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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 20534

FusionGeneSummary for MACROD2_SPTLC3

check button Fusion gene summary
Fusion gene informationFusion gene name: MACROD2_SPTLC3
Fusion gene ID: 20534
HgeneTgene
Gene symbol

MACROD2

SPTLC3

Gene ID

140733

55304

Gene nameMACRO domain containing 2serine palmitoyltransferase long chain base subunit 3
SynonymsC20orf133|C2orf133C20orf38|LCB 3|LCB2B|LCB3|SPT 3|SPT3|SPTLC2L|dJ718P11|dJ718P11.1|hLCB2b
Cytomap

20p12.1

20p12.1

Type of geneprotein-codingprotein-coding
DescriptionO-acetyl-ADP-ribose deacetylase MACROD2MACRO domain-containing protein 2[Protein ADP-ribosylglutamate] hydrolaseserine palmitoyltransferase 3long chain base biosynthesis protein 2blong chain base biosynthesis protein 3serine palmitoyltransferase, long chain base subunit 2-like (aminotransferase 2)serine-palmitoyl-CoA transferase 3
Modification date2018051920180506
UniProtAcc

A1Z1Q3

Q9NUV7

Ensembl transtripts involved in fusion geneENST00000217246, ENST00000310348, 
ENST00000464883, ENST00000402914, 
ENST00000378058, ENST00000407045, 
ENST00000399002, ENST00000378194, 
ENST00000476791, 
Fusion gene scores* DoF score10 X 10 X 8=8003 X 4 X 3=36
# samples 115
** MAII scorelog2(11/800*10)=-2.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MACROD2 [Title/Abstract] AND SPTLC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMACROD2

GO:0042278

purine nucleoside metabolic process

21257746

HgeneMACROD2

GO:0051725

protein de-ADP-ribosylation

23474712

TgeneSPTLC3

GO:0046520

sphingoid biosynthetic process

19648650


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPCPGTCGA-QT-A5XJ-01AMACROD2chr20

14474154

+SPTLC3chr20

13071731

+
TCGARVSKCMTCGA-EE-A29D-06AMACROD2chr20

14066374

+SPTLC3chr20

13090759

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000217246ENST00000399002MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
In-frameENST00000217246ENST00000378194MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
5CDS-intronENST00000217246ENST00000476791MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
In-frameENST00000310348ENST00000399002MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
In-frameENST00000310348ENST00000378194MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
5CDS-intronENST00000310348ENST00000476791MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-3CDSENST00000464883ENST00000399002MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-3CDSENST00000464883ENST00000378194MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-intronENST00000464883ENST00000476791MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-3CDSENST00000402914ENST00000399002MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-3CDSENST00000402914ENST00000378194MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-intronENST00000402914ENST00000476791MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-3CDSENST00000378058ENST00000399002MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-3CDSENST00000378058ENST00000378194MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-intronENST00000378058ENST00000476791MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-3CDSENST00000407045ENST00000399002MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-3CDSENST00000407045ENST00000378194MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
intron-intronENST00000407045ENST00000476791MACROD2chr20

14474154

+SPTLC3chr20

13071731

+
In-frameENST00000217246ENST00000399002MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
In-frameENST00000217246ENST00000378194MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
5CDS-intronENST00000217246ENST00000476791MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
In-frameENST00000310348ENST00000399002MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
In-frameENST00000310348ENST00000378194MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
5CDS-intronENST00000310348ENST00000476791MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-3CDSENST00000464883ENST00000399002MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-3CDSENST00000464883ENST00000378194MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-intronENST00000464883ENST00000476791MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-3CDSENST00000402914ENST00000399002MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-3CDSENST00000402914ENST00000378194MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-intronENST00000402914ENST00000476791MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-3CDSENST00000378058ENST00000399002MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-3CDSENST00000378058ENST00000378194MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-intronENST00000378058ENST00000476791MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-3CDSENST00000407045ENST00000399002MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-3CDSENST00000407045ENST00000378194MACROD2chr20

14066374

+SPTLC3chr20

13090759

+
intron-intronENST00000407045ENST00000476791MACROD2chr20

14066374

+SPTLC3chr20

13090759

+

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FusionProtFeatures for MACROD2_SPTLC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MACROD2

A1Z1Q3

SPTLC3

Q9NUV7

Removes ADP-ribose from glutamate residues in proteinsbearing a single ADP-ribose moiety. Inactive towards proteinsbearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, asignaling molecule generated by the deacetylation of acetylatedlysine residues in histones and other proteins.{ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712}. Serine palmitoyltransferase (SPT). The heterodimerformed with LCB1/SPTLC1 constitutes the catalytic core. Thecomposition of the serine palmitoyltransferase (SPT) complexdetermines the substrate preference. The SPTLC1-SPTLC3-SPTSSAisozyme uses both C14-CoA and C16-CoA as substrates, while theSPTLC1-SPTLC3-SPTSSB has the ability to use a broader range ofacyl-CoAs without apparent preference.{ECO:0000269|PubMed:19416851}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACROD2chr20:14066374chr20:13090759ENST00000217246+3176_990426Compositional biasNote=Poly-Lys
HgeneMACROD2chr20:14066374chr20:13090759ENST00000310348+3186_990449Compositional biasNote=Poly-Lys
HgeneMACROD2chr20:14474154chr20:13071731ENST00000217246+4176_9100426Compositional biasNote=Poly-Lys
HgeneMACROD2chr20:14474154chr20:13071731ENST00000310348+4186_9100449Compositional biasNote=Poly-Lys
HgeneMACROD2chr20:14066374chr20:13090759ENST00000217246+31777_7990426RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000217246+31790_9290426RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000310348+31877_7990449RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000310348+31890_9290449RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000217246+41777_79100426RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000217246+41790_92100426RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000217246+41797_102100426RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000310348+41877_79100449RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000310348+41890_92100449RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000310348+41897_102100449RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACROD2chr20:14066374chr20:13090759ENST00000217246+317247_38890426Compositional biasNote=Glu-rich
HgeneMACROD2chr20:14066374chr20:13090759ENST00000310348+318247_38890449Compositional biasNote=Glu-rich
HgeneMACROD2chr20:14066374chr20:13090759ENST00000378058+110247_3880214Compositional biasNote=Glu-rich
HgeneMACROD2chr20:14066374chr20:13090759ENST00000378058+1106_90214Compositional biasNote=Poly-Lys
HgeneMACROD2chr20:14066374chr20:13090759ENST00000402914+114247_388-154214Compositional biasNote=Glu-rich
HgeneMACROD2chr20:14066374chr20:13090759ENST00000402914+1146_9-154214Compositional biasNote=Poly-Lys
HgeneMACROD2chr20:14066374chr20:13090759ENST00000407045+16247_388-7999Compositional biasNote=Glu-rich
HgeneMACROD2chr20:14066374chr20:13090759ENST00000407045+166_9-7999Compositional biasNote=Poly-Lys
HgeneMACROD2chr20:14474154chr20:13071731ENST00000217246+417247_388100426Compositional biasNote=Glu-rich
HgeneMACROD2chr20:14474154chr20:13071731ENST00000310348+418247_388100449Compositional biasNote=Glu-rich
HgeneMACROD2chr20:14474154chr20:13071731ENST00000378058+110247_3880214Compositional biasNote=Glu-rich
HgeneMACROD2chr20:14474154chr20:13071731ENST00000378058+1106_90214Compositional biasNote=Poly-Lys
HgeneMACROD2chr20:14474154chr20:13071731ENST00000402914+114247_388-154214Compositional biasNote=Glu-rich
HgeneMACROD2chr20:14474154chr20:13071731ENST00000402914+1146_9-154214Compositional biasNote=Poly-Lys
HgeneMACROD2chr20:14474154chr20:13071731ENST00000407045+16247_388-7999Compositional biasNote=Glu-rich
HgeneMACROD2chr20:14474154chr20:13071731ENST00000407045+166_9-7999Compositional biasNote=Poly-Lys
HgeneMACROD2chr20:14066374chr20:13090759ENST00000217246+31759_24090426DomainMacro
HgeneMACROD2chr20:14066374chr20:13090759ENST00000310348+31859_24090449DomainMacro
HgeneMACROD2chr20:14066374chr20:13090759ENST00000378058+11059_2400214DomainMacro
HgeneMACROD2chr20:14066374chr20:13090759ENST00000402914+11459_240-154214DomainMacro
HgeneMACROD2chr20:14066374chr20:13090759ENST00000407045+1659_240-7999DomainMacro
HgeneMACROD2chr20:14474154chr20:13071731ENST00000217246+41759_240100426DomainMacro
HgeneMACROD2chr20:14474154chr20:13071731ENST00000310348+41859_240100449DomainMacro
HgeneMACROD2chr20:14474154chr20:13071731ENST00000378058+11059_2400214DomainMacro
HgeneMACROD2chr20:14474154chr20:13071731ENST00000402914+11459_240-154214DomainMacro
HgeneMACROD2chr20:14474154chr20:13071731ENST00000407045+1659_240-7999DomainMacro
HgeneMACROD2chr20:14066374chr20:13090759ENST00000217246+317185_19190426RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000217246+31797_10290426RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000310348+318185_19190449RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000310348+31897_10290449RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000378058+110185_1910214RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000378058+11077_790214RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000378058+11090_920214RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000378058+11097_1020214RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000402914+114185_191-154214RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000402914+11477_79-154214RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000402914+11490_92-154214RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000402914+11497_102-154214RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000407045+16185_191-7999RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000407045+1677_79-7999RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000407045+1690_92-7999RegionNote=Substrate binding
HgeneMACROD2chr20:14066374chr20:13090759ENST00000407045+1697_102-7999RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000217246+417185_191100426RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000310348+418185_191100449RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000378058+110185_1910214RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000378058+11077_790214RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000378058+11090_920214RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000378058+11097_1020214RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000402914+114185_191-154214RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000402914+11477_79-154214RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000402914+11490_92-154214RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000402914+11497_102-154214RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000407045+16185_191-7999RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000407045+1677_79-7999RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000407045+1690_92-7999RegionNote=Substrate binding
HgeneMACROD2chr20:14474154chr20:13071731ENST00000407045+1697_102-7999RegionNote=Substrate binding
TgeneSPTLC3chr20:14066374chr20:13090759ENST00000399002+51259_79275553TransmembraneHelical
TgeneSPTLC3chr20:14474154chr20:13071731ENST00000399002+31259_79202553TransmembraneHelical


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FusionGeneSequence for MACROD2_SPTLC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MACROD2_ENST00000217246_chr20_14474154_+_SPTLC3_ENST00000399002_chr20_13071731_+_451aa
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA
ANASLLGGGGGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEK
LLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKS
FGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVP
LLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDETSFELED

>In-frame_MACROD2_ENST00000217246_chr20_14474154_+_SPTLC3_ENST00000378194_chr20_13071731_+_228aa
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA
ANASLLGGGGGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEK

>In-frame_MACROD2_ENST00000310348_chr20_14474154_+_SPTLC3_ENST00000399002_chr20_13071731_+_451aa
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA
ANASLLGGGGGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEK
LLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKS
FGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVP
LLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDETSFELED

>In-frame_MACROD2_ENST00000310348_chr20_14474154_+_SPTLC3_ENST00000378194_chr20_13071731_+_228aa
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA
ANASLLGGGGGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEK

>In-frame_MACROD2_ENST00000217246_chr20_14066374_+_SPTLC3_ENST00000399002_chr20_13090759_+_368aa
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA
DTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVL
MGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGN
ENASVVPLLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDE

>In-frame_MACROD2_ENST00000217246_chr20_14066374_+_SPTLC3_ENST00000378194_chr20_13090759_+_145aa
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA

>In-frame_MACROD2_ENST00000310348_chr20_14066374_+_SPTLC3_ENST00000399002_chr20_13090759_+_368aa
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA
DTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVL
MGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGN
ENASVVPLLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARPELYDE

>In-frame_MACROD2_ENST00000310348_chr20_14066374_+_SPTLC3_ENST00000378194_chr20_13090759_+_145aa
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MACROD2_ENST00000217246_chr20_14474154_+_SPTLC3_ENST00000399002_chr20_13071731_+_1353nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGTTGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAA
GCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCATTAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAG
TTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAATCTTCAAACACAACAACACACAAAGCCTAGAGAAG
CTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGCATG
GAAGGTTCCATCGTGCATCTGCCCCAGATCATAGCTCTAAAGAAGAAATACAAGGCTTACCTCTACATAGATGAAGCTCACAGTATTGGG
GCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGTTCTTTGGACTAGACCCTCATGAAGTTGATGTGCTCATGGGCACATTCACCAAAAGT
TTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGAAGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCC
ATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAG
CAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCT
CTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCC
ACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTTTTAGAAGCTCTTGATGAA
ATGGGTGATCTCTTGCAACTGAAATATTCCCGGCACAAGAAGTCAGCACGTCCTGAGCTCTATGATGAGACGAGCTTTGAACTCGAAGAT

>In-frame_MACROD2_ENST00000217246_chr20_14474154_+_SPTLC3_ENST00000378194_chr20_13071731_+_684nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGTTGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAA
GCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCATTAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAG
TTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAATCTTCAAACACAACAACACACAAAGCCTAGAGAAG
CTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGGACC

>In-frame_MACROD2_ENST00000310348_chr20_14474154_+_SPTLC3_ENST00000399002_chr20_13071731_+_1353nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGTTGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAA
GCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCATTAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAG
TTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAATCTTCAAACACAACAACACACAAAGCCTAGAGAAG
CTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGCATG
GAAGGTTCCATCGTGCATCTGCCCCAGATCATAGCTCTAAAGAAGAAATACAAGGCTTACCTCTACATAGATGAAGCTCACAGTATTGGG
GCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGTTCTTTGGACTAGACCCTCATGAAGTTGATGTGCTCATGGGCACATTCACCAAAAGT
TTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGAAGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCC
ATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAG
CAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCT
CTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCC
ACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTTTTAGAAGCTCTTGATGAA
ATGGGTGATCTCTTGCAACTGAAATATTCCCGGCACAAGAAGTCAGCACGTCCTGAGCTCTATGATGAGACGAGCTTTGAACTCGAAGAT

>In-frame_MACROD2_ENST00000310348_chr20_14474154_+_SPTLC3_ENST00000378194_chr20_13071731_+_684nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGTTGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAA
GCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCATTAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAG
TTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAATCTTCAAACACAACAACACACAAAGCCTAGAGAAG
CTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGGACC

>In-frame_MACROD2_ENST00000217246_chr20_14066374_+_SPTLC3_ENST00000399002_chr20_13090759_+_1104nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTG
GTGGAGGGTGTCTACAGCATGGAAGGTTCCATCGTGCATCTGCCCCAGATCATAGCTCTAAAGAAGAAATACAAGGCTTACCTCTACATA
GATGAAGCTCACAGTATTGGGGCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGTTCTTTGGACTAGACCCTCATGAAGTTGATGTGCTC
ATGGGCACATTCACCAAAAGTTTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGAAGGACCTCGTGGATTATTTACGGGTTCACTCGCAT
AGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACT
CAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAAT
GAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTG
GTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACG
GTTTTAGAAGCTCTTGATGAAATGGGTGATCTCTTGCAACTGAAATATTCCCGGCACAAGAAGTCAGCACGTCCTGAGCTCTATGATGAG

>In-frame_MACROD2_ENST00000217246_chr20_14066374_+_SPTLC3_ENST00000378194_chr20_13090759_+_435nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTG

>In-frame_MACROD2_ENST00000310348_chr20_14066374_+_SPTLC3_ENST00000399002_chr20_13090759_+_1104nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTG
GTGGAGGGTGTCTACAGCATGGAAGGTTCCATCGTGCATCTGCCCCAGATCATAGCTCTAAAGAAGAAATACAAGGCTTACCTCTACATA
GATGAAGCTCACAGTATTGGGGCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGTTCTTTGGACTAGACCCTCATGAAGTTGATGTGCTC
ATGGGCACATTCACCAAAAGTTTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGAAGGACCTCGTGGATTATTTACGGGTTCACTCGCAT
AGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACT
CAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAAT
GAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTG
GTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACG
GTTTTAGAAGCTCTTGATGAAATGGGTGATCTCTTGCAACTGAAATATTCCCGGCACAAGAAGTCAGCACGTCCTGAGCTCTATGATGAG

>In-frame_MACROD2_ENST00000310348_chr20_14066374_+_SPTLC3_ENST00000378194_chr20_13090759_+_435nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_MACROD2_ENST00000217246_chr20_14474154_+_SPTLC3_ENST00000399002_chr20_13071731_+_3645nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGAAGAAAATACTCAGGAAACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACA
TCACATTGCTAGAGGTAGATGCTATAGTCAATGCCGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGT
TGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAAGCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCAT
TAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAGTTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAA
TCTTCAAACACAACAACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAA
AGATTCTCATCCTGGTGGAGGGTGTCTACAGCATGGAAGGTTCCATCGTGCATCTGCCCCAGATCATAGCTCTAAAGAAGAAATACAAGG
CTTACCTCTACATAGATGAAGCTCACAGTATTGGGGCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGTTCTTTGGACTAGACCCTCATG
AAGTTGATGTGCTCATGGGCACATTCACCAAAAGTTTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGAAGGACCTCGTGGATTATTTAC
GGGTTCACTCGCATAGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGAC
TGGATGGGACCACTCAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCA
TTATCTATGGCAATGAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGA
AAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGG
AGATGTTAGACACGGTTTTAGAAGCTCTTGATGAAATGGGTGATCTCTTGCAACTGAAATATTCCCGGCACAAGAAGTCAGCACGTCCTG
AGCTCTATGATGAGACGAGCTTTGAACTCGAAGATTAAGTTTCCTGGTCCTGAATGACACATAAAGACTTTGCGAGAAAGACCTCCCTCC
TTGCCTCACAAGGAATATAAATGGATTTCTCCCCCTTCCTCAGGACAATTTTGGTTCCCAGACCAGCTTGATTGAACTGAGGGAGACGTT
GTTGTTTTTAATGTCTCCAGCTTGGACTGCAGAGACAAAAACATGATTCCAGATTTAAGTCTCTCTTCTTCCAAGTATTCTACTAGAAAT
ACACACACACACACACACACACTTCTGAGAATATTTTTAATGGCAATAAGCCTGTGTTTTAGCTGCTACTGTGCAGACCCTTTCAGGGAT
TCCAACCAAATGCAAATGAGAGAATTTAAAATTTTTATTCAGTAAGTTCACTATGTGTTTACTTATTCCATCTGCAGATGTAAGTGAGTG
TGGTGGACAGTAGCCACCTTCCTTGTTCCACTCATAAAAGCATCAGCTAGATCTCATCTGTATCATGGGAAGTTCCAGGCAGGAGGGTAA
AGAAATGTTGTTTCTACCATTTGTCACATTTGGACGTTTTTCACAGACAAGTGTCAAAAGACATAGTTAATGTTTCGAGGGGGAAAGCAG
AACTGATCAACTGCGACTAGAGACGTCTTTGAAGGAAATTTTCCTTTTCCTCTTGCTGGTCTCCTACAGTTTTACAGCTGAGCTTTTGAG
GTTTGGAAAATTCAAGATGTTTGTTTCATAAGAAAAGGGGCAGAAAGCAAGCACAAGACACTTTTAGGTCTAGACTAAAATGGTAGTTAC
AACAATTTGAACCTTGTTGGTGCAGTGCACGGTGAATGCTTACCCTGCACAGCCTCTATTACCTTAAGGAATTAGTTGTCATTTTCCTAT
TGAATTTTGAGTAAATGGTGAAATTCAGTGTCCTTTAGAATCGACTCCCAAGACTATATTTGAAGAATGCATTGATTCAAGAAGGACATT
TAAAAGCAAATTCTGACTTTTTCAAGACCAACACACTTGTTTAGGCCTATTAAATTGTACTATCACTTGTTACATGCCCTCTGAATTGGG
AGAAAGTGGGCTTGCACACTTTGAGGTAACTAACTGTAATTTACTTGTGTTCTCTCTTTCTTGCTCTCCTTCTCAACATGAACACAAACC
TCTATGGAAAAGTAGCCTCTTGTTAATCTGATCTAGTTTGTATGGAAAAAGCCCATGGAGAACCTTATCTTTAACAAGCTCCCAGAGGGT
GCCCAGATTTGGAAATTCTAGAGAGCAGTGGTGACCTTTTAGCAAAGCTTCTGTAACAGTTCGAATGAGTTGCAGAACATTCCACTCCAT
CAAATGACACTGTAAACAAATCACTTCAAGAGAGGCTTGGTTTTGTGTGGCACAGATGGACCCAAGCTTTCATGCTGTGCACTGAGATAG
AAACTCCACCCGCAGCGCCTGCGATGGATGGAGCAGTGTGCCCTGATGCTCAAAGCGTATTAAAGGAAAAAAAGTGATCAGCATGGAAAG
TTTTTATGGGGAAATTATAACTCCAAGTGGGTGCATTGGTTTAAAAATGGATCACAATGATAGAGTTCTTCATGAATGTTTACAAGTTGT
AAGGAATACCGTTAGTGAAAGAGGAAAAGAAGTGGGTTCTGAAAATGCAGTTTCCCATCCAATGATTTTGATAACAAAATTCCAACTTTT
CTCAATGAAACTGATGCAGTATTATTTGTGCAAATAAAATGTGTCATAAATATGCAAAGAAAGGGAGACATACTGTTCTTATCTTGAATA
TGTGCATTTAAATGAATTGTCCAAAATGCATAAATGCCTTGCGTTCTATAAAGGAAACAGGAGGTCAAAAAGACAGCGAGATATCTAGTC

>In-frame_MACROD2_ENST00000217246_chr20_14474154_+_SPTLC3_ENST00000378194_chr20_13071731_+_1610nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGAAGAAAATACTCAGGAAACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACA
TCACATTGCTAGAGGTAGATGCTATAGTCAATGCCGCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGT
TGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAAGCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCAT
TAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAGTTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAA
TCTTCAAACACAACAACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAA
AGATTCTCATCCTGGTGGAGGGTGTCTACAGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCCATGAG
CCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAGCAACT
TGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCTCTGCT
TCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCCACTCC
CCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTGAGTACACCACAGGCCAACGGGAT
CTCAGTACCAGTACCTTGGATTCAAAGCAAGTCCTTTTGTTGAGACAGCTTGGGGTTCTCTGGGTTTCTCTTGGGTTATTTAGGAAAACA

>In-frame_MACROD2_ENST00000310348_chr20_14474154_+_SPTLC3_ENST00000399002_chr20_13071731_+_3250nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGTTGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAA
GCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCATTAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAG
TTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAATCTTCAAACACAACAACACACAAAGCCTAGAGAAG
CTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGCATG
GAAGGTTCCATCGTGCATCTGCCCCAGATCATAGCTCTAAAGAAGAAATACAAGGCTTACCTCTACATAGATGAAGCTCACAGTATTGGG
GCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGTTCTTTGGACTAGACCCTCATGAAGTTGATGTGCTCATGGGCACATTCACCAAAAGT
TTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGAAGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCC
ATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAG
CAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCT
CTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCC
ACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTTTTAGAAGCTCTTGATGAA
ATGGGTGATCTCTTGCAACTGAAATATTCCCGGCACAAGAAGTCAGCACGTCCTGAGCTCTATGATGAGACGAGCTTTGAACTCGAAGAT
TAAGTTTCCTGGTCCTGAATGACACATAAAGACTTTGCGAGAAAGACCTCCCTCCTTGCCTCACAAGGAATATAAATGGATTTCTCCCCC
TTCCTCAGGACAATTTTGGTTCCCAGACCAGCTTGATTGAACTGAGGGAGACGTTGTTGTTTTTAATGTCTCCAGCTTGGACTGCAGAGA
CAAAAACATGATTCCAGATTTAAGTCTCTCTTCTTCCAAGTATTCTACTAGAAATACACACACACACACACACACACTTCTGAGAATATT
TTTAATGGCAATAAGCCTGTGTTTTAGCTGCTACTGTGCAGACCCTTTCAGGGATTCCAACCAAATGCAAATGAGAGAATTTAAAATTTT
TATTCAGTAAGTTCACTATGTGTTTACTTATTCCATCTGCAGATGTAAGTGAGTGTGGTGGACAGTAGCCACCTTCCTTGTTCCACTCAT
AAAAGCATCAGCTAGATCTCATCTGTATCATGGGAAGTTCCAGGCAGGAGGGTAAAGAAATGTTGTTTCTACCATTTGTCACATTTGGAC
GTTTTTCACAGACAAGTGTCAAAAGACATAGTTAATGTTTCGAGGGGGAAAGCAGAACTGATCAACTGCGACTAGAGACGTCTTTGAAGG
AAATTTTCCTTTTCCTCTTGCTGGTCTCCTACAGTTTTACAGCTGAGCTTTTGAGGTTTGGAAAATTCAAGATGTTTGTTTCATAAGAAA
AGGGGCAGAAAGCAAGCACAAGACACTTTTAGGTCTAGACTAAAATGGTAGTTACAACAATTTGAACCTTGTTGGTGCAGTGCACGGTGA
ATGCTTACCCTGCACAGCCTCTATTACCTTAAGGAATTAGTTGTCATTTTCCTATTGAATTTTGAGTAAATGGTGAAATTCAGTGTCCTT
TAGAATCGACTCCCAAGACTATATTTGAAGAATGCATTGATTCAAGAAGGACATTTAAAAGCAAATTCTGACTTTTTCAAGACCAACACA
CTTGTTTAGGCCTATTAAATTGTACTATCACTTGTTACATGCCCTCTGAATTGGGAGAAAGTGGGCTTGCACACTTTGAGGTAACTAACT
GTAATTTACTTGTGTTCTCTCTTTCTTGCTCTCCTTCTCAACATGAACACAAACCTCTATGGAAAAGTAGCCTCTTGTTAATCTGATCTA
GTTTGTATGGAAAAAGCCCATGGAGAACCTTATCTTTAACAAGCTCCCAGAGGGTGCCCAGATTTGGAAATTCTAGAGAGCAGTGGTGAC
CTTTTAGCAAAGCTTCTGTAACAGTTCGAATGAGTTGCAGAACATTCCACTCCATCAAATGACACTGTAAACAAATCACTTCAAGAGAGG
CTTGGTTTTGTGTGGCACAGATGGACCCAAGCTTTCATGCTGTGCACTGAGATAGAAACTCCACCCGCAGCGCCTGCGATGGATGGAGCA
GTGTGCCCTGATGCTCAAAGCGTATTAAAGGAAAAAAAGTGATCAGCATGGAAAGTTTTTATGGGGAAATTATAACTCCAAGTGGGTGCA
TTGGTTTAAAAATGGATCACAATGATAGAGTTCTTCATGAATGTTTACAAGTTGTAAGGAATACCGTTAGTGAAAGAGGAAAAGAAGTGG
GTTCTGAAAATGCAGTTTCCCATCCAATGATTTTGATAACAAAATTCCAACTTTTCTCAATGAAACTGATGCAGTATTATTTGTGCAAAT
AAAATGTGTCATAAATATGCAAAGAAAGGGAGACATACTGTTCTTATCTTGAATATGTGCATTTAAATGAATTGTCCAAAATGCATAAAT
GCCTTGCGTTCTATAAAGGAAACAGGAGGTCAAAAAGACAGCGAGATATCTAGTCCTTCCACAAGGTATGGAAAGCAATAAACATCTTCC

>In-frame_MACROD2_ENST00000310348_chr20_14474154_+_SPTLC3_ENST00000378194_chr20_13071731_+_1215nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GCAAATGCCAGTCTTCTTGGAGGAGGAGGTGGCACCTTGGATAAGCACAAGGAGTTGGAGGACCTTGTGGCTAAGTTCCTGAATGTGGAA
GCAGCTATGGTCTTTGGGATGGGATTCGCAACTAACTCAATGAATATCCCAGCATTAGTTGGAAAGGGATGCCTCATTTTAAGTGATGAG
TTAAACCACACATCGCTTGTGCTTGGGGCCCGACTCTCAGGTGCAACCATAAGAATCTTCAAACACAACAACACACAAAGCCTAGAGAAG
CTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGGACC
TCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAA
AACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGC
AGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAA
GGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAG
CGGCACATACCCGGGAGATGTTAGACACGGTGAGTACACCACAGGCCAACGGGATCTCAGTACCAGTACCTTGGATTCAAAGCAAGTCCT
TTTGTTGAGACAGCTTGGGGTTCTCTGGGTTTCTCTTGGGTTATTTAGGAAAACAACACTGACAAAAGTCACTGCCAAAAAACAAGAGCT

>In-frame_MACROD2_ENST00000217246_chr20_14066374_+_SPTLC3_ENST00000399002_chr20_13090759_+_3396nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGAAGAAAATACTCAGGAAACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACA
TCACATTGCTAGAGGTAGATGCTATAGTCAATGCCGACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTC
GAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGCATGGAAGGTTCCATCGTGCATCTGCCCCAGATCATAG
CTCTAAAGAAGAAATACAAGGCTTACCTCTACATAGATGAAGCTCACAGTATTGGGGCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGT
TCTTTGGACTAGACCCTCATGAAGTTGATGTGCTCATGGGCACATTCACCAAAAGTTTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGA
AGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGAT
CACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAA
GACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTT
TTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTG
TTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTTTTAGAAGCTCTTGATGAAATGGGTGATCTCTTGCAACTGAAATATTCCCGGC
ACAAGAAGTCAGCACGTCCTGAGCTCTATGATGAGACGAGCTTTGAACTCGAAGATTAAGTTTCCTGGTCCTGAATGACACATAAAGACT
TTGCGAGAAAGACCTCCCTCCTTGCCTCACAAGGAATATAAATGGATTTCTCCCCCTTCCTCAGGACAATTTTGGTTCCCAGACCAGCTT
GATTGAACTGAGGGAGACGTTGTTGTTTTTAATGTCTCCAGCTTGGACTGCAGAGACAAAAACATGATTCCAGATTTAAGTCTCTCTTCT
TCCAAGTATTCTACTAGAAATACACACACACACACACACACACTTCTGAGAATATTTTTAATGGCAATAAGCCTGTGTTTTAGCTGCTAC
TGTGCAGACCCTTTCAGGGATTCCAACCAAATGCAAATGAGAGAATTTAAAATTTTTATTCAGTAAGTTCACTATGTGTTTACTTATTCC
ATCTGCAGATGTAAGTGAGTGTGGTGGACAGTAGCCACCTTCCTTGTTCCACTCATAAAAGCATCAGCTAGATCTCATCTGTATCATGGG
AAGTTCCAGGCAGGAGGGTAAAGAAATGTTGTTTCTACCATTTGTCACATTTGGACGTTTTTCACAGACAAGTGTCAAAAGACATAGTTA
ATGTTTCGAGGGGGAAAGCAGAACTGATCAACTGCGACTAGAGACGTCTTTGAAGGAAATTTTCCTTTTCCTCTTGCTGGTCTCCTACAG
TTTTACAGCTGAGCTTTTGAGGTTTGGAAAATTCAAGATGTTTGTTTCATAAGAAAAGGGGCAGAAAGCAAGCACAAGACACTTTTAGGT
CTAGACTAAAATGGTAGTTACAACAATTTGAACCTTGTTGGTGCAGTGCACGGTGAATGCTTACCCTGCACAGCCTCTATTACCTTAAGG
AATTAGTTGTCATTTTCCTATTGAATTTTGAGTAAATGGTGAAATTCAGTGTCCTTTAGAATCGACTCCCAAGACTATATTTGAAGAATG
CATTGATTCAAGAAGGACATTTAAAAGCAAATTCTGACTTTTTCAAGACCAACACACTTGTTTAGGCCTATTAAATTGTACTATCACTTG
TTACATGCCCTCTGAATTGGGAGAAAGTGGGCTTGCACACTTTGAGGTAACTAACTGTAATTTACTTGTGTTCTCTCTTTCTTGCTCTCC
TTCTCAACATGAACACAAACCTCTATGGAAAAGTAGCCTCTTGTTAATCTGATCTAGTTTGTATGGAAAAAGCCCATGGAGAACCTTATC
TTTAACAAGCTCCCAGAGGGTGCCCAGATTTGGAAATTCTAGAGAGCAGTGGTGACCTTTTAGCAAAGCTTCTGTAACAGTTCGAATGAG
TTGCAGAACATTCCACTCCATCAAATGACACTGTAAACAAATCACTTCAAGAGAGGCTTGGTTTTGTGTGGCACAGATGGACCCAAGCTT
TCATGCTGTGCACTGAGATAGAAACTCCACCCGCAGCGCCTGCGATGGATGGAGCAGTGTGCCCTGATGCTCAAAGCGTATTAAAGGAAA
AAAAGTGATCAGCATGGAAAGTTTTTATGGGGAAATTATAACTCCAAGTGGGTGCATTGGTTTAAAAATGGATCACAATGATAGAGTTCT
TCATGAATGTTTACAAGTTGTAAGGAATACCGTTAGTGAAAGAGGAAAAGAAGTGGGTTCTGAAAATGCAGTTTCCCATCCAATGATTTT
GATAACAAAATTCCAACTTTTCTCAATGAAACTGATGCAGTATTATTTGTGCAAATAAAATGTGTCATAAATATGCAAAGAAAGGGAGAC
ATACTGTTCTTATCTTGAATATGTGCATTTAAATGAATTGTCCAAAATGCATAAATGCCTTGCGTTCTATAAAGGAAACAGGAGGTCAAA

>In-frame_MACROD2_ENST00000217246_chr20_14066374_+_SPTLC3_ENST00000378194_chr20_13090759_+_1361nt
GCGTGCGCCCTGGGGCCCAAGTTGGGGCGCGCCGTGGCTAGAACACGGAGAGCGGCGGGCAGTGCAGCCAATGGGAGGCGGCGCTGCCTA
GCGGCTGGTAGGCGGTGCCTGCGCGGGTGTTAGGTTAGCGCGAGGCGTGACCTAGTTGACAGGCTCTGAGGTGCTGCTGTGGCGGCGTCC
GCGGGGCTGAGGCGGGTGGGAGCCGGAGCCGAGCGCGGGCTGAGGGAGGAGGGCGGCGACTGGAGAGCGGCGAGCGGCGAGCAGCGCAGG
ACGCAGAGCCTCTTTCACTTTTTCCCTGCTGAGTGCCCCCTCCCACCCCTCCCACTCCACACACACCCTGTTTGCCCGTGAGCCTGGGGA
ACTTGCAGCTTAAAGCCAGCCACCCCCACGGCAACATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTAT
TGAAGATGACCTTAGAAGAGAGACGCAAAGAATACCTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGG
GCAAGGGCCAAAATGATGAAGAAAATACTCAGGAAACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACA
TCACATTGCTAGAGGTAGATGCTATAGTCAATGCCGACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTC
GAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTGGTGGAGGGTGTCTACAGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGC
TGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGG
GCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAA
TGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGT
CGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTGAG
TACACCACAGGCCAACGGGATCTCAGTACCAGTACCTTGGATTCAAAGCAAGTCCTTTTGTTGAGACAGCTTGGGGTTCTCTGGGTTTCT
CTTGGGTTATTTAGGAAAACAACACTGACAAAAGTCACTGCCAAAAAACAAGAGCTCGTCAACAACAGCCAACACTGTGACCACTCAGTA

>In-frame_MACROD2_ENST00000310348_chr20_14066374_+_SPTLC3_ENST00000399002_chr20_13090759_+_3001nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTG
GTGGAGGGTGTCTACAGCATGGAAGGTTCCATCGTGCATCTGCCCCAGATCATAGCTCTAAAGAAGAAATACAAGGCTTACCTCTACATA
GATGAAGCTCACAGTATTGGGGCCGTGGGCCCAACCGGCCGGGGTGTCACGGAGTTCTTTGGACTAGACCCTCATGAAGTTGATGTGCTC
ATGGGCACATTCACCAAAAGTTTTGGAGCTTCAGGAGGTTACATAGCTGGAAGGAAGGACCTCGTGGATTATTTACGGGTTCACTCGCAT
AGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAGAGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACT
CAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAAGATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAAT
GAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTGGTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTG
GTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTCGGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACG
GTTTTAGAAGCTCTTGATGAAATGGGTGATCTCTTGCAACTGAAATATTCCCGGCACAAGAAGTCAGCACGTCCTGAGCTCTATGATGAG
ACGAGCTTTGAACTCGAAGATTAAGTTTCCTGGTCCTGAATGACACATAAAGACTTTGCGAGAAAGACCTCCCTCCTTGCCTCACAAGGA
ATATAAATGGATTTCTCCCCCTTCCTCAGGACAATTTTGGTTCCCAGACCAGCTTGATTGAACTGAGGGAGACGTTGTTGTTTTTAATGT
CTCCAGCTTGGACTGCAGAGACAAAAACATGATTCCAGATTTAAGTCTCTCTTCTTCCAAGTATTCTACTAGAAATACACACACACACAC
ACACACACTTCTGAGAATATTTTTAATGGCAATAAGCCTGTGTTTTAGCTGCTACTGTGCAGACCCTTTCAGGGATTCCAACCAAATGCA
AATGAGAGAATTTAAAATTTTTATTCAGTAAGTTCACTATGTGTTTACTTATTCCATCTGCAGATGTAAGTGAGTGTGGTGGACAGTAGC
CACCTTCCTTGTTCCACTCATAAAAGCATCAGCTAGATCTCATCTGTATCATGGGAAGTTCCAGGCAGGAGGGTAAAGAAATGTTGTTTC
TACCATTTGTCACATTTGGACGTTTTTCACAGACAAGTGTCAAAAGACATAGTTAATGTTTCGAGGGGGAAAGCAGAACTGATCAACTGC
GACTAGAGACGTCTTTGAAGGAAATTTTCCTTTTCCTCTTGCTGGTCTCCTACAGTTTTACAGCTGAGCTTTTGAGGTTTGGAAAATTCA
AGATGTTTGTTTCATAAGAAAAGGGGCAGAAAGCAAGCACAAGACACTTTTAGGTCTAGACTAAAATGGTAGTTACAACAATTTGAACCT
TGTTGGTGCAGTGCACGGTGAATGCTTACCCTGCACAGCCTCTATTACCTTAAGGAATTAGTTGTCATTTTCCTATTGAATTTTGAGTAA
ATGGTGAAATTCAGTGTCCTTTAGAATCGACTCCCAAGACTATATTTGAAGAATGCATTGATTCAAGAAGGACATTTAAAAGCAAATTCT
GACTTTTTCAAGACCAACACACTTGTTTAGGCCTATTAAATTGTACTATCACTTGTTACATGCCCTCTGAATTGGGAGAAAGTGGGCTTG
CACACTTTGAGGTAACTAACTGTAATTTACTTGTGTTCTCTCTTTCTTGCTCTCCTTCTCAACATGAACACAAACCTCTATGGAAAAGTA
GCCTCTTGTTAATCTGATCTAGTTTGTATGGAAAAAGCCCATGGAGAACCTTATCTTTAACAAGCTCCCAGAGGGTGCCCAGATTTGGAA
ATTCTAGAGAGCAGTGGTGACCTTTTAGCAAAGCTTCTGTAACAGTTCGAATGAGTTGCAGAACATTCCACTCCATCAAATGACACTGTA
AACAAATCACTTCAAGAGAGGCTTGGTTTTGTGTGGCACAGATGGACCCAAGCTTTCATGCTGTGCACTGAGATAGAAACTCCACCCGCA
GCGCCTGCGATGGATGGAGCAGTGTGCCCTGATGCTCAAAGCGTATTAAAGGAAAAAAAGTGATCAGCATGGAAAGTTTTTATGGGGAAA
TTATAACTCCAAGTGGGTGCATTGGTTTAAAAATGGATCACAATGATAGAGTTCTTCATGAATGTTTACAAGTTGTAAGGAATACCGTTA
GTGAAAGAGGAAAAGAAGTGGGTTCTGAAAATGCAGTTTCCCATCCAATGATTTTGATAACAAAATTCCAACTTTTCTCAATGAAACTGA
TGCAGTATTATTTGTGCAAATAAAATGTGTCATAAATATGCAAAGAAAGGGAGACATACTGTTCTTATCTTGAATATGTGCATTTAAATG
AATTGTCCAAAATGCATAAATGCCTTGCGTTCTATAAAGGAAACAGGAGGTCAAAAAGACAGCGAGATATCTAGTCCTTCCACAAGGTAT

>In-frame_MACROD2_ENST00000310348_chr20_14066374_+_SPTLC3_ENST00000378194_chr20_13090759_+_966nt
ATGTACCCCAGCAACAAGAAGAAAAAGGTGTGGAGAGAGGAGAAAGAACGTTTATTGAAGATGACCTTAGAAGAGAGACGCAAAGAATAC
CTAAGAGACTATATTCCCCTGAACAGCATTCTATCATGGAAGGAGGAGATGAAGGGCAAGGGCCAAAATGATGAAGAAAATACTCAGGAA
ACATCCCAGGTGAAGAAAAGTTTGACTGAAAAAGTTTCTCTCTATAGAGGTGACATCACATTGCTAGAGGTAGATGCTATAGTCAATGCC
GACACACAAAGCCTAGAGAAGCTCCTGAGAGATGCTGTCATCTATGGCCAGCCTCGAACCCGCAGAGCTTGGAAAAAGATTCTCATCCTG
GTGGAGGGTGTCTACAGGACCTCGTGGATTATTTACGGGTTCACTCGCATAGTGCTGTTTATGCTTCATCCATGAGCCCACCGATAGCAG
AGCAAATCATCAGATCACTAAAACTTATCATGGGACTGGATGGGACCACTCAAGGGCTGCAGAGAGTACAGCAACTTGCGAAAAACACAA
GATACTTCAGACAAAGACTGCAGGAAATGGGATTCATTATCTATGGCAATGAGAATGCTTCTGTTGTTCCTCTGCTTCTTTATATGCCTG
GTAAAGTAGCGGCTTTTGCAAGGCATATGCTAGAGAAAAAAATTGGAGTGGTGGTCGTGGGATTTCCAGCCACTCCCCTCGCAGAAGCTC
GGGCTCGGTTTTGTGTTTCAGCGGCACATACCCGGGAGATGTTAGACACGGTGAGTACACCACAGGCCAACGGGATCTCAGTACCAGTAC
CTTGGATTCAAAGCAAGTCCTTTTGTTGAGACAGCTTGGGGTTCTCTGGGTTTCTCTTGGGTTATTTAGGAAAACAACACTGACAAAAGT


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FusionGenePPI for MACROD2_SPTLC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MACROD2TERF1, TERF2SPTLC3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MACROD2_SPTLC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSPTLC3Q9NUV7DB00114Pyridoxal PhosphateSerine palmitoyltransferase 3small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for MACROD2_SPTLC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMACROD2C0004352Autistic Disorder1CTD_human
HgeneMACROD2C0023903Liver neoplasms1CTD_human
HgeneMACROD2C0236969Substance-Related Disorders1CTD_human