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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20522

FusionGeneSummary for MACROD1_PLA2G16

check button Fusion gene summary
Fusion gene informationFusion gene name: MACROD1_PLA2G16
Fusion gene ID: 20522
HgeneTgene
Gene symbol

MACROD1

PLA2G16

Gene ID

28992

11145

Gene nameMACRO domain containing 1phospholipase A2 group XVI
SynonymsLRP16AdPLA|H-REV107|H-REV107-1|HRASLS3|HREV107|HREV107-1|HREV107-3|HRSL3
Cytomap

11q13.1

11q12.3-q13.1

Type of geneprotein-codingprotein-coding
DescriptionO-acetyl-ADP-ribose deacetylase MACROD1MACRO domain-containing protein 1[Protein ADP-ribosylglutamate] hydrolaseHRAS-like suppressor 3Ca-independent phospholipase A1/2H-rev 107 protein homologHRAS-like suppressor 1adipose-specific PLA2adipose-specific phospholipase A2group XVI phospholipase A1/A2group XVI phospholipase A2renal carcinoma antigen NY-REN-65
Modification date2018051920180519
UniProtAcc

Q9BQ69

P53816

Ensembl transtripts involved in fusion geneENST00000255681, ENST00000538595, 
ENST00000323646, ENST00000415826, 
ENST00000394613, 
Fusion gene scores* DoF score11 X 2 X 11=2423 X 3 X 3=27
# samples 133
** MAII scorelog2(13/242*10)=-0.89649542424614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: MACROD1 [Title/Abstract] AND PLA2G16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMACROD1

GO:0042278

purine nucleoside metabolic process

21257746

HgeneMACROD1

GO:0051725

protein de-ADP-ribosylation

23474712

TgenePLA2G16

GO:0006644

phospholipid metabolic process

20100577


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-53-A4EZ-01AMACROD1chr11

63918711

-PLA2G16chr11

63381540

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000255681ENST00000323646MACROD1chr11

63918711

-PLA2G16chr11

63381540

-
5CDS-5UTRENST00000255681ENST00000415826MACROD1chr11

63918711

-PLA2G16chr11

63381540

-
5CDS-5UTRENST00000255681ENST00000394613MACROD1chr11

63918711

-PLA2G16chr11

63381540

-
5UTR-5UTRENST00000538595ENST00000323646MACROD1chr11

63918711

-PLA2G16chr11

63381540

-
5UTR-5UTRENST00000538595ENST00000415826MACROD1chr11

63918711

-PLA2G16chr11

63381540

-
5UTR-5UTRENST00000538595ENST00000394613MACROD1chr11

63918711

-PLA2G16chr11

63381540

-

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FusionProtFeatures for MACROD1_PLA2G16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MACROD1

Q9BQ69

PLA2G16

P53816

Removes ADP-ribose from glutamate residues in proteinsbearing a single ADP-ribose moiety. Inactive towards proteinsbearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, asignaling molecule generated by the deacetylation of acetylatedlysine residues in histones and other proteins. Plays a role inestrogen signaling. Binds to androgen receptor (AR) and amplifiesthe transactivation function of AR in response to androgen. Mayplay an important role in carcinogenesis and/or progression ofhormone-dependent cancers by feed-forward mechanism that activatesESR1 transactivation. Could be an ESR1 coactivator, providing apositive feedback regulatory loop for ESR1 signal transduction.Could be involved in invasive growth by down-regulating CDH1 inendometrial cancer cells. Enhances ESR1-mediated transcriptionactivity. {ECO:0000269|PubMed:17893710,ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849,ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746,ECO:0000269|PubMed:23474712}. Lipid-modifying enzyme that acts as major regulator ofadipocyte lipolysis by catalyzing the release of fatty acids fromphospholipids in adipose tissue (PubMed:19615464, PubMed:19047760,PubMed:20837014, PubMed:22605381, PubMed:22923616). Showsphospholipase A1 and A2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in variousphosphatidylcholines (PC) and phosphatidylethanolamine (PE)(PubMed:19615464, PubMed:19047760, PubMed:20837014,PubMed:22605381, PubMed:22923616). For most substrates,phospholipase A1 activity is much higher than phospholipase A2activity (PubMed:19047760). Phospholipase activity causesdecreased intracellular levels of ether-type lipids, affectingperoxisome metabolism (By similarity). May also haveacyltransferase activity: catalyzes both N-acylation ofphosphatidylethanolamine to form N-acyl-phosphatidylethanolamineand O-acylation of lyso-phosphatidylcholines to formphosphatidylcholines (PubMed:22605381, PubMed:25383759). Therelevance of acyltransferase activity in vivo is however unclearand would require additional evidences (PubMed:22605381,PubMed:25383759). Also has weak lysophospholipase activity (Bysimilarity). {ECO:0000250|UniProtKB:Q8R3U1,ECO:0000269|PubMed:17374643, ECO:0000269|PubMed:19047760,ECO:0000269|PubMed:19615464, ECO:0000269|PubMed:20837014,ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22923616,ECO:0000269|PubMed:25383759}. (Microbial infection) Acts as a host factor forpicornaviruses: required during early infection to promote viralgenome release into the cytoplasm (PubMed:28077878). May act as acellular sensor of membrane damage at sites of virus entry, whichrelocalizes to sites of membrane rupture upon virus unfection(PubMed:28077878). Facilitates safe passage of the RNA away fromLGALS8, enabling viral genome translation by host ribosome(PubMed:28077878). May also be involved in initiating poreformation, increasing pore size or in maintaining pores for genomedelivery (PubMed:28077878). The lipid-modifying enzyme activity isrequired for this process (PubMed:28077878).{ECO:0000269|PubMed:28077878}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for MACROD1_PLA2G16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for MACROD1_PLA2G16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
MACROD1BAG3, PARP1, IKBKG, XRCC6, XRCC5, IKBKB, ERC1, EIF2AK2, HNRNPU, CSTF3, YBX1, DHX9, DDX21, PPP2R1A, PTP4A1, H2AFX, PARP2, SUPT16H, HIST2H3PS2, XPC, SSRP1, HBA2, EXOC3, CETN2, LIG3, HBE1, RPA1, PTPN6, PTPN7, DLDPLA2G16UBQLN1, UBQLN4, PPP2R1A, HRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for MACROD1_PLA2G16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for MACROD1_PLA2G16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource