FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 20474

FusionGeneSummary for LYZ_CLDN18

check button Fusion gene summary
Fusion gene informationFusion gene name: LYZ_CLDN18
Fusion gene ID: 20474
HgeneTgene
Gene symbol

LYZ

CLDN18

Gene ID

4069

51208

Gene namelysozymeclaudin 18
SynonymsLYZF1|LZMSFTA5|SFTPJ
Cytomap

12q15

3q22.3

Type of geneprotein-codingprotein-coding
Descriptionlysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1claudin-18surfactant associated 5surfactant associated protein Jsurfactant, pulmonary associated protein J
Modification date2018052320180519
UniProtAcc

P61626

P56856

Ensembl transtripts involved in fusion geneENST00000261267, ENST00000549690, 
ENST00000548839, 
ENST00000343735, 
ENST00000183605, 
Fusion gene scores* DoF score19 X 13 X 6=14824 X 4 X 3=48
# samples 235
** MAII scorelog2(23/1482*10)=-2.68783968136146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: LYZ [Title/Abstract] AND CLDN18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLYZ

GO:0031640

killing of cells of other organism

9727055

HgeneLYZ

GO:0042742

defense response to bacterium

21093056

HgeneLYZ

GO:0050830

defense response to Gram-positive bacterium

21093056


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-BR-4267-01ALYZchr12

69747259

+CLDN18chr3

137751234

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000261267ENST00000343735LYZchr12

69747259

+CLDN18chr3

137751234

+
3UTR-3UTRENST00000261267ENST00000183605LYZchr12

69747259

+CLDN18chr3

137751234

+
3UTR-3UTRENST00000549690ENST00000343735LYZchr12

69747259

+CLDN18chr3

137751234

+
3UTR-3UTRENST00000549690ENST00000183605LYZchr12

69747259

+CLDN18chr3

137751234

+
intron-3UTRENST00000548839ENST00000343735LYZchr12

69747259

+CLDN18chr3

137751234

+
intron-3UTRENST00000548839ENST00000183605LYZchr12

69747259

+CLDN18chr3

137751234

+

Top

FusionProtFeatures for LYZ_CLDN18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LYZ

P61626

CLDN18

P56856

Lysozymes have primarily a bacteriolytic function; thosein tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Plays a major role in tight junction-specificobliteration of the intercellular space, through calcium-independent cell-adhesion activity. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LYZ_CLDN18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LYZ_CLDN18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LYZKHK, LRRK1, NME2, LTF, PARP11, USP1, USP25, CUL4B, CDK2, COPS6, CLU, GRK5, CRK, SMAD6, STAU1, AURKA, CEP57, NEDD1, TP53, FUS, RPS6KB2, NTRK1, MCM2, CRYAB, DDX31, FRMD1, HBM, SNX27, WWOX, CYLD, CDK1, TRIM25CLDN18THEM4, ACTBL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LYZ_CLDN18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for LYZ_CLDN18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLYZC0268389Amyloidosis, familial visceral1CTD_human;UNIPROT