cell cycleprogression, and facilitates NGFR-mediated apoptosis. May act as aregulator of the function of DLX family members. May enhanceubiquitin ligase activity of RING-type zinc finger-containing E3ubiquitin-protein ligases. Proposed to act through recruitmentand/or stabilization of the Ubl-conjugating enzyme (E2) at theE3:substrate complex. Plays a role in the circadian rhythmregulation. May act as RORA co-regulator, modulating theexpression of core clock genes such as ARNTL/BMAL1 and NFIL3,induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}. Involved in the apoptotic response after nerve growthfactor (NGF) binding in neuronal cells. Inhibits cell cycleprogression, and facilitates NGFR-mediated apoptosis. May act as aregulator of the function of DLX family members. May enhanceubiquitin ligase activity of RING-type zinc finger-containing E3ubiquitin-protein ligases. Proposed to act through recruitmentand/or stabilization of the Ubl-conjugating enzyme (E2) at theE3:substrate complex. Plays a role in the circadian rhythmregulation. May act as RORA co-regulator, modulating theexpression of core clock genes such as ARNTL/BMAL1 and NFIL3,induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MAGED1_MAGED1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MAGED1_MAGED1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MAGED1_MAGED1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MAGED1_MAGED1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource