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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 20524

FusionGeneSummary for MACROD1_TBC1D22A

check button Fusion gene summary
Fusion gene informationFusion gene name: MACROD1_TBC1D22A
Fusion gene ID: 20524
HgeneTgene
Gene symbol

MACROD1

TBC1D22A

Gene ID

28992

25771

Gene nameMACRO domain containing 1TBC1 domain family member 22A
SynonymsLRP16C22orf4|HSC79E021
Cytomap

11q13.1

22q13.31

Type of geneprotein-codingprotein-coding
DescriptionO-acetyl-ADP-ribose deacetylase MACROD1MACRO domain-containing protein 1[Protein ADP-ribosylglutamate] hydrolaseTBC1 domain family member 22Aputative GTPase activator
Modification date2018051920180523
UniProtAcc

Q9BQ69

Q8WUA7

Ensembl transtripts involved in fusion geneENST00000255681, ENST00000538595, 
ENST00000337137, ENST00000380995, 
ENST00000407381, ENST00000355704, 
ENST00000472791, ENST00000406733, 
Fusion gene scores* DoF score11 X 2 X 11=2428 X 6 X 7=336
# samples 138
** MAII scorelog2(13/242*10)=-0.89649542424614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: MACROD1 [Title/Abstract] AND TBC1D22A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMACROD1

GO:0042278

purine nucleoside metabolic process

21257746

HgeneMACROD1

GO:0051725

protein de-ADP-ribosylation

23474712


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-61-2104-01AMACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000255681ENST00000337137MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
In-frameENST00000255681ENST00000380995MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
In-frameENST00000255681ENST00000407381MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
In-frameENST00000255681ENST00000355704MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5CDS-intronENST00000255681ENST00000472791MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5CDS-intronENST00000255681ENST00000406733MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-3CDSENST00000538595ENST00000337137MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-3CDSENST00000538595ENST00000380995MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-3CDSENST00000538595ENST00000407381MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-3CDSENST00000538595ENST00000355704MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-intronENST00000538595ENST00000472791MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+
5UTR-intronENST00000538595ENST00000406733MACROD1chr11

63918711

-TBC1D22Achr22

47274549

+

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FusionProtFeatures for MACROD1_TBC1D22A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MACROD1

Q9BQ69

TBC1D22A

Q8WUA7

Removes ADP-ribose from glutamate residues in proteinsbearing a single ADP-ribose moiety. Inactive towards proteinsbearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, asignaling molecule generated by the deacetylation of acetylatedlysine residues in histones and other proteins. Plays a role inestrogen signaling. Binds to androgen receptor (AR) and amplifiesthe transactivation function of AR in response to androgen. Mayplay an important role in carcinogenesis and/or progression ofhormone-dependent cancers by feed-forward mechanism that activatesESR1 transactivation. Could be an ESR1 coactivator, providing apositive feedback regulatory loop for ESR1 signal transduction.Could be involved in invasive growth by down-regulating CDH1 inendometrial cancer cells. Enhances ESR1-mediated transcriptionactivity. {ECO:0000269|PubMed:17893710,ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849,ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746,ECO:0000269|PubMed:23474712}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACROD1chr11:63918711chr22:47274549ENST00000255681-311159_161172225RegionSubstrate binding
HgeneMACROD1chr11:63918711chr22:47274549ENST00000255681-311172_174172225RegionSubstrate binding
TgeneTBC1D22Achr11:63918711chr22:47274549ENST00000337137+313222_446212518DomainRab-GAP TBC
TgeneTBC1D22Achr11:63918711chr22:47274549ENST00000355704+111222_446134440DomainRab-GAP TBC
TgeneTBC1D22Achr11:63918711chr22:47274549ENST00000380995+39222_446165325DomainRab-GAP TBC

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACROD1chr11:63918711chr22:47274549ENST00000255681-311141_322172225DomainMacro
HgeneMACROD1chr11:63918711chr22:47274549ENST00000255681-311179_184172225RegionSubstrate binding
HgeneMACROD1chr11:63918711chr22:47274549ENST00000255681-311267_273172225RegionSubstrate binding


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FusionGeneSequence for MACROD1_TBC1D22A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000337137_chr22_47274549_+_478aa
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRTKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKETFAFIEHTYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA
IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRID
EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWD

>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000380995_chr22_47274549_+_332aa
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRTKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKETFAFIEHTYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA

>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000407381_chr22_47274549_+_478aa
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRTKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKETFAFIEHTYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA
IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRID
EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWD

>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000355704_chr22_47274549_+_478aa
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLS
TSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRTKKDKQLNEKISLLRSDITKLEVDAIVNAEELRRLSW
SGIPKPVRPMTWKLLSGYLPANVDRRPATLQRKQKETFAFIEHTYDSRNDEVHQDTYRQIHIDIPRMSPEALILQPKVTEIFERILFIWA
IRHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTVDVSGVPAEVLCNIEADTYWCMSKLLDGIQDNYTFAQPGIQMKVKMLEELVSRID
EQVHRHLDQHEVRYLQFAFRWMNNLLMREVPLRCTIRLWDTYQSEPDGFSHFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWD


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000337137_chr22_47274549_+_1434nt
ATGTCTCTACAGAGCCGACTGTCCGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACAC
TTGGCGGGTGCCACGAGGACCCGCAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGA
GTTGGGGCGTGGGGGGCGGCGGCGGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGC
ACCTCCACCGACTGGAAGGAGGCGAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTC
AGGCTGAAGAAGATCCCGACATGGAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTC
AATGAGAAAATCTCCCTGCTCCGCAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGG
TCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTC
CAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATC
CACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCG
ATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCA
GAGGAGGTGGACACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTG
CTGGATGGCATTCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGAT
GAGCAAGTGCACCGGCACCTGGACCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTG
CCCCTGCGTTGTACCATCCGCCTGTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTT
CTCGTGAGATGGAGGAAGGAAATACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGAT

>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000380995_chr22_47274549_+_996nt
ATGTCTCTACAGAGCCGACTGTCCGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACAC
TTGGCGGGTGCCACGAGGACCCGCAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGA
GTTGGGGCGTGGGGGGCGGCGGCGGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGC
ACCTCCACCGACTGGAAGGAGGCGAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTC
AGGCTGAAGAAGATCCCGACATGGAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTC
AATGAGAAAATCTCCCTGCTCCGCAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGG
TCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTC
CAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATC
CACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCG
ATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGCCTTT
CCAGGTTGTGGTCGGCCTCAGATTCCCATCCTTGCTGTGATCTGGAGAGATGAGCCTTACCCGAGGACAGATGAACAGATTATCCTCAGA

>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000407381_chr22_47274549_+_1434nt
ATGTCTCTACAGAGCCGACTGTCCGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACAC
TTGGCGGGTGCCACGAGGACCCGCAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGA
GTTGGGGCGTGGGGGGCGGCGGCGGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGC
ACCTCCACCGACTGGAAGGAGGCGAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTC
AGGCTGAAGAAGATCCCGACATGGAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTC
AATGAGAAAATCTCCCTGCTCCGCAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGG
TCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTC
CAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATC
CACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCG
ATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCA
GAGGAGGTGGACACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTG
CTGGATGGCATTCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGAT
GAGCAAGTGCACCGGCACCTGGACCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTG
CCCCTGCGTTGTACCATCCGCCTGTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTT
CTCGTGAGATGGAGGAAGGAAATACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGAT

>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000355704_chr22_47274549_+_1434nt
ATGTCTCTACAGAGCCGACTGTCCGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACAC
TTGGCGGGTGCCACGAGGACCCGCAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGA
GTTGGGGCGTGGGGGGCGGCGGCGGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGC
ACCTCCACCGACTGGAAGGAGGCGAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTC
AGGCTGAAGAAGATCCCGACATGGAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTC
AATGAGAAAATCTCCCTGCTCCGCAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGG
TCCGGAATCCCTAAGCCAGTGCGTCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTC
CAGAGAAAACAAAAAGAATATTTTGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATC
CACATAGACATCCCTCGCATGAGCCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCG
ATCCGCCACCCAGCCAGTGGATACGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCA
GAGGAGGTGGACACGGTGGACGTCTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTG
CTGGATGGCATTCAGGACAACTACACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGAT
GAGCAAGTGCACCGGCACCTGGACCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTG
CCCCTGCGTTGTACCATCCGCCTGTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTT
CTCGTGAGATGGAGGAAGGAAATACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000337137_chr22_47274549_+_3568nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGT
CTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTA
CACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGA
CCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCT
GTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAAT
ACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCT
GGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACT
GTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCA
CCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGA
GAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCC
TCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGC
CATCTCATACCTACTCTGAAATGCAAAACTTCTATTCTGTTGAGTGAAAGAATAAAATGTAGACAAAATCTAGACCGAGACGTTGCGCTG
ACCCGGGGTCTCTGTGCCGCGAGGTCCCCTCACAGCTGTATTTCACTGCTGCTGGCCCTTTCCCTCCGTGTGTTTTCCTGCTTGCTTGGT
TTAAACGTGGCTGGGAAGCTGAAGGCTGGAGTCCAAGCCGTGAGCCCGCCGAGTGCCTGGGAGGCCGTGGGACCAAAGGCTGGGAGCAGA
GGGAGGCCTCGCCATCGCCTTACTTTCCACCTTGAACCTCTTTTACAAGAGAGAAACCCCCACCTCCCTGAGGTCCAGGGCCAAGTGGCC
CCGCCACGCAGGTAGGCGCCGGCCTCAGCCAGAGCCCCTGGAGGCCCACCCAGGCTGTCGGGCCATGTTGGGCTGGCAGACGGGCAGGGG
GTCGCGTCCCTGTCATCAAAGCCCTGAACCACAGTGCTCTTCTCACCGCAGCCTGGAAGCGGAATGAGCTTTTGGAGACTTCCTGGGACT
TGCTGTCCTTGTCCAGGTCTGCCAGGTGTAGGGGAGGTGTGACTGGTTCCATCATGGACCGGTTCCTCCATGGACCGGTTCCTCCGTGGA
CCGGTTCCGCCATGGACCGGTTCCGCCATGGACCACTCCTGCCCTGGACCACTCCTGCCCTGGACCGGTTCTGCCGTGGACTGGTTCCCG
CCGTGGACCAGTTCCCGCTGTATACTGGTTCTGCCCTGGACTGGTTCCCGCTGTGGACTGGTTCCTTGGGGCTCTAAGTGCGGAAGGGCC
CAGAGCTGGTCCCTGCCCAGCGCCCTGCTAGGGCTGTGTCCTTGGCTCCAGGGGCCTTGGGACTGGCTTCCCAGCGTTCCCTCGGTGTGT
CACAGGCTGCATGACCCCTGGAATGCGGGCAGGGCCACAGCCACAGTCTGTCTGATCCCTGAGCCCAGGACAGGCTCACGTCCTCAGCGA
CCCACTGGTGACTGACTTCCCAGACTCTCCTCTGTCCCTCAGGAGCAGCCGTGTCCTCTCCCAGGCCCTAGGACACTGCCAGAGACTGTG
GGACATACAGGCATAAGTGATGTGTGTGTTTCTGCTTCTGTTTTAAAAATCCAGGGTCATTACACACAGCATGGAAATTAGCACAAAATG
CTGTGCAAACGTCAGATGCTCCCAAACCAGCAAAGGGATGGGCTTGCTTCACATCAGATGCGGGCACGCCTTACCCCTGCCTTCCGTGTC
CCCACCCCAGGGTCAAGGGTTCCTCAGACCAGCCATGCCTCCTCCTCCTGCCGCCTCCTTTTCTAGATGGGGAGGGGATTCCGTCACAAG
AAGAGCCGCCCCTCGGCCGTGTGCAGGAAGCCCCATGTCGCTTTGCCGAGATCAGCCCTGGGAGGATCCCCTTCTCCAGCTCAGATCATG
CCGTGTGGCCAGAAGGCTGCGGACACAACTGACCTGCTTCTCGAGGTGGTTGATGTTTTAAACAGGAAGCTCCACGGAGTTCAGCCCTGT
GTGCATTTCCTCATGTATGTAAACGCCAAGACTGAATGTGAGAGGTGTTGGCCGCGGGCCTTAAGTCTGAGCAGATCCATCTGGAATGTT

>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000380995_chr22_47274549_+_1063nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGCCTTTCCAGGTTGTGGTCGGCCTCAGAT

>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000407381_chr22_47274549_+_1958nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGT
CTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTA
CACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGA
CCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCT
GTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAAT
ACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCT
GGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACT
GTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCA
CCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGA
GAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCC
TCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGC

>In-frame_MACROD1_ENST00000255681_chr11_63918711_-_TBC1D22A_ENST00000355704_chr22_47274549_+_1961nt
GAGAGACACTCCCGAGCGCCGTAAATAGAGTCCAAGTGGGCGGAGAGCCGTCCCGCGCCGCCCGCTCATGTCTCTACAGAGCCGACTGTC
CGGCCGCCTGGCACAGCTGCGCGCGGCGGGGCAGCTGCTCGTCCCCCCGCGCCCCCGGCCCGGACACTTGGCGGGTGCCACGAGGACCCG
CAGCAGCACGTGCGGTCCCCCGGCGTTCCTGGGCGTGTTCGGCCGCCGTGCGCGGACCTCGGCGGGAGTTGGGGCGTGGGGGGCGGCGGC
GGTGGGGCGGACAGCCGGGGTGCGCACTTGGGCCCCCCTGGCCATGGCGGCGAAGGTGGACCTGAGCACCTCCACCGACTGGAAGGAGGC
GAAATCCTTTCTGAAGGGCCTGAGTGACAAGCAGCGGGAGGAACATTACTTCTGCAAGGACTTTGTCAGGCTGAAGAAGATCCCGACATG
GAAGGAGATGGCGAAAGGGGTGGCTGTGAAGGTGGAGGAGCCCAGGTATAAAAAGGACAAGCAGCTCAATGAGAAAATCTCCCTGCTCCG
CAGCGACATCACCAAGCTGGAGGTGGACGCCATCGTCAACGCCGAGGAATTACGGAGGTTGAGCTGGTCCGGAATCCCTAAGCCAGTGCG
TCCAATGACGTGGAAGCTCCTCTCAGGTTACCTTCCCGCCAATGTAGACCGGAGACCAGCCACTCTCCAGAGAAAACAAAAAGAATATTT
TGCATTTATTGAGCACTATTACGATTCTAGGAACGACGAAGTTCACCAGGACACATACAGGCAGATCCACATAGACATCCCTCGCATGAG
CCCTGAAGCGTTGATCCTGCAGCCCAAGGTGACGGAGATTTTTGAAAGGATCTTGTTCATATGGGCGATCCGCCACCCAGCCAGTGGATA
CGTTCAGGGTATAAATGATCTCGTCACTCCTTTCTTTGTGGTCTTCATTTGTGAATACATAGAGGCAGAGGAGGTGGACACGGTGGACGT
CTCCGGCGTGCCCGCAGAGGTGCTGTGCAACATCGAGGCCGACACCTACTGGTGCATGAGCAAGCTGCTGGATGGCATTCAGGACAACTA
CACCTTTGCCCAACCTGGGATTCAAATGAAAGTGAAAATGTTAGAAGAACTCGTGAGCCGGATTGATGAGCAAGTGCACCGGCACCTGGA
CCAACACGAAGTGAGATACCTGCAGTTTGCCTTCCGCTGGATGAACAACCTGCTGATGAGGGAGGTGCCCCTGCGTTGTACCATCCGCCT
GTGGGACACCTACCAGTCTGAACCGGACGGCTTTTCTCATTTCCACTTGTACGTGTGCGCTGCTTTTCTCGTGAGATGGAGGAAGGAAAT
ACTAGAAGAAAAAGATTTTCAAGAGCTGCTGCTCTTCCTCCAGAACCTGCCCACAGCCCACTGGGATGATGAGGACATCAGCCTGTTGCT
GGCCGAGGCCTACCGCCTCAAGTTTGCTTTTGCCGACGCCCCCAATCACTACAAGAAATGAGCCCAGGCCCACCCGCAGCTGGCCTCACT
GTCCCGGGTGGCGCGCCCCACCTGCCTGGCTGGTGGTAGGCCCCTGTGAGCTGGTCCCGGGCTGCTAAAAGGCCTTGTGAGGTGGCCCCA
CCCTCCAGGGGAGCTGGTGAAGATGGGCCACAGACCTGGTCTAGGGCTGACAAAGACAGGGACAGCCTTTGTTTTCTGAGATACCAAAGA
GAGCCAGGGGAGGGCCCCGGGTTCGGCGGCCAGAGGCAGGTCAGGGGTCCCCTCTCCCTCTCCCTGCAATGTCCTTGCCAAATGACTGCC
TCGTGCTGCCCCTAGTCCGGGGCAGCCTAGGAGGCCGACCCTCTTTGGAGTCCTGCTGTCTGGGTGCCAGGGCCGGAACGAGGTAGTGGC


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FusionGenePPI for MACROD1_TBC1D22A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MACROD1BAG3, PARP1, IKBKG, XRCC6, XRCC5, IKBKB, ERC1, EIF2AK2, HNRNPU, CSTF3, YBX1, DHX9, DDX21, PPP2R1A, PTP4A1, H2AFX, PARP2, SUPT16H, HIST2H3PS2, XPC, SSRP1, HBA2, EXOC3, CETN2, LIG3, HBE1, RPA1, PTPN6, PTPN7, DLDTBC1D22AYWHAB, HSPA1L, ACBD3, FDXR, ACSL4, FLYWCH2, BIRC6, ARFGEF1, QSOX2, MICU1, KIRREL, MICU2, DNAJB4, SUPT6H, EFNB3, EPHA4, EXOG, METTL13, PVRL2, DNAJB5, AMBRA1, CERK, TBC1D22B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MACROD1_TBC1D22A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MACROD1_TBC1D22A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource