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Fusion gene ID: 20456 |
FusionGeneSummary for LYRM4_FARS2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: LYRM4_FARS2 | Fusion gene ID: 20456 | Hgene | Tgene | Gene symbol | LYRM4 | FARS2 | Gene ID | 57128 | 10667 |
Gene name | LYR motif containing 4 | phenylalanyl-tRNA synthetase 2, mitochondrial | |
Synonyms | C6orf149|CGI-203|COXPD19|ISD11 | COXPD14|FARS1|HSPC320|PheRS|SPG77 | |
Cytomap | 6p25.1 | 6p25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | LYR motif-containing protein 4homolog of yeast Isd11mitochondrial matrix Nfs1 interacting protein | phenylalanine--tRNA ligase, mitochondrialdJ236A3.1 (phenylalanine-tRNA synthetase)dJ520B18.2 (FARS1 (phenylalanine-tRNA synthetase))mitochondrial PHERSphenylalanine tRNA ligase 2, mitochondrialphenylalanine translasephenylalanine-tRNA synthetase 1 ( | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9HD34 | O95363 | |
Ensembl transtripts involved in fusion gene | ENST00000330636, ENST00000468929, ENST00000464010, ENST00000480566, ENST00000500576, ENST00000606472, | ENST00000324331, ENST00000274680, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 9 X 7 X 7=441 |
# samples | 4 | 11 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/441*10)=-2.00327513203286 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LYRM4 [Title/Abstract] AND FARS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | FARS2 | GO:0006432 | phenylalanyl-tRNA aminoacylation | 10329163 |
Tgene | FARS2 | GO:0008033 | tRNA processing | 10329163 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | CESC | TCGA-LP-A5U2-01A | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
TCGA | RV | SKCM | TCGA-D3-A2J9-06A | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000330636 | ENST00000324331 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
In-frame | ENST00000330636 | ENST00000274680 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
intron-3CDS | ENST00000468929 | ENST00000324331 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
intron-3CDS | ENST00000468929 | ENST00000274680 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
In-frame | ENST00000464010 | ENST00000324331 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
In-frame | ENST00000464010 | ENST00000274680 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
In-frame | ENST00000480566 | ENST00000324331 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
In-frame | ENST00000480566 | ENST00000274680 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
In-frame | ENST00000500576 | ENST00000324331 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
In-frame | ENST00000500576 | ENST00000274680 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
intron-3CDS | ENST00000606472 | ENST00000324331 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
intron-3CDS | ENST00000606472 | ENST00000274680 | LYRM4 | chr6 | 5216851 | - | FARS2 | chr6 | 5613402 | + |
In-frame | ENST00000330636 | ENST00000324331 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
Frame-shift | ENST00000330636 | ENST00000274680 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
In-frame | ENST00000468929 | ENST00000324331 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
Frame-shift | ENST00000468929 | ENST00000274680 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
In-frame | ENST00000464010 | ENST00000324331 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
Frame-shift | ENST00000464010 | ENST00000274680 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
In-frame | ENST00000480566 | ENST00000324331 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
Frame-shift | ENST00000480566 | ENST00000274680 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
In-frame | ENST00000500576 | ENST00000324331 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
Frame-shift | ENST00000500576 | ENST00000274680 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
intron-3CDS | ENST00000606472 | ENST00000324331 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
intron-3CDS | ENST00000606472 | ENST00000274680 | LYRM4 | chr6 | 5260881 | - | FARS2 | chr6 | 5771524 | + |
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FusionProtFeatures for LYRM4_FARS2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LYRM4 | FARS2 |
Required for nuclear and mitochondrial iron-sulfurprotein biosynthesis. {ECO:0000269|PubMed:17331979,ECO:0000269|PubMed:19454487}. | Is responsible for the charging of tRNA(Phe) withphenylalanine in mitochondrial translation. To a lesser extent,also catalyzes direct attachment of m-Tyr (an oxidized version ofPhe) to tRNA(Phe), thereby opening the way for delivery of themisacylated tRNA to the ribosome and incorporation of ROS-damagedamino acid into proteins. {ECO:0000269|PubMed:19549855,ECO:0000269|PubMed:22833457}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >FARS2 | chr6:5216851 | chr6:5613402 | ENST00000274680 | + | 4 | 7 | 358_450 | 355 | 452 | Domain | FDX-ACB |
Tgene | >FARS2 | chr6:5216851 | chr6:5613402 | ENST00000324331 | + | 4 | 7 | 358_450 | 355 | 452 | Domain | FDX-ACB |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | FARS2 | chr6:5260881 | chr6:5771524 | ENST00000274680 | + | 5 | 7 | 358_450 | 405 | 452 | Domain | FDX-ACB |
Tgene | FARS2 | chr6:5260881 | chr6:5771524 | ENST00000324331 | + | 5 | 7 | 358_450 | 405 | 452 | Domain | FDX-ACB |
Tgene | FARS2 | chr6:5216851 | chr6:5613402 | ENST00000274680 | + | 4 | 7 | 157_160 | 355 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5216851 | chr6:5613402 | ENST00000274680 | + | 4 | 7 | 186_188 | 355 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5216851 | chr6:5613402 | ENST00000274680 | + | 4 | 7 | 193_195 | 355 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5216851 | chr6:5613402 | ENST00000324331 | + | 4 | 7 | 157_160 | 355 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5216851 | chr6:5613402 | ENST00000324331 | + | 4 | 7 | 186_188 | 355 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5216851 | chr6:5613402 | ENST00000324331 | + | 4 | 7 | 193_195 | 355 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5260881 | chr6:5771524 | ENST00000274680 | + | 5 | 7 | 157_160 | 405 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5260881 | chr6:5771524 | ENST00000274680 | + | 5 | 7 | 186_188 | 405 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5260881 | chr6:5771524 | ENST00000274680 | + | 5 | 7 | 193_195 | 405 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5260881 | chr6:5771524 | ENST00000324331 | + | 5 | 7 | 157_160 | 405 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5260881 | chr6:5771524 | ENST00000324331 | + | 5 | 7 | 186_188 | 405 | 452 | Region | Note=Substrate binding |
Tgene | FARS2 | chr6:5260881 | chr6:5771524 | ENST00000324331 | + | 5 | 7 | 193_195 | 405 | 452 | Region | Note=Substrate binding |
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FusionGeneSequence for LYRM4_FARS2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_LYRM4_ENST00000330636_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_166aa MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQPLSKYPAVINDISFWLPSENY >In-frame_LYRM4_ENST00000330636_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_166aa MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQPLSKYPAVINDISFWLPSENY >In-frame_LYRM4_ENST00000464010_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_166aa MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQPLSKYPAVINDISFWLPSENY >In-frame_LYRM4_ENST00000464010_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_166aa MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQPLSKYPAVINDISFWLPSENY >In-frame_LYRM4_ENST00000480566_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_166aa MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQPLSKYPAVINDISFWLPSENY >In-frame_LYRM4_ENST00000480566_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_166aa MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQPLSKYPAVINDISFWLPSENY >In-frame_LYRM4_ENST00000500576_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_166aa MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQPLSKYPAVINDISFWLPSENY >In-frame_LYRM4_ENST00000500576_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_166aa MAASSRAQVLSLYRAMLRESKRFSAYNYRTYAVRRIRDAFRENKNVKDPVEIQTLVNKAKRDLGVIRRQPLSKYPAVINDISFWLPSENY >In-frame_LYRM4_ENST00000330636_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_75aa >In-frame_LYRM4_ENST00000468929_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_75aa >In-frame_LYRM4_ENST00000464010_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_75aa >In-frame_LYRM4_ENST00000480566_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_75aa >In-frame_LYRM4_ENST00000500576_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_75aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_LYRM4_ENST00000330636_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_498nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGAACA TATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTAC GCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAG ACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCC >In-frame_LYRM4_ENST00000330636_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_498nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGAACA TATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTAC GCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAG ACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCC >In-frame_LYRM4_ENST00000464010_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_498nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGAACA TATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTAC GCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAG ACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCC >In-frame_LYRM4_ENST00000464010_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_498nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGAACA TATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTAC GCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAG ACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCC >In-frame_LYRM4_ENST00000480566_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_498nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGAACA TATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTAC GCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAG ACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCC >In-frame_LYRM4_ENST00000480566_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_498nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGAACA TATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTAC GCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAG ACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCC >In-frame_LYRM4_ENST00000500576_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_498nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGAACA TATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTAC GCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAG ACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCC >In-frame_LYRM4_ENST00000500576_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_498nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGAACA TATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTAC GCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAG ACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCC >In-frame_LYRM4_ENST00000330636_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_225nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGGACG CACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTG >In-frame_LYRM4_ENST00000468929_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_225nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGGACG CACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTG >In-frame_LYRM4_ENST00000464010_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_225nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGGACG CACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTG >In-frame_LYRM4_ENST00000480566_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_225nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGGACG CACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTG >In-frame_LYRM4_ENST00000500576_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_225nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGGACG CACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_LYRM4_ENST00000330636_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_704nt GCGCCCGCCCCCGAAGCGGCGCGGGACGCCTGGCGCCGTCCGCGATCCGCAGGGCTGCCCGCTTAGGCTTAGGCCCGGCCCGCTGGCAAA GCCGAGCCGCAGCATTTTATTTCGTTCGTGGTTTCCGCACAGGCTGGAGTTTCGTGGGTTGGGTCGTACTTGGGACCTCGGCGAAGAGGA CCCGTTTATTTTTTTTTCTTTCCAAAATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGC GTTTCAGCGCCTACAATTACAGAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAA TTCAAACCCTAGTGAATAAAGCCAAGAGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTT CATTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATC TCATAGACAAGTTTGTACATCCAAAGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGA >In-frame_LYRM4_ENST00000330636_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_855nt GCGCCCGCCCCCGAAGCGGCGCGGGACGCCTGGCGCCGTCCGCGATCCGCAGGGCTGCCCGCTTAGGCTTAGGCCCGGCCCGCTGGCAAA GCCGAGCCGCAGCATTTTATTTCGTTCGTGGTTTCCGCACAGGCTGGAGTTTCGTGGGTTGGGTCGTACTTGGGACCTCGGCGAAGAGGA CCCGTTTATTTTTTTTTCTTTCCAAAATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGC GTTTCAGCGCCTACAATTACAGAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAA TTCAAACCCTAGTGAATAAAGCCAAGAGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTT CATTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATC TCATAGACAAGTTTGTACATCCAAAGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGA GAGAGGTCAGGCACATCCACCAGGCCTTGCAGGAGGCTGCAGTCCAGCTGTTGGGTGTGGAGGGCAGGTTCTGATGTCACCACTTCACTC AGGCTGCAGCCCTCTTGGGGCTCCAGGATTTGCTGAAAGAGAAAAAGATATGGTTTGTGAACTGGGGCATCAATCATCTTTTGATAAATG >In-frame_LYRM4_ENST00000464010_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_498nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGAACA TATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTAC GCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAG ACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCC >In-frame_LYRM4_ENST00000464010_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_649nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGAACA TATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG AGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCTGAGAATTAC GCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTACATCCAAAG ACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCC TTGCAGGAGGCTGCAGTCCAGCTGTTGGGTGTGGAGGGCAGGTTCTGATGTCACCACTTCACTCAGGCTGCAGCCCTCTTGGGGCTCCAG GATTTGCTGAAAGAGAAAAAGATATGGTTTGTGAACTGGGGCATCAATCATCTTTTGATAAATGGATCAGTTTTAGGACTTTCAGAAAAT >In-frame_LYRM4_ENST00000480566_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_507nt CTTTCCAAAATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAAT TACAGAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAAT AAAGCCAAGAGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCT GAGAATTACGCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTA CATCCAAAGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATC >In-frame_LYRM4_ENST00000480566_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_658nt CTTTCCAAAATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAAT TACAGAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAAT AAAGCCAAGAGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTTCATTCTGGTTGCCCTCT GAGAATTACGCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATCTCATAGACAAGTTTGTA CATCCAAAGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATC CACCAGGCCTTGCAGGAGGCTGCAGTCCAGCTGTTGGGTGTGGAGGGCAGGTTCTGATGTCACCACTTCACTCAGGCTGCAGCCCTCTTG GGGCTCCAGGATTTGCTGAAAGAGAAAAAGATATGGTTTGTGAACTGGGGCATCAATCATCTTTTGATAAATGGATCAGTTTTAGGACTT >In-frame_LYRM4_ENST00000500576_chr6_5216851_-_FARS2_ENST00000324331_chr6_5613402_+_704nt GCGCCCGCCCCCGAAGCGGCGCGGGACGCCTGGCGCCGTCCGCGATCCGCAGGGCTGCCCGCTTAGGCTTAGGCCCGGCCCGCTGGCAAA GCCGAGCCGCAGCATTTTATTTCGTTCGTGGTTTCCGCACAGGCTGGAGTTTCGTGGGTTGGGTCGTACTTGGGACCTCGGCGAAGAGGA CCCGTTTATTTTTTTTTCTTTCCAAAATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGC GTTTCAGCGCCTACAATTACAGAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAA TTCAAACCCTAGTGAATAAAGCCAAGAGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTT CATTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATC TCATAGACAAGTTTGTACATCCAAAGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGA >In-frame_LYRM4_ENST00000500576_chr6_5216851_-_FARS2_ENST00000274680_chr6_5613402_+_855nt GCGCCCGCCCCCGAAGCGGCGCGGGACGCCTGGCGCCGTCCGCGATCCGCAGGGCTGCCCGCTTAGGCTTAGGCCCGGCCCGCTGGCAAA GCCGAGCCGCAGCATTTTATTTCGTTCGTGGTTTCCGCACAGGCTGGAGTTTCGTGGGTTGGGTCGTACTTGGGACCTCGGCGAAGAGGA CCCGTTTATTTTTTTTTCTTTCCAAAATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGC GTTTCAGCGCCTACAATTACAGAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAGAAAATAAAAATGTAAAGGATCCTGTAGAAA TTCAAACCCTAGTGAATAAAGCCAAGAGAGACCTTGGAGTAATTCGTCGACAGCCTCTTAGCAAATATCCGGCTGTGATCAATGATATTT CATTCTGGTTGCCCTCTGAGAATTACGCAGAAAATGATTTCTATGACTTAGTCCGAACAATTGGAGGAGACCTGGTGGAAAAGGTTGATC TCATAGACAAGTTTGTACATCCAAAGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGA GAGAGGTCAGGCACATCCACCAGGCCTTGCAGGAGGCTGCAGTCCAGCTGTTGGGTGTGGAGGGCAGGTTCTGATGTCACCACTTCACTC AGGCTGCAGCCCTCTTGGGGCTCCAGGATTTGCTGAAAGAGAAAAAGATATGGTTTGTGAACTGGGGCATCAATCATCTTTTGATAAATG >In-frame_LYRM4_ENST00000330636_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_431nt GCGCCCGCCCCCGAAGCGGCGCGGGACGCCTGGCGCCGTCCGCGATCCGCAGGGCTGCCCGCTTAGGCTTAGGCCCGGCCCGCTGGCAAA GCCGAGCCGCAGCATTTTATTTCGTTCGTGGTTTCCGCACAGGCTGGAGTTTCGTGGGTTGGGTCGTACTTGGGACCTCGGCGAAGAGGA CCCGTTTATTTTTTTTTCTTTCCAAAATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGC GTTTCAGCGCCTACAATTACAGGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAG >In-frame_LYRM4_ENST00000468929_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_234nt CTTTCCAAAATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAAT TACAGGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCAC >In-frame_LYRM4_ENST00000464010_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_225nt ATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAATTACAGGACG CACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCACCAGGCCTTG >In-frame_LYRM4_ENST00000480566_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_234nt CTTTCCAAAATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTTCAGCGCCTACAAT TACAGGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAGAGGTCAGGCACATCCAC >In-frame_LYRM4_ENST00000500576_chr6_5260881_-_FARS2_ENST00000324331_chr6_5771524_+_431nt GCGCCCGCCCCCGAAGCGGCGCGGGACGCCTGGCGCCGTCCGCGATCCGCAGGGCTGCCCGCTTAGGCTTAGGCCCGGCCCGCTGGCAAA GCCGAGCCGCAGCATTTTATTTCGTTCGTGGTTTCCGCACAGGCTGGAGTTTCGTGGGTTGGGTCGTACTTGGGACCTCGGCGAAGAGGA CCCGTTTATTTTTTTTTCTTTCCAAAATGGCAGCCTCCAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGC GTTTCAGCGCCTACAATTACAGGACGCACAAGACCAGCCACTGCTACCGCATCACGTACCGCCACATGGAACGGACTCTGTCCCAGAGAG |
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FusionGenePPI for LYRM4_FARS2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LYRM4 | PVRL2, ZWINT, HLA-DPB1, NDUFAB1, CDNF, NFS1, ISCU, LYRM4, FXN, IDE, NRD1, CHCHD2, PMPCA, PMPCB, HOGA1, DDAH1, ECH1, BCKDHA, C1QBP, KLHL22, GPX7 | FARS2 | USP45, G3BP2, ICT1, ISG15, CUL3, RCBTB2, KRT13, KRT31, TRIM27, TADA2A, TFCP2, MKRN3, STX11, CALCOCO2, MID2, IKZF3, APPL1, ADAMTSL4, AGTRAP, TRIM54, HMBOX1, CMTM5, KRT40, KRTAP10-7, KRTAP10-9, KRTAP10-5, KRTAP10-3, NOTCH2NL, ENO1, SHMT2, NXF1, HIST1H1A, ZC3H3, HNRNPA1, GAMT, STAT5A, TOMM40, CHST15, NEDD1, CHCHD2, MRPL38, HIST1H1E, HIST1H1T, ZCRB1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LYRM4_FARS2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LYRM4_FARS2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LYRM4 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | LYRM4 | C3810055 | COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 19 | 1 | UNIPROT |
Tgene | FARS2 | C3554168 | COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 14 | 2 | ORPHANET;UNIPROT |