FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 20392

FusionGeneSummary for LUC7L2_CHD2

check button Fusion gene summary
Fusion gene informationFusion gene name: LUC7L2_CHD2
Fusion gene ID: 20392
HgeneTgene
Gene symbol

LUC7L2

CHD2

Gene ID

51631

1826

Gene nameLUC7 like 2, pre-mRNA splicing factorDS cell adhesion molecule
SynonymsCGI-59|CGI-74|LUC7B2CHD2|CHD2-42|CHD2-52
Cytomap

7q34

21q22.2

Type of geneprotein-codingprotein-coding
Descriptionputative RNA-binding protein Luc7-like 2LUC7-like 2Down syndrome cell adhesion molecule
Modification date2018052320180519
UniProtAcc

O14647

Ensembl transtripts involved in fusion geneENST00000541515, ENST00000394196, 
ENST00000557381, ENST00000420239, 
ENST00000536619, ENST00000554122, 
Fusion gene scores* DoF score9 X 9 X 6=4865 X 7 X 2=70
# samples 117
** MAII scorelog2(11/486*10)=-2.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/70*10)=0
Context

PubMed: LUC7L2 [Title/Abstract] AND CHD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCHD2

GO:0042327

positive regulation of phosphorylation

19196994

TgeneCHD2

GO:0048842

positive regulation of axon extension involved in axon guidance

18585357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI078265LUC7L2chr7

139030246

-CHD2chr15

93568126

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000541515ENST00000394196LUC7L2chr7

139030246

-CHD2chr15

93568126

-
intron-intronENST00000541515ENST00000557381LUC7L2chr7

139030246

-CHD2chr15

93568126

-
intron-intronENST00000541515ENST00000420239LUC7L2chr7

139030246

-CHD2chr15

93568126

-
intron-intronENST00000541515ENST00000536619LUC7L2chr7

139030246

-CHD2chr15

93568126

-
intron-intronENST00000541515ENST00000554122LUC7L2chr7

139030246

-CHD2chr15

93568126

-

Top

FusionProtFeatures for LUC7L2_CHD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LUC7L2

CHD2

O14647

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. DNA-binding helicase that specifically binds to thepromoter of target genes, leading to chromatin remodeling,possibly by promoting deposition of histone H3.3. Involved inmyogenesis via interaction with MYOD1: binds to myogenic generegulatory sequences and mediates incorporation of histone H3.3prior to the onset of myogenic gene expression, promoting theirexpression (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for LUC7L2_CHD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for LUC7L2_CHD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for LUC7L2_CHD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for LUC7L2_CHD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHD2C0014544Epilepsy1CTD_human
TgeneCHD2C3809278EPILEPTIC ENCEPHALOPATHY, CHILDHOOD-ONSET1UNIPROT