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Fusion gene ID: 20560 |
FusionGeneSummary for MAFK_MAFK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAFK_MAFK | Fusion gene ID: 20560 | Hgene | Tgene | Gene symbol | MAFK | MAFK | Gene ID | 7975 | 7975 |
| Gene name | MAF bZIP transcription factor K | MAF bZIP transcription factor K | |
| Synonyms | NFE2U|P18 | NFE2U|P18 | |
| Cytomap | 7p22.3 | 7p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor MafKbasic-leucine zipper transcription factor MafKerythroid transcription factor NF-E2 p18 subunitnuclear factor erythroid-2, ubiquitous (p18)v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein Kv-maf avian muscu | transcription factor MafKbasic-leucine zipper transcription factor MafKerythroid transcription factor NF-E2 p18 subunitnuclear factor erythroid-2, ubiquitous (p18)v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein Kv-maf avian muscu | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | O60675 | O60675 | |
| Ensembl transtripts involved in fusion gene | ENST00000343242, | ENST00000343242, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: MAFK [Title/Abstract] AND MAFK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAFK | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9150357 |
| Tgene | MAFK | GO:0000122 | negative regulation of transcription by RNA polymerase II | 9150357 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB055092 | MAFK | chr7 | 1582337 | + | MAFK | chr7 | 1581666 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000343242 | ENST00000343242 | MAFK | chr7 | 1582337 | + | MAFK | chr7 | 1581666 | + |
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FusionProtFeatures for MAFK_MAFK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAFK | MAFK |
| Since they lack a putative transactivation domain, thesmall Mafs behave as transcriptional repressors when they dimerizeamong themselves (PubMed:9150357). However, they seem to serve astranscriptional activators by dimerizing with other (usuallylarger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1,NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385). Small Maf proteinsheterodimerize with Fos and may act as competitive repressors ofthe NF-E2 transcription factor (PubMed:9150357).{ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9150357}. | Since they lack a putative transactivation domain, thesmall Mafs behave as transcriptional repressors when they dimerizeamong themselves (PubMed:9150357). However, they seem to serve astranscriptional activators by dimerizing with other (usuallylarger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1,NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9150357, PubMed:8932385). Small Maf proteinsheterodimerize with Fos and may act as competitive repressors ofthe NF-E2 transcription factor (PubMed:9150357).{ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9150357}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for MAFK_MAFK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for MAFK_MAFK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for MAFK_MAFK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAFK_MAFK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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