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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20490

FusionGeneSummary for LZTS2_LZTS2

check button Fusion gene summary
Fusion gene informationFusion gene name: LZTS2_LZTS2
Fusion gene ID: 20490
HgeneTgene
Gene symbol

LZTS2

LZTS2

Gene ID

84445

84445

Gene nameleucine zipper tumor suppressor 2leucine zipper tumor suppressor 2
SynonymsLAPSER1LAPSER1
Cytomap

10q24.31

10q24.31

Type of geneprotein-codingprotein-coding
Descriptionleucine zipper putative tumor suppressor 2leucine zipper, putative tumor suppressor 2protein LAPSER1leucine zipper putative tumor suppressor 2leucine zipper, putative tumor suppressor 2protein LAPSER1
Modification date2018052220180522
UniProtAcc

Q9BRK4

Q9BRK4

Ensembl transtripts involved in fusion geneENST00000370223, ENST00000370220, 
ENST00000370223, ENST00000370220, 
Fusion gene scores* DoF score1 X 1 X 1=11 X 1 X 1=1
# samples 11
** MAII scorelog2(1/1*10)=3.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: LZTS2 [Title/Abstract] AND LZTS2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM462893LZTS2chr10

102766570

+LZTS2chr10

102763431

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000370223ENST00000370223LZTS2chr10

102766570

+LZTS2chr10

102763431

+
Frame-shiftENST00000370223ENST00000370220LZTS2chr10

102766570

+LZTS2chr10

102763431

+
Frame-shiftENST00000370220ENST00000370223LZTS2chr10

102766570

+LZTS2chr10

102763431

+
Frame-shiftENST00000370220ENST00000370220LZTS2chr10

102766570

+LZTS2chr10

102763431

+

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FusionProtFeatures for LZTS2_LZTS2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LZTS2

Q9BRK4

LZTS2

Q9BRK4

Negative regulator of katanin-mediated microtubulesevering and release from the centrosome. Required for centralspindle formation and the completion of cytokinesis. Maynegatively regulate axonal outgrowth by preventing the formationof microtubule bundles that are necessary for transport within theelongating axon. Negative regulator of the Wnt signaling pathway.Represses beta-catenin-mediated transcriptional activation bypromoting the nuclear exclusion of beta-catenin.{ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760,ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943,ECO:0000269|PubMed:18490357}. Negative regulator of katanin-mediated microtubulesevering and release from the centrosome. Required for centralspindle formation and the completion of cytokinesis. Maynegatively regulate axonal outgrowth by preventing the formationof microtubule bundles that are necessary for transport within theelongating axon. Negative regulator of the Wnt signaling pathway.Represses beta-catenin-mediated transcriptional activation bypromoting the nuclear exclusion of beta-catenin.{ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760,ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943,ECO:0000269|PubMed:18490357}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LZTS2_LZTS2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LZTS2_LZTS2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LZTS2_LZTS2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LZTS2_LZTS2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource