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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20492

FusionGeneSummary for LZTS3_TPP1

check button Fusion gene summary
Fusion gene informationFusion gene name: LZTS3_TPP1
Fusion gene ID: 20492
HgeneTgene
Gene symbol

LZTS3

TPP1

Gene ID

9762

1200

Gene nameleucine zipper tumor suppressor family member 3tripeptidyl peptidase 1
SynonymsPROSAPIP1CLN2|GIG1|LPIC|SCAR7|TPP-1
Cytomap

20p13

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionleucine zipper putative tumor suppressor 3ProSAP/Shank-interacting protein 1leucine zipper, putative tumor suppressor family member 3proSAP-interacting protein 1proline rich synapse associated protein interacting protein 1tripeptidyl-peptidase 1cell growth-inhibiting gene 1 proteingrowth-inhibiting protein 1lysosomal pepstatin insensitive proteasetripeptidyl aminopeptidasetripeptidyl peptidase I
Modification date2018051920180523
UniProtAcc

O60299

O14773

Ensembl transtripts involved in fusion geneENST00000329152, ENST00000360342, 
ENST00000337576, 
ENST00000299427, 
ENST00000533371, ENST00000534644, 
ENST00000528657, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 7 X 1=49
# samples 29
** MAII scorelog2(2/4*10)=2.32192809488736log2(9/49*10)=0.877143252214467
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LZTS3 [Title/Abstract] AND TPP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA367977LZTS3chr20

3143315

-TPP1chr11

6635271

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000329152ENST00000299427LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-3UTRENST00000329152ENST00000533371LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-intronENST00000329152ENST00000534644LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-intronENST00000329152ENST00000528657LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-3UTRENST00000360342ENST00000299427LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-3UTRENST00000360342ENST00000533371LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-intronENST00000360342ENST00000534644LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-intronENST00000360342ENST00000528657LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-3UTRENST00000337576ENST00000299427LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-3UTRENST00000337576ENST00000533371LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-intronENST00000337576ENST00000534644LZTS3chr20

3143315

-TPP1chr11

6635271

+
intron-intronENST00000337576ENST00000528657LZTS3chr20

3143315

-TPP1chr11

6635271

+

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FusionProtFeatures for LZTS3_TPP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LZTS3

O60299

TPP1

O14773

May be involved in promoting the maturation of dendriticspines, probably via regulating SIPA1L1 levels at the postsynapticdensity of synapses. {ECO:0000250|UniProtKB:Q8K1Q4}. Lysosomal serine protease with tripeptidyl-peptidase Iactivity. May act as a non-specific lysosomal peptidase whichgenerates tripeptides from the breakdown products produced bylysosomal proteinases. Requires substrates with an unsubstitutedN-terminus (By similarity). {ECO:0000250|UniProtKB:Q9EQV6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LZTS3_TPP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LZTS3_TPP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LZTS3_TPP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LZTS3_TPP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTPP1C1876161CEROID LIPOFUSCINOSIS, NEURONAL, 215CTD_human;ORPHANET;UNIPROT
TgeneTPP1C0027877Neuronal Ceroid-Lipofuscinoses2CTD_human
TgeneTPP1C0002395Alzheimer's Disease1CTD_human
TgeneTPP1C0033578Prostatic Neoplasms1CTD_human
TgeneTPP1C1836474SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 71ORPHANET;UNIPROT