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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20407

FusionGeneSummary for LUC7L3_MIA-RAB4B

check button Fusion gene summary
Fusion gene informationFusion gene name: LUC7L3_MIA-RAB4B
Fusion gene ID: 20407
HgeneTgene
Gene symbol

LUC7L3

MIA-RAB4B

Gene ID

51747

100529262

Gene nameLUC7 like 3 pre-mRNA splicing factorMIA-RAB4B readthrough (NMD candidate)
SynonymsCRA|CREAP-1|CROP|LUC7A|OA48-18|hLuc7A-
Cytomap

17q21.33

19q13.2

Type of geneprotein-codingncRNA
Descriptionluc7-like protein 3CRE-associated protein 1LUC7-like 3cAMP regulatory element-associated protein 1cisplatin resistance-associated-overexpressed proteinokadaic acid-inducible phosphoprotein OA48-18-
Modification date2018052320180329
UniProtAcc

O95232

Ensembl transtripts involved in fusion geneENST00000505658, ENST00000393227, 
ENST00000311571, ENST00000240304, 
ENST00000544170, ENST00000503798, 
ENST00000600729, 
Fusion gene scores* DoF score12 X 8 X 6=5761 X 1 X 1=1
# samples 141
** MAII scorelog2(14/576*10)=-2.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: LUC7L3 [Title/Abstract] AND MIA-RAB4B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB500866LUC7L3chr17

48828940

+MIA-RAB4Bchr19

41284182

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000505658ENST00000600729LUC7L3chr17

48828940

+MIA-RAB4Bchr19

41284182

+
3UTR-intronENST00000393227ENST00000600729LUC7L3chr17

48828940

+MIA-RAB4Bchr19

41284182

+
intron-intronENST00000311571ENST00000600729LUC7L3chr17

48828940

+MIA-RAB4Bchr19

41284182

+
intron-intronENST00000240304ENST00000600729LUC7L3chr17

48828940

+MIA-RAB4Bchr19

41284182

+
intron-intronENST00000544170ENST00000600729LUC7L3chr17

48828940

+MIA-RAB4Bchr19

41284182

+
intron-intronENST00000503798ENST00000600729LUC7L3chr17

48828940

+MIA-RAB4Bchr19

41284182

+

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FusionProtFeatures for LUC7L3_MIA-RAB4B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LUC7L3

O95232

MIA-RAB4B

Binds cAMP regulatory element DNA sequence. May play arole in RNA splicing. {ECO:0000269|PubMed:16462885}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LUC7L3_MIA-RAB4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LUC7L3_MIA-RAB4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LUC7L3_MIA-RAB4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LUC7L3_MIA-RAB4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource