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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 20393

FusionGeneSummary for LUC7L2_ETV1

check button Fusion gene summary
Fusion gene informationFusion gene name: LUC7L2_ETV1
Fusion gene ID: 20393
HgeneTgene
Gene symbol

LUC7L2

ETV1

Gene ID

51631

2115

Gene nameLUC7 like 2, pre-mRNA splicing factorETS variant 1
SynonymsCGI-59|CGI-74|LUC7B2ER81
Cytomap

7q34

7p21.2

Type of geneprotein-codingprotein-coding
Descriptionputative RNA-binding protein Luc7-like 2LUC7-like 2ETS translocation variant 1ets variant gene 1ets-related protein 81
Modification date2018052320180523
UniProtAcc

P50549

Ensembl transtripts involved in fusion geneENST00000541515, ENST00000430479, 
ENST00000399357, ENST00000420159, 
ENST00000343495, ENST00000242066, 
ENST00000405192, ENST00000405358, 
ENST00000403527, ENST00000405218, 
ENST00000403685, ENST00000476720, 
Fusion gene scores* DoF score9 X 9 X 6=48611 X 14 X 3=462
# samples 1127
** MAII scorelog2(11/486*10)=-2.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(27/462*10)=-0.774933444365227
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LUC7L2 [Title/Abstract] AND ETV1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneETV1

GO:0045944

positive regulation of transcription by RNA polymerase II

12750007


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-CH-5745-01ALUC7L2chr7

139045068

+ETV1chr7

13978871

-
TCGARVPRADTCGA-EJ-5510-01ALUC7L2chr7

139045068

+ETV1chr7

13978871

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000541515ENST00000430479LUC7L2chr7

139045068

+ETV1chr7

13978871

-
intron-3CDSENST00000541515ENST00000399357LUC7L2chr7

139045068

+ETV1chr7

13978871

-
intron-3CDSENST00000541515ENST00000420159LUC7L2chr7

139045068

+ETV1chr7

13978871

-
intron-3CDSENST00000541515ENST00000343495LUC7L2chr7

139045068

+ETV1chr7

13978871

-
intron-3CDSENST00000541515ENST00000242066LUC7L2chr7

139045068

+ETV1chr7

13978871

-
intron-3CDSENST00000541515ENST00000405192LUC7L2chr7

139045068

+ETV1chr7

13978871

-
intron-3CDSENST00000541515ENST00000405358LUC7L2chr7

139045068

+ETV1chr7

13978871

-
intron-3CDSENST00000541515ENST00000403527LUC7L2chr7

139045068

+ETV1chr7

13978871

-
intron-3CDSENST00000541515ENST00000405218LUC7L2chr7

139045068

+ETV1chr7

13978871

-
intron-3CDSENST00000541515ENST00000403685LUC7L2chr7

139045068

+ETV1chr7

13978871

-
intron-5UTRENST00000541515ENST00000476720LUC7L2chr7

139045068

+ETV1chr7

13978871

-

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FusionProtFeatures for LUC7L2_ETV1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LUC7L2

ETV1

P50549

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for LUC7L2_ETV1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for LUC7L2_ETV1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
LUC7L2RNPS1, YWHAG, YWHAQ, PTCD3, LUC7L2, PEA15, NKAP, SSFA2, SVIL, KLHL20, ALB, ATRX, LINC00341, NAT9, NDUFA4L2, LPL, UNC119, MAN2A2, MAP1LC3B, FAM173A, NAP1L5, NASP, NUTF2, OFD1, SAT1, ZCCHC10, CDK5RAP2, CCDC53, FXR1, CHD3, KIAA1377, PTN, NSF, ULK2, RRP1B, MEPCE, IKBKG, NEDD4, RBM39, NOP56, NDEL1, EXOC1, GSK3B, GADD45G, AIMP2, PDPK1, CDC37, CDK4, SETDB1, PIK3R3, JMJD6, ELAVL1, CUL3, COPS5, CAND1, HAP1, APP, RPL19, RPL15, RPL18A, RPL7A, RPS4X, SNRPD2, RPLP0P6, BARD1, PAXIP1, CD81, SRPK2, SRPK1, TARDBP, CARS, HSPA4L, ARFIP1, ATP6V1C1, PBDC1, IVNS1ABP, MAN2B1, STAT3, SHMT2, STAU1, HUWE1, NFYA, SRSF6, SRSF7, APPBP2, EZH2, SUZ12, RNF2, EAF1, TRA2A, ZRANB2, LUC7L, CSNK2A2, LARP7, ZC3H18, BCLAF1, THRAP3, PRPF4B, CCDC9, ACIN1, C17orf85, C1QBP, PABPC4, GPATCH8, U2AF2, PAIP1, UBE2O, RBM22, PNN, LARP1, LARP1B, SRSF1, SNW1, CLASRP, PAIP2B, SRRT, CSNK2A1, CCDC12, LUC7L3, MOV10, CDC40, DDX46, SF3A1, ZC3H14, CPSF6, SNRNP27, CLK3, IK, CASC3, FAM98A, FTL, SNRNP70, MKRN2, SCAF11, MKRN1, TRA2B, SRSF8, SRSF12, SRSF10, SREK1, CLK2, HNRNPR, DDX5, PABPC1, PRPF6, PRPF8, RBM8A, RPL22, SNRPD3, SRSF11, TIA1, SF3B3, SNRNP200, SNRPD1, SNRPE, SYNCRIP, U2AF1, SFN, NTRK1, CNTRL, OTUB1, RC3H1, CRBN, FTH1, PPIL4, ISY1, SRRM2, INO80B, RPAP3, FOXA1, TRIM25, UHRF2ETV1SPI1, MAPK8, MAPK3, MAPK14, MAPKAPK2, EP300, KAT2B, RFWD2, RPS6KA5, NSMCE2, CCND3, NCOA3, NCOA2, JUN, UBE2I, STK40, DET1, TP53, TERT, ATR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for LUC7L2_ETV1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for LUC7L2_ETV1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneETV1C0033578Prostatic Neoplasms2CTD_human